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Specially commissioned lectures by leading world experts.

                                                                                                                                                                                                                                                                 

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The Biomedical & Life Sciences Collection

Latest Releases

The immunology underlying rheumatic diseases

The immunology underlying rheumatic diseases

Dr. Hussein Al-Mossawi
University of Oxford, UK

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The emergence of the SARS-CoV-2 Omicron variant

The emergence of the SARS-CoV-2 Omicron variant

Prof. Emma Thomson
University of Glasgow, UK

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How is Omicron different?

How is Omicron different?

Prof. Emma Thomson
University of Glasgow, UK

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The mononuclear phagocyte system - tissue resident macrophages: distribution and functions

The mononuclear phagocyte system - tissue resident macrophages: distribution and functions

Prof. Emeritus Siamon Gordon
University of Oxford, UK

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The mononuclear phagocyte system: tissue resident macrophages - activation and regulation

The mononuclear phagocyte system: tissue resident macrophages - activation and regulation

Prof. Emeritus Siamon Gordon
University of Oxford, UK

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Signal transduction by leukocyte receptors

Signal transduction by leukocyte receptors

Dr. Omer Dushek
University of Oxford, UK

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Lineage decisions in the thymus: T cell lineage commitment

Lineage decisions in the thymus: T cell lineage commitment

Prof. Bruno Silva-Santos
University of Lisbon, Portugal

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Lineage decisions in the thymus: αβ and γδ T cell lineages

Lineage decisions in the thymus: αβ and γδ T cell lineages

Prof. Bruno Silva-Santos
University of Lisbon, Portugal

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Modulating  gene expression to treat diseases

Modulating gene expression to treat diseases

Dr. Navneet Matharu
University of California San Francisco, USA

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Regulation of ATMPs in Europe: present and future

Regulation of ATMPs in Europe: present and future

Dr. Ana Hidalgo-Simon
European Medicines Agency, The Netherlands

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Immunotherapy: CARs on the fast-track to treat cancer

Immunotherapy: CARs on the fast-track to treat cancer

Dr. Joseph A. Fraietta
University of Pennsylvania, USA

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Live Webinar: Treating autoimmune and inflammatory diseases with enhanced regulatory T-cells
Prof. David Klatzmann | Sorbonne University, France

Interleukin-2 (IL-2) is the main cytokine supporting regulatory T-cells (Tregs) development, survival and suppressive activity. However, Tregs cannot produce IL-2 and fully depend on exogenous IL-2.

Treg cell therapy products are grown for weeks in culture medium containing IL-2 concentration that are 10,000-fold higher than the IL-2 serum concentration in humans. This generates “IL-2 addicted” Tregs that might not survive well and/or function optimally when reinjected in patients. We reasoned that Tregs that could produce their own IL-2 would have markedly improved therapeutic potential. What did we discover?

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