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 發報日期 : 2021/08/16 發行期數:268 
 
 
 

最新消息

 
 
 
 
新書展示
 
 
展期:2021-08-016 ~ 2021-08-23
 
 
 
 
 
 
 
免費電子資源
 
 
聯合國政府間氣候變遷問題小組(Intergovernmental Panel on Climate Change)近期公布的《第6次氣候變遷評估報告-物理科學基礎報告》
 
 
 
 
 
 
 
免費電子資源
 
 
Uni-edit團隊提供之電子書,透過此書瞭解期刊同儕審稿意見對您的論文的意義。
 
 
 
 
 
 
 
奬項
 
 
賀林坤陽博士、江尚殷博士、陳鈺軒博士、劉彥呈博士榮獲第十七屆李天德醫藥獎之傑出論文獎
 
 
 
 
 
 

館務公告

 
 
疫情期間開館政策
 
 
疫情期間開館政策
 
 
即日起至2021/8/23僅開放院內同仁憑識別證入館.
 
 
 
 
 
 

教育訓練課程

 
 
 
 
【生物資訊系列 】7:Prying into Cancer Omic from R(In English)(實體課程)
 
2021-08-27(五)14:00~16:00
陳彥劦先生 (博士研究生, 中研院生醫所)
生化所 209 研討室
 
 
 
   
 
 
 

資料庫介紹

 
 
 
 
HSTalks新片上架
 
 
HSTalks: The Biomedical & Life Sciences Collection
八月份新片上架囉!
 
 
 
 
 
IPA維修公告
 
 
IPA維修公告
 
 
IPA 將於 2021/08/14(六)AM 08:00 ~ 11:00 進行系統維護,暫時無法連線使用
 
 
 
 
 
 
 
Wiley Digital TextBooks電子教科書試用
 
 
試用期限:即日起至 9/7 日止
相關設定:IP管控,若瀏覽後欲借閱書籍請先註冊個人帳號 ,每本書3個複本、每個人一次可借3本書、借閱期7天
 
 
 
 
 
 
 
BioCyc版本升級至25.1
 
 
25.1版小升級包括更新BioCyc網頁及下載資料量。
 
 
 
 
 
 

Blog

 
 
 
 
QIAGEN IPA 2021夏季更新(上)
 
 
QIAGEN IPA 路徑分析軟體在本季度釋出重大更新,提供新模式搜尋及數據分析,詳細更新內容請參閱服務推廣.
 
 
 
 
 
 

生命組演講公告

 
 
 
 
8/19 植微所演講
 
 
講題:The special case of Taiwan for studies on plant and microbial biogeography
主講者:Dr. Stavros Veresoglou
時間:2021-08-19 15:00
地點:Presented via Cisco Webex
 
 
 
 
 
 
 
8/19 生醫所演講
 
 
講題:Inherited Arrhythmia Syndromes: From the clinic to the lab
主講者:蔡文欽博士
時間:2021-08-19 16:00 - 17:00 pm
地點:Webex only
 
 
 
 
 
8/23 植微所演講
 
 
8/23 植微所演講
 
 
講題:Expansion of gene regulatory network in plants upon environmental changes: what is kept and what is lost throughout evolution
主講者:Dr. Ting-Ying Wu
時間:2021-08-23 15:00
地點:Presented via Cisco Webex
 
 
 
 
 
8/24 分生所演講
 
 
8/24 分生所演講
 
 
講題:Pentraxin 3’s biological roles and therapeutic potential in inflammation-associated diseases
主講者:Dr. 王育民
時間:2021-08-24 11:00 am
地點:Online Webex
 
 
 
 
 
 
 
8/30 生醫所演講
 
 
講題:Development of Bifunctional Anticancer Agents
主講者:Dr. 李德章
時間:2021-08-30 11:00-12:00 am
地點:Webex Meeting
 
 
 
 
 
 
 
8/30 農生中心演講
 
 
講題:淺談植物新藥開發的理想與現實
主講者:涂倉榮先生
時間:2021-08-30 11:00 AM
地點:Presented by Webex Meeting
 
 
 
 
 
 

研討會資訊

 
 
 
 
關懷中心線上心理健康講座
 
 
主題:職場人際關係
講師:蘇絢慧心理師
對象:本院全體同仁
時間:2021年8月20日(五)下午2點-4點
*可登錄2小時環境教育認證時數。
 
 
 
 
 
 

生命組研究成果重要發現

 
 
 
 
找到「彼得潘」基因?斑馬魚需要ddx52才能轉大人
 
 
動物個體的發育通常進展快速,就像行進中的火車,直到抵達終點(成年的階段)才會停止。雖然在自然界中有少數的例外存在,比如帝王斑蝶,可以在過冬遷徙的時候,長時間延遲成年期的發育。複雜的脊椎動物是不是也具備這樣的能力?
 
 
 
 
 
 
 
 
地膽草倍半萜內酯deoxyelephantopin及其衍生物 DETD-35 抑制BRAFV600E突變種黑色素瘤在小鼠體內之肺轉移
 
 
黑色素瘤是臨床上具難治性且預後差之高轉移性癌症疾病。因此,開發治療轉移性黑色素瘤的新藥物是迫切急需的。我們建立一嗜肺臟轉移之人類BRAFV600E突變種黑色素瘤A375LM5IF4g/Luc細胞株,藉由體外以及異源性NOD/SCID小鼠肺轉移模型研究發現,植物倍半萜內脂deoxyelephantopin(DET)及其衍生物DETD-35藉由調節肺部腫瘤微環境之肺血管的通透性、血管新生(VEGF+、CD31+)和 EMT標誌蛋白質來抑制黑色素瘤在小鼠體內之肺部轉移。
 
 
 
 
 
 
 
 
A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells
 
 
Hemagglutinin (HA) is the immunodominant protein of the influenza virus. We previously showed that mice injected with a monoglycosylated influenza A HA (HAmg) produced cross-strain-reactive antibodies and were better protected than mice injected with a fully glycosylated HA (HAfg) during lethal dose challenge. We employed a single B-cell screening platform to isolate the cross-protective monoclonal antibody (mAb) 651 from mice immunized with the HAmg of A/ Brisbane/59/2007 (H1N1) influenza virus (Bris/07).
 
 
 
 
 
 
 
 
Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability
 
 
Phenotypic variation is a fundamental prerequisite for cell and organism evolution by natural selection. Whereas the role of stochastic gene expression in phenotypic diversity of genetically identical cells is well studied, not much is known regarding the relationship between stochastic gene expression and individual behavioral variation in animals. We demonstrate that a specific miRNA (miR-466f-3p) is upregulated in the hippocampus of a portion of individual inbred mice upon a Morris water maze task
 
 
 
 
 
 
 
 
Atypical antipsychotics and CD36 pathway
 
 
Clinical reports indicate that schizophrenia patients taking atypical antipsychotic drugs suffer from metabolism diseases including atherosclerosis. However, the mechanisms underlying the detrimental effect of atypical antipsychotic drugs on atherosclerosis remain to be explored.
 
 
 
 
 
 
 
 
Development of a Novel Cytokine Vehicle Using Filamentous Phage Display for Colorectal Cancer Treatment
 
 
Due to its highly immunogenic nature and the great engineerability, filamentous phage has shown promising antitumor activities in preclinical studies. Previous designs of antitumor phage mainly focused on tumor targeting using a cancer-specific moiety displayed on the minor capsid protein, pIII. In this work, we developed a new therapeutic platform of filamentous phage, in which the major capsid protein pVIII was utilized for displaying an antitumor cytokine.
 
 
 
 
 
 
 
 
Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood
 
 
Adults with obesity exhibit a restrictive pattern, whereas children with obesity exhibit an obstructive pattern. However, the transition process remains unclear. We performed a systematic search for studies reporting on body mass index and pulmonary function in children.
 
 
 
 
 
 
 
 
Fungal F8-Culture Filtrate Induces Tomato Resistance against Tomato Yellow Leaf Curl Thailand Virus
 
 
番茄是全球重要的經濟作物,然而,由粉蝨傳播的begomoviruses (whitefly-transmitted begomoviruses, WTBs) 所引發的番茄黃化捲葉病 (tomato yellow leaf curl disease) 嚴重危害全球番茄產量。在本篇研究中,我們評估了先前實驗室已開發的植物抗病毒免疫誘導劑-F8真菌培養濾液,是否能誘導番茄對抗台灣主要的 WTB-番茄黃葉捲曲泰國病毒 (tomato yellow leaf curl Thailand virus, TYLCTHV)。
 
 
 
 
 
 
 
 
Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans
 
 
Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A moiety, inducing inflammatory caspase oligomerization and activation, which is identified as the noncanonical inflammasome pathway. Galectins, β-galactoside–binding proteins, bind to various gram-negative bacterial LPS, which display β-galactoside–containing polysaccharide chains. Galectins are mainly present intracellularly, but their interactions with cytosolic microbial glycans have not been investigated.
 
 
 
 
 
 
 
 
iTARGEX analysis of yeast deletome reveals novel regulators of transcriptional buffering in S phase and protein turnover
 
 
跨所團隊打造識別「生物性狀決定基因」的穿雲箭「iTARGEX」,一個全新的生物資訊工具,從剔除單一基因後的整體基因表現量變化與生物特徵進行一系列的相關性分析去預測參與調節特定性狀的基因。
 
 
 
 
 
 
 
 
Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer
 
 
Targeted-therapy failure in treating nonsmall cell lung cancer (NSCLC) frequently occurs because of the emergence of drug resistance and genetic mutations. The same mutations also result in aerobic glycolysis, which further antagonizes outcomes by localized increases in lactate, an immune suppressor.
 
 
 
 
 
 
 
 
PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression
 
 
Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the development of anticancer therapeutic strategies. Despite its severe adverse effects, selinexor, a selective first-in-class inhibitor of the common nuclear export receptor XPO1, was developed to target nucleocytoplasmic protein shuttling and received accelerated FDA approval in 2019 in combination with dexamethasone as a fifth-line therapeutic option for adults with relapsed refractory multiple myeloma (RRMM).
 
 
 
 
 
 
 
 
Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity
 
 
Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD.
 
 
 
 
 
 
 
 
 
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