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 Date : 2022/09/26 No:295 
 
 
 

Recent News

 
 
 
 
New Books
 
 
Period: 2022-09-26 ~ 2022-10-03
 
 
 
 
 
Significant Research Achievements of poster show Dr. Chuan Ku, Dr. Han-Chung Wu
 
 
Significant Research Achievements of poster show Dr. Chuan Ku, Dr. Han-Chung Wu

 
 
Date: 9/26/2022-10/30/2022
Place: Life Science Library
 
 
 
 
 
IPA Maintenance Announcement
 
 
IPA Maintenance Announcement

 
 
IPA will be unavailable during our Latest Release 08:00 October 1, 2022 to 03:00 October 3, 2022.
 
 
 
 
 
 

Training Courses

 
 
 
 
【Clinical Trial Lecture-Basic Course】Lesson 3-Ethical regulations of clinical trials.(In Chinese)
 
2022-09-27(Tue)10:00~12:00
Dr. CHIH-LIU LIN
B1 Auditorium, Institute of Statistical Science
 
 
 
 
Plan your success into the school of your dream (in Chinese)
 
2022-09-29(Thu)14:00~15:30
Dr. Evon Wu (Postdoctoral research scholar, University of California, Berkeley)
Online
 
 
 
 
 
 
Writing Winning Resumes(In English)
 
2022-10-03(Mon)14:00~15:30
Dr. Evon Wu (Postdoctoral research scholar, University of California, Berkeley)
Online
 
 
 
 
Local alignments & BLAST, online and offline(In English)(Online)
 
2022-10-06(Thu)14:00~16:00
Dr. Wen-Dar Lin (Associate Research Specialist , Institute of Plant and Microbial Biology, Academia Sinica)
Online
 
 
 
 
   
 
 
 

Database Introduction

 
 
 
 
HSTalks New Releases
 
 
HSTalks: The Biomedical & Life Sciences Collection New Releases for September.
 
 
 
 
 
 

Video Service

 
 
 
 
Download ebook for free
 
 
The Ultimate Guide to ANOVA
 
 
 
 
 
 

Lectures

 
 
 
 
9/28 IPMB Seminar
 
 
Topic:Enigma of Plant Immune Activation- Everything is Connected
Speaker:Dr. Wei-Lin Wan
Date:2022-09-28 10:00 ~ 11:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
9/28 IBMS(NPAS) Seminar
 
 
Topic:Spatio-temporal transcriptional regulation of diversified astrocyte functions
Speaker:Dr. Teng-Wei Huang
Date:2022-09-28 11:00 ~ 12:00
Place:1F Auditorium (B106), IST
 
 
 
 
 
 
 
9/28 BRCAS Seminar
 
 
Topic:Effects of Polystyrene Nanoplastics on Zebrafish (Danio rerio) Embryos
Speaker:Mr. Phunsin Kantha
Date:2022-09-28 13:00 ~ 14:00
Place:F203, College of Science Building, NTNU Gongguan Campus
 
 
 
 
 
 
 
9/30 BRC Seminar
 
 
Topic:Development of Nucleic Acid Ratios as Eukaryotes Growth Rate Indices
Speaker:Mr. Wye Lup Kong
Date:2022-09-30 14:00 ~ 15:00
Place:Auditorium, 1st Floor, Interdisciplinary Research Building
 
 
 
 
 
 
 
9/30 IBC Seminar
 
 
Topic:Glial proteostasis in neurodegeneration
Speaker:Dr. Margaret S. Ho
Date:2022-09-30 15:00 ~ 16:00
Place:IBC R209
 
 
 
 
 
 
 
10/3 IPMB Seminar
 
 
Topic:Recognition of microbes and regulation of plant immunity
Speaker:Dr. Pierre Buscaill
Date:2022-10-03 10:00 ~ 11:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 

Important Research

 
 
 
 
CLEC5A and TLR2 are critical in SARS-CoV-2 induced NET formation and lung inflammation
 
 
In severe and fatal ARDS cases, SARS-CoV-2 infection has robust pulmonary inflammation and disproportionate immune response that may lead to high levels of circulating cytokines, intravascular coagulopathy, thrombotic tendency, and even multiple organ dysfunction......
 
 
 
 
 
 
 
 
Studies on infected farmed minks provide new insight into the origin and evolution of SARS-CoV-2
 
 
It is generally recognized that viruses should acquire adaptive changes when spillover to a new host. However, previous studies on human infections of SARS-CoV-2 did not find such selection signature. The SARS-CoV-2 outbreaks in 2020 on Netherlands mink farms provides us the opportunity to study the early evolution of SARS-CoV-2 in minks. Dr. Shu-Miaw Chaw’s team at Biodiversity Research Center and Dr. Hurng-Yi Wang’s at National Taiwan University College of Medicine found very different evolutionary patterns between the two hosts’ viruses......
 
 
 
 
 
 
 
 
Identifying regulators of early maize leaf development by LCM
 
 
A team led by Dr. Wen-Hsiung Li used laser-capture microdissection to isolate pre-BS and pre-M cells in early leaf development in maize, a C4 plant. From the transcriptomes of these cells they identified transcription factors (e.g., ANT1) that control leaf development and constructed a gene regulatory network, increasing our understanding the regulation of maize leaf development......
 
 
 
 
 
 
 
 
A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies
 
 
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed vaccines, diagnostic tools, and therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Outbreaks of more infectious variants continue to diminish the utility of available vaccines and drugs. Thus, the effectiveness of vaccines and drugs against the most current variants is a primary consideration in the continual analyses of clinical data that supports updated regulatory decisions. The first two vaccines granted Emergency Use Authorizations (EUAs), BNT162b2 and mRNA-1273, still show more than 60% protection efficacy against the most widespread current SARS-CoV-2 variant, Omicron. This variant carries more than 30 mutations in the spike protein, which has largely abrogated the neutralizing effects of therapeutic antibodies. Fortunately, some neutralizing antibodies and antiviral COVID-19 drug treatments have shown continued clinical benefits......
 
 
 
 
 
 
 
 
A hybrid mRNA vaccine induced broadly neutralizing antibodies against Omicron and other SARS-CoV-2 variants
 
 
Wuhan wild-type strain-based vaccines became almost ineffective against new SARS-CoV-2 variants. Academia Sinica mRNA Alpha team constructed a hybrid mRNA vaccine containing mutations of Omicron and Delta variants. When used as a booster in mice previously immunized with wild-type vaccine, the hybrid vaccine induced high titers of broadly neutralizing antibodies against all tested variants, as well as T cell responses against conserved T cell epitope. This hybrid vaccine also includes important mutation sites of Omicron BA.4/5, its effectiveness against the new dominant strains is being explored......
 
 
 
 
 
 
 
 
 
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