中央研究院生命科學圖書館 -- 生命組研究成果

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生命組研究成果

細胞與個體生物學研究所 - 郭紘志 Hung-Chih Kuo 著作

期刊 68

Chen TC, Chou YJ, Wu YX, Lo JE, Lin CY, Tseng YH, Chu YC, Chen WL, Hu FR, Su WF, Kuo HC*. Biocompatible neuronal stimulant-embedded poly(γ-benzyl-L-glutamate) peptide-based scaffolds promote differentiation, growth and functional maturation of human induced pluripotent stem cell-derived retinal ganglion cells. Journal of the Taiwan Institute of Chemical Engineers. xx, x-x, 2023-11-21. [JCR]　[WOS]
Siew JJ, Chen HM, Chiu FL, Lee CW, Chang YM, Chen HL, Nguyen TNA, Liao HT, Liu M, Hagar HT, Sun YC, Lai HL, Kuo MH, Blum D, Buée L, Jin LW, Chen SY, Ko TM, Huang JR, Kuo HC, Liu FT, Chern Y. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. JOURNAL OF CLINICAL INVESTIGATION. x, x-x, 2023-11-21. [JCR]　[WOS]
Tsai TY, Chen CY, Lin TW, Lin TC, Chiu FL, Shih O, Chang MY, Lin YC, Su AC, Chen CM, Jeng US, (Kuo HC), Chang CF, Chen YR. Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity. COMMUNICATIONS BIOLOGY. 6(1), 767, 2023-07-21. [JCR]　[WOS]
Weng YT, Chen HM, Chien T, Chiu FL, (Kuo HC), Chern Y. TRAX Provides Neuroprotection for Huntington's Disease Via Modulating a Novel Subset of MicroRNAs. MOVEMENT DISORDERS. 37(10), 2008-2020, 2022-10. [JCR]　[WOS]
Hou PS, (Kuo HC*). Central nervous system organoids for modeling neurodegenerative diseases. IUBMB LIFE. 74(8), 812-825, 2022-08. [JCR]　[WOS]
Deng N, Wu YY, Feng Y, Hsieh WC, Song JS, Lin YS, Tseng YH, Liao WJ, Chu YF, Liu YC, Chang EC, Liu CR, Sheu SY, Su MT, (Kuo HC), Cohen SN, Cheng TH. Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes. PNAS. 119(32), 1-9, 2022-08. [JCR]　[WOS]
An HL, (Kuo HC), Tang TK. Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 10:830432, 1-18, 2022-03. [JCR]　[WOS]
Liu YJ, (Kuo HC), Chern Y. A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS. NEUROBIOLOGY OF DISEASE. 160, 105531, 2021-12. [JCR]　[WOS]
Chiang SY, Wu HC, lIN sy, Chen HY, Wang CF, Yeh NH, Shih JH, Huang YS, (Kuo HC), Chou SJ, cHEN rh. Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization. SCIENCE ADVANCES. 7(7), 6093, 2021-02. [JCR]　[WOS]
Wu YY, (Kuo HC)*. Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases. JOURNAL OF BIOMEDICAL SCIENCE. 27(1):49, 2020-04. [JCR]　[WOS]
Huang HP, Chiang W, Chuang CY, Stone L, Kang CK, Hwu WL, (Kuo HC)*. Using Human Pompe Disease Induced Pluripotent Stem Cells-derived Neural Cells for Identifying Chemicals with Therapeutic Potential. HUMAN MOLECULAR GENETICS. 28(23):3880-3894, 2019-12. [JCR]　[WOS]
Chen WC, Chang LH, Huang SS, Huang YJ, Chih CL, (Kuo HC), Lee YH, Lee IH. Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain. JOURNAL OF NEUROINFLAMMATION. 16(1):187, 2019-10. [JCR]　[WOS]
Huang CC, Chen MJ, Lan CW, Wu CE, Huang MC, (Kuo HC), Ho HN. Hyperactive CREB signaling pathway involved in the pathogenesis of polycystic ovarian syndrome revealed by patient-specific induced pluripotent stem cell modeling. FERTILITY AND STERILITY. 112(3),594-607, 2019-09. [JCR]　[WOS]
Yu CY, and (Kuo HC)*. The emerging roles and functions of circular RNAs and their generation. JOURNAL OF BIOMEDICAL SCIENCE. 26,29, 2019-04. [JCR]　[WOS]
Chuang CY, Yang CC, Soong BW, Yu CY, Chen SH, Huang HP, (Kuo HC)*. Modeling spinocerebellar ataxias 2 and 3 with iPSCs reveals a role for glutamate in disease pathology. SCIENTIFIC REPORTS. 9,1166, 2019-02. [JCR]　[WOS]
Wu YY, Chiu FL, Yeh CS, (Kuo HC)*. Opportunities and challenges of induced pluripotent stem cells in neurodegenerative diseases. OPEN BIOLOGY. 9(1), 180177, 2019-01. [JCR]　[WOS]
Chien T, Weng YT, Chang SY, Lai HL, Chiu FL, Kuo HC, Chuang DM, Chern Y. GSK3beta negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons. Molecular psychiatry. 23(12), 2375-2390, 2018-12-23. [JCR]　[WOS]
Weldemariam MM, Han CL, Shekari F, Kitata RB, Chuang CY, Hsu WT, (Kuo HC), Choong WK, Sung TY, He FC, Chung MCM, Salekdeh GH, Chen YJ. Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins. JOURNAL OF PROTEOME RESEARCH. 17(12), 4138-4151, 2018-12. [JCR]　[WOS]
Yu CY, Chuang CY and (Kuo HC)*. Trans-spliced long non-coding RNA: an emerging regulator of pluripotency. CELLULAR AND MOLECULAR LIFE SCIENCES. 75(18), 3339-3351, 2018-09. [JCR]　[WOS]
Chiu HP, Chiu H, Yang CF, Lee YL, Chiu FL, (Kuo HC), Lin RJ, Lin YL. Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein. PLOS PATHOGENS. 14(7), e1007166, 2018-07-17. [JCR]　[WOS]
Chuang TJ, Chen YJ, Chen CY, Mai TL, Wang YD, Yeh CS, Yang MY, Hsiao YT, Chang TH, Kuo TC, Cho HH, Shen CN, (Kuo HC), Lu MY, Chen YH, Sieh SC, Chiang TW. Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cells. NUCLEIC ACIDS RESEARCH. 46(7), 3671-3691, 2018-04. [JCR]　[WOS]
Lai CY, Liu YJ, Lai HL, Chen HM, Kuo HC, Liao YP, Chern Y. The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration. Frontiers in neuroscience. 12, 187, 2018-03-20. [JCR]　[WOS]
Tien WS, Chen PM, Chuang CY, Lui SM, (Kuo HC), Chen YJ, Wu KP. Combining membrane proteomics and computational three-way pathway analysis revealed signalling pathways preferentially regulated in human iPSCs and human ESCs. SCIENTIFIC REPORTS. 7(1), 15055, 2017-11. [JCR]　[WOS]
Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, (Kuo, HC)*. The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. NATURE COMMUNICATIONS. 8(1), 1149, 2017-10. [JCR]　[WOS]
Lee IH, Huang SS, Chuang CY, Liao KH, Chang LH, Chuang CC, Su YS, Lin HJ, Hsieh JY, Su SH, Lee OK, Wang HW, (Kuo HC)* . Delayed epidural transplantation of human induced pluripotent stem cell-derived neural progenitors enhances functional recovery after stroke. SCIENTIFIC REPORTS. 7(1), 1943, 2017-05. [JCR]　[WOS]
Hou PS, Chuang CY, Yeh CH, Chiang W, Liu HJ, Lin TN, (Kuo HC)*. Direct conversion of human fibroblasts into neural progenitors via the use of transcription factors highly enriched in human ESC-derived neural progenitors. STEM CELL REPORTS. 8(1), 54-68, 2017-01. [JCR]　[WOS]
Sudhir P, Kumari MP, Hsu WT, Chen CH, (Kuo HC)*, Chen CH*. Integrative omics connects N-glycoproteome-wide alterations with pathways and regulatory events in induced pluripotent stem cells. SCIENTIFIC REPORTS. 6, 36109, 2016-11. [JCR]　[WOS]
Yu CY and (Kuo HC)*. The trans-spliced long noncoding RNA tsRMST impedes human ESC differentiation through WNT5A-mediated inhibition of the epithelial-to-mesenchymal transition. STEM CELLS. 34(8), 2052-2062, 2016-03. [JCR]　[WOS]
Chiu FL, Lin JT, Chuang CY, Chien T, Chen CM, Chen KH, Hsiao HY, Lin YS, Chern Y*, (Kuo HC)*. Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington’s disease iPSCs. HUMAN MOLECULAR GENETICS. 24(21), 6066-6079, 2015-11. [JCR]　[WOS]
Hsu LC, Nama S, Cui Y, Chang CP, Wang CF, (Kuo HC), Toubould JD, and Chou SJ. Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis . PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(39), 12199-12204, 2015-09. [JCR]　[WOS]
Hsiao HY, Chen YC, Huang CH, Chen CC, Hsu YH, Chen HM, Chiu FL, (Kuo HC), Chen C, Chern Y . Aberrant astrocytes impair vascular reactivity in Huntington disease. ANNALS OF NEUROLOGY. 78(2), 178-192, 2015-08. [JCR]　[WOS]
Chuang CY, Huang MC, Chen HF, Tseng LH, Yu CY, Stone L, Huang HP, Ho HN, (Kuo HC)*. Granulosa cell-derived induced pluripotent stem cells exhibit pro-trophoblastic differentiation potential . STEM CELL RESEARCH AND THERAPY. 6, 14, 2015-02. [JCR]　[WOS]
Mo CF, Wu FC, Tai KY, Chang WC, Chang KW, (Kuo HC), Ho HN, Chen HF, Lin SP. Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines. STEM CELL RESEARCH AND THERAPY. 6, 1, 2015-01. [JCR]　[WOS]
Chen HF, Jan PS, (Kuo HC), Wu FC, Lan CW, Huang MC, Chien CL, Ho HN. Granulosa cells and retinoic acid co-treatment enrich potential germ cells from manually selected Oct4-EGFP expressing human embryonic stem cells. REPRODUCTIVE BIOMEDICINE ONLINE. 29(3), 319-332, 2014-09. [JCR]　[WOS]
Hsiao HY, Chiu FL, Chen CM, Wu YR, Chen HM, Chen YC, (Kuo HC), Cherm Y. Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease. HUMAN MOLECULAR GENETICS. 23(16), 4328-4344, 2014-08. [JCR]　[WOS]
Yu CY, Liu HJ, (Kuo HC)*, Chuang TJ*. Is an Observed Non-co-linear RNA Product Spliced in trans, in cis, or Just in vitro?. NUCLEIC ACIDS RESEARCH. 42(14), 9410-9423, 2014-08. [JCR]　[WOS]
Kao TH, Liao HF, Wolf D, Tai KY, Chuang CY, Lee HS, (Kuo HC), Hata K, Zhang X, Cheng X, Goff SP, Ooi SK, Bestor TH, Lin SP. Ectopic DNMT3L triggers assembly of a repressive complex for retroviral silencing in somatic cells. JOURNAL OF VIROLOGY. 88(18), 10680-10695, 2014-07. [JCR]　[WOS]
Chen HF, Yu CY, Chen MJ, Chou SH, Chiang MS, Chou WH, Ko BS, Huang HP, (Kuo HC)*, Ho HN*. Characteristic expression of major histocompatibility complex and immune privilege genes in human pluripotent stem cells and the derivatives. CELL TRANSPLANTATION. 24(1), 25-36, 2014-01. [JCR]　[WOS]
Lin YI, Chiu FL, Yeang CH, ChenHF, Chuang CY, Yang SY, Hou PS, Sintupisut N, Ho HN, (Kuo HC)*, Lin KI*. Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. STEM CELL REPORTS. 2(2), 189-204, 2014-01. [JCR]　[WOS]
Shetty AS, Godbole G, Hou PS, Chaudhary R, Monuki ES, (Kuo HC), Rema V, Tole S. Lhx2 regulates a cortex-specific mechanism for barrel formation in the cortex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 110(50), E4913-E4921, 2013-12. [JCR]　[WOS]
Sudhir PR, Kumari M, Hsu WT, Massiot J, Chen CH, (Kuo HC)*, Chen CH*. Quantitative Proteomics of Protein Complexes and Their Implications for Cell Reprograming and Pluripotency. JOURNAL OF PROTEOME RESEARCH. 12(12), 5878-5890, 2013-12. [JCR]　[WOS]
Wu CS, Yu CY, Chuang CY, Hsiao M, Kao CF, (Kuo HC)*, Chuang TJ*. Integrative transcriptome sequencing identifies trans-splicing events with important roles in human embryonic stem cell pluripotency. GENOME RESEARCH. 24(1), 25-36, 2013-09. [JCR]　[WOS]
Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien Cl, (Kuo HC)*. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. NUCLEIC ACIDS RESEARCH. 41(16), 7753-7770, 2013-09. [JCR]　[WOS]
Wu YC, Ling TY, Lu SH, (Kuo HC), Ho HN, Yeh SD, Shen CN, Huang YH. Chemotherapeutic sensitivity of testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4. CANCER RESEARCH. 72(19), 4963-4973, 2012-10. [JCR]　[WOS]
Huang HP, Chuang CY, and (Kuo HC)*. Induced pluripotent stem cell technology for disease modeling and drug screening with emphasis on lysosomal storage diseases. STEM CELL RESEARCH AND THERAPY. 3, 34, 2012-08. [JCR]　[WOS]
Chuang CY, Lin KI, Hsiao M, Chen HF, Huang YH, Lin SP, Ho HN, (Kuo HC)*. Meiotic competent human germ cell-like cells derived from human embryonic stem cells induced by BMP4/WNT3a signaling and OCT4/EpCAM selection. JOURNAL OF BIOLOGICAL CHEMISTRY. 287(18), 14389-14401, 2012-04. [JCR]　[WOS]
Chen YF, Tseng CY, Wang HW, (Kuo HC), Yang VW, Lee OK. Rapid Generation of Mature Hepatocyte-like Cells from Human Induced Pluripotent Stem Cells by an Efficient Three-Step Protocol. HEPATOLOGY. 55(4), 1193-1203, 2012-04. [JCR]　[WOS]
Huang HP, Chen PH, Hwu WL, Chuang CY, Chien YH, Lee S, Chien CL, Li LT, Chen HF, Ho HN, Chen CH and (Kuo HC)*. Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification. HUMAN MOLECULAR GENETICS. 20(24), 4851-4864, 2011-12. [JCR]　[WOS]
Huang HP, Chen PH, Yu CY, Chuang CY, Stone L, Hsiao WC, Li CL, Tsai SC, Chen KV, Chen HF, Ho HN, and (Kuo HC)*. Epithelial Cell Adhesion Molecule Complex Proteins Promote Transcription Factor-mediated Pluripotency Reprogramming. JOURNAL OF BIOLOGICAL CHEMISTRY. 286(38), 33520-33532, 2011-09. [JCR]　[WOS]
Chen HF, Chuang CY, Lee WC, Huang HP, Wu HC, Ho HN, Chen YJ, and (Kuo HC)*. Surface marker epithelial cell adhesion molecule and E-cadherin facilitate the identification and selection of induced pluripotent stem cells . STEM CELL REVIEWS AND REPORTS. 7(3), 722-735, 2011-09. [JCR]　[WOS]
Huang HP, Yu CY, Chen HF, Chen PH, Chuang CY, Lin SJ, Huang ST, Chan WH, Ueng TH, Ho HN, and (Kuo HC)*. Factors from human embryonic stem cell-derived fibroblast-like cells promote topology-dependent hepatic differentiation in primate embryonic stem cells and human induced pluripotent stem cells . JOURNAL OF BIOLOGICAL CHEMISTRY. 285(43), 33510-33519., 2010-10. [JCR]　[WOS]
Chen HF, (Kuo HC), Lin SP, Chien CL, Chiang MS, Ho HN. Hypoxic culture maintains self-renewal and enhances embryoid body formation of human embryonic stem cells. TISSUE ENGINEERING. 16(9), 2901-2913., 2010-09. [JCR]　[WOS]
Laowtammathron C, Cheng ECh, Cheng PH, Snyder BR, Yang SH, Johnson Z, Lorthongpanich C, (Kuo HC), Parnpai R, Chan AW. Monkey hybrid stem cells develop cellular features of Huntington's disease. BMC CELL BIOLOGY. 11:12, 2010-02. [JCR]　[WOS]
International Stem Cell Banking Initiative. Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. STEM CELL REVIEWS AND REPORTS. 5(4), 301-314, 2009-12. [JCR]　[WOS]
Chen HF, Chuang CY, Hsieh YK, Chang HW, Ho HN, (Kuo HC)*. Novel human embryonic stem cell autogenetic feeders support undifferentiation of human ES cells in xeno-free culture. HUMAN REPRODUCTION. 24(5), 1114-1125, 2009-05. [JCR]　[WOS]
Huang YH, Chin CC, Ho HN, Chou CK, Shen CN, (Kuo HC), Wu TJ, Wu YC, Hung YC, ChangCC, Ling TY. Pluripotency of Mouse Spermatogonial Stem Cells Maintained by IGF-1 Dependent Pathway. FASEB JOURNAL. 23(7), 2076-2087, 2009-02. [JCR]　[WOS]
Chen, HF, (Kuo HC), Chen W, Wu FC, Yang YS, Ho HN. A reduced oxygen tension (5%) is not benefical for maintaining undifferentiation of human embryonic stem cells in routine culture with short splitting intervals. HUMAN REPRODUCTION. 24(1), 71-80, 2009-01. [JCR]　[WOS]
Kao CF, Chuang CY, Chen CH and (Kuo HC)*. Human Pluripotent Stem Cells: Current Status and Future Perspectives. CHINESE JOURNAL OF PHYSIOLOGY. 51(4), 214-225, 2008-08. [JCR]　[WOS]
Cheng CJ,Wu YC, Shu JA, Ling TY, (Kuo HC), Wu JY, Chang EE, Chang SC and Huang. Aberrant expression and distribution of the OCT-4 transcription factor in. JOURNAL OF BIOMEDICAL SCIENCE. 14(6), 797-807, 2007-11. [JCR]　[WOS]
Chen HF,( Kuo HC), Chien CL, Shun CT, Yao YL, Ip PL, Chuang CY, Wang CC, Yang YS and Ho HN. Derivation, characterization and differentiation of human embryonic stem cells: comparing serum-containing versus serum-free media and evidences of germ cell differentiation. HUMAN REPRODUCTION. 22(2), 567-577, 2007-01. [JCR]　[WOS]
Mitalipov SM, (Kuo HC), Byrne J, Clepper L, Meisner LF, Zeir JR and Wolf DP. Isolation and characterization of novel rhesus monkey embryonic stem cell lines. STEM CELLS. 24(10), 2177-2186, 2006. [JCR]　[WOS]
Fujimoto A, Mitalipov SM, (Kuo HC) and Wolf DP. Imprinted gene expression in monkey embryos and embryonic stem cells. STEM CELLS. 24(3), 595-603, 2005. [JCR]　[WOS]
Lester LB, (Kuo HC), Andrews L, Nauert B and Wolf DP. Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY. 16(2), 42-46, 2004. [JCR]　[WOS]
Wolf DP, (Kuo HC), Pau KY F and Lester L. Progress with non-human primate embryonic stem cells. BIOLOGY OF REPRODUCTION. 71(6), 1766-1771, 2004. [JCR]　[WOS]
Salli U, Reddy AP, Salli N, Lu NZ, (Kuo HC), Pau FK, Wolf DP, and Bethea CL. Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons. EXPERIMENTAL NEUROLOGY. 188(2), 351-364, 2004. [JCR]　[WOS]
(Kuo HC), Pau KYf, Yeoman RY, Mitalipov SM, Okano H and Wolf DP. Differentiation of monkey embryonic stem cells into neural lineages. BIOLOGY OF REPRODUCTION. 68(5), 1727-1735, 2003. [JCR]　[WOS]
Mitalipov SM, (Kuo HC), Hennebold JD and Wolf PD. Oct-4 expression in pluripotent cells of the rhesus monkey. BIOLOGY OF REPRODUCTION. 69(6), 1785-1792, 2003. [JCR]　[WOS]
S. Pickering, N. Polidoropoulos, J. Caller, P. Scriven, C.M. Ogilvie and P. Braude. Preimplantation Genetic Diagnosis Study Group*. The first 100 cycles of preimplantation genetic diagnosis (PGD) at the Guy’s and St Thomas’ Center: strategies and outcomes. FERTILITY AND STERILITY. 79(1), 81-90, 2003. [JCR]　[WOS]

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