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 Date : 2025/07/07 No:364 
 
 
 

Recent News

 
 
 
 
New Books
 
Period: 2025-07-07~ 2025-07-14
 
 
 
 
 
 

Training Courses

 
 
 
【Bioinformatics series】Annotation and enrichment analysis(In Chinese)(Physical and Video Class)
 
2025-07-08(Tue)14:00~16:00
Dr.EN-YU LAI(Institute of Statistical Science, Academia Sinica)
Research Building of Environmental Changes, AS, 6005 Room
 
 
 
 
【LSL eResources series】Advanced IPA Training Based on a Long COVID Multi-Omics Study Course Introduction(In Chinese)(Physical and Video Class)
 
2025-07-11(Fri)09:30~12:00
Ms.Christine Hsiung(Deputy project Manager,GGA Corp)
2F Computer classroom, Bldg. D, NBRP
 
 
 
 
 
 
【Bioinformatics series】Networks and Pathways analysis(In Chinese)(Physical and Video Class)
 
2025-07-22(Tue)14:00~16:00
Dr.EN-YU LAI(Institute of Statistical Science, Academia Sinica)
Research Building of Environmental Changes, AS, 6005 Room
 
 
 
   
 
 
 

Video Service

 
 
 
 
Welcome to browse the video service of LSL courses

 
6/26-EndNote 21 Essentials (Windows & Mac)(In English)
6/12-Taiwan Biobank Metabolomics Data Analysis Workshop (in Chinese)
5/28-BioData Made Easy: Excel + ChatGPT(In Chinese)
 
 
 
 
 
 

Lectures

 
 
 
 
7/9 IBMS Seminar

 
Topic:Brain & AI: A Dialogue on the Essence of Intelligence
Speaker:Please visit the website for more information
Date:2025-07-09 13:30 - 16:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 
 
7/10 IBC Seminar

 
Topic:Deciphering the roles of intracellular vesicle at the late stages of viral infection by imaging driven approaches
Speaker:Dr. I-Hsuan Wang (IBMS)
Date:2025-07-10 11:00 - 12:00
Place:IBC R209
 
 
 
 
 
 
 
7/11 BRCAS Seminar

 
Topic:Implications of Habitat Quality on the Resilience and Conservation of Reef Fishes Across Life Stages
Speaker:Mr. Felipe Mattos (TIGP Biodiversity Program, Academia Sinica)
Date:2025-07-11 12:30 - 13:30
Place:Auditorium, 1st Floor, Interdisciplinary Research Building
 
 
 
 
 
 
 
7/14 IBMS Seminar

 
Topic:Reprogramming the TME for cancer treatment: our journey from bench to bedside
Speaker:Dr. Ping-Chih Ho (Univ. of Lausanne, Switzerland)
Date:2025-07-14 11:00 - 12:15
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
7/14 ABRC Seminar

 
Topic:Аnti-obesity and Longevity Promotion Properties of Dietary Plants and Herbs
Speaker:Prof. Dr. Milen I. Georgiev (Head of Department of Plant Cell Biotechnology at CPSBB and Metabolomics Lab at Institute of Microbiology (Bulgarian Academy of Sciences), Bulgaria
Date:2025-07-14 11:00 - 13:00
Place:Auditorium A134, Agricultural Technology Building
 
 
 
 
 
 
 
7/15 IBMS Seminar

 
Topic:The role and regulatory mechanism of a long noncoding RNA and its associated nucleic acid modification in hypoxia-induced tumor progression
Speaker:Dr. Kai-Wen Hsu (China Medical Univ.)
Date:2025-07-15 11:00 - 12:15
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
7/15 NPAS Seminar

 
Topic:Properties and functions of axonal mitochondria in cortical pyramidal neurons
Speaker:Dr. Yusuke Hirabayashi (Univ. of Tokyo)
Date:2025-07-15 11:00 - 12:00
Place:1F Auditorium (B106), IST
 
 
 
 
 
 
 
7/16 GRC Seminar

 
Topic:Advancing Covalent Ligand Discovery Beyond Cysteine
Speaker:Prof. Ku-Lung (Ken) Hsu (University of Texas, USA)
Date:2025-07-16 10:30 - 12:00
Place:1F Auditorium, Genomics Research Center
 
 
 
 
 
 
 
7/16 IBMS Seminar

 
Topic:Role of BTG3 in Nucleotide Excision Repair
Speaker:Jack Acedera (TIGP-MM Student)
Date:2025-07-16 15:00 - 16:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 
 
7/18 IBMS Seminar

 
Topic:Deciphering the role of pulmonary fibroblast-derived stem cell factor in regulating ILC3 function in neutrophilic asthma
Speaker:Jheng-Syuan Shao (TIGP-MM Student)
Date:2025-07-18 15:00 - 16:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 
 
7/21 IBMS Seminar

 
Topic:Large-scale brain decoding - taking account of physiological diversity
Speaker:Dr. Blake Richards (McGill Univ.)
Date:2025-07-21 11:00 - 12:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 

Important Research

 
 
 
 
The Role of 2

 
This review covers the catalytic mechanisms and molecular functions of 2'-O-Me in different RNA species, discusses its physiological importance, and highlights the methods for transcriptome-wide mapping of this modification.
 
 
 
 
 
 
 
CMTR1-catalyzed 2

 
Our findings highlight the role of CMTR1 in regulating NMDAR signaling, which is critical for synaptic plasticity and memory consolidation.
 
 
 
 
 
 
 
Impacts of D-aspartate on the aggregation kinetics and structural polymorphism of amyloid β peptide 1-42

 
Here, we showed by thioflavin T fluorescence that the isomerization of L-Asp at different positions of amyloid β peptide 1-42 (Aβ42) generates opposing effects on its aggregation kinetics.These findings provide crucial insights into how the conversion from L- to D-Asp influences the aggregation propensity and amyloid polymorphism of Aβ42.
 
 
 
 
 
 
 
Extracellular matrix induces trophoblast HtrA4 expression: Implications for the pathogenesis of placenta accreta spectrum

 
ECM in decidua and myometrium induced trophoblast HtrA4 expression. Decidual HtrA1 inhibited HtrA4-induced trophoblast invasion. Without the inhibition of HtrA1, HtrA4 expression and invasion was upregulated in the trophoblasts of patients with PAS. The reciprocal effects of HtrA4 and HtrA1 at the maternal-fetal interface may be involved in the pathogenesis of PAS.
 
 
 
 
 
 
 
Comparative genomics of the plant-pathogenic bacterium ‘Candidatus Phytoplasma solani’

 
This work presents the most complete genomic dataset of ‘Ca. P. solani’ to date and reveals the remarkable plasticity of its genome structure and pathogenic gene content. These findings lay a foundation for future functional studies of effectors and advance our understanding of the complex interactions among phytopathogenic bacteria, insect vectors, and plant hosts. The results may also inform the development of disease management strategies, such as molecular diagnostics or breeding for resistance.
 
 
 
 
 
 
 
Lignocellulose degradation in bacteria and fungi: cellulosomes and industrial relevance

 
Lignocellulose is a plant-based material and one of the most common sources for making sustainable biofuels. However, turning it into fuel on a large scale is still difficult. One of the main problems is that the enzymes used to break it down are expensive and not efficient enough. To solve this, researchers are exploring better ways to make these enzymes work faster and cost less. One promising idea is to build enzyme complexes similar to those found in bacteria, called cellulosomes.
 
 
 
 
 
 
 
 
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