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 發報日期 : 2021/07/05 發行期數:265 
 
 
 

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新書展示
 
 
展期:2021-07-05 ~ 2021-07-12
 
 
 
 
 
 
 
期刊投稿折扣
 
 
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(NAR機構會員驗證網址修復中,相關問題請洽生圖)
 
 
 
 
 
 
 
恭喜吳素幸所長獲選美國植物生物學會通訊終身會員
 
 
該獎項為美國以外的傑出植物生物學家提供美國植物生物學家協會的終身會員資格和協會出版物。
 
 
 
 
 
 

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試用期限:2021/7/5~2021/9/4
 
 
 
 
 
 
 
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「提升免疫,吃出健康」演講影片
 
 
面對疫情,我們該怎麼吃,能提高免疫力呢?歡迎欣賞精彩的影片內容。
 
 
 
 
 
 

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生命組演講公告

 
 
 
 
植微所演講
 
 
講題:The Role of Phosphocholine in Root Development
主講者:Dr.諾海安
時間:2021-07-16 10:30
地點:Presented by Webex Meeting
 
 
 
 
 
 
 
國家生技研究園區學苑7月生醫創業講座線上英文演講
 
 
講題:Innovation Roadmap and business model
主講者:Heerd Jan Hoogeveen (Managing Director, Startup Utrecht)
時間:7/7, 7/9, 7/14, 7/16
地點:線上演講
 
 
 
 
 
 

生命組研究成果重要發現

 
 
 
 
H3K4 Methylation in Aging and Metabolism
 
 
During the process of aging, extensive epigenetic alterations are made in response to both exogenous and endogenous stimuli. Here, we summarize the current state of knowledge regarding one such alteration, H3K4 methylation (H3K4me), as it relates to aging in different species.
 
 
 
 
 
 
 
 
Identification of COVID-19 B-cell epitopes with phage-displayed peptide library
 
 
To find disease-specific B-cell epitopes that correspond to or mimic natural epitopes, we used phage display technology to determine the targets of specific antibodies present in the sera of immune-responsive COVID-19 patients.
 
 
 
 
 
 
 
 
Experimental evolution improves mitochondrial genome quality control in Saccharomyces cerevisiae and extends its replicative lifespan
 
 
The mitochondrion is an ancient endosymbiotic organelle that performs many essential functions in eukaryotic cells.1–3 Mitochondrial impairment often results in physiological defects or diseases.2–8 Since most mitochondrial genes have been copied into the nuclear genome during evolution,9 the regulatory and interaction mechanisms between the mitochondrial and nuclear genomes are very complex. Multiple mechanisms, including antioxidant, DNA repair, mitophagy, and mitochondrial biogenesis pathways, have been shown to monitor the quality and quantity of mitochondria.
 
 
 
 
 
 
 
 
Plastic rewiring of Sef1 transcriptional networks and the potential of non-functional transcription factor binding in facilitating adaptive evolution
 
 
Prior and extensive plastic rewiring of a transcriptional network, followed by a functional switch of the conserved transcriptional regulator, can shape the evolution of a new network with diverged functions. The presence of three distinct iron regulatory systems in fungi that use orthologous transcriptional regulators suggests that these systems evolved in that manner.
 
 
 
 
 
 
 
 
Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7
 
 
Toll-like receptor (TLR) signaling is critical for defense against pathogenic infection, as well as for modulating tissue development. Activation of different TLRs triggers common inflammatory responses such as cytokine induction. Here, we reveal differential impacts of TLR3 and TLR7 signaling on transcriptomic profiles in bone marrow-derived macrophages (BMDMs).
 
 
 
 
 
 
 
 
Infection-induced inflammation from specific inborn errors of immunity to COVID-19
 
 
Inborn error of immunity (IEIs) are a group of genetically-defined disorders leading to defective immunity. Some IEIs have been linked to mutations of immune receptors or signaling molecules, resulting in defective signaling of respective cascades essential for combating specific pathogens. However, it remains incompletely understood why in selected IEIs, such as X-linked lymphoproliferative syndrome type-2 (XLP-2), hypo-immune response to specific pathogens results in persistent inflammation.
 
 
 
 
 
 
 
 
Activation of Prp28 ATPase at the Heart of Spliceosome for Spliceosomal Remodeling
 
 
Rubik’s Cube is one of the most popular 3D combinatorial games that captivates the world with its amazing complexity hidden behind the deceptively simplistic six bright colors. Remarkably, the most accomplished players can solve a completely scrambled Rubik’s Cube in less than twelve seconds. Few people, however, know that there is an equally complex Rubik’s Cube-like molecular machine in the cell. This machine is called “Spliceosome”, which must be sequentially remodeled or tweaked, just like the Rubik’s Cube, before it can be properly functioning in the gene expression pathway.
 
 
 
 
 
 
 
 
Anti-Siglec-3 mAb as immune checkpoint inhibitor to combat Hepatitis B infection
 
 
Hepatitis B virus (HBV) infection is a worldwide health problem. According to WHO’s report, there are over 257 million peoples globally infected by hepatitis B virus. HBV infection is prevalent in China, Taiwan, and Southeast Asia countries. Approximately 887,000 individuals die each year from HBV-related liver diseases or liver cancer.
 
 
 
 
 
 
 
 
 
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