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 Date : 2022/05/09 No:285 

Recent News

New Books
Period: 2022-05-09 ~ 2022-05-16

Training Courses

Clarivate Cortellis MetaCore Molecular Pathway Analysis Solution(In Chinese)
WeiChun Lin( Product and Sales Specialist, VtR Incorporated)
IPA advanced training course (in Chinese)
Mr. Gene Chen (Deputy Manager, Molecular Science Center, GGA Corp.)
IPA advanced training course (in English)
Mr. Gene Chen (Deputy Manager, Molecular Science Center, GGA Corp.)


5/11 IPMB Seminar
Topic:2022 Academician Hsien-Wen Li Lectureship: Hunting for unique and useful rice genes
Speaker:Dr. Tuan-hua David Ho
Date:2022-05-11 15:00 ~ 16:30
Place:A134、A133 (Synchronous Broadcasting)
5/12 IBC Seminar
Topic:New tools and methods for understanding tryptophan C-mannosylation
Speaker:Dr. Ethan Goddard-Borger
Date:2022-05-12 11:00 ~ 12:00
Place:IBC R209
5/16 ICOB Seminar
Topic:Evolution of Phagocytic Cell Lineages – a Transcriptome Journey
Speaker:Prof. Sebastian D. Fugmann
Date:2022-05-16 11:00 ~ 12:00
Place:1F, Auditorium, Institute of Cellular and Organismic Biology
5/19 IBC Seminar
Topic:Synthetic glycans in molecular imaging and drug discovery
Speaker:Dr. Lina Cui
Date:2022-05-19 11:00 ~ 12:00
Place:IBC R209
5/19 IBMS Seminar
Topic:Stem Cells and 3D-printed Scaffold in Tissue Revascularization.
Speaker:Dr. Shaw-Fang Yet
Date:2022-05-19 16:00 ~ 17:00
Place:B1C Auditorium, IBMS
5/23 IBMS Seminar
Topic:Student Thesis Seminar- Biophysical and functional study in TALK1 potassium channels.
Speaker:Mr. Wen-Hao Tsai
Date:2022-05-23 16:00 ~ 17:00
Place:B1A Lecture Room (Basement, Old Building), IBMS

Important Research

Multicolor live-cell imaging identifies asynthetic fission
Cell division is a fundamental process for life. Besides mitosis in somatic cells and meiosis in germ cells, a research team led by Dr. Chen-Hui Chen at the Institute of Cellular and Organismic Biology, Academia Sinica discovered a deviant form of cell division in live zebrafish larvae that accounts for a drastic increase of cell number during development. The study is published in April 2022 in the journal Nature......
How 2 isozymes account for the biosynthesis of phosphatidylcholine?
The bottleneck reaction of plant phosphatidylcholine (PC) biosynthesis has long been an open question. The team led by Dr. Yuki Nakamura previously demonstrated that a pair of methyltransferase PMT1 and PMT3 is responsible for PC biosynthesis in Arabidopsis. However, how these two isoforms redundantly function in vivo remained unknown......
A new metabolic pathway for seed oil biosynthesis in Arabidopsis
The research team led by Dr. Yuki Nakamura found that plant seeds use a new pathway similar to that in animals for oil production and a key enzyme PLMT is responsible for the process. Overexpression of PLMT in planta increased TAG content in seeds while affecting the vegetative growth of the plants, suggesting that this pathway is favorable for seed oil biosynthesis but not for vegetative growth. These findings may contribute to the understanding of the metabolic map of seed oil biosynthesis and also for the development of a new strategy to engineer seed oil contents in different plant species......
A role of chloroplast phospholipid in gene regulation
Phosphatidylglycerol (PG) is the only major phospholipid class in the thylakoid membrane of chloroplasts, which is essential for the function of photosynthesis. An international research collaboration team by Institute of Plant and Microbial Biology, Academia Sinica, Osaka Prefectural University, The University of Tokyo, Kyoto University, and RIKEN Center for Sustainable Resource Science used an Arabidopsis mutant deficient in PG biosynthesis and revealed a novel role of PG in controlling plastid-encoded gene expression and light induction of nuclear photosynthetic genes......
A third pathway for membrane lipid remodeling by GDPD6 in phosphate-starved plants
Phosphorus is an essential nutrient for plant viability. Under phosphorus starvation, plants may utilize phosphate source by replacing membrane lipids from phospholipids to galactolipids, a process termed membrane lipid remodeling. In addition to the 2 established pathways, we found an involvement of the 3rd pathway mediated by GDPD6. We showed that GDPD6 mediates root growth of phosphate-starved plants via the production of glycerol 3-phosphate (G3P). Our results reveal a novel function of G3P in promoting root growth and an importance of the 3rd pathway in phosphorus-starved plants......
Bacteria-based cancer therapy: use TNF-α to mediate Trojan Horse
Kurt Yun Mou’s research group in the Institute of Biomedical Sciences at Academia Sinica developed a novel cancer therapy and published their results in “Molecular Therapy” in Apri this year. Taking the advantage of TNF-α as a pro-tumor signal, Mou’s group successfully designed an immunotoxin, which can piggyback on TNF-α and co-internalize into cancer cells for cell killing. The study further developed E. coli as a “live drug”, which can colonize and replicate in tumors, to constantly deliver the immunotoxin and stimulate the TNF-α expression. As a result, the treatment greatly suppressed the tumor growth in a syngeneic murine melanoma model......
A lipid viewpoint on the plant endoplasmic reticulum stress response
To deal with environmental stresses, eukaryotes have evolved sophisticated cellular mechanisms such as the unfolded protein response (UPR), which is conserved among yeasts, mammals, higher plants, and green algae. In this review, Dr. Kazue Kanehara lab highlights the plant UPR from the perspective of membrane phospholipids, focusing on the most abundant ones, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), in eukaryotic cells. The ratio of PtdCho to PtdEtn and unsaturation of fatty acyl tails in both phospholipids are critical factors for the UPR, but the biosynthetic pathways responsible for PtdCho and PtdEtn are distinct in animals and plants......
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