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 Date : 2023/11/27 No:323 

Recent News

New Books
Period: 2023-11-27 ~ 2023-12-04
Henry Stewart Talks November recently added.


Training Courses

【Clinical Trial Lecture-Basic Course】Lesson 5-Study design in Phase I clinical trials(In Chinese)(Physical and Video Class)
Dr.Mey Wang
B1 Auditorium, Institute of Statistical Science
【Clinical Trial Lecture-Basic Course】Lesson 6-Study design in Phase II clinical trials(In Chinese)(Physical and Video Class)
Dr.Mey Wang
Research Building of Environmental Changes, AS, 6005 Room

Video Service

Welcome to browse the video service of LSL courses



11/28 IMB Seminar

Topic:Calcium, ATP, and ROS: A Mitochondrial Love-Hate Triangle
Speaker:Dr. Shey-Shing Sheu (Thomas Jefferson University, USA)
Date:2023-11-28 11:00 - 12:00
Place:B1 Auditorium, Institute of Molecular Biology
11/28 GRC Seminar

Topic:Navigating the Future of Scientific Publishing with Cell Press
Speaker:Steve Mao, Ph.D. (Editor-in-Chief, Cancer Cell, USA)
Date:2023-11-28 15:30 - 16:30
Place:Auditorium, Genomics Research Center
11/29 GRC Seminar

Topic:Selective Degradation of Mitochondria: How to Choose and Segregate the Bad Parts?
Speaker:Zee-Fen Chang, Chair Professor (National Taiwan University)
Date:2023-11-29 15:30 - 17:00
Place:1F Auditorium, Genomics Research Center
11/30 IBC Seminar

Topic:Oscillations to Select, Transport, and Grow
Speaker:Dr. Yu-Ling Shih (IBC)
Date:2023-11-30 11:00 - 12:00
Place:IBC R209
12/4 ABRC Seminar

Topic:Herbal medicines modulate B cell-mediated humoral immunity against cancer
Speaker:Dr. Yu-Ling Lin (Assistant Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica)
Date:2023-12-04 11:00 - 12:00
Place:Auditorium A134, Agricultural Technology Building
12/5 IMB Seminar

Topic:From bench to clinic- an overview of biologics drug development
Speaker:Dr. Carolyn T. Hsu (Associate Director CMC Clinical Program Management R&D Integration & Program Management Alkermes, Waltham, MA)
Date:2023-12-05 11:00 - 12:00
Place:1F Auditorium, Institute of Molecular Biology, Academia Sinica
12/6 IMB Seminar

Topic:The dynamic brain: understanding the synaptic basis of behavior
Speaker:Dr. Yi Zuo (Professor Department of Molecular Cell & Developmental Biology University of California Santa Cruz, CA)
Date:2023-12-06 11:00 - 12:00
Place:B1 Auditorium, Institute of Molecular Biology, Academia Sinica
12/6 GRC Seminar

Topic:Advances in Genome-Edited Hematopoietic Stem Cells for Ameliorating Age-Related Declines: New Clinical Paradigms
Speaker:Yu-ChiauShyu, Ph.D.
Date:2023-12-06 15:00 - 16:30
Place:1F Auditorium, Genomics Research Center
12/8 IBC Seminar

Topic:Listen to heme! You are exhausted for fighting against tumors
Speaker:Dr. Ping-Chih Ho (University of Lausanne, Switzerland)
Date:2023-12-08 11:00 - 12:00
Place:IBC R209

Important Research

A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine

Many AAA+ (ATPases associated with diverse cellular activities) proteins function as protein or DNA remodelers by threading the substrate through the central pore of their hexameric assemblies. In this ATP-dependent translocating state, the substrate is gripped by the pore loops of the ATPase domains arranged in a universal right-handed spiral staircase organization.
PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly

Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency through compartmentalizing DNPS enzymes during stressed conditions. However, the mechanism underpinning purinosome assembly and its pathophysiological functions remains elusive.
Terpene Synthases in the Biosynthesis of Drimane-Type Sesquiterpenes across Diverse Organisms

Drimane-type sesquiterpenes (DTSs) are significant terpenoid natural products characterized by their unique C15 bicyclic skeleton. They are produced by various organisms including plants, fungi, bacteria and marine organisms, and exhibit a diverse array of bioactivities.
An interactome of histone deacetylase HDA19

HISTONE DEACETYLASE 19 (HDA19) belongs to class 1 of the Reduced Potassium Dependence3/Histone Deacetylase-1 (RPD3/HDA1) superfamily and is possibly the most intensively studied HDA.
Protein Phosphorylation Orchestrates Acclimations to Ambient pH

Environment pH (pHe) is a key parameter dictating a surfeit of conditions critical to plant survival and fitness. To elucidate the mechanisms that recalibrate cytoplasmic and apoplastic pH homeostasis, Dharmesh Jain and Wolfgang Schmidt conducted a comprehensive proteomic/phosphoproteomic inventory of plants subjected to transient exposure to acidic or alkaline pH, an approach that covered the majority of protein-coding genes of the reference plant Arabidopsis thaliana.
An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time

Homologous recombination (HR)-mediated DNA repair is a prerequisite for maintaining genome stability. Cancer cells displaying HR deficiency (HRD) are selectively eliminated by poly(ADP-ribose) polymerase inhibitors (PARPis).
Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations

ost cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with host membranes via a viral entry fusion protein complex comprising 11 proteins: A16, A21, A28, F9, G3, G9, H2, J5, L1, L5 and O3.
Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex

Virus-mediated membrane fusion involves conformational changes of the viral fusion protein to fuse the opposing viral and host lipid bilayers. Unlike all other known viruses that contain a single fusion protein, poxviruses harbor a multimeric protein complex of 11 subunits, termed the entry fusion complex (EFC), to mediate fusion with host membranes.
Key processes required for the different stages of fungal carnivory by a nematode-trapping fungus

Nematodes are ubiquitous in soil and are the most abundant animals on Earth. Some fungi have evolved the ability to prey on nematodes in nutrient-deficient environments.
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