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 Date : 2022/05/23 No:286 

Recent News

New Books
Period: 2022-05-23 ~ 2022-05-30

Database Introduction

HSTalks New Releases
HSTalks: The Biomedical & Life Sciences Collection New Releases for May.
Database Trial
CAB Abstracts with Full Text
Trial Period:Current until June 30


5/24 IMB Seminar
Topic:Light at the end of a tunnel: new insights into effector translocation in smut fungi
Speaker:Dr. Regine Kahmann v
Date:2022-05-24 15:00 ~ 16:00
Place:online webinar
5/26 IBC Seminar
Topic:Nanoscale imaging of biomolecules using molecule anchorable gel-enabled nanoscale in-situ fluorescence microscopy (MAGNIFY)
Speaker:Dr. Yongxin (Leon) Zhao
Date:2022-05-26 11:00 ~ 12:00
Place:IBC R209
5/27 IPMB Seminar
Topic:Genomic Investigation of Agrobacterium Biology
Speaker:Dr. Chih‐Horng Kuo
Date:2022-05-27 11:00 ~ 12:00
Place:A134、A133 (Synchronous Broadcasting)
5/30 IBMS Seminar
Topic:Harnessing Structures and Dynamics of Biomolecules for Drug Discovery
Speaker:Dr. Lin, Jung-Hsin
Date:2022-05-30 11:00 ~ 12:00
5/31 IMB Seminar
Topic:Mapping the genotypes of cooperation
Speaker:Dr. Shu-Ting You
Date:2022-05-31 11:00 ~ 12:00
Place:IMB 1F Auditorium
6/1 IBC Seminar
Topic:Multiple Roles for Campylobacter Glycoconjugates
Speaker:Dr. Christine Szymanski
Date:2022-06-01 11:00 ~ 12:00
Place:IBC R209
6/2 IBMS Seminar
Topic:Emergence of tonotopic map in early somatosensory pathway: mechanoreceptors, synaptic networks and transformation of neural coding
Speaker:Dr. Kuo-Sheng Lee
Date:2022-06-02 15:00 ~ 16:00
Place:Webex Link

Important Research

Noise canceling in gene expression by uORFs
Gene expression can be noisier than we realize. Burst transcription can be unproductive or even detrimental if not adequately controlled. Our study reveals that upstream open reading frames (uORFs) can cancel the expression noise by reducing the protein production rate......
Rebirth of Phoenix – identity crisis under neural remodeling
Despite that our brain is functional in the toddler age, the functional construction of our brain is underway throughout the childhood and adolescence. For insects like butterflies and fruit flies (Drosophila melanogaster) which experience different life cycles with the larval-to-adult transition, their nervous systems undergo the drastic modification during metamorphosis......
Molecular insights of how oncogene suppressor BAP1’s nuclear import is regulated by TNPO1
BRCA1-associated protein 1 (BAP1) is an important tumor suppressor that belongs to the ubiquitin C-terminal hydrolase (UCH) family. BAP1 regulates several key cellular pathways through its ability to remove a small protein tag (ubiquitin) from the target proteins, a function known as deubiquitination (DUB) activity. BAP1 is implicated in transcriptional regulation, chromatin remodeling, cell cycle progression, cell differentiation and cell death, DNA damage response, and DNA repair......
Co-option of SHOOT MERISTEMLESS network regulates protocorm-like-body development in Phalaenopsis aphrodite
The protocorm is a structure that is formed upon germination of an orchid seed. It lacks cotyledons and is ovoid in shape. Protocorm-like body (PLB), on the other hand, is a protocorm-like organ induced from somatic tissues. PLBs have been widely used for orchid micropropagation. Because of its unique structure and its application in the orchid industry, PLB development has drawn considerable interest from orchid and developmental biologists......
PD‐1 levels can predict spontaneous functional cure in inactive chronic hepatitis B carriers
Hepatitis B is a viral infection that attacks the liver. It causes both acute and chronic disease that can lead to liver cirrhosis and liver cancer. Identifying carriers requires a blood test for hepatitis B surface antigen (HBsAg), which must be repeated regularly to ensure virus inactive......
Differential effects of glucose and N-acetylglucosamine on genome instability
Aberrant sugar metabolism is linked to an increased risk of pancreatic cancer. Previously, we found that high glucose induces genome instability and de novo oncogenic KRAS mutation preferentially in pancreatic cells through dysregulation of O-GlcNAcylation......
Extensive sampling of Saccharomyces cerevisiae in Taiwan reveals ecology and evolution of predomesticated lineages
The ecology and genetic diversity of the model yeast Saccharomyces cerevisiae before human domestication remain poorly understood. Taiwan is regarded as part of this yeast's geographic birthplace, where the most divergent natural lineage was discovered. Here, we extensively sampled the broadleaf forests across this continental island to probe the ancestral species’ diversity......
Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3
Many synaptic proteins form biological condensates via liquid-liquid phase separation (LLPS). Synaptopathy, a key feature of autism spectrum disorders (ASD), is likely relevant to the impaired phase separation and/or transition of ASD-linked synaptic proteins. Here, we report that LLPS and zinc-induced liquid-to-gel phase transition regulate the synaptic distribution and protein-protein interaction of cortactin-binding protein 2 (CTTNBP2), an ASD-linked protein. CTTNBP2 forms self-assembled condensates through its C-terminal intrinsically disordered region and facilitates SHANK3 co-condensation at dendritic spines......
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