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 發報日期 : 2024/03/18 發行期數:331 
 
 
 

最新消息

 
 
 
 
新書展示
 
展期:2024-3-18 ~ 2024-3-25
 
 
 
 
 
 
 
中研院重要研究成果展:洪志銘博士
 
展期 : 3/18/2024-4/12/2024
 
 
 
 
 
 
 
中研院重要研究成果展:林子皓博士
 
展期 : 3/18/2024-4/12/2024
 
 
 
 
 
 
 
敬請把握參觀「驚豔臺灣生物多樣性特展」
 
展出日期:2023/10/14~2024/03/31
展出時間:週一至週五 08:30 ~ 18:00
(國定例假日除外)
 
 
 
 
 
 
 
Henry Stewart Talks 3月份新增演講內容,請多加利用
 
 
 
 
 
 
 

教育訓練課程

 
 
 
【生物資訊系列】3:GWAS: From QC to trait associations(In Chinese)(實體+線上課程)
 
2024-04-02(二)14:00~16:00
陳佳煒先生(統計所)
統計所 B1 演講廳
 
 
 
 
閱讀領航講座第一季:從期刊論文到童書繪本:讓科學知識拿得到、讀得懂、用得上(In Chinese)(實體+線上課程)【院內同仁可提報一個小時環境教育時數】
 
2024-03-26(二)14:30~15:30
Dr.林大利
農業部生物多樣性研究所 副研究員
澳洲昆士蘭大學生物學博士
生圖生態館一樓
 
 
 
 
   
 
 
 

Blog

 
 
 
 
運動改造大腦:活化憂鬱腦、預防失智腦,IQ和EQ大進步的關鍵
 
運動可以減少肌肉的靜止張力,中斷通往大腦的焦慮回饋迴路,一旦身體鎮定下來,大腦就比較不容易憂慮。運動還能產生讓身心平靜的化學變化。
 
 
 
 
 
 
 

生命組演講公告

 
 
 
 
3/19 分生所演講
 
講題:Regulation of Mre11 nuclease activity through Rad50 and its function in DSB repair and meiotic crossover formation
主講者:Dr. Miki Shinohara (Professor, Agricultural Technology and Innovation Research Institute, Kindai University)
時間:2024-03-19 10:00 - 11:00
地點:中央研究院分子生物研究所B1演講廳
 
 
 
 
 
 
 
3/19 分生所演講
 
講題:Control of assembly/disassembly of DNA-protein complexes in homologous recombination
主講者:Dr. Akira Shinohara (Professor, Institute for Protein Research, Osaka University)
時間:2024-03-19 11:00 - 12:00
地點:中央研究院分子生物研究所B1演講廳
 
 
 
 
 
 
 
3/19 生醫所演講
 
講題:Novel approaches to microbiome therapeutics for immune disorders
主講者:Dr. Jose C. Clemente (Mount Sinai School of Medicine, USA)
時間:2024-03-19 11:00 - 12:00
地點:生醫所地下室B1B演講廳
 
 
 
 
 
 
 
3/20 基因體中心
 
講題:Leverage the Actinobacterial Strain Collection and Genome Database for Natural Products and Drug Discovery
主講者:沈奔 教授 (The Herbert Wertheim Institute for Biomedical Innovation & Technology, USA)
時間:2024-03-20 10:30 - 12:00
地點:基因體研究中心一樓演講廳
 
 
 
 
 
 
 
3/20 生化所演講
 
講題:May the gut be with you: harnessing gut barrier and microbiota for controlling inflammatory diseases
主講者:Cheng-Yuan Kao博士(美國Amgen Inc.)
時間:2024-03-20 14:00 - 15:00
地點:生化所209研討室
 
 
 
 
 
 
 
3/21 基因體演講
 
講題:How to publish with Nature Portfolio
主講者:黃慶裕 博士 (Nature Communocations- Immunology team 主編)
時間:2024-03-21 10:00 - 11:30
地點:基因體研究中心一樓演講廳
 
 
 
 
 
 
 
3/21 生醫所演講
 
講題:Endothelial-mesenchymal transition in atrial fibrillation and dysfunction of arteriovenous fistulas
主講者:葉勇信博士 (長庚紀念醫院)
時間:2024-03-21 11:00 - 12:00
地點:生醫所地下室B1C演講廳
 
 
 
 
 
3/21 生醫所演講
 
 
3/21 生醫所演講
 
講題:KATP channels in metabolic sensing: mechanistic insights from cryoEM structures
主講者:邢秀玲博士 (Oregon Health and Science Univ.)
時間:2024-03-21 11:00 - 12:00
地點:跨領域大樓一樓演講廳
 
 
 
 
 
 
 
3/21 分生所演講
 
講題:Quantitative Understanding of Cell Cycle Regulation through Live Imaging of CDK Activity
主講者:Dr. Dr. Hironori Sugiyama (Postdoctoral Research Fellow, Japan Society for the Promotion of Science, National Institute for Basic Biology, Japan)
時間:2024-03-21 14:00 - 15:00
地點:中央研究院分子生物研究所1F演講廳
 
 
 
 
 
 
 
3/22 生化所演講
 
講題:Medical Applications of Bacteriophages as a Personalized Medicine in Infectious Diseases
主講者:陳立光醫師 (慈濟大學)
時間:2024-03-22 11:00 - 12:00
地點:生化所209研討室
 
 
 
 
 
 
 
3/25 生醫所演講
 
講題:Optical dissection of rhythmic behaviors in a worm
主講者:Christopher Fang-Yen 教授 (The Ohio State Univ.)
時間:2024-03-25 11:00 - 12:00
地點:跨領域大樓一樓演講廳
 
 
 
 
 
 
 
3/25 生醫所演講
 
講題:Targeting UFMylation and long non-coding RNA for cancer immunotherapy
主講者:李育儒博士 (助研究員)
時間:2024-03-25 11:00 - 12:00
地點:生醫所地下室B1C演講廳
 
 
 
 
 
 
 
3/26 分生所演講
 
講題:From Molecular Biology to Biotech CEO
主講者:Dr. Anna Akhmanova (Professor, Division of Cell Biology, Utrecht University)
時間:2024-03-26 11:00 - 12:00
地點:中央研究院分子生物研究所B1演講廳
 
 
 
 
 
 
 
3/26 生醫所演講
 
講題:Hypothalamic cell types and circuits that drive survival behaviors
主講者:Yeka Aponte 教授 (NIDA, USA)
時間:2024-03-26 11:00 - 12:00
地點:跨領域大樓一樓演講廳
 
 
 
 
 
 
 
3/27 分生所演講
 
講題:Synaptic Integration and Plasticity in the Barn Owl Auditory System
主講者:Dr. William DeBello (Associate Professor, CNS and NPB, University of California, Davis)
時間:2024-03-27 11:00 - 12:00
地點:中央研究院分子生物研究所1F演講廳
 
 
 
 
 
 
 
3/27 生醫所演講
 
講題:Genetic mechanisms of coronary artery calcification
主講者:Dr. Alexandre Stewart (Univ. of Ottawa Heart Inst.)
時間:2024-03-27 11:00 - 12:00
地點:生醫所地下室B1C演講廳
 
 
 
 
 
 
 
3/27 分生所演講
 
講題:Metabolic crosstalk and symbiosis in the tumor microenvironment
主講者:Dr. Ping-Chih Ho 何秉志 (Professor, Department of Oncology, University of Lausanne Ludwig Institute for Cancer Research, Switzerland)
時間:2024-03-27 14:00 - 15:00
地點:中央研究院分子生物研究所B1演講廳
 
 
 
 
 
 
 
3/28 生醫所演講
 
講題:Deciphering development and function of the cerebellum using zebrafish
主講者:Masahiko Hibi 教授 (Nagoya Univ., Japan)
時間:2024-03-28 11:00 - 12:00
地點:跨領域大樓一樓演講廳
 
 
 
 
 
 
 
3/28 分生所演講
 
講題:Advancing long COVID research through mouse model development
主講者:Dr. Peiwen Lu (Associate Research Scientist, Department of Immunobiology, Yale University School of Medicine)
時間:2024-03-28 11:00 - 12:00
地點:分子生物研究所1F演講廳
 
 
 
 
 
 
 
3/29 植微所演講
 
講題:Exploring Mysteries of Agrobacterium-Mediated Germline Transformation in Arabidopsis
主講者:賴爾珉研究員(中央研究院植物暨微生物學研究所)
時間:2024-03-29 11:00 - 12:00
地點:中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳
 
 
 
 
 
 

生命組研究成果重要發現

 
 
 
 
Comparative analysis of Deinagkistrodon acutus venom from Taiwan and China utilizing chromatographic, electrophoretic, and bioinformatic approaches, along with ELISA employing a monospecific antivenom
 
Deinagkistrodon acutus is a medically important pitviper inhabiting mainly South China and Taiwan. The hemorrhagic effects of its envenoming are compatible to its venom, which is abundant in metalloproteases (svMPs) and C-type lectin-like proteins.
 
 
 
 
 
 
 
 
Bacterial pseudaminic acid binding to Siglec-10 induces a macrophage interleukin-10 response and suppresses phagocytosis
 
Pseudaminic acid (Pse) on pathogenic bacteria exopolysaccharide engages with the sialic acid-binding immunoglobulin-type lectin (Siglec)-10 receptor on macrophages via the critical 7-N-acetyl group.
 
 
 
 
 
 
 
 
Immunometabolic features of natural killer cells are associated with infection outcomes in critical illness
 
Immunosuppression increases the risk of nosocomial infection in patients with chronic critical illness. This exploratory study aimed to determine the immunometabolic signature associated with nosocomial infection during chronic critical illness.
 
 
 
 
 
 
 
 
In vivo CRISPR screening directly targeting testicular cells
 
CRISPR-Cas9 short guide RNA (sgRNA) library screening is a powerful approach to understand the molecular mechanisms of biological phenomena.
 
 
 
 
 
 
 
 
Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs
 
Engineering human enzymes for therapeutic applications is attractive but introducing new amino acids may adversely affect enzyme stability and immunogenicity.
 
 
 
 
 
 
 
 
A Facile NMR Method for Pre-MRI Evaluation of Trigger-Responsive T1 Contrast Enhancement
 
There is a growing interest in developing paramagnetic nanoparticles as responsive magnetic resonance imaging (MRI) contrast agents, which feature switchable T1 image contrast of water protons upon biochemical cues for better discerning diseases.
 
 
 
 
 
 
 
 
Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation
 
K2-capsular Klebsiella pneumoniae is a hypervirulent pathogen that causes fatal infections. Here, we describe a phage tailspike protein, named K2-2, that specifically depolymerizes the K2 capsular polysaccharide (CPS) of K. pneumoniae into tetrasaccharide repeating units.
 
 
 
 
 
 
 
 
 
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