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 Date : 2024/11/04 No:347 
 
 
 

Recent News

 
 
 
 
New Books
 
Period: 2024-11-4 ~ 2024-11-11
 
 
 
 
 
 

Training Courses

 
 
 
【Clinical Trial Lecture-Basic Course】Lesson 4—Study design of Phase I clinical trialstrials(In Chinese)(Physical and Video Class)
 
2024-11-12(Tue)10:00~12:00
Dr.Mey Wang
Research Building of Environmental Changes, AS, 6005 Room
 
 
 
   
 
 
 

Lectures

 
 
 
 
11/5 IBC Seminar
 
Topic:Genome Mining for New Natural Products and New Chemistry
Speaker:Dr. Wilfred A. van der Donk (University of Illinois, USA)
Date:2024-11-05 15:30 - 17:00
Place:IBC 103 Auditorium
 
 
 
 
 
 
 
11/6 IPMB Seminar
 
Topic:Idioblasts in Plants: Co-option and Neofunctionalization of Stomatal Transcription Factors for Defense Against Herbivores in Brassicales
Speaker:Dr. Makoto Shirakawa (Assistant Professor, Nara Institute of Science and Technology Japan)
Date:2024-11-06 10:00 - 12:00
Place:Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica
 
 
 
 
 
 
 
11/6 IBMS Seminar
 
Topic:In vitro modelling to study mechanisms of HIV persistence and HBV pathogenesis
Speaker:Dr. Tokameh Mahmoudi (Erasmus MC, Netherlands)
Date:2024-11-06 11:00 - 12:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 
 
11/6 IMB Seminar
 
Topic:Fungal behavior with bacteria, plant or microfluidic devices
Speaker:Dr. Norio Takeshita (Associate Professor, Microbiology Research Center for Sustainability (MiCS), University of Tsukuba, Japan)
Date:2024-11-06 11:00 - 12:00
Place:1F Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
11/6 GRC Seminar
 
Topic:Sulfation on Glycans is an Important Determinant in Functional Glycomics
Speaker:Prof. Kay-Hooi Khoo (Academia Sinica)
Date:2024-11-06 14:00 - 15:00
Place:1F Auditorium, Genomics Research Center
 
 
 
 
 
 
 
11/7 IBMS Seminar
 
Topic:RNA Viruses Unleashed: Bridging Science and Healing
Speaker:Dr. Shin-Ru Shih (Chang Gung Univ.)
Date:2024-11-07 11:00 - 12:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 
 
11/7 IBC Seminar
 
Topic:SciLifeLab - the Swedish national cryoEM facility
Speaker:Dr. Piotr Draczkowski (Medical University of Lublin, Poland)
Date:2024-11-07 11:00 - 12:00
Place:IBC R209
 
 
 
 
 
 
 
11/11 ICOB Seminar
 
Topic:Building a Sensory System: Development and Evolution of the Anterior Lateral Line System
Speaker:Dr. Victoria Prince (Professor, Department of Organismal Biology and Anatomy, The University of Chicago, USA)
Date:2024-11-11 11:00 - 12:00
Place:1F, Auditorium, Institute of Cellular and Organismic Biology
 
 
 
 
 
 
 
11/11 IMB Seminar
 
Topic:Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing
Speaker:Dr. Henry Yue Hon Ng (Postdoctoral Scientist, Department of Physiology, University of California San Francisco, USA)
Date:2024-11-11 14:00 - 15:00
Place:Conference Room N301, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
11/11 GRC Seminar
 
Topic:Skeletal Stem Cells: from Development & Disease to Regenerative Medicine
Speaker:1F Auditorium, Genomics Research Center
Date:2024-11-11 14:00 - 15:30
Place:Prof. Wei Hsu (Harvard University, USA)
 
 
 
 
 
 
 
11/12 ICOB Seminar
 
Topic:Defining ALS Disease Mechanisms at Single Cell Resolution
Speaker:Dr. Aaron Gitler (Professor, Department of Genetics, Stanford University, USA)
Date:2024-11-12 11:00 - 12:00
Place:1F, Auditorium, Institute of Cellular and Organismic Biology
 
 
 
 
 
 
 
11/12 IPMB Seminar
 
Topic:Protein interaction mapping reveals widespread targeting of development-related host transcription factors by phytoplasma effectors
Speaker:Dr. Miguel Correa Marrero (Postdoctoral Researcher, Institute of Molecular Systems Biology, ETH Zürich / SIB Swiss Institute of Bioinformatics, Switzerland)
Date:2024-11-12 11:00 - 13:00
Place:Multifunction Room R106, Institute of Plant and Microbial Biology, Academia Sinica
 
 
 
 
 
 
 
11/12 IMB Seminar
 
Topic:A force to be reckoned with: cilia in left-right axis development
Speaker:Dr. Shiaulou Yuan (Assistant Professor, Harvard Medical School, USA)
Date:2024-11-12 11:00 - 12:00
Place:B1 Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
11/13 NPAS Seminar
 
Topic:Genetically encoded fluorescent biosensors for neural metabolism
Speaker:Dr. Yusuke Nasu (Assistant Research Fellow, IBC)
Date:2024-11-13 11:00 - 12:00
Place:1F Auditorium (B106), IST
 
 
 
 
 
 
 
11/13 IMB Seminar
 
Topic:Regulatory control of neuron differentiation: from chromatin to connectivity
Speaker:Dr. Adrian W Moore (Team Leader, Laboratory for Neurodiversity, RIKEN Center for Brain Science, Japan)
Date:2024-11-13 11:00 - 12:00
Place:
 
 
 
 
 
 
 
11/14 IBMS Seminar
 
Topic:Implementation of An AI-ECG System in Cardiovascular Healthcare: Insights from Pragmatic Randomized Control Trials
Speaker:Dr. Chin-Sheng Lin (Tri-Service General Hospital)
Date:2024-11-14 11:00 - 12:00
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
11/14 IBMS Seminar
 
Topic:Regulation of potassium channels by drugs and unexpected auxiliary proteins
Speaker:Dr. Harley Kurata (Univ. of Alberta, Canada)
Date:2024-11-14 14:00 - 15:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 

Seminars

 
 
 
 
Mini-symposium on Liquid-liquid Phase Separation
 
Speaker:Dr. Tanja Mittag (St. Jude Children's Research Hospital, USA)
Date:2024-11-06 10:00 - 17:15
Place:IBC 103 Auditorium
 
 
 
 
 
 
 
Frontiers Conference in Natural Medicine & Healthcare
 
Speaker:Please visit the conference website for more details.
Date:2024-11-11 08:30 ~ 2024-11-12 12:20
Place:International Conference Hall, Humanities and Social Sciences Building (HSSB), Academia Sinica
 
 
 
 
 
 

Important Research

 
 
 
 
A new class of plant GTPase with roles in intracellular trafficking
 
A forward genetic screen conducted in the Verslues laboratory found that mutation of the Non-Phototrophic Hypocotyl3 (NPH3)-domain protein NRL5 causes plants to become hypersensitive to drought stress because of mis-regulated proline metabolism.
 
 
 
 
 
 
 
 
Predicting Protein Synergistic Effect in Arabidopsis using Epigenome Profiling
 
Histone modifications can regulate transcription epigenetically by marking specific genomic loci, which can be mapped using chromatin immunoprecipitation sequencing (ChIP-seq).
 
 
 
 
 
 
 
 
Protocol for phospho-SrcKD: rPTPεD1 complex preparation and BLI binding assays to demonstrate their exosite interface
 
Here, we present a protocol for the in vitro phosphorylation of Src kinase domain (SrcKD), preparation of phospho-SrcKD in complex with the D1 domain of rPTP epsilon (rPTPεD1), and binding assays using biolayer interferometry (BLI).
 
 
 
 
 
 
 
 
Coupling and Activation of the β1 Adrenergic Receptor - The Role of the Third Intracellular Loop
 
G protein-coupled receptors (GPCRs) belong to the most diverse group of membrane receptors with a conserved structure of seven transmembrane (TM) α-helices connected by intracellular and extracellular loops.
 
 
 
 
 
 
 
 
Helicobacter pylori PldA modulates TNFR1-mediated p38 signaling pathways to regulate macrophage responses for its survival
 
Helicobacter pylori, a dominant member of the gastric microbiota was associated with various gastrointestinal diseases and presents a significant challenge due to increasing antibiotic resistance.
 
 
 
 
 
 
 
 
Glycosyl oxazolines serve as active donors for iterative synthesis of type I oligosaccharides
https://www.ibc.sinica.edu.tw/Research/ViewLP?DatetimeStr=20241021174642
 
Synthesis of Galβ1 → 3GlcNAc-repeating saccharides is limited mainly by the formation of less-reactive oxazolines.
 
 
 
 
 
 
 
 
Role of IL3RA in a Family with Lumbar Spinal Stenosis
 
Lumbar spinal stenosis (LSS) is a degenerative spinal condition characterized by the narrowing of the spinal canal, resulting in low back pain (LBP) and limited leg mobility.
 
 
 
 
 
 
 
 
Combinatorial leaky probiotic for anticancer immunopotentiation and tumor eradication
 
Combination therapies present a compelling therapeutic regimen against the immunosuppressive and heterogeneous microenvironment of solid tumors.
 
 
 
 
 
 
 
 
SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front
 
Tumor invasion is the hallmark of tumor malignancy. The invasive infiltration pattern of tumor cells located at the leading edge is highly correlated with metastasis and unfavorable patient outcomes.
 
 
 
 
 
 
 
 
Protocol for detecting homologous recombination activity in cancer cells by adenovirus-based functional assay
 
Cancer cells with homologous recombination deficiency (HRD) exhibit a distinctive vulnerability to poly(ADP-ribose) polymerase inhibitors (PARPis).
 
 
 
 
 
 
 
 
Harnessing the Power of Sugar-Based Nanoparticles: A Drug-Free Approach to Enhance Immune Checkpoint Inhibition against Glioblastoma and Pancreatic Cancer
 
Cancer cells have a high demand for sugars and express diverse carbohydrate receptors, offering opportunities to improve delivery with multivalent glycopolymer materials.
 
 
 
 
 
 
 
 
Hop2-Mnd1 functions as a DNA sequence fidelity switch in Dmc1-mediated DNA recombination
 
Homologous recombination during meiosis is critical for chromosome segregation and also gives rise to genetic diversity. Genetic exchange between homologous chromosomes during meiosis is mediated by the recombinase Dmc1, which is capable of recombining DNA sequences with mismatches.
 
 
 
 
 
 
 
 
Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA
 
Interhomolog recombination in meiosis requires a meiosis-specific recombinase, Dmc1. In Saccharomyces cerevisiae, the Mei5-Sae3 complex facilitates the loading of Dmc1 onto the replication protein A (RPA)-coated single-stranded DNA (ssDNA) to form nucleoprotein filaments.
 
 
 
 
 
 
 
 
 
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