Period: 2025-07-21~ 2025-07-28

Turnitin will take a 6-hour maintenance on August, 9 23:00 - August, 10 5:00. The system will be out of service during this period.

7/8-Annotation and enrichment analysis(In Chinese)

This new event aims to showcase Academia Sinica’s research achievements, foster interdisciplinary exchanges, and enhance the sense of academic community.

Topic：The Biology Behind PD-1 Blockade
Speaker：Arlene Sharpe, MD, PhD (Harvard Medical School)
Date：2025-07-22 11:00 - 12:00
Place：B1C Lecture Room, IBMS

Topic：Creating Cellular Identity: How Transcription Factors Make a Difference
Speaker：Dr. Makoto Shirakawa (Nara Institute of Science and Technology (NAIST), Japan)
Date：2025-07-22 15:00 - 17:00
Place：Auditorium A134, Agricultural Technology Building, Academia Sinica

Topic：Integrating Mass Spectrometry, Databases, and Bioinformatics to Advance Natural Product Research for Human Health
Speaker：Dr. Sakda Khoomrung (Siriraj Hospital, Mahidol University, Thailand)
Date：2025-07-23 14:00 - 15:00
Place：IBC R209

Topic：Nanotechnology vs. Melanoma: The Nano-Revolution Shaping Future Medicine
Speaker：Dr. Hui-Min David Wang (National Chung Hsing University)
Date：2025-07-24 11:00 - 12:00
Place：IBC R209

Topic：Beyond Poleward Migration: Cryptic Lineages and Biogeographic Structure of Acropora Corals in East Asia
Speaker：Ms. Savanna Wenhua Chow (TIGP Biodiversity Program, Academia Sinica)
Date：2025-07-24 13:30 - 14:30
Place：Auditorium, 1st Floor, Interdisciplinary Research Building

Topic：Neutrophils: One-Trick Leukocytes?
Speaker：Dr.Lai Guan Ng(Shanghai Immune Therapy Institute Professor)
Date：2025-07-24 11:00 - 12:00
Place： IMB 1F Auditorium

Topic：My Journey: How I Ended Up Here
Speaker：Dr. John Wang
Date：2025-07-25 14:00 - 15:00
Place：Auditorium, 1st Floor, Interdisciplinary Research Building

Topic：The Fruit Fly Files:Investigating Disease with a Tiny Helper
Speaker：Dr.Tau-Yang Lin
Date：2025-08-01 10:00 - 12:00
Place：1F, Auditorium, ICOB

Topic：From Pharmacology to Single-Molecular Techniques:Exploring Biomedical Research Across Scales
Speaker：Dr.Wan-Chen Huang
Date：2025-08-01 10:00 - 12:00
Place：1F, Auditorium, ICOB

In eukaryotic cells, reactive oxygen species (ROS) serve as crucial signaling components. ROS are potentially toxic, so constant adjustments are needed to maintain cellular health.Our findings thus support the use of SN-ROP to elucidate intricate redox networks and their implications in immune cell function and disease.

Various DNA damage response factors form biomolecular condensates at DNA lesions. Targeting phase separation in DNA repair factor assemblies may provide a potential anti-cancer strategy.

Skin exposure to UV rays from sunlight results in the formation of mutagenic DNA photolesions that are repaired by the nucleotide excision repair (NER) machinery.Our findings revealed that by influencing the cellular localization of VCP/p97, BTG3 is critical for the proper execution of NER to protect cells from UV-induced damage and skin carcinogenesis.

Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response.

Targeting nanocarriers to tumors to increase their therapeutic efficacy requires selection of appropriate cancer targets and may depend on the particular formulation under investigation.

The APOBEC3 family of cytidine deaminases restricts retroviruses like HIV-1 by mutating viral DNA.

The emerging pediatric pathogen Kingella kingae elaborates a lipopolysaccharide (LPS) that is extended with a galactofuranose homopolymer called galactan, which is a key virulence determinant that contributes to resistance to complement-mediated and neutrophil-mediated killing.

This study describes the utility of p-acetoxybenzyl carbonate (ABC) group for the protection of hydroxyl functions.

TAR DNA binding protein 43 kD (TDP-43) aggregation is associated with several neurodegenerative diseases and limiting TDP-43 aggregates could offer therapeutic benefit.

Here, we investigate the cellular and molecular basis of adhesion between the nematode Caenorhabditis elegans and its natural predator, the nematode-trapping fungus Arthrobotrys oligospora, which employs specialized adhesive nets to capture its prey.

During social interactions, individuals interpret others' behaviors differently depending on their distance - too close or too far can alter perception. How animals integrate social cues (such as behavior) with spatial distance (via depth vision) to guide their responses is a frontier in neuroscience research.

Animals exhibit diverse behavioral adaptations to predation, driving coevolution across the Tree of Life.

The study serves as a wakeup call that heterogeneity is an intrinsic property of microbes. Microbes may be small but they can work together to increase species survival.

Here, we present a single-tip IMAC-HILIC approach that integrates immobilized metal affinity chromatography (IMAC) and hydrophilic interaction chromatography (HILIC) materials within one pipet tip, enabling concurrent enrichment and sequential elution of phosphopeptides and N-glycopeptides. This integrated workflow effectively reduces phosphopeptide coelution during N-glycopeptide elution and streamlines sample processing. In direct comparison with the tandem-tip TIMAHAC method, our single-tip strategy achieves a comparable identification depth and offers superior quantitative accuracy for both phosphopeptides and N-glycopeptides.

Cell division is a fundamental process essential for cellular proliferation. In plants, the formation of the cell plate—a structure unique to plant cytokinesis—differs markedly from mechanisms in animal cells due to the presence of a rigid cell wall.

We directly treated mouse neuroblastoma to modulate the cholesterol content and found that cholesterol depletion inhibited the internalization of poly-GR into the cells and reduced cytotoxicity. These findings reveal that the conformation of poly-GR and the lipid composition influence its membrane penetration, offering insights into potential therapeutic strategies for C9ORF72-related diseases.

Here, we report an optimized Ribo-seq protocol and analysis pipeline for the model green alga, Chlamydomonas reinhardtiii (Chlamydomonas).