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謝明勳老師實驗室最近研發出了高維生素B1的稻米。該研究團隊把一個來自大腸桿菌，與維生素B1合成有關的基因轉殖到水稻與阿拉伯芥中，結果發現轉殖植物內的維生素B1含量提高了。謝老師的研究團隊進一步以具有胚乳專一性的啟動子來驅動該大腸桿菌的基因，結果發現轉殖水稻的糙米與白米增加了約25-30% 的維生素B1。 |
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曾經想過希望自己可以多長個幾公分嗎？那侏儒症患者呢？本院細胞與個體生物學研究所李宜靜研究團隊，建立一細胞篩選系統，從植物萃取物中分離出有效成分，希望可以幫助侏儒症患者長高。
骨骼生長受到精確調控，纖維細胞生長因子受體 3 (FGFR3) 扮演重要角色。FGFR3 在胎兒發育晚期，骨骼生長板的軟骨細胞中大量表現，抑制胎兒骨骼的生長。 |
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Fork reversal is a conserved mechanism to prevent stalled replication forks from collapsing. Formation and protection of reversed forks are two crucial steps in ensuring fork integrity and stability. Five RAD51 paralogs, namely, RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, which share sequence and structural similarity to the recombinase RAD51, play poorly defined mechanistic roles in these processes. |
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Eukaryotic dehydrodolichyl diphosphate synthases (DHDDSs), cis-prenyltransferases (cis-PTs) synthesizing precursors of dolichols to mediate glycoprotein biosynthesis require partners, e.g. Nus1 in yeast and NgBR in animals, which are cis-PTs homologues without activity but to boost the DHDDSs activity. |
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This study sheds light on the role of PHRF1 in the invasion of colorectal cancer HCT116-p53-/- cells, which harbor the oncogenic KrasG13D mutation and lack p53. These findings provide novel insights regarding the role of PHRF1 in invasion by modulating SOX4 expression in colorectal cancer HCT116-p53-/- cells. |
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Photolyases, a ubiquitous class of flavoproteins, use blue light to repair DNA photolesions. In this work, we determined the structural mechanism of the photolyase-catalyzed repair of a cyclobutane pyrimidine dimer (CPD) lesion using time-resolved serial femtosecond crystallography (TR-SFX). |
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Phycobilisomes (PBS) are antenna megacomplexes that transfer energy to photosystems II and I in thylakoids. PBS likely evolved from a basic, inefficient form into the predominant hemidiscoidal shape with radiating peripheral rods. |
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阿茲海默症的關鍵因素包括β澱粉樣蛋白斑塊、過度磷酸化tau (pTau) 和小膠質細胞活化。Galectin-3是一種 β-半乳糖苷結合蛋白，它在tau病理（tauopathy）中的作用仍不清楚。我們的研究顯示Galectin-3在tauopathy的病人和小鼠的小膠質細胞中表達上調。 |
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DMSP(dimethylsulfoniopropionate) 是重要全球硫循環分子，主要由海洋植物性浮游生物和微生物產生。珊瑚礁是高DMSP生產棲地，其中不僅浮游生物和微生物製造該分子，珊瑚本身也參與製造DMSP，DMSP代謝被視為珊瑚對抗熱逆境一個重要的機制和手段，其中DMSP分解後的DMS (dimethylsulfide) 是知名的氣候冷化氣體，具有極優的抗氧化能力，可以幫忙珊瑚清除熱逆境引起的大量自由基。 |
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Proteins can spontaneously tie a variety of intricate topological knots through twisting and threading of the polypeptide chains. Recently developed artificial intelligence algorithms have predicted several new classes of topological knotted proteins, but the predictions remain to be authenticated experimentally. |
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The structure determination of protein tyrosine phosphatase (PTP): phospho-protein complexes, which is essential to understand how specificity is achieved at the amino acid level, remains a significant challenge for protein crystallography and cryoEM due to the transient nature of binding interactions. |
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