Period: 2023-11-13 ~ 2023-11-20

Topic：The role of non coding RNA in genome stability in cancer and aging
Speaker：Dr. Fabrizio d’Adda di Fagagna (IGM-CNR, Italy)
Date：2023-11-14 11:00 - 12:00
Place：B1C Lecture Room, IBMS

Topic：Assembling the ciliary membrane in normal and disease states
Speaker：Dr. Christopher Westlake (National Institutes of Health, USA)
Date：2023-11-14 11:00 - 12:00
Place：B1 Auditorium, Institute of Molecular Biology

Topic：The Pursuit of Breakthrough, My Journey in cryo-EM to make impossible possible
Speaker：Dr. Meng-Chiao Ho (IBC)
Date：2023-11-16 11:00 - 12:00
Place：IBC R209

Topic：ABO-histocompatibility: Glycotechnology tools allow a new framework for organ transplantation
Speaker：Dr. Lori West (University of Alberta, Canada))
Date：2023-11-20 11:00 - 12:00
Place：IBC R209

Topic：Soft Matter, Particle and Fluid Dynamics in Microfluidics
Speaker：Dr. M. Vijay Kumar (Indian Institute of Science Bangalore, India)
Date：2023-11-21 10:30 - 12:30
Place：Conference Room N401, Institute of Molecular Biology, Academia Sinica

Topic：Bamboo Mosaic Virus and Its Subviral Agents: Useful Models for Exploring Research Dimensions in Virology
Speaker：Dr. Na-Sheng Lin (Distinguished Research Fellow, Institute of Plant and Microbial Biology, Academia Sinica)
Date：2023-11-22 15:00 - 16:30
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：Engineering pyrrolysyl-tRNA synthetase for the biosynthesis of heterochiral proteins and novel PTM enzymes Engineering pyrrolysyl-tRNA synthetase for the biosynthesis of heterochiral proteins and novel PTM
Speaker：Dr. Yane-Shih Wang (IBC)
Date：2023-11-23 11:00 - 12:00
Place：IBC R209

Topic：From parasitic weeds to medicinal herbs: Discovery of a novel plasma membrane phylloquinone biosynthetic pathway
Speaker：Dr. Chung-Jui Tsai (Professor & Eminent Scholar, School of Forestry and Natural Resources/ Department of Plant Biology/Department of Genetics, University of Georgia, USA)
Date：2023-11-23 11:00 - 12:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：Genetic determinants of cardiometabolic traits and biomarker levels in Taiwanese: Focused on the Asian-specific variants
Speaker：Dr. Yu-Lin Ko (Taipei Tzu Chi Hospital)
Date：2023-11-23 16:00 - 17:00
Place：B1B Lecture Room, IBMS

Topic：Sexual Dimorphisms in Aedes Mosquito Hearing Systems and Behaviors
Speaker：Dr. Matthew P. Su (YLC Designated Assistant Professor, Graduate School of Science, Institute for Advanced Research, Nagoya University, Japan)
Date：2023-11-24 11:00 - 12:00
Place：1F, Auditorium, Institute of Cellular and Organismic Biology

Topic：dsRNA-protein nanoparticles for effective long-distance transport, delivery, and gene silencing in plants
Speaker：Dr. Yi Li (Professor, Department of Plant Science, University of Connecticut, USA)
Date：2023-11-24 11:00 - 13:00
Place：Dr. Yi Li (Professor, Department of Plant Science, University of Connecticut, USA)

Most eukaryotic genes contain sequences that interrupt the genes’ continuity yet are not translated into proteins. These sequences are removed at the RNA level in a process termed RNA splicing, which occurs on a large ribonucleoprotein complex known as the spliceosome.

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In a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. This cellular diversity can be assessed by measuring DNA methylation patterns. The loci with variable methylation patterns are informative of cellular heterogeneity and may serve as biomarkers of diseases and developmental progression. Cell-to-cell methylation heterogeneity can be evaluated through single-cell methylomes or computational techniques for pooled cells.

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mRNA-based vaccines and therapeutics have tremendous potential as clinical treatments. In a recently published review article, Dr. Han-Chung Wu’s group at the Institute of Cellular and Organismic Biology (ICOB) and Biomedical Translation Research Center (BioTReC) comprehensively discuss the latest research results, current clinical trials, and future development potential of mRNA drugs.

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Metabolic reprogramming is a hallmark of cancer. Cancer cells alter various cellular metabolism pathways to meet the high demand on bioenergetics and biosynthesis and to adapt the harsh tumor microenvironment. However, it remains unclear whether other strategies of metabolic alterations can be exploited by cancer cells for maintaining their proliferation and survival.

Heart failure remains a significant global cause of mortality, characterized by the adult human heart's inability to repair itself or compensate for the loss of cardiac muscle cells. Cell therapy, specifically employing stem cells, has emerged as a promising avenue for restoring lost cardiac muscle cells and reviving heart function.

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