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Genome integrity is threatened by solar ultraviolet (UV) light, which reacts with adjacent DNA pyrimidine bases to produce undesirable covalent bonds. As the most common UV-induced lesion, cyclobutane pyrimidine dimers (CPDs) have been strongly linked to cancer. |
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The canine anti-TNF-α monoclonal antibody is a potential therapeutic option for treating canine arthritis. The current treatments for arthritis in dogs have limitations due to side effects, emphasizing the need for safer and more effective therapies. |
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Efficiently delivering exogenous materials into primary neurons and neural stem cells (NSCs) has long been a challenge in neurobiology. |
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生物體當暴露在可與核酸作用的物理和化學因子下，可能會導致DNA與RNA的修飾(又稱NA Modifications)，此作用已知與多種疾病有關，包括癌症。 |
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在正常細胞開始異常增生、型態變異進而轉變為癌症前，有一個過渡期，病理學上稱之為「癌前病變」，而胰臟上皮內瘤（以下簡稱PanIN）是胰臟癌中最常見也是最早形成的癌前病變。現今文獻指出，超過90%的胰臟上皮內瘤和胰臟癌病例都有KRAS基因突變的情況。然而，單單KRAS基因的突變就可以驅動最早期PanIN的生成？當然，「真相不只有一個」。 |
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Hirudins, natural sulfo(glyco)proteins, are clinical anticoagulants that directly inhibit thrombin, a key coagulation factor. Their potent thrombin inhibition primarily results from antagonistic interactions with both the catalytic and non-catalytic sites of thrombin. |
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