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 Date : 2024/02/05 No:328 
 
 
 

Recent News

 
 
 
 
New Books
 
Period: 2024-2-5 ~ 2024-2-12
 
 
 
 
 
 

LSL Announcement

 
 
We will be closed from Feb. 8, 2024 to Feb. 14, 2024 for Chinese New Year's Day. Please return items in the book drop outside the entrance of LSL.
 
 
We will be closed from Feb. 8, 2024 to Feb. 14, 2024 for Chinese New Year

 
 
 
 
 
 
 

Training Courses

 
 
 
【Clinical Trial Lecture-Basic Course】Lesson 9-Medical device clinical trials(In Chinese)(Physical and Video Class)
 
2024-02-20(Tue)10:00~12:00
B1 Auditorium, Institute of Statistical Science
 
 
 
   
 
 
 

Lectures

 
 
 
 
2/16 ICOB Seminar

 
Topic:Cellular Plasticity of the Bone Marrow Niche Promotes Hematopoietic Stem Cell Regeneration
Speaker:Dr. Hiroyuki Hirakawa (Postdoctoral Fellow, Columbia University, USA)
Date:2024-02-16 09:00 - 10:00
Place:Webinar
Meeting Link: https://asmeet.webex.com/asmeet/j.php?MTID=me17b5478d415725dda49102d797843c3
Meeting Number: 2516 408 1217
Meeting password: 0216
 
 
 
 
 
 

Important Research

 
 
 
 
Light-driven DNA repair at atomic and picosecond resolution revealed via time-resolved serial femtosecond crystallography

 
Genome integrity is threatened by solar ultraviolet (UV) light, which reacts with adjacent DNA pyrimidine bases to produce undesirable covalent bonds. As the most common UV-induced lesion, cyclobutane pyrimidine dimers (CPDs) have been strongly linked to cancer.
 
 
 
 
 
 
 
 
Structure-Based Development of a Canine TNF-α-Specific Antibody Using Adalimumab as a Template

 
The canine anti-TNF-α monoclonal antibody is a potential therapeutic option for treating canine arthritis. The current treatments for arthritis in dogs have limitations due to side effects, emphasizing the need for safer and more effective therapies.
 
 
 
 
 
 
 
 
Improved CaP Nanoparticles for Nucleic Acid and Protein Delivery to Neural Primary Cultures and Stem Cells

 
Efficiently delivering exogenous materials into primary neurons and neural stem cells (NSCs) has long been a challenge in neurobiology.
 
 
 
 
 
 
 
 
A Novel Adductomics Workflow Incorporating FeatureHunter Software: Rapid Detection of Nucleic Acid Modifications for Studying the Exposome

 
Exposure to the physicochemical agents that interact with nucleic acids (NA) may lead to modification of DNA and RNA (i.e., NA modifications), which have been associated with various diseases, including cancer.
 
 
 
 
 
 
 
 
Unveiling the Mystery of Cancer-Causing KRAS Gene Driving Pancreatic Precancerous Lesions

 
As normal cells undergo abnormal proliferation, morphological changes, and eventually transform into cancer, there is a transitional phase known as "precancerous lesions" in pathology. Pancreatic Intraepithelial Neoplasia (PanIN) is the most common and earliest form of precancerous lesion in pancreatic cancer. Current literature indicates that over 90% of PanINs and pancreatic cancer cases exhibit mutations in the KRAS gene. However, can the mutation of the KRAS gene alone drive the early formation of PanINs? Certainly, "there is more than one truth."
 
 
 
 
 
 
 
 
Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech-Derived Peptides on Binding and Inhibitory Activity Against Thrombin

 
Hirudins, natural sulfo(glyco)proteins, are clinical anticoagulants that directly inhibit thrombin, a key coagulation factor. Their potent thrombin inhibition primarily results from antagonistic interactions with both the catalytic and non-catalytic sites of thrombin.
 
 
 
 
 
 
 
 
 
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