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此論文中以高機械性質吸水性聚合物(聚丙烯酸鉀)將生物樣品放大了40倍(三維體積為六萬四千倍)，並利用貝索層光顯微鏡進行放大樣品掃描以達到三維奈米層級的解析度。 |
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Light chain (AL) amyloidosis is the most common systemic amyloid disease characterized by abnormal accumulation of amyloid fibrils derived from immunoglobulin light chains (LCs). Both full-length (FL) LCs and their isolated variable (VL) and constant (CL) domains contribute to amyloid deposits in multiple organs, with the VL domain predominantly forming the fibril core. |
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A class of tetrahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivatives were synthesized under environmentally friendly conditions using water as the solvent. |
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Colon cancer development may be initiated by multiple factors, including chronic inflammation, genetic disposition, and gut dysbiosis. The loss of beneficial bacteria and increased abundance of detrimental microbes exacerbates disease progression. |
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Free oligosaccharides in human milk have many biological functions for infant health. The reducing end of most human milk oligosaccharides is lactose, and caprine milk was reported to contain oligosaccharides structurally similar to those present in human milk. |
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In the present work, bacterial glycosyltransferases are utilized to construct ganglioside glycans in a convergent approach via a sugar‒nucleotide regeneration system and one-pot multienzyme reactions. |
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Proteasomes generate antigenic peptides presented on cell surfaces—a process that, in neuroglia, is highly responsive to external stimuli. However, the function of the self-antigens presented by CNS parenchymal cells remains unclear. Here, we report that the fidelity of neuroglial self-antigens is crucial to suppress encephalitogenic T cell responses by elevating regulatory T (Treg) cell populations. |
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This study highlights the importance of posttranslational modifications of RBPs, particularly FMRP, as a molecular switch that regulates the transport of specific mRNAs in response to synaptic activity. |
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Gut microbiota affect transplantation outcomes; however, the influence of immunosuppression and cell therapy on the gut microbiota in cardiovascular care remains unexplored. |
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Glycosidic switch liposome (GSL) technology efficiently encapsulates and stabilizes potent anticancer drugs in liposomes using a reversible glucuronide ester. |
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Adult human hearts exhibit limited regenerative capacity. Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. |
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Protein glycosylation plays a versatile role in regulating homeostasis, such as cell migration, protein sorting, and the immune response. |
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Proprioceptors are primary mechanosensory neurons to monitor the status of muscle contraction and/or body position (1). |
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The IL-17B/IL-17RB oncogenic signaling axis promotes pancreatic cancer progression through interaction with mixed-lineage kinase 4 (MLK4). |
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The adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits, are essential for glucose homeostasis. |
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![Green Synthesis of Tetrahydropyrazino[2,1-a:5,4-a′]diisoquinolines as SARS-CoV-2 Entry Inhibitors](https://lsl.sinica.edu.tw/Activities/epaper/files/354/20250205140223.jpg)
