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In eukaryotic cells, reactive oxygen species (ROS) serve as crucial signaling components. ROS are potentially toxic, so constant adjustments are needed to maintain cellular health.Our findings thus support the use of SN-ROP to elucidate intricate redox networks and their implications in immune cell function and disease. |
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Various DNA damage response factors form biomolecular condensates at DNA lesions. Targeting phase separation in DNA repair factor assemblies may provide a potential anti-cancer strategy. |
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Skin exposure to UV rays from sunlight results in the formation of mutagenic DNA photolesions that are repaired by the nucleotide excision repair (NER) machinery.Our findings revealed that by influencing the cellular localization of VCP/p97, BTG3 is critical for the proper execution of NER to protect cells from UV-induced damage and skin carcinogenesis. |
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Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response. |
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Targeting nanocarriers to tumors to increase their therapeutic efficacy requires selection of appropriate cancer targets and may depend on the particular formulation under investigation. |
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The APOBEC3 family of cytidine deaminases restricts retroviruses like HIV-1 by mutating viral DNA. |
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The emerging pediatric pathogen Kingella kingae elaborates a lipopolysaccharide (LPS) that is extended with a galactofuranose homopolymer called galactan, which is a key virulence determinant that contributes to resistance to complement-mediated and neutrophil-mediated killing. |
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This study describes the utility of p-acetoxybenzyl carbonate (ABC) group for the protection of hydroxyl functions. |
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TAR DNA binding protein 43 kD (TDP-43) aggregation is associated with several neurodegenerative diseases and limiting TDP-43 aggregates could offer therapeutic benefit. |
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在本研究中，林副研究員負責魚類耳石的分類鑑定與群聚構造重建。林副研究目前仍有多項與STRI研究團隊進行中的合作計畫，該團隊長期關注加勒比海珊瑚礁生態系的時空變遷。 |
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Here, we investigate the cellular and molecular basis of adhesion between the nematode Caenorhabditis elegans and its natural predator, the nematode-trapping fungus Arthrobotrys oligospora, which employs specialized adhesive nets to capture its prey. |
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During social interactions, individuals interpret others' behaviors differently depending on their distance - too close or too far can alter perception. How animals integrate social cues (such as behavior) with spatial distance (via depth vision) to guide their responses is a frontier in neuroscience research. |
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Animals exhibit diverse behavioral adaptations to predation, driving coevolution across the Tree of Life. |
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這項研究提醒我們，微生物可是非常靈活的。微生物縱然細小，團結起來會帶來意想不到的效果，並增加物種的存活率。 |
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我們提出了一種單微量滴管IMAC-HILIC方法，該方法將固定化金屬親和層析（Immobilized Metal Affinity Chromatography, IMAC）與親水性作用層析（Hydrophilic Interaction Chromatography, HILIC）的材料整合於單一微量滴管內，使磷酸化胜肽與N-醣基化胜肽能同時富集並依序洗脫。此整合流程優化了N-醣基化胜肽的洗脫溶液，有效降低了N-醣基化胜肽洗脫時磷酸化胜肽的共洗脫情形，並簡化了樣品處理步驟。相較於傳統的串聯微量滴管方法（TIMAHAC），此單微量滴管策略在胜肽鑑定深度上具備相似的效能，且提高了兩種修飾胜肽的定量準確性。 |
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HYCCIN2 是 SH3P2–DRP1A 複合物於擬南芥胚胎細胞分裂期間正確導向細胞板的關鍵調控因子 |
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We directly treated mouse neuroblastoma to modulate the cholesterol content and found that cholesterol depletion inhibited the internalization of poly-GR into the cells and reduced cytotoxicity. These findings reveal that the conformation of poly-GR and the lipid composition influence its membrane penetration, offering insights into potential therapeutic strategies for C9ORF72-related diseases. |
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本研究建立並優化了模式綠藻Chlamydomonas reinhardtii的核糖體足跡測序（Ribo-seq）實驗與分析流程，顯著提升了核糖體保護片段對主要開放閱讀框的對應率、降低基因編碼區的對應偏差，並展現高度的三核苷酸週期性。 |
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