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Period: 2025-2-17 ~ 2025-2-24 |
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| | It's time for the 2024 back issue magazines giveaway! Up to five per person. |
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| | Added a one-year flow cytometry data analysis software FlowJo Group License. The funds are raised by each unit in need. Please contact us if you have any needs. |
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| | | | | | 【Clinical Trial Lecture-Basic Course】Lesson 10—Clinical considerations for the development of advanced therapy medicinal products(In Chinese)(Physical and Video Class) | | | 2025-02-25（Tue）10:00~12:00
Dr.JI-XUN CHEN(CDE,Taiwan)
Research Building of Environmental Changes, AS, 6005 Room
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Topic：Development of methods for modeling and studying human gonad development and function
Speaker：Dr. Philip Jordan (Professor, Biochemistry and Molecular Biology Dept., Uniformed Service University of Health Sciences, Bethesda, MD, USA)
Date：2025-02-18 11:00 - 12:00
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica |
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Topic：Mechanisms of chromatin balancing
Speaker：Dr. Jia-Ray Yu (Virginia Tech)
Date：2025-02-19 14:00 - 15:00
Place：B1B Lecture Room, IBMS |
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Topic：Evolution and Development of Germline Cells
Speaker：Dr. Jean-René Huynh (Senior Group leader, Evolution and Development of Germ Cells, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Paris, France)
Date：2025-02-20 10:00 - 11:00
Place：1F, Auditorium, Institute of Cellular and Organismic Biology |
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Topic：Nano- and Bio-Materials-enabled Drug Delivery Technologies for Disease Therapy
Speaker：Dr. Wei Chen (Assistant Research Fellow, GRC)
Date：2025-02-20 16:00 - 17:00
Place：B1B Lecture Room, IBMS |
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Topic：Sample Preparation of Electron Microscopy: Especially in the Use of Freezing
Speaker：Dr. Wann-Neng Jane (Research Specialist, Institute of Plant and Microbial Biology, Academia Sinica)
Date：2025-02-21 11:00 - 13:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica |
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Topic：A fissure's matter: Alternative splicing controls cerebellar foliation and its therapeutic implications
Speaker：Dr. Tarn, Woan-Yuh (Distinguished Research Fellow)
Date：2025-02-24 11:00 - 12:00
Place：B1C Auditorium, IBMS |
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Topic：Exploring a Novel Regulatory Mechanism of Flower Formation in Orchids
Speaker：Dr. Chang-Hsien Yang (Academician from Academia Sinica & Chair Professor from National Chung Hsing University)
Date：2025-02-24 11:00 - 12:00
Place：IBC R209 |
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Topic：Telomeres from worms to mammals
Speaker：Dr. Junho Lee (Professor of Biological Sciences, Seoul National University)
Date：2025-02-25 10:00 - 11:00
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica |
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Topic：What Makes Us Human – Lessons Learned from Neocortical Neural Circuits
Speaker：Prof. Gábor Tamás (Member of Hungarian Academy of Sciences)
Date：2025-02-25 11:00 - 12:00
Place：1F Auditorium (B106), IST |
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Topic：Harnessing replication stress at ALT telomeres
Speaker：Dr. Hilda Pickett (Professor, Faculty of Medicine and Health, University of Sydney)
Date：2025-02-25 11:10 - 12:10
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica |
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This study introduces a novel approach to high-resolution biological imaging by combining potassium polyacrylate-based hydrogels with Bessel lightsheet microscopy. The expansion microscopy (ExM) method achieves a 40-fold linear expansion, corresponding to a volumetric enlargement of 64,000 times. |
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Light chain (AL) amyloidosis is the most common systemic amyloid disease characterized by abnormal accumulation of amyloid fibrils derived from immunoglobulin light chains (LCs). Both full-length (FL) LCs and their isolated variable (VL) and constant (CL) domains contribute to amyloid deposits in multiple organs, with the VL domain predominantly forming the fibril core. |
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A class of tetrahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivatives were synthesized under environmentally friendly conditions using water as the solvent. |
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Colon cancer development may be initiated by multiple factors, including chronic inflammation, genetic disposition, and gut dysbiosis. The loss of beneficial bacteria and increased abundance of detrimental microbes exacerbates disease progression. |
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Free oligosaccharides in human milk have many biological functions for infant health. The reducing end of most human milk oligosaccharides is lactose, and caprine milk was reported to contain oligosaccharides structurally similar to those present in human milk. |
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In the present work, bacterial glycosyltransferases are utilized to construct ganglioside glycans in a convergent approach via a sugar‒nucleotide regeneration system and one-pot multienzyme reactions. |
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Proteasomes generate antigenic peptides presented on cell surfaces—a process that, in neuroglia, is highly responsive to external stimuli. However, the function of the self-antigens presented by CNS parenchymal cells remains unclear. Here, we report that the fidelity of neuroglial self-antigens is crucial to suppress encephalitogenic T cell responses by elevating regulatory T (Treg) cell populations. |
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This study highlights the importance of posttranslational modifications of RBPs, particularly FMRP, as a molecular switch that regulates the transport of specific mRNAs in response to synaptic activity. |
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Gut microbiota affect transplantation outcomes; however, the influence of immunosuppression and cell therapy on the gut microbiota in cardiovascular care remains unexplored. |
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Glycosidic switch liposome (GSL) technology efficiently encapsulates and stabilizes potent anticancer drugs in liposomes using a reversible glucuronide ester. |
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Adult human hearts exhibit limited regenerative capacity. Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. |
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Protein glycosylation plays a versatile role in regulating homeostasis, such as cell migration, protein sorting, and the immune response. |
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Proprioceptors are primary mechanosensory neurons to monitor the status of muscle contraction and/or body position (1). |
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The IL-17B/IL-17RB oncogenic signaling axis promotes pancreatic cancer progression through interaction with mixed-lineage kinase 4 (MLK4). |
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The adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits, are essential for glucose homeostasis. |
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Tel：+886-2-2789-9829 Fax：+886-2-2653-5662
Address：128 Sec. 2 Academia Rd, Nankang, Taipei 115 Taiwan R.O.C. (Eco Pavilion)
@2021 Academia Sinica Life Science Library e-News Paper, All Rights Reserved
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![Green Synthesis of Tetrahydropyrazino[2,1-a:5,4-a′]diisoquinolines as SARS-CoV-2 Entry Inhibitors](https://lsl.sinica.edu.tw/Activities/epaper/files/354/20250205140223.jpg)
