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 Date : 2025/09/15 No:369 
 
 
 

Recent News

 
 
 
 
New Books
 
Period:2025-09-15~ 2025-09-22
 
 
 
 
 
 
 
2025 Academia Sinica Open House

 
 
 
 
 
 
 

Training Courses

 
 
 
【Bioinformatics series】 GWAS Fundamentals and Advanced Applications: Bridging Genes and Diseases(In Chinese)(Physical Class)
 
2025-09-18(Thu)13:30~17:00
Ms.Chia-Ni Hsiung(National Tsing Hua University)
2F Computer classroom, Bldg. D, NBRP
 
 
 
 
【Clinical Trial series】Lesson 1—Basic concepts of clinical trials(In Chinese)(Physical and Video Class)
 
2025-09-23(Tue)10:00~12:00
Dr.Mey Wang
Research Building of Environmental Changes, AS, 6005 Room
 
 
 
 
 
 
【LSL eResources series】Using TAIR for Plant Research: Practical Tools for Arabidopsis and Crops(In Chinese)(Physical and Video Class)
 
2025-09-25(Thu)10:00~12:00
Dr.Ho-Ming Chen(Associate Research Fellow, ABRC)
A133 Room, Agricultural Technology Building
 
 
 
 
【Bioinformatics series】Alternative-splicing detection by NGS(In English)(Physical and Video Class)
 
2025-09-30(Tue)14:00~16:00
Dr.Wen-Dar Lin (Associate Research Specialist, IPMB, AS)
Research Building of Environmental Changes, AS, 6005 Room
 
 
 
 
   
 
 
 

Video Service

 
 
 
 
Welcome to browse the video service of LSL courses

 
9/2-Gene annotation and orthology assignment for newly-sequenced organisms(In Chinese)
9/9-With Life Science Library, Research Gets Easier!(In Chinese)
9/10-Turnitin training course for instructor (in Chinese)
9/12-Ingenuity Pathway Analysis (IPA) Advanced Applications Workshop: Multi-omics Oncology Case (FAP) + Real-world Drug Toxicity Mechanisms (APAP)(In English)
9/16-Leveraging Biomedical Video Resources: From Theory to Practice (In Chinese)
 
 
 
 
 
 

Lectures

 
 
 
 
09/17 IPMB Seminar

 
Topic:Rhizoctonia Genomics: Sclerotia-forming capability and fungicide resistance
Speaker:Dr. Hao-Xun Chang (Associate Professor, Department of Plant Pathology and Microbiology, National Taiwan University, Taiwan)
Date:2025-09-17 11:00 - 13:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
09/18 IBMS Seminar

 
Topic:TRIB2 deficiency enhances thermogenesis and prevents obesity by impairing the recruitment of MYCBP2 E3 ligase to degrade UCP1
Speaker:Dr. Chang, Yi-Cheng (Joint Associate Research Fellow)
Date:2025-09-18 16:00 - 17:00
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
09/19 IMB Seminar

 
Topic:IMB Founders Lectureship: Experimental Evolution and Physiology in the Brewer’s Yeast
Speaker:Dr. Andrew W. Murray (Herchel Smith Professor of Molecular Genetics, Harvard Universit
Date:2025-09-19 14:30 - 16:00
Place:B1 Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
09/22 ICOB Seminar

 
Topic:Unraveling Vesicle Trafficking in the Spatiotemporal Coordination of Collective Cell Migration
Speaker:Dr. Chuen-Chuen Jang (National Cheng Kung University)
Date:2025-09-22 11:00 - 12:30
Place:Auditorium, ICOB
 
 
 
 
 
 
 
09/22 ABRC Seminar

 
Topic:Cell-cell communications with peptide hormone-receptor pairs in various plants
Speaker:Dr. Hidefumi Shinohara (Associate Professor, Faculty of Bioscence and Biotechnology, Fukui Prefectural University, JAPAN)
Date:2025-09-22 11:00 - 13:00
Place:Auditorium A134, Agricultural Technology Building
 
 
 
 
 
 
 
09/22 IPMB Seminar

 
Topic:Reproductive “isolation” on fern leaves: Evolution of dimorphic syndromes in the genus Tectaria
Speaker:Associate Professor Li-Yaung Kuo (Institute of Molecular & Cellular Biology, National Tsing Hua University, Taiwan)
Date:2025-09-22 15:00 - 17:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
09/22 BRCAS Seminar

 
Topic:New Frontiers in Fungal Ecology: Partnerships Beyond the Seed Plant Realm
Speaker:Dr. Ko-Hsuan Chen (Biodiversity Research Center, Academia Sinica)
Date:2025-09-22 15:00 - 16:30
Place:Auditorium, 1st Floor, Interdisciplinary Research Building
 
 
 
 
 
 
 
09/23 IMB Seminar

 
Topic:Nonsense-mediated mRNA decay in human health and disease
Speaker:Dr. Lynne Maquat (J. Lowell Orbison Endowed Chair and Professor, Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester)
Date:2025-09-23 13:30 - 14:30
Place:
 
 
 
 
 
 
 
09/24 IPMB Seminar

 
Topic:Spatiotemporal dynamics of glycerolipid metabolism in plant growth control
Speaker:Dr. Yuki Nakamura (Team Director, RIKEN Center for Sustainable Resource Science (CSRS), Japan)
Date:2025-09-24 15:00 - 17:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
09/24 IPMB Seminar

 
Topic:Development of EGAO (Ethanol-based Global Agricultural Optimization) technology and its application for the carbon-neutral sustainable agriculture
Speaker:Dr. Motoaki Seki (Team Director, RIKEN Center for Sustainable Resource Science (CSRS), Japan)
Date:2025-09-24 15:00 - 17:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
09/26 IPMB Seminar

 
Topic:ROC & ROL on mobile mRNA: the hitchhiker’s guide to the plasmodesmata
Speaker:Dr. Tien-Shin Yu (Institute of Plant and Microbial Biology, Academia Sinica)
Date:2025-09-26 11:00 - 12:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
09/30 IBMS Seminar

 
Topic:Targeting Adipocytes to Combat Metabolic Cardiovascular Disease: A Translational Approach
Speaker:Dr. Xinliang (Xin) Ma (Thomas Jefferson Univ.)
Date:2025-09-30 14:00 - 15:00
Place:B1A Lecture Room, IBMS
 
 
 
 
 
 
 
10/03 BRCAS Seminar

 
Topic:Right Traits, Right Time, Right Mountains: Natural Experiments in Berberis Diversification
Speaker:Dr. Chih-Chieh Yu (Field Museum of Natural History, Chicago, USA)
Date:2025-10-03 10:00 - 11:30
Place:Auditorium, 1st Floor, Interdisciplinary Research Building
 
 
 
 
 
 
 
10/07 IBMS Seminar

 
Topic:CD27 Agonism Enhances Long-Lived CD4⁺ T Cell Vaccine Responses Critical for Anti-Tumor Immunity
Speaker:Dr. Bin-Jin Hwang (Duke Univ.)
Date:2025-10-07 11:00 - 12:15
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
10/13 IPMB Seminar

 
Topic:Motility and life clarified by minimal synthetic bacterium, JCVI-syn3
Speaker:Prof. Makoto Miyata (Department of Biology, Osaka Metropolitan University, Japan)
Date:2025-10-13 11:00 - 13:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
10/13 ABRC Seminar

 
Topic:Understanding Resistance and Susceptibility to Downy Mildew: Mechanisms, Trade-offs, and Translation to Breeding
Speaker:Prof. Guido Van den Ackerveken (Chair and Professor of Translational Plant Biology, Department of Biology, Utrecht University, Netherlands;Scientific Director of CropXR, Utrecht, Netherlands)
Date:2025-10-13 14:00 - 16:00
Place:Auditorium A134, Agricultural Technology Building
 
 
 
 
 
 

Important Research

 
 
 
 
Gut microbiota-derived formate exacerbates pulmonary metastasis in cancer

 
Microbiota-derived formate plays a critical role in enhancing pulmonary metastasis by modulating cancer cell metabolism.
 
 
 
 
 
 
 
Narrowband Ultraviolet B Induces Peripheral Regulatory T Cells to Exert Antigen-Specific Immune Suppression

 
Our findings suggest UVB can induce antigen-specific Tregs in a clinical setting, highlighting its potential for broader immunosuppressive applications.
 
 
 
 
 
 
 
Galectins in Inflammatory Skin Diseases: Mechanisms and Therapeutic Potential

 
By synthesizing current research, this review underscores the opportunities for further studies to clarify the regulatory mechanisms of galectins in skin inflammation, aiming to enhance therapeutic strategies.
 
 
 
 
 
 
 
Hypoxia‑induced genome‑wide DNA demethylation by DNMT3A and EMT of cancer cells

 
Our findings have revealed a missing link between the HIF-1α pathway and the O2-sensing KDM pathway. Finally, the active DNA demethylation activity of DNMT3A has now emerged as a new potential target for therapeutic development to prevent EMT and metastasis of cancer cells.
 
 
 
 
 
 
 
Comprehensive analysis of repetitive extragenic palindrome sequences identified in bacteria and archaea using a new web-based tool, RepRanger

 
We demonstrate that RepRanger represents a versatile tool for discovering REPs in bacteria and archaea, providing new insights into their functions and sequence diversity.
 
 
 
 
 
 
 
Structural Dissection of Vaccinia G9 Identifies Residues Essential for Membrane Fusion and Complex Assembly

 
These results establish G9 as a central EFC component and underscore its potential as a target for antiviral development.
 
 
 
 
 
 
 
New mechanistic insights into Prp22-mediated exon ligation and mRNA release

 
These findings change the current view of splicing fidelity control and offer new mechanistic insights into Prp22-mediated mRNA release. The paper is recognized as Breakthrough Article by NAR.
 
 
 
 
 
 
 
The RNA degradation enzyme RNase E is essential for early flagellar assembly in Escherichia coli

 
These results identify RNase E as a key flagellar biogenesis regulator, revealing novel posttranscriptional control mechanisms.
 
 
 
 
 
 
 
Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes

 
We report that several Saccharomyces cerevisiae homologous recombination proteins exhibit anti-MMR activities, including Rad51, Rad54, Rad59, and synapsis-promoting ZMM proteins (Mer3, Zip1, Zip4, and Msh4) in SK1/S288c hybrid meiosis.
 
 
 
 
 
 
 
Comparative transcriptomics reveals context- and strain-specific regulatory programs of Agrobacterium during plant colonization

 
These findings demonstrate that studying Agrobacterium in real plant contexts and incorporating diverse strains is essential to capture its full biology and improve transformation efficiency.
 
 
 
 
 
 
 
TISCalling: leveraging machine learning to identify translational initiation sites in plants and viruses

 
The research group developed a new computational tool called TISCalling, which is designed to find and identify the start signals for protein production (translation initiation sites, or TISs) in plant and plant viral genomes.
 
 
 
 
 
 
 
ENA1, a newly identified root NA exporter in Arabidopsis, modulates zinc homeostasis

 
The findings open up new avenues for developing plants with enhanced phytoremediation capacity and improved nutritional value through targeted manipulation of NA transport.
 
 
 
 
 
 
 
Transposable elements drive evolution and perturb gene expression in Brassica rapa and B. oleracea

 
These findings shed light on how TEs shape genome evolution in crops and highlight their untapped potential for breeding and genome engineering.
 
 
 
 
 
 
 
Revisiting the co-crystal structure of a DNA glycosylase with photocaged substrate: a suitable time-resolved crystallography target?

 
This work therefore not only demonstrates that hOgg1 is well suited for time-resolved crystallography, but also that such analysis is necessary to determine further steps in its reaction.
 
 
 
 
 
 
 
Multiplex bead immunoassay in ABO-A2-incompatible kidney transplantation

 
Our ABO antibody assay reproducibly measures graft-specific anti-A-II antibodies, providing information beyond anti-A titers that may increase transplant access for ABO-B and ABO-O candidates.
 
 
 
 
 
 
 
 
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