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 Date : 2026/06/08 No:386 
 
 
 

Recent News

 
 
 
 
New Books
 
Period:2026-06-08~2026-06-15
 
 
 
 
 
Library Closing Notice
 
 
Library Closing Notice
 
The Life Science Library will be closed on Friend,June 19
 
 
 
 
 
 

Training Courses

 
 
 
AI-Assisted Writing: Mindset Upgrades and Practical Techniques(In Chinese)(Physical Class)
 
2026-06-17(Wed)14:00~17:00
Dr.Chao-Hsiang Hung(Assistant Professor, Dept. Psychology and Counseling, University of Taipei)
1F Auditorium, ICOB
 
 
 
 
【Bioinformatics series】Taiwan Biobank Metabolomics Data Analysis Workshop (in Chinese)(Physical Class)
 
2026-06-24(Wed)14:00~16:00
Dr.Chung-Ke Chang(Chief Strategy Officer)
Ms.Sing-Huei Wu(Data Analyst)
(Taiwan Biobank)
2F Computer classroom, Bldg. D, NBRP
 
 
 
 
 
 
【LSL eResources series】EndNote 2025 Essentials (Windows & Mac)(In English)(Video Class)
 
2026-06-25(Thu)14:00~16:00
Mr. Max Lin(Shou Ray Information Service Co., Ltd.)
Online
 
 
 
   
 
 
 

Lectures

 
 
 
 
06/09 IBC Seminar
 
Topic:Unusual Enzyme Reactions in Natural Product Biosynthesis
Speaker:Dr. Ikuro Abe (The University of Tokyo, Japan)
Date:2026-06-09 11:00 - 12:00
Place:IBC R209
 
 
 
 
 
 
 
06/10 GRC Seminar
 
Topic:Bench-to-Bedside: Decoding the PDAC Ecosystem to Drive AI Diagnostics and Precision Therapeutics
Speaker:Assistant Professor Chun-Mei Hu (Genomics Research Center)
Date:2026-06-10 10:30 - 11:30
Place:1F Auditorium, Genomics Research Center
 
 
 
 
 
 
 
06/11 IBC Seminar
 
Topic:Coding or non-coding? Illuminating the “dark matter” of the proteome
Speaker:Dr. Jin Chen (Altos Labs Institute of Science, USA)
Date:2026-06-11 11:00 - 12:00
Place:IBC R209
 
 
 
 
 
 
 
06/11 IBMS Seminar
 
Topic:Metabolic Programming in Early Life: Ketone Signaling and Epigenetic Control of Adipose Plasticity
Speaker:Fu-Jung Lin, PhD (NTU)
Date:2026-06-11 16:00 - 17:00
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
06/12 IPMB Seminar
 
Topic:Functional interaction of JMJ28 and GCN5 in regulating ABA and drought responses
Speaker:Ms. Wen-Chi Liao (Institute of Plant and Microbial Biology, Academia Sinica)
Date:2026-06-12 10:30 - 11:30
Place:Multifunction Room R106, Institute of Plant and Microbial Biology (IPMB) Building, Academia Sinica
 
 
 
 
 
 
 
06/12 IPMB Seminar
 
Topic:Genome-wide survey of ribosome collision in de-etiolating Arabidopsis
Speaker:Dr. Yueh Cho (Institute of Plant and Microbial Biology, Academia Sinica)
Date:2026-06-12 10:30 - 11:30
Place:Multifunction Room R106, Institute of Plant and Microbial Biology (IPMB) Building, Academia Sinica
 
 
 
 
 
 
 
06/12 GRC Seminar
 
Topic:Exploring Cutting-Edge Advancements in Dementia Treatment
Speaker:Dean Chaur-Jong Hu (Taipei Medical University)
Date:2026-06-12 11:00 - 12:00
Place:1F Auditorium, Genomics Research Center
 
 
 
 
 
 
 
06/15 IPMB Seminar
 
Topic:Plant-microbe-climate interactions in the phyllosphere
Speaker:Dr. Sheng Yang He (Duke University, USA)
Date:2026-06-15 15:00 - 16:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
06/16 IBC Seminar
 
Topic:Phase separation in telomere maintenance of ALT cancers
Speaker:Dr. Huaiying Zhang (Carnegie Mellon University, USA)
Date:2026-06-16 11:00 - 12:00
Place:IBC R209
 
 
 
 
 
 
 
06/16 IBMS Seminar
 
Topic:Targeting Lipid Metabolism in Pancreatic Cancer
Speaker:Caleb Cheng (Uni. of Michigan Medical Scientist Training Program)
Date:2026-06-16 11:00 - 12:00
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
06/16 IMB Seminar
 
Topic:Engineering Longevity - Computationally-guided reprogramming of single-cell aging
Speaker:Dr. Nan Hao (University of California, San Diego)
Date:2026-06-16 11:00 - 12:00
Place:1F Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
06/17 IPMB Seminar
 
Topic:Arrested Development temporal regulation of cell identity during plant embryogenesis
Speaker:Dr. Margot Smit (ZMBP, Tübingen University, Germany)
Date:2026-06-17 11:00 - 12:20
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
 
 
 
 
 
 
 
06/22 IBC Seminar
 
Topic:Protein biogenesis and quantity control at the ribosome
Speaker:Dr. Zhewang Lin (National University of Singapore, Singapore)
Date:2026-06-22 11:00 - 12:00
Place:IBC R209
 
 
 
 
 
 

Important Research

 
 
 
 
FUT8-Dependent Core Fucosylation: Essential for Platelet Function and a Target in Thrombosis
 
Our results suggest that FUT8 in platelets may be a therapeutic target for thrombosis-related cardiovascular diseases
 
 
 
 
 
 
 
Stereocontrolled spirocyclization of exo-glycals with arylamines for the synthesis of (1 S)-spiro-tetrahydroquinoline glycosides
 
Herein, we present a ZnCl2-promoted coupling of exo-glycals and arylamines for the stereospecific synthesis of (1S)-spiro-tetrahydroquinoline glycosides in a one-pot fashion.
 
 
 
 
 
 
 
Allosteric network of dynamic coupling within BAP1-UCH revealed by methyl NMR
 
BRCA1-associated protein 1 (BAP1) is a tumor suppressor whose deubiquitinase (DUB) activity is essential for transcriptional regulation and is frequently compromised in cancer by mutations clustered in its ubiquitin carboxyl-terminal hydrolase (UCH) domain.
 
 
 
 
 
 
 
SN38 PLGA nanoparticles provide sustained antitumor efficacy and ameliorate colitis severity in a murine colitis-associated cancer model
 
This study aimed to improve SN38 delivery using poly(lactic-co-glycolic acid) (PLGA) nanoparticles and to evaluate their efficacy and safety in vitro and in a murine colitis-associated CRC model.
 
 
 
 
 
 
 
Robust and interpretable machine learning for affinity prioritization of designed protein interactors
 
Our tool offers a timely, cost-effective approach to rapidly identifying high-affinity binders from large candidate pools, thus facilitating state-of-the-art protein design
 
 
 
 
 
 
 
Metabolic thermodynamics: pertinent reference state and energy potentials
 
We supply algorithms to transform between states. This preserves interoperability across diverse organelles, media and between enzymology and chemical engineering, while facilitating reuse.
 
 
 
 
 
 
 
Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes
 
These findings provide quantitative design principles for safer, lower-trauma, high-density neural interfaces.
 
 
 
 
 
 
 
Asymmetric dimeric assembly of Suv3 helicase facilitates processive RNA unwinding
 
Here, we present near-atomic-resolution cryogenic electron microscopy structures of Suv3 captured in four functional states: the apo form, two binary complexes with ADP and single-stranded RNA (ssRNA), and a ternary complex with ssRNA and an ATP analog (AMP-PNP).
 
 
 
 
 
 
 
Crystal structure of the CD33/Fab-10C8 complex elucidates the mechanism of antibody antagonism in HBV-induced immunosuppression
 
These findings provide a structural framework for designing Siglec-targeted immunotherapies against chronic viral infections and immune disorders.
 
 
 
 
 
 
 
 
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