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 發報日期 : 2024/04/01 發行期數:332 
 
 
 

最新消息

 
 
 
 
新書展示
 
展期:2024-4-1 ~ 2024-4-8
 
 
 
 
 
 

館務公告

 
 
生圖將於4/4、4/5清明連假暫停服務,特此公告。
 
 
生圖將於4/4、4/5清明連假暫停服務,特此公告。
 
 
 
 
 
 
 

教育訓練課程

 
 
 
【生物資訊系列】4:PRS(In Chinese)(實體+線上課程)
 
2024-04-16(二)14:00~16:00
陳佳煒先生(統計所)
統計所 B1 演講廳
 
 
 
   
 
 
 

Blog

 
 
 
 
春天草坪上的迴旋舞者—綬草
 
清明時節,望著一株株的綬草,螺旋狀的花序盤旋而上,宛若青草地上一柱柱輕煙裊繞的線香,在細雨紛飛中顯得格外的悽清。
 
 
 
 
 
 
 

生命組演講公告

 
 
 
 
4/2 生化所演講
 
講題:Acrigen Biosciences: Building a High Precision Gene Editing Platform
主講者:David Rabuka博士 (美國Acrigen Biosciences Inc.)
時間:2024-04-02 11:00 - 12:00
地點:生化所209研討室
 
 
 
 
 
 
 
4/2 分生所演講
 
講題:Advancing long COVID research through mouse model development
主講者:Dr. Si-Han Chen (Senior Scientist, Lead Discovery and Optimization Bristol Myers Squibb, USA)
時間:2024-04-02 11:00 - 12:00
地點:分子生物研究所1F演講廳
 
 
 
 
 
 
 
4/8 細生所演講
 
講題:What is aging, and why do we die of it?
主講者:Dr. Edward Giniger (Senior Investigator, Axon Guidance and Neural Connectivity Section, NINDS, NIH, US)
時間:2024-04-08 11:00 - 12:00
地點:細生所1樓演講廳
 
 
 
 
 
 
 
4/8 生醫所演講
 
講題:Unraveling a Mystery: How Do NK Cells Recognize Cancer Cells via NKp46 Receptor?
主講者:李典璋博士 (Takeda Oncology)
時間:2024-04-08 11:00 - 12:00
地點:生醫所地下室B1C演講廳
 
 
 
 
 
 
 
4/12 生醫所演講
 
講題:AI-Enhanced Precision Medicine for Diabetic Kidney Disease
主講者:蔡亭芬 博士 (國立陽明交通大學)
時間:2024-04-12 11:00 - 12:00
地點:生醫所地下室B1B演講廳
 
 
 
 
 
 

生命組研究成果重要發現

 
 
 
 
Modeling alternative translation initiation sites in plants reveals evolutionarily conserved cis-regulatory codes in eukaryotes
 
mRNA translation relies on identifying translation initiation sites (TISs) in mRNAs. Alternative TISs are prevalent across plant transcriptomes, but the mechanisms for their recognition are unclear.
 
 
 
 
 
 
 
 
Expression of low-sulfated keratan sulfate in non-mucinous ovarian carcinoma
 
Keratan sulfate glycosaminoglycan is composed of repeating N-acetyllactosamine (LacNAc) disaccharide units consisting of galactose (Gal) and N-acetylglucosamine (GlcNAc), both often 6-O-sulfated.
 
 
 
 
 
 
 
 
Structural Insight into the ZFAND1-p97 Interaction Involved in Stress Granule Clearance
 
Arsenite-induced stress granule (SG) formation can be cleared by the ubiquitin-proteasome system aided by the ATP-dependent unfoldase p97.
 
 
 
 
 
 
 
 
Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human α-Galactosidase
 
The use of pharmacological chaperones (PCs) to stabilize specific enzymes and impart a therapeutic benefit is an emerging strategy in drug discovery. However, designing molecules that can bind optimally to their targets at physiological pH remains a major challenge.
 
 
 
 
 
 
 
 
DDX3 regulates cancer immune surveillance via 3
 
Programmed death-1 (PD-1)/PD ligand-1 (PD-L1)-mediated immune escape contributes to cancer development and has been targeted as an anti-cancer strategy.
 
 
 
 
 
 
 
 
胞核內輸蛋白α參與RNA干擾機制負調控竹嵌紋病毒的累積
 
胞核內輸蛋白α (importin α)是屬於核運輸蛋白(karyopherin)家族成員,參與了許多RNA 靜默相關蛋白質進入細胞核的運輸。
 
 
 
 
 
 
 
 
精準化學修飾新篇章 從天然物啟發到高效罕病藥物開發
 
「天然ㄟ尚好!」科學家過去從天然物中分離出許多具有初步生物活性的小分子,然而這些分子往往需要透過化學改良和修飾(chemical modification)方能發揮其潛力。設計及合成出「更精準」、「更有效」的分子以提升藥效並減低副作用,是天然物藥物開發過程中最具挑戰性的課題。
 
 
 
 
 
 
 
 
硫酸雙醣分子可修復蛋白質增益毒性 漸凍人治療新思路
 
ALS病患因脊髓、腦幹或大腦運動皮質區運動神經元的退化,引起全身肌肉漸進性的萎縮與僵直,在台灣又稱作「漸凍人症」,知名的科學家史蒂芬‧霍金(Stephen William Hawking)與前美國棒球明星盧‧賈里格(Henry Louis Gehrig),皆是ALS的患者。
 
 
 
 
 
 
 
 
發現全球17山區暖化嚴重!中研院跨域研究登《自然》期刊
 
探討了全球山區等溫線移動速度與生物反應之間的複雜關係。研究團隊運用熱力學第二定律,輔以衛星資料、生物資料進行驗證,開世界之先,研擬出計算山區氣候速度的方式,並發現全球各山區的海拔每上升1,000公尺,溫度遞減率為3℃到9℃不等,變異極大。
 
 
 
 
 
 
 
 
Comparative analysis of Deinagkistrodon acutus venom from Taiwan and China utilizing chromatographic, electrophoretic, and bioinformatic approaches, along with ELISA employing a monospecific antivenom
 
Deinagkistrodon acutus is a medically important pitviper inhabiting mainly South China and Taiwan. The hemorrhagic effects of its envenoming are compatible to its venom, which is abundant in metalloproteases (svMPs) and C-type lectin-like proteins.
 
 
 
 
 
 
 
 
 
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