生命組研究成果
期刊
- Wang YW, Chen SC, Gu DL, Yeh YC, Tsai JJ, Yang KT, Jou YS, Chou TY, Tang TK*. A novel HIF1alpha-STIL-FOXM1 axis regulates tumor metastasis. Journal of biomedical science. 29(1), 24, 2022-04. [JCR] [WOS]
- An HL, Kuo HC, Tang TK*. Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein. Frontiers in Cell and Developmental Biology. 10, 1-18, 2022-03. [JCR] [WOS]
- Chang CH, Chen TY, Lu IL, Li RB, Tsai JJ, Lin PY, Tang TK*. CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum. Genes & development. 35(21-22), 1445-1460, 2021-11. [JCR] [WOS]
- Chou EJ, Tang TK*. Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position. Cells. 10(6), 1441, 2021-06. [JCR] [WOS]
- Chen TY, Huang BM, Tang TK, Chao YY, Xiao XY, Lee PR, Yang LY, Wang CY. Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response. Cell death and differentiation. 28, 1865–1879, 2021-01. [JCR] [WOS]
- Lin YN, Lee YS, Li SK, Tang TK*. Loss of CPAP in developing mouse brain and its functional implication in human primary microcephaly. Journal of cell science. 133(12), 1-14, 2020-06. [JCR] [WOS]
- Tsai JJ, Hsu WB, Liu JH, Chang CW, Tang TK*. CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis. Scientific reports. 9(1), 6037, 2019-04. [JCR] [WOS]
- Wu CT, Chen HY, Tang TK*. Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis. Nature cell biology. 20(2), 175-185, 2018-01. [JCR] [WOS]
- Wang ZH, Chang YY, Wu JG, Lin CY, An HL, Luo SC, Tang TK, Su WF. Novel 3D Neuron Regeneration Scaffolds Based on Synthetic Polypeptide Containing Neuron Cue. Macromolecular Bioscience. 1700251, 1-12, 2017-12. [JCR] [WOS]
- Chen HY, Wu CT, Tang CC, Lin YN, Wang WJ, Tang TK*. Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles. Nature communications. 8(1), 247, 2017-08. [JCR] [WOS]
- Alvarez-Cabrera AL, Delgado S, Gil-Carton D, Mortuza GB, Montoya G, Sorzano CO, Tang TK, Carazo JM. Electron Microscopy Structural Insights into CPAP Oligomeric Behavior: A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome. Frontiers in molecular biosciences. 4, 17, 2017-03. [JCR] [WOS]
- Chang CW, Hsu WB, Tsai JJ, Tang CC, Tang TK*. CEP295 interacts with microtubules and is required for centriole elongation. Journal of cell science. 129, 2501-2513, 2016-07. [JCR] [WOS]
- Chang HF, Lee YS, Tang TK, Cheng JY. Pulsed DC Electric Field-Induced Differentiation of Cortical Neural Precursor Cells. PloS one. 11(6), e0158133, 2016-06. [JCR] [WOS]
- Chou EJ, Hung LY, Tang CJ, Hsu WB, Wu HY, Liao PC, Tang TK*. Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis. Cell reports. 14, 2975-2987, 2016-03. [JCR] [WOS]
- Kuo-Tai Yang, Chieh-Ju C. Tang and Tang K. Tang*. Possible role of Aurora-C in meiosis. Frontiers in Oncology. 5, 178, 2015-08. [JCR] [WOS]
- Tang K. Tang. Centriole biogenesis in multiciliated cells. NATURE CELL BIOLOGY. 15, 1400-1402, 2013-12. [JCR] [WOS]
- Lin, Y-N., Wu, C-T., Lin, Y-C., Hsu, W-B., Tang, C-J. C., Chang, C-W., and Tang, T.K.*. CEP120 interacts with CPAP and positively regulates centriole elongation. JOURNAL OF CELL BIOLOGY. 202(2), 211-219, 2013-07. [JCR] [WOS]
- Yang, S-T., Yen, C-J., Lai, C-H., Lin, Y-J., Chang, K-C., Lee, J-C., Liu, Y-W., Chang-Liao, P-Y., Hsu, L-S., Chang, W-C., Hung, W-C., Tang, T.K., Liu, Y-W., and Hung, L-Y. SUMOylated CPAP is required for IKK-mediated NF-κB activation and enhances HBx-induced NF-κB signaling in HCC. JOURNAL OF HEPATOLOGY. 58(6), 1157-1164, 2013-06. [JCR] [WOS]
- Lin, Y-C., Chang, C-W., Hsu, W-B., Tang, C-J. C., Lin, Y-N., Chou, E-J., Wu, C-T., and Tang, T.K.*. Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly. EMBO Journal. 32, 1141-1154, 2013-04. [JCR] [WOS]
- Wu KS, Tang TK. CPAP is required for cilia formation in neuronal cells. Biology open. 1(6), 559-565, 2012-06. [JCR] [WOS]
- Tang, C-J.C., Lin, S-Y., Hsu, W-B., Lin, Y-N., Wu, C-T., Lin, Y-C., Chang, C-W., Wu, K-S., and Tang, T.K*. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO Journal. 30, 4790-4804, 2011-11. [JCR] [WOS]
- Yang, K-T., Li, S-K., Chang, C-C., Tang, C-J.C., Lin, Y-N., Lee, S-C., and Tang, T. K.* . Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mouse. MOLECULAR BIOLOGY OF THE CELL. 21, 2371-2383, 2010. [JCR] [WOS]
- Chou, C-C., Lou, Y-C., Tang, T.K., and Chen, C. Structure and DNA binding characteristics of the three-Cys2-His2 domain of mouse testis zinc finger protein. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 78, 2202-2212, 2010. [JCR] [WOS]
- Chieh-Ju C. Tang, Ru-Huei Fu, Kuo-Sheng Wu, Wen-Bin Hsu, and Tang K. Tang. CPAP is a cell-cycle regulated protein that controls centriole length. NATURE CELL BIOLOGY. 11(7), 825-831, 2009-07. [JCR] [WOS]
- Huang, S-C., Cho, A., Norton, S., Liu, E. S., Yang, G., Zhou, A., Munagala, I. D., Ou, A. C., Wickrema, A., Tang, T. K., Benz, E. J. Jr. Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5’ exons of protein 4.1R gene. BLOOD. 114, 4233-4242, 2009. [JCR] [WOS]
- Wen-Bin Hsu, Liang-Yi Hung, Chieh-Ju. C. Tang, Chia-Li Su, Yulin Chang, Tang K. Tang*. Functional characterization of the microtubule-binding and -destabilizing domains of CPAP and d-SAS-4. EXPERIMENTAL CELL RESEARCH. 314, 2591-2602, 2008. [JCR] [WOS]
- C. Y. Chen, M. A. Olayioye, G. J. Lindeman and T. K. Tang. CPAP interacts with 14-3-3 in a cell cycle-dependent manner. Biochemical and Biophysical Research Communications. 342(4), 1203-1210, 2006. [JCR] [WOS]
- J. H. Cho, C. J. Chang, C. Y. Chen and T. K. Tang. Depletion of CPAP by RNAi disrupts centrosome integrity and induces multipolar spindles. Biochemical and Biophysical Research Communications. 339(3), 742-747, 2006. [JCR] [WOS]
- C. J. Tang, C. Y. Lin and T. K. Tang. Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Dev Biol. 290, 398-410, 2006. [JCR] [WOS]
- H. L. Chen, C. J. Tang, C. Y. Chen and T. K. Tang. Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. J Biomed Sci. 12, 297-310, 2005. [JCR] [WOS]
- L. Y. Hung, H. L. Chen, C. W. Chang, B. R. Li and T. K. Tang. Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly. Mol Biol Cell. 15, 2697-2706, 2004. [JCR] [WOS]
- C.J. Tang, H.M. Hu and T.K. Tang. NuMA (Nuclear Mitotic Apparatus Protein) expression and function in mouse oocyte and early embryo. J Biomed Sci. 11, 370-376, 2004. [JCR] [WOS]
- B. Peng, K. D. Sutherland, E. Y. Sum, M. Olayioye, S. Wittlin, T. K. Tang, G. J. Lindeman and J. E. Visvader. CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity. Mol Endocrinol. 16, 2019-2033, 2002. [JCR] [WOS]
- S. H. Chen, T. K. Tang. Mutational analysis of the phosphorylation sites of the Aie1 (Aurora-C) kinase in vitro. DNA Cell Biol. 21, 41-46, 2002. [JCR] [WOS]
- C. J. Tang, C. K. Chuang, H. M. Hu and T. K. Tang. The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. J Biol Chem. 276, 19631-19639, 2001. [JCR] [WOS]
- H. M. Hu, C. K. Chuang, M. J. Lee, T. C. Tseng and T. K. Tang. Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1. DNA Cell Biol. 19, 679-688, 2000. [JCR] [WOS]
- W. Kuo, J. Lin and T. K. Tang. Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. Int J Cancer. 85, 857-864, 2000. [JCR] [WOS]
- L. Y. Hung, C. J. Tang and T. K. Tang. Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex. Mol Cell Biol. 20, 7813-7825, 2000. [JCR] [WOS]
- C. L. Hou, C. Tang, S. R. Roffler and T. K. Tang. Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus. Blood. 96, 747-753, 2000. [JCR] [WOS]
- Y. S. Cheng, T. K. Tang and M. Hwang. Amino acid conservation and clinical severity of human glucose-6-phosphate dehydrogenase mutations. J Biomed Sci. 6, 106-114, 1999. [JCR] [WOS]
- W. Lin, C. H. Lai, C. J. Tang, C. J. Huang and T. K. Tang. Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. Biochemical and Biophysical Research Communications. 264(3), 789-795, 1999. [JCR] [WOS]
- C. S. Huang, Y. C. Sung, M. J. Huang, C. S. Yang, W. S. Shei and T. K. Tang. Content of reduced glutathione and consequences in recipients of glucose-6-phosphate dehydrogenase deficient red blood cells. Am J Hematol. 57, 187-192, 1998. [JCR] [WOS]
- W. Y. Kuo, T. K. Tang. Effects of G6PD overexpression in NIH3T3 cells treated with tert-butyl hydroperoxide or paraquat. Free Radical Biology and Medicine. 24, 1130-1138, 1998. [JCR] [WOS]
- T. C. Tseng, S. H. Chen, Y. P. Hsu and T. K. Tang. Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. DNA Cell Biol. 17, 823-833, 1998. [JCR] [WOS]
- C. J. Tang, T. K. Tang. The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation. Blood. 92, 1442-1447, 1998. [JCR] [WOS]
- T. K. Tang. Free radical theory of erythrocyte aging. J Formos Med Assoc. 96, 779-783, 1997. [JCR] [WOS]
- H. L. Chen, M. J. Huang, C. S. Huang and T. K. Tang. Two novel glucose 6-phosphate dehydrogenase deficiency mutations and association of such mutations with F8C/G6PD haplotype in Chinese. J Formos Med Assoc. 96, 948-954, 1997. [JCR] [WOS]
- H. L. Chen, M. J. Huang, C. S. Huang and T. K. Tang. G6PD NanKang (517 T-->C; 173 Phe-->Leu): a new Chinese G6PD variant associated with neonatal jaundice. Hum Hered. 46, 201-204, 1996. [JCR] [WOS]
- T. K. Tang, W. Y. Huang, C. J. Tang, M. Hsu, T. A. Cheng and K. H. Chen. Molecular basis of glucose-6-phosphate dehydrogenase (G6PD) deficiency in three Taiwan aboriginal tribes. Hum Genet. 95, 630-632, 1995. [JCR] [WOS]
- T. K. Tang, C. H. Yeh, C. S. Huang and M. J. Huang. Expression and biochemical characterization of human glucose-6-phosphate dehydrogenase in Escherichia coli: a system to analyze normal and mutant enzymes. Blood. 83, 1436-1441, 1994. [JCR] [WOS]
- Y. L. Ko, S. A. Chen, T. K. Tang, J. L. Lin, C. E. Chiang, J. J. Chen, M. S. Teng, M. S. Chang, W. P. Lien and C. W. Wu. No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family: evidence for genetic heterogeneity. Hum Genet. 94, 364-366, 1994. [JCR] [WOS]
- T. K. Tang, C. J. Tang, Y. J. Chao and C. W. Wu. Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various NuMA isoforms. J Cell Sci. 107, 1389-1402, 1994. [JCR] [WOS]
- J. P. Huang, C. J. Tang, G. H. Kou, V. T. Marchesi, E. J. Benz, Jr. and T. K. Tang. Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing. J Biol Chem. 268, 3758-3766, 1993. [JCR] [WOS]
- T. K. Tang, K. B. Tam and S. C. Huang. High-level and erythroid-specific expression of human glucose-6-phosphate dehydrogenase in transgenic mice. J Biol Chem. 268, 9522-9525, 1993. [JCR] [WOS]
- T. K. Tang, T. M. Hong, C. Y. Lin, M. L. Lai, C. H. Liu, H. J. Lo, M. E. Wang, L. B. Chen, W. T. Chen, W. Ip and et al. Nuclear proteins of the bovine esophageal epithelium. I. Monoclonal antibody W2 specifically reacts with condensed nuclei of differentiated superficial cells. J Cell Sci. 104, 237-247, 1993. [JCR] [WOS]
- T. K. Tang, C. J. Tang, Y. L. Chen and C. W. Wu. Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1. J Cell Sci. 104, 249-260, 1993. [JCR] [WOS]
- T. K. Tang, C. S. Huang, M. J. Huang, K. B. Tam, C. H. Yeh and C. J. Tang. Diverse point mutations result in glucose-6-phosphate dehydrogenase (G6PD) polymorphism in Taiwan. Blood. 79, 2135-2140, 1992. [JCR] [WOS]
- Chang, J-G., Chiou, S-S., Perng, L-I., Chen, T-C., Liu, T-C., Lee, L-S., Chen, P-H., and Tang, T. K. Molecular characterization of G6PD deficiency by natural and amplification created restriction sites - Five mutations account for most G6PD deficiency cases in Taiwan. Blood. 80, 1079-1082, 1992. [JCR] [WOS]
- T. K. Tang, Y. L. Ko and W. P. Lien. A StuI RFLP in the human beta-spectrin gene (SPTB). Nucleic Acids Res. 19, 2515, 1991. [JCR] [WOS]
- C. J. Tang, T. K. Tang. Rapid localization of membrane skeletal protein 4.1 (EL1) to human chromosome 1p33----p34.2 by nonradioactive in situ hybridization. Cytogenet Cell Genet. 57, 119, 1991. [JCR] [WOS]
- T. K. Tang, K. B. Tam and S. Chien. Two RFLPs in the human protein 4.1 gene (EL1). Nucleic Acids Res. 19, 6057, 1991. [JCR] [WOS]
- T. K. Tang, Z. Qin, T. L. Leto, V. T. Marchesi, E. J. Benz Jr. Heterogeneity of mRNA and protein products arising from the protein 4.1 gene in erythroid and non-erythroid tissues. J. Cell Biol. 110, 617-624, 1990. [JCR] [WOS]
- F. F. Costa, P. Agre, P. C. Watkins, J. C. Winkelmann, T. K. Tang, K. M. John, S. E. Lux, B. G. Forget. Linkage of dominant Hereditary Spherocytosis to the gene for the erythrocyte membrane skeletal protein ankyrin. New Engl. J. Med. 323, 1046-1050, 1990. [JCR] [WOS]
- T. K. Tang, T. L. Leto, I. Correas, M. A. Alonso, V. T. Marchesi and E. J. Benz Jr. Selective expression of an erythroid specific isoform of protein 4.1. Proceedings of the National Academy of Sciences of the United States of America. 85(11), 3713-3717, 1988. [JCR] [WOS]
專書
- Yang KT, Lin YN, Li SK, Tang TK . Studying the roles of Aurora-C kinase during meiosis in mouse oocytes in Methods in molecular biology (Clifton, N.J.). 957, 189-202, 2013.