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ENT1 inhibition links adenosine homeostasis to oligodendrocyte-associated metabolic pathways and supports further investigation as a potential therapeutic approach for tauopathy-associated network dysfunction. |
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We show that the C-terminal region, especially Gly256 to Ala281, of SUB1A-1 is associated with increased steady-state protein levels, and that its removal is associated with reduced accumulation and effects consistent with increased turnover in this assay. |
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Through synthetic access to 3,3diFNeu5Ac, more potent and stable inhibitors of STs and NEUs were developed, which can serve as better tools to probe the functions of sialoglycans. |
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The central dogma of protein folding theory is that the amino acid sequence determines protein structure. |
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G protein-coupled receptors (GPCRs) are central physiological signal transducers and represent a primary class of therapeutic targets. |
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Polynucleotide phosphorylase (PNPase) is a highly conserved exoribonuclease crucial for RNA degradation across all domains of life. |
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研究結果顯示，法屬圭亞那的 Xylaria 多樣性遠比過去所認知的更為豐富且複雜，並為未來熱帶真菌多樣性與生物地理研究建立一套整合性的分類學基礎。 |
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