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Period: 2023-12-11 ~ 2023-12-18 |
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Title：Revealing ecological characters, metagenomes and its potential functions of coral-associated bacterial aggregates in the coral, Stylophora pistillata
Date：12/11/2023-12/24/2023 |
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H1 Connect database introduction (Formerly known as Faculty Opinions) |
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Dr. Wong emphasized that“By designing the consensus sequence of hemagglutinin (HA) from different influenza viruses, and trimming the sugar molecules on the surface of the HA protein, particularly on the regions that are difficult to mutate making them fully exposed and recognized by the immune system, is the key to successfully develop molecular vaccines that are protective against a variety of influenza viruses." |
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Topic：Runaway Transcription and Its Genome-Wide Impact
Speaker：Dr. Gene-Wei Li (Associate Professor Department of Biology Massachusetts Institute of Technology Cambridge, MA)
Date：2023-12-13 11:00 - 12:00
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica |
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Topic：From Method Development to Total Synthesis of Natural Metabolites for Structure-Activity Relationship Study
Speaker：Dr. Kwok-Kong Tony Mong (National Yang Ming Chiao Tung University, Taiwan)
Date：2023-12-14 11:00 - 12:00
Place：IBC R209 |
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Topic：Conserved Cell Fating Mechanisms in Brain Development
Speaker：Tzumin Lee, MD, PhD (Peter D. Meister Professor, Life Sciences Institute, Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Howard Hughes Medical Institute)
Date：2023-12-14 11:00 - 12:30
Place：1F, Auditorium, Institute of Cellular and Organismic Biology |
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Topic：Deciphering Microbial Influence on Host Behavior and Physiology in Drosophila
Speaker：Dr. Adam C.N. Wong (University of Florida, USA)
Date：2023-12-15 11:00 - 12:00
Place：IBC R209 |
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Topic：Protein-based fluorescent biosensors for investigating neural metabolism
Speaker：Dr. Yusuke Nasu (The University of Tokyo, Japan)
Date：2023-12-18 11:00 - 12:00
Place：IBC R209 |
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Topic：US Venture Capital 101: Learn about how US VCs pick their winner and how to craft a storyline
Speaker：Dr. Hsin-Fang Momo Wu (Chef Business Development Officer, Botrista Technology Inc, USA)
Date：2023-12-18 11:00 - 13:00
Place：Auditorium A134, Agricultural Technology Building |
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Topic：Why microglia belong to the neurovascular unit, and radial glia are NOT the cortical neural progenitors
Speaker：Prof. Kuan, Chia-Yi (Alex) (Dept. of Neuroscience Univ. of Virginia School of Med., USA)
Date：2023-12-21 11:00 - 12:00
Place：1F Auditorium Interdisciplinary Research Building for Science and Technology(B106) |
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Topic：Programming bacteria for multiplexed DNA detection
Speaker：Dr. Yu-Yu Cheng (University of Wisconsin-Madison, USA)
Date：2023-12-21 11:00 - 12:00
Place：IBC R209 |
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Topic：Electric Cell-Substrate Impedance Sensing: A Morphological Biosensor for Cell Research
Speaker：Dr. Chun-Min Lo (Nat'l Yang Ming Chiao Tung Univ.)
Date：2023-12-21 16:00 - 17:00
Place：B1B Lecture Room, IBMS |
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Dr. Ming-Hsiun Hsieh’s laboratory has created transgenic rice with enhanced vitamin B1 in the seed. The research group introduced a bacterial gene encoding thiamin monophosphate kinase into Arabidopsis and rice, creating an additional route for thiamin diphosphate biosynthesis and increasing total vitamin B1. |
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Have you ever wished you were taller? Dr. Yi-Ching Lee led a team developed a screening system to identify bioactive compounds from plant extracts that may help achondroplasia patients grow taller.
Overactivation mutations in FGFR3 lead to a group of short-limbed dwarfism and certain types of cancer. Achondroplasia is the most common form of human dwarfism caused by FGFR3 overactivation mutations. |
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Fork reversal is a conserved mechanism to prevent stalled replication forks from collapsing. Formation and protection of reversed forks are two crucial steps in ensuring fork integrity and stability. Five RAD51 paralogs, namely, RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, which share sequence and structural similarity to the recombinase RAD51, play poorly defined mechanistic roles in these processes. |
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Eukaryotic dehydrodolichyl diphosphate synthases (DHDDSs), cis-prenyltransferases (cis-PTs) synthesizing precursors of dolichols to mediate glycoprotein biosynthesis require partners, e.g. Nus1 in yeast and NgBR in animals, which are cis-PTs homologues without activity but to boost the DHDDSs activity. |
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This study sheds light on the role of PHRF1 in the invasion of colorectal cancer HCT116-p53-/- cells, which harbor the oncogenic KrasG13D mutation and lack p53. These findings provide novel insights regarding the role of PHRF1 in invasion by modulating SOX4 expression in colorectal cancer HCT116-p53-/- cells. |
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Photolyases, a ubiquitous class of flavoproteins, use blue light to repair DNA photolesions. In this work, we determined the structural mechanism of the photolyase-catalyzed repair of a cyclobutane pyrimidine dimer (CPD) lesion using time-resolved serial femtosecond crystallography (TR-SFX). |
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Phycobilisomes (PBS) are antenna megacomplexes that transfer energy to photosystems II and I in thylakoids. PBS likely evolved from a basic, inefficient form into the predominant hemidiscoidal shape with radiating peripheral rods. |
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Phycobilisomes (PBS) are antenna megacomplexes that transfer energy to photosystems II and I in thylakoids. PBS likely evolved from a basic, inefficient form into the predominant hemidiscoidal shape with radiating peripheral rods. |
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DMSP (dimethylsulfoniopropionate) is an important global sulfur cycle molecule, primarily produced by marine phytoplankton and microorganisms. Coral reefs are habitats with high DMSP production, where not only planktonic microorganisms generate this molecule, but the corals themselves can also produce DMSP. The metabolism of DMSP is considered one of the most crucial mechanisms and means for corals to counteract heat stress. Among its breakdown products, DMS (dimethylsulfide) is a well-known climate-cooling gas with potent antioxidative abilities, aiding corals in clearing excessive free radicals induced by heat stress. |
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Proteins can spontaneously tie a variety of intricate topological knots through twisting and threading of the polypeptide chains. Recently developed artificial intelligence algorithms have predicted several new classes of topological knotted proteins, but the predictions remain to be authenticated experimentally. |
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The structure determination of protein tyrosine phosphatase (PTP): phospho-protein complexes, which is essential to understand how specificity is achieved at the amino acid level, remains a significant challenge for protein crystallography and cryoEM due to the transient nature of binding interactions. |
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