Period: 2025-10-27~ 2025-11-03

10/20-AI-Powered WoS & JCR: Easily Unlock SCIE/SSCI Scientific Treasures and Top Journal Rankings! (In Chinese)
10/14-Single cell analysis (In Chinese)

Topic：The Immunology of Eating
Speaker：Dr. Andrew Wang (Associate Professor of Medicine and Immunobiology, Yale School of Medicine, New Haven, CT, USA)
Date：2025-10-28 11:00 - 12:00
Place：

Topic：Beneficial Partners and Dangerous Foes: Microbial Influences on Coral Bleaching
Speaker：Dr. Toshiyuki Takagi (The University of Tokyo)
Date：2025-10-28 15:00 - 16:30
Place：Auditorium, 1st Floor, Interdisciplinary Research Building

Topic：Phylogenetic and Evolutionary Insights into Independent Gametophyte Ferns of the​ Tropical Genus Lomariopsis (Lomariopsidaceae)
Speaker：Dr. Li-Yaung Kuo (National Tsing Hua University)
Date：2025-10-29 15:00 - 16:30
Place：Auditorium, 1st Floor, Interdisciplinary Research Building

Topic：Molecular dialog between roots and associated microbiota and its influence on the host growth-defense coordination
Speaker：Professor Ryohei Thomas Nakano (Hokkaido University, Sapporo, Japan)
Date：2025-11-04 11:00 - 13:00
Place：Auditorium A134, Agricultural Technology Building, Academia Sinica

Topic：Acid-activated ASOR/Tmem206 Cl⁻ channels: Structure, function, and role in macropinocytosis
Speaker：Dr. Thomas Jentsch (Leibniz-Forschungsinstitut für Molekulare Pharmakologie)
Date：2025-11-04 11:00 - 12:00
Place：1F Auditorium (B106), IST

Topic：Hyperphosphorylated Tau Oligomers Drive Monocyte-Mediated Tauopathy and Neurodegeneration
Speaker：Dr. Hong-Ru Chen (Yang Ming Chiao Tung Univ.)
Date：2025-11-06 14:00 - 15:15
Place：B1B Lecture Room, IBMS

Topic：Pattern-recognition receptors: Past, present and future
Speaker：Dr. Pok Man Ngou (Postdoctoral Researcher, RIKEN CSRS, Japan)
Date：2025-11-10 10:00 - 12:00
Place：Auditorium A134, Agricultural Technology Building, Academia Sinica

Topic：Recent Advances in Plant and Microbial Biology
Speaker：Please visit the website for more information
Date：2025-10-28 09:10 - 12:20
Place：Auditorium A134, Agricultural Technology Building, Academia Sinica

Speaker：Please visit the website for more information
Date：2025-11-05 10:00 - 16:20
Place：B1 Auditorium, Institute of Molecular Biology, Academia Sinica

Topic：Minisymposium on “Multidisciplinary conversations on the theme of biomolecular structures”
Date：Nov. 03, 2025 (Mon.) 10:00-17:50 (9:30開始報到)

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication deficits, accompanied by restricted and repetitive behaviors. Our findings suggest that loss-of-function in the Cav3.2 channel contributes to ASD-like phenotypes through disrupted GABAergic signaling and that pharmacological enhancement of GABAergic signaling may offer a potential therapeutic approach for individuals with ASD carrying the CACNA1H mutations.

Our findings demonstrate that inosine is a vital fuel for astrocytes under inflammatory stress and that Ent2 is the key transporter controlling astrocytes to utilize this fuel.

Ligands for the aryl hydrocarbon receptor (AhR), such as kynurenine derived from the tumor microenvironment, are well-known immunosuppressants.Through specific interaction between SP65 and CD11c, CH223191 is specifically transported to DCs. This inhibits AhR function, promoting IL-12 and IFN-γ production in DCs and NK cells, respectively.

The Taiwan Precision Medicine Initiative recruited more than half a million Taiwanese residents, providing a large dataset of genetic profiles and electronic medical record data for people with Han Chinese ancestry. Using extensive phenotypic data, we conducted comprehensive genomic analyses across the medical phenome with individuals genetically similar to Han Chinese reference populations.

Han Chinese comprise nearly 20% of the global population yet remain underrepresented in genetic studies 1,2, creating an urgent need for large-scale cohorts to advance precision medicine.

Light chain (AL) amyloidosis is a life-threatening systemic disorder caused by the aggregation and deposition of antibody light chain (LC) fragments in multiple organs, including the heart and kidneys.

In this study, we investigated the molecular mechanisms of ribosome stalling induced by an engineered ribosomal arrest peptide (eRAP).

We report cryo-EM structures of human 26S proteasome in a complex with a K11/K48-branched Ub chain. The structures revealed a multivalent substrate recognition mechanism involving a hitherto unknown K11-linked Ub binding site at the groove formed by RPN2 and RPN10 in addition to the canonical K48-linkage binding site formed by RPN10 and RPT4/5 coiled-coil.

The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are two major pathways for maintaining cellular protein homeostasis. Increasing evidence has highlighted the complex interactions and crosstalk between these pathways; however, the specific molecules and mechanisms mediating the interplay between the UPS and autophagy are still not fully elucidated.

Our results demonstrate that incipient endosymbioses employ mitochondrial remodeling and endosymbiont metabolic reprogramming to actively regulate transitions between mutualistic and parasitic states, revealing how symbiotic partnerships navigate environmental pressures during their incipient stage of evolutionary establishment.

Here, we show that the arginine-rich motif (ARM) of P20 directs its nucleolar localization, enabling its interaction with FIB in the nucleolus and Cajal bodies, where FIB methylates the ARM.

In a new study, an international team of researchers has discovered a remarkable strategy in which stinkbugs form a defensive alliance with fungi, using them to physically protect their eggs from wasp parasitism.

This finding reveals that plant immune networks can diversify according to organ-specific functions.

Chronic hepatitis B (CHB) is a major global health concern primarily due to hepatocellular carcinoma (HCC) development.Serum HBsAg levels <100 IU/mL effectively identify patients with inactive CHB with negligible HCC risk and limited viral activity, which is important in optimising surveillance strategies and defining partial HBV cure.