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 Date : 2021/08/16 No:268 

Recent News

New Books
Period: 2021-08-16 ~ 2021-08-23
Free Online Resources

The IPCC has finalized the first part of the Sixth Assessment Report, Climate Change 2021: The Physical Science Basis, the Working Group I contribution to the Sixth Assessment Report. It was finalized on 6 August 2021 during the 14th Session of Working Group I and 54th Session of the IPCC.
Free Online Resources

What Must You Know About Journal Peer Reviewers?

Congratulations to Dr.Kung-Yang Lin、Dr.Shang-Yin Chiang、Dr.Yu-Hsuan and Dr.Yen-Chen Liu Chen for receiving the Outstanding Thesis Award from Tien Te Lee Biomedical foundation.

LSL Announcement

Library service updates
Library service updates

Only open to AS staff wearing I.D. badges.(Period : From now until August 23 , 2021)

Training Courses

【Bioinformatics series 】7:Prying into Cancer Omic from R(In English)
Mr. Yen-Hsieh Chen (Institute of Biomedical Sciences, Academia Sinica)
209 Seminar Room, IBC

Database Introduction

HSTalks New Releases

HSTalks: The Biomedical & Life Sciences Collection
New Releases for August
IPA Maintenance
IPA Maintenance

IPA will have a scheduled system maintenance Aug 14, 2021 from 8:00-11:00 am
Wiley Digital TextBooks Trial

Please grasp the trial period of Wiley Digital Textbooks, which expires on 9/7/2021.
BioCyc 25.1 Released

Version 25.1 is a minor release that includes updates to the BioCyc website and downloadable data files.
Version 25.1 of BioCyc contains 19,535 Pathway/Genome Databases. A total of 1,750 new genomes were added, of which 1710 are for NCBI reference/representative genomes.


8/19 IPMB Seminar

Topic:The special case of Taiwan for studies on plant and microbial biogeography
Speaker:Dr. Stavros Veresoglou
Date:2021-08-19 15:00
Place:Presented via Cisco Webex
8/19 IBMS Seminar

Topic:Inherited Arrhythmia Syndromes: From the clinic to the lab
Speaker:Wen-Chin Tsai, M.D., Ph.D.
Date:2021-08-19 16:00 - 17:00 pm
Place:Webex only
8/23 IPMB Seminar
8/23 IPMB Seminar

Topic:Expansion of gene regulatory network in plants upon environmental changes: what is kept and what is lost throughout evolution
Speaker:Dr. Ting-Ying Wu
Date:2021-08-23 15:00
Place:Presented via Cisco Webex
8/24 IMB Seminar
8/24 IMB Seminar

Topic:Pentraxin 3’s biological roles and therapeutic potential in inflammation-associated diseases
Speaker:Dr. Ju-Ming Wang
Date:2021-08-24 11:00 am
Place:Online Webex
8/30 IBMS Seminar

Topic:Development of Bifunctional Anticancer Agents
Speaker:Dr. Lee, Te-Chang
Date:2021-08-30 11:00-12:00 am
Place:Webex Meeting
8/30 ABRC Seminar

Date:2021-08-30 11:00 AM
Place:Presented by Webex Meeting

Important Research

The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish

Vertebrate animals usually display robust growth trajectories during juvenile stages, and reversible suspension of this growth momentum by a single genetic determinant has not been reported. Here, we report a single genetic factor that is essential for juvenile growth in zebrafish.
Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice

Melanoma is a highly metastatic disease with an increasing rate of incidence worldwide. It is treatment refractory and has poor clinical prognosis; therefore, development of new therapeutic agents for metastatic melanoma are urgently required. In this study we created a lung-seeking A375LM5IF4g/Luc BRAFV600E mutant melanoma cell clone and investigated the bioefficacy of a plant sesquiterpene lactone deoxyelephantopin (DET) and its novel semi-synthetic derivative, DETD-35 in suppressing metastatic A375LM5IF4g/Luc melanoma growth in vitro and in a xenograft mouse model.
A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells

Hemagglutinin (HA) is the immunodominant protein of the influenza virus. We previously showed that mice injected with a monoglycosylated influenza A HA (HAmg) produced cross-strain-reactive antibodies and were better protected than mice injected with a fully glycosylated HA (HAfg) during lethal dose challenge. We employed a single B-cell screening platform to isolate the cross-protective monoclonal antibody (mAb) 651 from mice immunized with the HAmg of A/ Brisbane/59/2007 (H1N1) influenza virus (Bris/07).
Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability

Phenotypic variation is a fundamental prerequisite for cell and organism evolution by natural selection. Whereas the role of stochastic gene expression in phenotypic diversity of genetically identical cells is well studied, not much is known regarding the relationship between stochastic gene expression and individual behavioral variation in animals. We demonstrate that a specific miRNA (miR-466f-3p) is upregulated in the hippocampus of a portion of individual inbred mice upon a Morris water maze task
Atypical antipsychotics and CD36 pathway

Clinical reports indicate that schizophrenia patients taking atypical antipsychotic drugs suffer from metabolism diseases including atherosclerosis. However, the mechanisms underlying the detrimental effect of atypical antipsychotic drugs on atherosclerosis remain to be explored.
Development of a Novel Cytokine Vehicle Using Filamentous Phage Display for Colorectal Cancer Treatment

Due to its highly immunogenic nature and the great engineerability, filamentous phage has shown promising antitumor activities in preclinical studies. Previous designs of antitumor phage mainly focused on tumor targeting using a cancer-specific moiety displayed on the minor capsid protein, pIII. In this work, we developed a new therapeutic platform of filamentous phage, in which the major capsid protein pVIII was utilized for displaying an antitumor cytokine.
Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood

Adults with obesity exhibit a restrictive pattern, whereas children with obesity exhibit an obstructive pattern. However, the transition process remains unclear. We performed a systematic search for studies reporting on body mass index and pulmonary function in children.
Fungal F8-Culture Filtrate Induces Tomato Resistance against Tomato Yellow Leaf Curl Thailand Virus

Tomato (Solanum lycopersicum) is an important economic crop worldwide. However, tomato production is jeopardized by the devastating tomato yellow leaf curl disease caused by whitefly-transmitted begomoviruses (WTBs). In this study, we evaluated the efficacy of our previously developed plant antiviral immunity inducer, fungal F8-culture filtrate, on tomato to combat tomato yellow leaf curl Thailand virus (TYLCTHV), the predominant WTB in Taiwan.
Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans

Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A moiety, inducing inflammatory caspase oligomerization and activation, which is identified as the noncanonical inflammasome pathway. Galectins, β-galactoside–binding proteins, bind to various gram-negative bacterial LPS, which display β-galactoside–containing polysaccharide chains. Galectins are mainly present intracellularly, but their interactions with cytosolic microbial glycans have not been investigated.
iTARGEX analysis of yeast deletome reveals novel regulators of transcriptional buffering in S phase and protein turnover

Cross-institution team creates “iTARGEX“ to identify biological trait determinants, a new bioinformatics tool, for in silico prediction of regulators linked to biological traits.
Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer

Targeted-therapy failure in treating nonsmall cell lung cancer (NSCLC) frequently occurs because of the emergence of drug resistance and genetic mutations. The same mutations also result in aerobic glycolysis, which further antagonizes outcomes by localized increases in lactate, an immune suppressor.
PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression

Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the development of anticancer therapeutic strategies. Despite its severe adverse effects, selinexor, a selective first-in-class inhibitor of the common nuclear export receptor XPO1, was developed to target nucleocytoplasmic protein shuttling and received accelerated FDA approval in 2019 in combination with dexamethasone as a fifth-line therapeutic option for adults with relapsed refractory multiple myeloma (RRMM).
Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD.
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