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Period: 2024-1-22 ~ 2024-1-29 |
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Topic：Fungal-bacterial interactions alter microbial fitness and the evolution of antibiotic resistance
Speaker：Dr. Yu-Ying Phoebe Hsieh (Postdoctoral Fellow, Fred Hutchinson Cancer Center, Seattle, WA)
Date：2024-01-24 11:00 - 12:00
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica |
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Topic：Breaking the Silence: How to Make Small Plant Mouths that Support Our Sustenance
Speaker：Dr. Keiko Torii (Investigator, Howard Hughes Medical Institute/Johnson and Johnson Centennial Chair in Plant Cell Biology, Professor, Department of Molecular Biosciences, The University of Texas at Austin)
Date：2024-01-24 15:00 - 16:30
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica |
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Topic：Elucidating Proneural Gene Regulatory Features to Understand Brain Development and Promote Brain Repair
Speaker：Dr. Carol Schuurmans (Professor, Department of Biochemistry, University of Toronto)
Date：2024-01-24 15:30 - 16:30
Place： |
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Topic：Lung organoids: miniature lungs with maximum potential
Speaker：Dr. Ya-Wen Chen (Associate Professor, Departments of Otolaryngology, Cell, Developmental and Regenerative Biology, and Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, NY)
Date：2024-01-26 11:00 - 12:00
Place：1F, Auditorium, Institute of Cellular and Organismic Biology |
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Topic：Genetic conflicts during meiosis drive rapid evolution of chromatin proteins
Speaker：Dr. Ching-Ho Chang (Postdoctoral Fellow, Fred Hutchinson Cancer Center, Seattle, WA)
Date：2024-01-29 11:00 - 12:00
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica |
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Topic：Controlling protein machinery for biosensing, biocatalysis, and biochemical information processing
Speaker：Dr. David H. Kwan (Concordia University, Canada)
Date：2024-01-29 11:00 - 12:00
Place：IBC R209 |
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Topic：Exploring the Cellular Odyssey: A Multi-omics Adventure
Speaker：Dr. Chih-Yi Gabriela Lin (Senior Research Scientist, MiNA therapeutics, UK)
Date：2024-01-29 11:00 - 12:00
Place：1F, Auditorium, Institute of Cellular and Organismic Biology |
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Topic：Visualizing enzyme catalysis and DNA repair by temperature-resolved cryo-EM and time-resolved XFEL
Speaker：Academician Ming Daw Tsai (Institute of Biological Chemistry, Academia Sinica, Taiwan)
Date：2024-01-31 10:30 - 12:00
Place：Auditorium, Genomics Research Center |
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Topic：Profiling RNA at chromatin targets in situ by antibody-targeted tagmentation
Speaker：Dr. Nadiya Khyzha (Postdoctoral Fellow, Fred Hutchinson Cancer Center, Seattle, WA)
Date：2024-01-31 11:00 - 12:00
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica |
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Topic：Filtering Aspect of Animal Embryogenesis toward Phenotypic Diversification
Speaker：Dr. Naoki Irie (Professor, Research Center for Integrative Evolutionary Science, SOKENDAI, Japan)
Date：2024-01-31 11:00 - 12:00
Place：1F, Auditorium, Institute of Cellular and Organismic Biology |
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Topic：Quantitative 3D cell imaging using soft X-ray tomography
Speaker：Dr. Jian-Hua Chen (Staff Scientist, National Center for X-ray Tomography, Lawrence Berkeley National Laboratory, USA)
Date：2024-01-31 15:00 - 16:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica |
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A mutant of ubiquitin C-terminal hydrolase L1 (UCHL1) detected in early-onset neurodegenerative patients, UCHL1R178Q, showed higher catalytic activity than wild-type UCHL1 (UCHL1WT). Lying within the active-site pocket, the arginine is part of an interaction network that holds the catalytic histidine in an inactive arrangement. |
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High-sugar diets (HSDs) often lead to obesity and type 2 diabetes, both metabolic syndromes associated with stem cell dysfunction. However, it is unclear whether excess dietary sugar affects stem cells. Here, we report that HSD impairs stem cell function in the intestine and ovaries of female Drosophila prior to the onset of insulin resistance, a hallmark of type 2 diabetes. |
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Knotted proteins are fascinating to biophysicists because of their robust ability to fold into intricately defined three-dimensional structures with complex and topologically knotted arrangements. |
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The tumor microenvironment (TME) presents differential selective pressure (DSP) that favors the growth of cancer cells, and monovalent therapy is often inadequate in reversing the cancer cell dominance in the TME. |
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Activation of effector T cells leads to upregulation of PD-1, which can inhibit T cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTMs), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and inter-protein interactions. |
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