vol.40 No.6
Original Article
Latent Tuberculosis Infection Among New Immigrant in Taiwan: A Cross-Sectional Study of Tuberculosis Contacts, 2016–2020
DOI: 10.6524/EB.202403_40(6).0001Pei-Ling Chen1*, Hsiu-Yun Lo1, Shiang-Lin Yang1,, Jo-Shan Wang1,, Chi-Fang Feng1,, Pei-Chun Chan1,2, Chi-Tai Fang2,3,4
2024 Vol.40 No.6
Correspondence Author: Pei-Ling Chen1*
Abstract:
Based on the literature review, the distribution of tuberculosis (TB) cases in high-income countries mostly showed a continuous decline in domestic cases or maintained a low incidence rate. However, the incidence of TB in foreign-born people had increased or remained higher than domestic cases. In some advanced countries with a low incidence of TB, it is even more apparent to recognize that immigrants from TB high burden countries have a relatively higher incidence, mortality, and latent TB infection (LTBI) rate.
The 58,047 childbearing females of age between 15–49 years old contacts (38,674 contacts of Taiwanese and 388 contacts of new immigrants) who were in the TB database from 2016 to June 2020 with complete identity and gender information were analyzed for the results of the Interferon-γ-release assay (IGRA) test. In terms of the prevalence of LTBI, the contact of new immigrants as index cases’ cohabitants had a higher risk of having IGRA-positive than Taiwanese counterparts (27.8% vs. 14.5%, aOR: 2.08; 95% CI: 1.55–2.78); the contacts of new-immigrants as index cases’ colleague also had a higher possibility to have IGRA-positive than Taiwanese (29.3% vs. 7.4%, aOR: 4.62; 95% CI: 3.18–6.72).
According to the result of this study, compared to Taiwanese women of the same age (15–49 years old), the prevalence of LTBI among new-immigrant women was higher. We need to consider whether to refer to the WHO recommendations to provide latent tuberculosis infection screening and preventive treatment services for new immigrants from countries with a high burden of tuberculosis to avoid future diseases.
Keywords:New-immigrant, immigrant, foreign spouse, tuberculosis, latent tuberculosis infection
Original Article
The Evolution of Latent Tuberculosis Infection Regimens And Analysis of The Completion Rates, Taiwan, 2016–2022
DOI: 10.6524/EB.202403_40(6).0002Shu-Chun Liao, Pei-Fang Lai, Hsiu-Yun Lo*, Chi-Fang Feng, Pin-Hui Lee, Pei-Chun Chan, Chia-Chi Lee
2024 Vol.40 No.6
Correspondence Author: Hsiu-Yun Lo*
Abstract:
Treating latent tuberculosis infection (LTBI) is an important strategy for achieving TB elimination. Due to its effectiveness and safety, Isoniazid (INH) is the preferred regimen worldwide. However, the longer treatment duration of 6-12 months has resulted in lower completion rates. In line with the World Health Organization guidelines and international experience, Taiwan’s National TB Program has updated its LTBI treatment guidelines to include shorter regimens such as 3HP, 4R, 3HR, and 1HP as alternative options. This retrospective study aimed to analyze the LTBI treatment regimens and compare the completion rates between 2016 and 2022, using the TB database obtained from the Taiwan Centers for Disease Control, to illustrate the progress and scaling up of LTBI treatment in Taiwan.
Keywords:Tuberculosis, contact, latent tuberculosis infection, shorter treatment regimen
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