展期：2024-1-22 ~ 2024-1-29

好生活從「少物」開始！

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講題：Fungal-bacterial interactions alter microbial fitness and the evolution of antibiotic resistance
主講者：Dr. 謝侑穎 (Postdoctoral Fellow, Fred Hutchinson Cancer Center, Seattle, WA)
時間：2024-01-24 11:00 - 12:00
地點：中央研究院分子生物研究所B1演講廳

講題：Breaking the Silence: How to Make Small Plant Mouths that Support Our Sustenance
主講者：Dr. Keiko Torii (Investigator, Howard Hughes Medical Institute/Johnson and Johnson Centennial Chair in Plant Cell Biology, Professor, Department of Molecular Biosciences, The University of Texas at Austin)
時間：2024-01-24 15:00 - 16:30
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

講題：Elucidating Proneural Gene Regulatory Features to Understand Brain Development and Promote Brain Repair
主講者：Dr. Carol Schuurmans (Professor, Department of Biochemistry, University of Toronto)
時間：2024-01-24 15:30 - 16:30
地點：分生所B1演講廳

講題：Lung organoids: miniature lungs with maximum potential
主講者：Dr. Ya-Wen Chen (Associate Professor, Departments of Otolaryngology, Cell, Developmental and Regenerative Biology, and Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, NY)
時間：2024-01-26 11:00 - 12:00
地點：細生所1樓演講廳

講題：Genetic conflicts during meiosis drive rapid evolution of chromatin proteins
主講者：Dr. 張景賀 (Postdoctoral Fellow, Fred Hutchinson Cancer Center, Seattle, WA)
時間：2024-01-29 11:00 - 12:00
地點：中央研究院分子生物研究所B1演講廳

講題：Controlling protein machinery for biosensing, biocatalysis, and biochemical information processing
主講者：David H. Kwan教授 (加拿大Concordia University)
時間：2024-01-29 11:00 - 12:00
地點：生化所209室

講題：Exploring the Cellular Odyssey: A Multi-omics Adventure
主講者：Dr. Chih-Yi Gabriela Lin (Senior Research Scientist, MiNA therapeutics, UK)
時間：2024-01-29 11:00 - 12:00
地點：細生所1樓演講廳

講題：Visualizing enzyme catalysis and DNA repair by temperature-resolved cryo-EM and time-resolved XFEL
主講者：蔡明道 院士 (中央研究院生化研究所，臺灣)
時間：2024-01-31 10:30 - 12:00
地點：基因體研究中心一樓演講廳

講題：Profiling RNA at chromatin targets in situ by antibody-targeted tagmentation
主講者：Dr. Nadiya Khyzha (Postdoctoral Fellow, Fred Hutchinson Cancer Center, Seattle, WA)
時間：2024-01-31 11:00 - 12:00
地點：中央研究院分子生物研究所B1演講廳

講題：Filtering Aspect of Animal Embryogenesis toward Phenotypic Diversification
主講者：Dr. Naoki Irie (Professor, Research Center for Integrative Evolutionary Science, SOKENDAI, Japan)
時間：2024-01-31 11:00 - 12:00
地點：細生所1樓演講廳

講題：Quantitative 3D cell imaging using soft X-ray tomography
主講者：Dr. Jian-Hua Chen (Staff Scientist, National Center for X-ray Tomography, Lawrence Berkeley National Laboratory, USA)
時間：2024-01-31 15:00 - 16:00
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

A mutant of ubiquitin C-terminal hydrolase L1 (UCHL1) detected in early-onset neurodegenerative patients, UCHL1R178Q, showed higher catalytic activity than wild-type UCHL1 (UCHL1WT). Lying within the active-site pocket, the arginine is part of an interaction network that holds the catalytic histidine in an inactive arrangement.

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高糖飲食通常會導致肥胖和第 2 型糖尿病，這兩種代謝症候群都與幹細胞功能障礙有關。 然而，過量的糖是否會影響幹細胞尚不清楚。 我們發現在胰島素抗性（2 型糖尿病的標誌）出現之前，過量的糖就已經損害雌性果蠅腸道和卵巢中的幹細胞功能。

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Knotted proteins are fascinating to biophysicists because of their robust ability to fold into intricately defined three-dimensional structures with complex and topologically knotted arrangements.

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The tumor microenvironment (TME) presents differential selective pressure (DSP) that favors the growth of cancer cells, and monovalent therapy is often inadequate in reversing the cancer cell dominance in the TME.

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Activation of effector T cells leads to upregulation of PD-1, which can inhibit T cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTMs), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and inter-protein interactions.

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