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 發報日期 : 2021/08/02 發行期數:267 
 
 
 

最新消息

 
 
 
 
新書展示
 
 
展期:2021-08-02 ~ 2021-08-09
 
 
 
 
 
 
 
賀分生所薛雁冰副研究員榮獲第17屆李天德青年醫藥科技獎
 
 
 
 
 
 
 
 

館務公告

 
 
生圖二級防疫開館政策
 
 
生圖二級防疫開館政策
 
 
7/27-8/9僅開放院內同仁憑識別證入館,請掃描簡訊實聯制、量額温、戴口罩、保持社交距離
 
 
 
 
 
 

資料庫介紹

 
 
 
 
IPA 2021年夏季發布的新功能
 
 
New Canonical Signaling Pathway
Updates to four existing Canonical Signaling Pathways
>300,000 new findings (bringing the total in IPA to over 8.1 million)
>6000 new datasets (for a total of >96,000) are now available in Analysis Match, Activity Plot and Pattern Search
 
 
 
 
 
Turnitin修護公告
 
 
Turnitin修護公告
 
 
Turnitin 將於 2021/08/14(六)PM 23:00 ~ 2021/08/15(日)AM 01:00 進行系統維護,在此期間用戶將無法登入或是無法產生報告。
 
 
 
 
 
 

影音服務

 
 
 
 
徐尚德老師Podcast 專訪:SARS-CoV-2 Variants
 
 
生化所徐尚德老師接受 Podcast 英文教學頻道「英文小宇宙」專訪,講述 SARS-CoV-2 variants 的現況和研究成果。
 
 
 
 
 
 

Blog

 
 
 
 
八里夏季的紅螯螳臂蟹
 
 
每年的五到八月是陸蟹繁殖的高峰期,在淡水河兩岸及鄰近的竹圍紅樹林沿岸以及關渡沿線,較能看見紅螯螳臂蟹的蹤跡......
 
 
 
 
 
 

生命組演講公告

 
 
 
 
8/10 植微所演講
 
 
講題:利用比較基因體學探討水稻之馴化及在地適應關係
主講者:吳正杰先生
時間:2021-08-10 11:00
地點:Presented by Webex Meeting
 
 
 
 
 
 
 
8/10 分生所演講
 
 
講題:Anti-interferon-γ autoantibodies underlie the adult immune dysregulations: from antibodies to infections
主講者:Dr. 顧正崙
時間:8/10 11:00am
地點:Online Webex
 
 
 
 
 
 
 
8/13 植微所演講
 
 
講題1:Unraveling the regulatory roles of the clock protein LWD1 in gene expression regulation underlying Arabidopsis photomorphogenesis and photoperiodic flowering
主講者:Dr.黃俊凱
講題2:Big data analyses for identifying direct target genes of the clock protein LWD1
主講者:Dr.林心仁
時間:2021-08-13 10:30
地點:Presented by Webex Meeting
 
 
 
 
 
 

研討會資訊

 
 
 
 
EndNote 核心功能線上講座
 
 
時間: 8/5 12:10 - 13:10
主辦者: 碩睿資訊公司
 
 
 
 
 
 
 
邁向開放取用 (OA) 的出版之路:現況與未來,一次搞懂
 
 
日期: 2021年8月26日(四) 15:00-17:00 pm
主辦: 國研院科政中心CONCERT、科技部圖書服務計畫化學中心總圖書室 Chem Library、全球最大非營利科學組織ACS美國化學會
協辦: iGroup Taiwan
 
 
 
 
 
 
 
營運計畫書撰寫實務課程及工作坊 | 讓大師帶你寫BP
 
 
國家生技研究園區學苑推出「營運計畫書撰寫實務課程及工作坊」8/7即將正式開課!
 
 
 
 
 
 

生命組研究成果重要發現

 
 
 
 
真正的英雄——「鋼鐵人」
 
 
施臥虎老師實驗室的研究發現將IMA1 和 IMA2 胜肽透過異位表現的方式能增加轉錄因子MYB72和東莨菪鹼 8-羥化酶(SCOPOLETIN 8-HYDROXYLASE, S8H)之基因表現可以誘導兒茶酚香豆素(fraxetin)的生合成和分泌兒茶酚香豆素(7,8-dihydroxy-6-methoxycoumarin),促進植物在鈣質土壤下的環境生長,此反應機制與環境的pH值息息相關(Gautam et al., 2021)
 
 
 
 
 
 
 
 
Ustilago maydis的特殊功能效應子Vp1在玉米質外體中加工以促進致病力
 
 
U. maydis 憑著釋放大量的效應蛋白使玉米引起黑穗病。對於大部分效應蛋白的分子機制並不清楚,因此阻礙了我們對真菌毒力機制的理解。其中一個新穎的效應蛋白,Vp1,透過序列切割獲得專門的功能,以促進真菌對寄主的寄生能力及致病力。目前對於此效應蛋白為何需要在質外體進行處理並不了解。然而,處理後的效應蛋白會決定其致病力功能,且對Vp1定位至植物細胞核是必要的。
 
 
 
 
 
 
 
 
Condition-dependent structural collapse in the intrinsically disordered N-terminal domain of prion protein
 
 
Prion protein is composed of a structure-unsolved N-terminal domain and a globular C-terminal domain. Under limited trypsin digestion, mouse recombinant prion protein can be cleaved into two parts at residue Lys105. Here, we termed these two fragments as the N-domain (sequence 23-105) and the C-domain (sequence 106-230). In this study, the structural properties of the N-domain, the C-domain, and the full-length protein were explored using small-angle X-ray scattering, analytical ultracentrifugation, circular dichroism spectroscopy, and the 8-anilino-1-naphthalenesulfonic acid binding assay. The conformation and size of the prion protein were found to change sensitively under the solvent conditions.
 
 
 
 
 
 
 
 
Structure-activity relationship of avocadyne
 
 
Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively in avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression.
 
 
 
 
 
 
 
 
Preparation of High-Temperature Sample Grids for Cryo-EM
 
 
The sample grids for cryo-electron microscopy (cryo-EM) experiments are usually prepared at a temperature optimal for the storage of biological samples, mostly at 4 °C and occasionally at room temperature. Recently, we discovered that the protein structure solved at low temperature may not be functionally relevant, particularly for proteins from thermophilic archaea. A procedure was developed to prepare protein samples at higher temperatures (up to 70 °C) for cryo-EM analysis.
 
 
 
 
 
 
 
 
Structural and bioinformatic analyses of Azemiops venom serine proteases reveal close phylogeographic relationships to pitvipers from eastern China and the New World
 
 
The semi-fossil and pit-less Azemiops feae is possibly the most primitive crotalid species. Here, we have cloned and sequenced cDNAs encoding four serine proteases (vSPs) from the venom glands of Chinese A. feae. Full amino-acid sequences of the major vSP (designated as AzKNa) and three minor vSPs (designated as AzKNb, AzKNc and Az-PA) were deduced. Using Protein-BLAST search, the ten most-similar vSPs for each Azemiops vSP have been selected for multiple sequence alignment, and all the homologs are crotalid vSPs.
 
 
 
 
 
 
 
 
尋找會對抗新冠病毒的人類及其他靈長類的ACE2突變
 
 
目前已知人類會感染新冠病毒,但其他靈長類呢? 新冠病毒是透過其 S-蛋白(spike protein, 刺突蛋白)與人類 ACE2(血管收縮素轉化酶2)的結合而感染人類。ACE2在與 S-蛋白結合的介面上有 27 個胺基酸,如果在這些位點上產生突變則很可能影響ACE2與S-蛋白結合的親和力,進而影響感染效率。從人類基因序列數據庫中,我們在這27個位點上找到了 9 個突變。
 
 
 
 
 
 
 
 
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