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許多 AAA+（與多種細胞活動相關的 ATP 酶）蛋白質透過將底物穿過其六聚體組件的中心孔來充當蛋白質或 DNA 重塑劑。在這種 ATP 依賴性易位狀態下，底物被排列成通用右手螺旋樓梯組織的 ATP 酶結構域的孔環所抓住。 |
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Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency through compartmentalizing DNPS enzymes during stressed conditions. However, the mechanism underpinning purinosome assembly and its pathophysiological functions remains elusive. |
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Drimane-type sesquiterpenes (DTSs) are significant terpenoid natural products characterized by their unique C15 bicyclic skeleton. They are produced by various organisms including plants, fungi, bacteria and marine organisms, and exhibit a diverse array of bioactivities. |
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HDA19屬於Reduced Potassium Dependence3/Histone Deacetylase-1（RPD3/HDA1）超家族的第一類，是一種經過深入研究的組蛋白去乙醯化酶。 |
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環境pH（pHe）是植物生存和適應的關鍵參數，影響著多項與植物生理狀態和適應性相關的條件。為了深入了解植物重新調節細胞質和細胞外pH穩態的機制，博士生達米西和施臥虎研究員進行了對植物在短時間內受到酸性或鹼性pH刺激的全面蛋白質/磷酸蛋白質組學分析。 |
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Homologous recombination (HR)-mediated DNA repair is a prerequisite for maintaining genome stability. Cancer cells displaying HR deficiency (HRD) are selectively eliminated by poly(ADP-ribose) polymerase inhibitors (PARPis). |
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ost cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex comprising 11 proteins: A16, A21, A28, F9, G3, G9, H2, J5, L1, L5 and O3. |
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Virus-mediated membrane fusion involves conformational changes of the viral fusion protein to fuse the opposing viral and host lipid bilayers. Unlike all other known viruses that contain a single fusion protein, poxviruses harbor a multimeric protein complex of 11 subunits, termed the entry fusion complex (EFC), to mediate fusion with host membranes. |
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Nematodes are ubiquitous in soil and are the most abundant animals on Earth. Some fungi have evolved the ability to prey on nematodes in nutrient-deficient environments. |
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