Period: 2024-7-15 ~ 2024-7-22

Life Science Group members can loan out 2 books at a time for 14 days with no renewals start from the second week.

Topic：Isolation and characterization of giant viruses infecting amoeba
Speaker：Dr. Masaharu Takemura
Date：2024-07-16 11:00 - 12:00
Place： 1F Auditorium, Institute of Molecular Biology, Academia Sinica

Topic：Dissecting the mechanism by which tubulin acetyltransferases access and modify the confined microtubule lumen
Speaker：Dr. Shih-Chieh Jeff Ti
Date：2024-07-18 11:00 - 12:00
Place：1F Auditorium, Institute of Molecular Biology, Academia Sinica

Topic：Expanding the Ligandable Proteome Using Tyrosine-Reactive Electrophiles
Speaker：Dr. Ku-Lung (Ken) Hsu (Univ. of Texas at Austin)
Date：2024-07-18 16:00 - 17:00
Place：生醫所地下室B1B演講廳

Topic：Understanding Protein Dynamics for Structure-based Drug Design: Design Stories of Crizotinib, Lorlatinib and Repotrectinib
Speaker：Dr. J. Jean Cui (Scientific Founder, President, and CEO of BlossomHill Therapeutics, Inc.)
Date：2024-07-22 10:30 - 11:30
Place：C212 Lecture Room, National Biotechnology Research Park

Topic：Constructing and Deconstructing an Awesome Organelle
Speaker：Dr. Pierre Gönczy (Professor and EMBO Member, EPFL (Swiss Federal Institute of Technology), Lausanne, Switzerland)
Date：2024-07-22 11:00 - 12:00
Place：1F, Auditorium, Institute of Cellular and Organismic Biology

Topic：Exploring the dynamics of respiratory virus infections in the nasal cavity
Speaker：Dr. Chien-Ting Wu (UT Southwestern Medical Center)
Date：2024-07-22 14:00 - 15:00
Place：B1B Lecture Room, IBMS

Topic：From Stereocontrolled Glycosylation to Automated Chemical Synthesis
Speaker：Prof. Alexei V Demchenko (Saint Louis University, USA)
Date：2024-07-22 15:00 - 17:00
Place：1F Auditorium, Genomics Research Center

Topic：Present and Future of Cell and Gene Therapy: an Example
Speaker：Miguel Forte (MD, PhD) (International Society for Cell and Gene Therapy, ISCT)
Date：2024-07-23 10:00 - 12:00
Place：C201 Conference Hall, National Biotechnology Research Park (No. 99, Aly 130, Sec. 1, Academia Rd., Nangang District, Taipei City 11571, Taiwan)

Topic：Physiology and Pathophysiology of ATP-sensitive K+ channel
Speaker：Dr. Kenju Shimomura (Fukushima Medical Univ.)
Date：2024-07-23 11:00 - 12:00
Place：B1B Lecture Room, IBMS

Topic：Distinct roles of IL-27 in regulating intestinal homeostasis in health and disease
Speaker：Dr. L-Fan Lu
Date：2024-07-23 11:00 - 12:00
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica

Topic：Molecular dynamics between plant-insect interaction using parasitic plant, Cuscuta campestris
Speaker：Dr. Kanako Bessho-Uehara (Assistant Professor, Graduate School of Life Sciences, Tohoku University, Japan)
Date：2024-07-24 15:00 - 16:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：From Immunogenomics to Immunotherapy
Speaker：Prof Yusuke Nakamura
Date：2024-07-24 15:00 - 17:00
Place：C212 Lecture Room, National Biotechnology Research Center

Topic：In situ structural biology by cryo-electron tomography
Speaker：Dr. Yi-Wei Chang (University of Pennsylvania, USA)
Date：2024-07-25 11:00 - 12:00
Place：IBC R209

Topic：Autotrophic Metabolism in Changing Environments
Speaker：Prof. Ivan Berg (University of Münster, Germany)
Date：2024-07-26 10:00 - 11:30
Place：Auditorium, 1st Floor, Interdisciplinary Research Building

Date: 2024-07-16 08:50 - 12:30
Place: B1A Meeting Room, IBMS

Klebsiella pneumoniae provides influential prototypes for lipopolysaccharide O antigen (OPS) biosynthesis in Gram-negative bacteria. Sequences of OPS-biosynthesis gene clusters in serotypes O4 and O7 suggest fundamental differences in the organization of required enzyme modules compared to other serotypes.

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The development of immune cell engagers (ICEs) can be limited by logistical and functional restrictions associated with fusion protein designs, thus limiting immune cell recruitment to solid tumors.

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Capsules are long-chain carbohydrate polymers that envelop the surfaces of many bacteria, protecting them from host immune responses.

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The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that can control cellular levels of protein fucosylation have consequently emerged as being of high interest.

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Natural environments surrounding cells are highly complex, containing multiple chemical species whose concentrations dynamically change.

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Splicing variants are a major class of pathogenic mutations, but redundant and degenerate splicing signals hinder functional assessments of sequence variations within introns.

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Immune cells that infiltrate the tumor microenvironment (TME) play crucial roles in shaping cancer development and influencing clinical outcomes and therapeutic responses.

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Over 80% of the patients with pancreatic ductal adenocarcinoma (PDAC) have cachexia/wasting syndrome. Cachexia is associated with reduced survival, decreased quality of life, and higher metastasis rates.

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Local translation at synapses is important for rapidly remodeling the synaptic proteome to sustain long-term plasticity and memory. While the regulatory mechanisms underlying memory-associated local translation have been widely elucidated in the postsynaptic/dendritic region, there is no direct evidence for which RNA-binding protein (RBP) in axons controls target-specific mRNA translation to promote long-term potentiation (LTP) and memory.

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Plants use nucleotide-binding domain and leucine-rich repeat-containing proteins (NLRs) as intracellular immune receptors to recognize pathogen effectors and limit pathogen spread.

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Plants use nucleotide-binding domain and leucine-rich repeat-containing proteins (NLRs) to recognize pathogens. In solanaceous plants, the NRC (NLR required for cell death) family forms a complex network with helper and sensor NLRs to resist pathogens.

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