展期：2024-11-4 ~ 2024-11-11

在製作影片之前，首先需要找到與主題相關的科學文獻。這些文獻將提供必要的背景知識和研究結果，幫助我們更好地理解主題並撰寫影片內容。

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講題：Genome Mining for New Natural Products and New Chemistry
主講者：Wilfred A. van der Donk教授 (美國伊利諾大學)
時間：2024-11-05 15:30 - 17:00
地點：生化所103講堂

講題：Idioblasts in Plants: Co-option and Neofunctionalization of Stomatal Transcription Factors for Defense Against Herbivores in Brassicales
主講者：Dr. Makoto Shirakawa (Assistant Professor, Nara Institute of Science and Technology Japan)
時間：2024-11-06 10:00 - 12:00
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

講題：In vitro modelling to study mechanisms of HIV persistence and HBV pathogenesis
主講者：Dr. Tokameh Mahmoudi (Erasmus MC, Netherlands)
時間：2024-11-06 11:00 - 12:00
地點：生醫所地下室B1C演講廳

講題：Fungal behavior with bacteria, plant or microfluidic devices
主講者：Dr. Norio Takeshita (Associate Professor, Microbiology Research Center for Sustainability (MiCS), University of Tsukuba, Japan)
時間：2024-11-06 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：Sulfation on Glycans is an Important Determinant in Functional Glycomics
主講者：邱繼輝 特聘研究員 (中央研究院)
時間：2024-11-06 14:00 - 15:00
地點：基因體研究中心一樓演講廳

講題：RNA Viruses Unleashed: Bridging Science and Healing
主講者：施信如博士 (長庚大學)
時間：2024-11-07 11:00 - 12:00
地點：生醫所地下室B1C演講廳

講題：SciLifeLab - the Swedish national cryoEM facility
主講者：Piotr Draczkowski 教授 (波蘭盧布林醫學大學)
時間：2024-11-07 11:00 - 12:00
地點：生化所209研討室

講題：Building a Sensory System: Development and Evolution of the Anterior Lateral Line System
主講者：Dr. Victoria Prince (Professor, Department of Organismal Biology and Anatomy, The University of Chicago, USA)
時間：2024-11-11 11:00 - 12:00
地點：細生所1樓演講廳

講題：Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing
主講者：Dr. Henry Yue Hon Ng (Postdoctoral Scientist, Department of Physiology, University of California San Francisco, USA)
時間：2024-11-11 14:00 - 15:00
地點：中央研究院分子生物研究所3樓N301會議室

講題：Skeletal Stem Cells: from Development & Disease to Regenerative Medicine
主講者：Wei Hsu教授 (美國哈佛大學)
時間：2024-11-11 14:00 - 15:30
地點：基因體研究中心一樓演講廳

講題：Defining ALS Disease Mechanisms at Single Cell Resolution
主講者：Dr. Aaron Gitler (Professor, Department of Genetics, Stanford University, USA)
時間：2024-11-12 11:00 - 12:00
地點：細生所1樓演講廳

講題：Protein interaction mapping reveals widespread targeting of development-related host transcription factors by phytoplasma effectors
主講者：Dr. Miguel Correa Marrero (Postdoctoral Researcher, Institute of Molecular Systems Biology, ETH Zürich / SIB Swiss Institute of Bioinformatics, Switzerland)
時間：2024-11-12 11:00 - 13:00
地點：中央研究院植物暨微生物學研究所多功能會議室 R106會議室

講題：A force to be reckoned with: cilia in left-right axis development
主講者：Dr. Shiaulou Yuan (Assistant Professor, Harvard Medical School, USA)
時間：2024-11-12 11:00 - 12:00
地點：中央研究院分子生物研究所B1演講廳

講題：Genetically encoded fluorescent biosensors for neural metabolism
主講者：那須雄介博士 (生化所助研究員)
時間：2024-11-13 11:00 - 12:00
地點：跨領域大樓一樓演講廳

講題：Regulatory control of neuron differentiation: from chromatin to connectivity
主講者：Dr. Adrian W Moore (Team Leader, Laboratory for Neurodiversity, RIKEN Center for Brain Science, Japan)
時間：2024-11-13 11:00 - 12:00
地點：中央研究院分子生物研究所B1演講廳

講題：Implementation of An AI-ECG System in Cardiovascular Healthcare: Insights from Pragmatic Randomized Control Trials
主講者：林錦生博士 (三軍總醫院)
時間：2024-11-14 11:00 - 12:00
地點：生醫所地下室B1B演講廳

講題：Regulation of potassium channels by drugs and unexpected auxiliary proteins
主講者：Dr. Harley Kurata (Univ. of Alberta, Canada)
時間：2024-11-14 14:00 - 15:00
地點：生醫所地下室B1C演講廳

主講者：Tanja Mittag教授 (美國St. Jude Children's Research Hospital)
時間：2024-11-06 10:00 - 17:15
地點：生化所103講堂

主講者：詳細資訊請見研討會網站
時間：2024-11-11 08:30 ~ 2024-11-12 12:20
地點：中央研究院人文社會科學館國際會議廳

韋保羅實驗室進行正向遺傳學篩選發現，非光營養性-下胚軸3 (NPH3)結構域蛋白 NRL5的突變會導致植物因脯胺酸代謝失調而對乾旱逆境變得過度敏感。進一步的實驗發現，NRL5和其他NPH3結構域蛋白儘管與已知的GTP酶沒有相似性，但仍具有GTP酶活性。

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我們研究在阿拉伯芥中，調控蛋白如何透過修飾組蛋白來控制基因的表達。我們分析了1500筆染色質免疫沉澱測序（ChIP-seq）的數據，並利用機器學習建立了一個表觀基因組譜，用來預測調控蛋白的功能，從而了解它們在表觀遺傳和基因調控中的角色。

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Here, we present a protocol for the in vitro phosphorylation of Src kinase domain (SrcKD), preparation of phospho-SrcKD in complex with the D1 domain of rPTP epsilon (rPTPεD1), and binding assays using biolayer interferometry (BLI).

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G protein-coupled receptors (GPCRs) belong to the most diverse group of membrane receptors with a conserved structure of seven transmembrane (TM) α-helices connected by intracellular and extracellular loops.

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Helicobacter pylori, a dominant member of the gastric microbiota was associated with various gastrointestinal diseases and presents a significant challenge due to increasing antibiotic resistance.

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Synthesis of Galβ1 → 3GlcNAc-repeating saccharides is limited mainly by the formation of less-reactive oxazolines.

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Lumbar spinal stenosis (LSS) is a degenerative spinal condition characterized by the narrowing of the spinal canal, resulting in low back pain (LBP) and limited leg mobility.

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Combination therapies present a compelling therapeutic regimen against the immunosuppressive and heterogeneous microenvironment of solid tumors.

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Tumor invasion is the hallmark of tumor malignancy. The invasive infiltration pattern of tumor cells located at the leading edge is highly correlated with metastasis and unfavorable patient outcomes.

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Cancer cells with homologous recombination deficiency (HRD) exhibit a distinctive vulnerability to poly(ADP-ribose) polymerase inhibitors (PARPis).

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Cancer cells have a high demand for sugars and express diverse carbohydrate receptors, offering opportunities to improve delivery with multivalent glycopolymer materials.

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Homologous recombination during meiosis is critical for chromosome segregation and also gives rise to genetic diversity. Genetic exchange between homologous chromosomes during meiosis is mediated by the recombinase Dmc1, which is capable of recombining DNA sequences with mismatches.

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Interhomolog recombination in meiosis requires a meiosis-specific recombinase, Dmc1. In Saccharomyces cerevisiae, the Mei5-Sae3 complex facilitates the loading of Dmc1 onto the replication protein A (RPA)-coated single-stranded DNA (ssDNA) to form nucleoprotein filaments.

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