展期：2024-7-15 ~ 2024-7-22

限生命組同仁借閱，每次借閱以 2 本為限且不續借

休息睡覺也是一種本能，曾幾何時，人們為了追求所謂更好的生活，把我們與生俱來的本能給忘了。

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講題：Isolation and characterization of giant viruses infecting amoeba
主講者：Dr. Masaharu Takemura
時間：2024-07-16 11:00 - 12:00
地點：中央研究院分子生物研究所1F演講廳

講題：Dissecting the mechanism by which tubulin acetyltransferases access and modify the confined microtubule lumen
主講者：Dr. Shih-Chieh Jeff Ti
時間：2024-07-18 11:00 - 12:00
地點：中央研究院分子生物研究所1F演講廳

講題：Expanding the Ligandable Proteome Using Tyrosine-Reactive Electrophiles
主講者：Dr. Ku-Lung (Ken) Hsu (Univ. of Texas at Austin)
時間：2024-07-18 16:00 - 17:00
地點：生醫所地下室B1B演講廳

講題：Understanding Protein Dynamics for Structure-based Drug Design: Design Stories of Crizotinib, Lorlatinib and Repotrectinib
主講者：崔景榮院士 (美國BlossomHill Therapeutics公司聯合創始人、總裁兼首席執行長)
時間：2024-07-22 10:30 - 11:30
地點：國家生技研究園區C212演講廳

講題：Constructing and Deconstructing an Awesome Organelle
主講者：Dr. Pierre Gönczy (Professor and EMBO Member, EPFL (Swiss Federal Institute of Technology), Lausanne, Switzerland)
時間：2024-07-22 11:00 - 12:00
地點：細生所1樓演講廳

講題：Exploring the dynamics of respiratory virus infections in the nasal cavity
主講者：吳千鼎博士 (UT Southwestern Medical Center)
時間：2024-07-22 14:00 - 15:00
地點：生醫所地下室B1B演講廳

講題：From Stereocontrolled Glycosylation to Automated Chemical Synthesis
主講者：Demchenko 教授 (美國Saint Louis University)
時間：2024-07-22 15:00 - 17:00
地點：基因體研究中心一樓演講廳

講題：Present and Future of Cell and Gene Therapy: an Example
主講者：Miguel Forte（MD, PhD）(國際細胞和基因治療協會 ISCT)
時間：2024-07-23 10:00 - 12:00
地點：國家生技研究園區C棟2樓C201國際會議廳 (臺北市南港區研究院路一段130巷99號)

講題：Physiology and Pathophysiology of ATP-sensitive K+ channel
主講者：Kenju Shimomura 博士 (Fukushima Medical Univ.)
時間：2024-07-23 11:00 - 12:00
地點：生醫所地下室B1B演講廳

講題：Distinct roles of IL-27 in regulating intestinal homeostasis in health and disease
主講者：Dr. L-Fan Lu
時間：2024-07-23 11:00 - 12:00
地點：中央研究院分子生物研究所B1演講廳

講題：Molecular dynamics between plant-insect interaction using parasitic plant, Cuscuta campestris
主講者：Dr. Kanako Bessho-Uehara (Assistant Professor, Graduate School of Life Sciences, Tohoku University, Japan)
時間：2024-07-24 15:00 - 16:00
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

講題：From Immunogenomics to Immunotherapy
主講者：中村祐輔教授
時間：2024-07-24 15:00 - 17:00
地點：國家生技研究園區 C212演講廳

講題：In situ structural biology by cryo-electron tomography
主講者：張毅偉教授 (美國University of Pennsylvania)
時間：2024-07-25 11:00 - 12:00
地點：生化所209研討室

講題：Autotrophic Metabolism in Changing Environments
主講者：Prof. Ivan Berg (University of Münster, Germany)
時間：2024-07-26 10:00 - 11:30
地點：跨領域科技研究大樓1樓演講廳

時間: 2024-07-16 08:50 - 12:30
地點: 生醫所地下室B1A演講廳

Klebsiella pneumoniae provides influential prototypes for lipopolysaccharide O antigen (OPS) biosynthesis in Gram-negative bacteria. Sequences of OPS-biosynthesis gene clusters in serotypes O4 and O7 suggest fundamental differences in the organization of required enzyme modules compared to other serotypes.

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The development of immune cell engagers (ICEs) can be limited by logistical and functional restrictions associated with fusion protein designs, thus limiting immune cell recruitment to solid tumors.

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Capsules are long-chain carbohydrate polymers that envelop the surfaces of many bacteria, protecting them from host immune responses.

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The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that can control cellular levels of protein fucosylation have consequently emerged as being of high interest.

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Natural environments surrounding cells are highly complex, containing multiple chemical species whose concentrations dynamically change.

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Splicing variants are a major class of pathogenic mutations, but redundant and degenerate splicing signals hinder functional assessments of sequence variations within introns.

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Immune cells that infiltrate the tumor microenvironment (TME) play crucial roles in shaping cancer development and influencing clinical outcomes and therapeutic responses.

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Over 80% of the patients with pancreatic ductal adenocarcinoma (PDAC) have cachexia/wasting syndrome. Cachexia is associated with reduced survival, decreased quality of life, and higher metastasis rates.

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Local translation at synapses is important for rapidly remodeling the synaptic proteome to sustain long-term plasticity and memory. While the regulatory mechanisms underlying memory-associated local translation have been widely elucidated in the postsynaptic/dendritic region, there is no direct evidence for which RNA-binding protein (RBP) in axons controls target-specific mRNA translation to promote long-term potentiation (LTP) and memory.

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植物利用含有核苷酸結合域和富含亮氨酸重複序列的蛋白質 (NLRs) 作為細胞內免疫受體，以識別病原體效應蛋白並限制病原體的擴散。儘管有些NLRs單獨作用，許多NLRs特化為偵測型NLRs來檢測病原體效應蛋白，及輔助型NLRs來介導免疫反應。

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植物利用含有核苷酸結合域和富含亮氨酸重複序列的蛋白質 (NLRs) 來識別病原體。在茄科植物中，許多輔助型和偵測型NLRs形成複雜的NRC免疫受體網絡來抵抗病原體。然而，茄科植物之外的NRC免疫受體網絡的進化和功能仍不清楚。

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