展期：2025-11-24~ 2025-12-01

講題：誰能推動全球衝突相關性暴力（CRSV）的終結？— 個人故事的力量與行動主義的角色
主講者：Ms. Nadia Murad 2018 Nobel Peace Laureate and Human Rights Activist, Washington DC/USA
時間：114年12月1日(一)下午兩點開始
地點：本院人文社會科學館三樓第二會議室

黃尾鴝雌雄異色，雄鳥鮮豔、雌鳥樸素；為臺灣冬候鳥，常見於灌木與園區間獨自活動。

講題：Chromatin Dysregulation, a Driver of Oncogenesis
主講者：Dr. G Greg Wang (Dept. of Pharmacology and Cancer Biology, Duke University School of Medicine)
時間：2025-11-25 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：Transition from Biogenic Amines to Aldehyde Capture: Establishing a Quantitative Analytical Method through Reductive Amination
主講者：梁世欣 博士 (高雄醫學大學)
時間：2025-11-25 11:00 - 12:15
地點：生醫所地下室B1B演講廳

講題：Leveraging the population history to understand the architecture of complex traits in diverse human populations
主講者：Dr. Charleston W. K. Chiang (Univ. of Southern California)
時間：2025-11-25 15:00 - 16:15
地點：生醫所地下室B1B演講廳

講題：Decoding Epigenetic Roadblocks in Cellular Reprogramming
主講者：Tamer T. Önder教授 (土耳其科曲大學)
時間：2025-11-26 10:30 - 12:00
地點：基因體研究中心三樓會議室

講題：Rewiring Biology with E. coli
主講者：Dr. Hirotada Mori (Visiting Professor, Institute of Molecular Medicine, National Cheng Kung University, Tainan, Taiwan)
時間：2025-11-26 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：The Brain’s Fuel Dilemma: From Glucose Deficits to Fat Utilization Energetic stress impairs long-range axons and induces inflammation
主講者：Dr. Hui-Chen Lu (Indiana Univ. Bloomington)
時間：2025-11-28 11:00 - 12:00
地點：跨領域大樓一樓演講廳

講題：Postdoc Seminar: Theory for Optimal Estimation and Control under Resource Limitations and its Applications to Biological Information Processing and Decision-Making
主講者：Dr. Takehiro Tottori (Special Postdoctoral Researcher, Lab for Neural Computation and Adaptation, RIKEN Center for Brain Science, Japan)
時間：2025-12-01 10:30 - 11:30
地點：中央研究院分子生物研究所一樓演講廳

講題：Patterning and Cell Fate in Drosophila Embryos in the Absence of All Maternal Gradients
主講者：Dr. Eric WIESCHAUS (1995年諾貝爾獎得主，美國普林斯頓大學)
時間：2025-12-02 09:00 - 10:00
地點：國家生技研究園區國際會議廳

講題：Cargo transport by the dynein/dynactin motor
主講者：Dr. Andrew Carter (MRC Program Leader, MRC LMB, Cambridge, UK)
時間：2025-12-02 11:00 - 12:00
地點：中央研究院分子生物研究所B1演講廳

講題：Uncovering Plant Defence Networks using Systems Biology: From Grapevine–Botrytis and Water Stress Studies to the PlantaeViz Platform
主講者：Dr. José Tomás Matus Picero (Institute for Integrative Systems Biology: Valencia, Spain)
時間：2025-12-03 11:00 - 13:00
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

講題：Postdoc Seminar: Genomic and Functional Landscapes of ecDNA-Driven Cancers
主講者：Dr. Shu Zhang (Postdoctoral Fellow, Paul Mischel’s and Howard Y. Chang’s Lab, Pathology Department, Stanford University)
時間：2025-12-03 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：The tumor microenvironment in pancreatic cancer – new clinical challenges, but more opportunities
主講者：Lei Zheng教授 (美國德州大學)
時間：2025-12-03 14:00 - 15:30
地點：基因體研究中心一樓演講廳

講題：The Mutational Landscape of Adrenal Glands with Aldosterone-producing Lesions at Single-cell Resolution
主講者：Dr. Elena Aisha Azizan (Nat'l Univ. of Malaysia)
時間：2025-12-04 11:00 - 12:15
地點：生醫所地下室B1B演講廳

講題：Postdoc Seminar: Computational analysis of internal states during memory modification learning in an Alzheimer’s disease mouse model
主講者：Dr. Mei-Lun Huang (Graduate School of Biostudies, Kyoto University)
時間：2025-12-04 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：Structural biology in the age of AI
主講者：Tom C. Terwilliger教授 (美國Los Alamos國家實驗室)
時間：2025-12-05 11:00 - 12:00
地點：生化所209研討室

講題：Plants and Fungi: An Adventure That Began more than 400 Million Years Ago
主講者：Prof. Paola Bonfante (Professor Emerita, Department of Life Sciences and Biological Systems, University of Torino, Accademia dei Lincei, Italy)
時間：2025-12-08 11:00 - 13:00
地點：本院農科大樓1樓A134演講廳

講題：Translation Under Surveillance: Ribosome Quality Control and tRNA Modifications in Cell Physiology
主講者：Dr. Colin Chih-Chien Wu 吳志謙 (RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute)
時間：2025-12-08 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：Activation mechanism and evolutionary history of NLR proteins in rice
主講者：請見活動內容
時間：2025-11-25 14:30 - 15:30
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

時間：2025-11-28 15:00 - 17:15
地點：生化所103講堂

The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are two major pathways for maintaining cellular protein homeostasis.

Human trophoblast stem (TS) cells differentiate into syncytiotrophoblasts (STBs) through cell-cell fusion, forming the outermost layer of the placental villus to enable nutrient and gas exchange between the mother and fetus.

Ubiquitin-specific proteases (USPs), comprising the largest deubiquitinase family, are generally thought to have poor discrimination of ubiquitin (Ub) linkage types, but a number of USPs show preference toward certain linkages.

研究團隊透過系統發育分析與觸手冠的轉錄體定序，進一步揭示三類動物的觸手冠不僅表現出共同的基因組成，還共同利用了脊椎動物頭部發育的相關基因，證明觸手冠是同源器官，而非各自平行演化下的濾食構造。這項發現不僅解決了觸手冠動物單系性的百年爭議，也展示了基因體結構分析在重建深層演化關係上的潛力。

Nearly 70 years after the discovery of the SC, this team also demonstrated for the first time that the true physiological function of SC in meiosis is to suppress MMR, thereby promoting genetic diversity in gamates or fungal sexual spores.

Through genetic screening, we identify the splicing factor Sf3b1 as functioning cell-autonomously in neuronal dendrite growth and maintenance.

Here, using an AI-powered mapping platform, BM-auto (Brain Mapping with Auto-ROI correction), to analyze a Thy1-YFP reporter, we show that different ASD-associated mutations cause distinct circuit abnormalities but share common deficits in the piriform cortex, a region regulating olfactory discrimination and social behavior patterns.

本篇論文的發表不僅提供未來精準醫療、免疫治療與感染防治策略的重要參考架構，更將促進新一代抗體藥物的創新與研發，加速我國生醫研究與產業發展的國際接軌。