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mRNA translation relies on identifying translation initiation sites (TISs) in mRNAs. Alternative TISs are prevalent across plant transcriptomes, but the mechanisms for their recognition are unclear. |
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Keratan sulfate glycosaminoglycan is composed of repeating N-acetyllactosamine (LacNAc) disaccharide units consisting of galactose (Gal) and N-acetylglucosamine (GlcNAc), both often 6-O-sulfated. |
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Arsenite-induced stress granule (SG) formation can be cleared by the ubiquitin-proteasome system aided by the ATP-dependent unfoldase p97. |
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The use of pharmacological chaperones (PCs) to stabilize specific enzymes and impart a therapeutic benefit is an emerging strategy in drug discovery. However, designing molecules that can bind optimally to their targets at physiological pH remains a major challenge. |
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Programmed death-1 (PD-1)/PD ligand-1 (PD-L1)-mediated immune escape contributes to cancer development and has been targeted as an anti-cancer strategy. |
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胞核內輸蛋白α (importin α)是屬於核運輸蛋白(karyopherin)家族成員，參與了許多RNA 靜默相關蛋白質進入細胞核的運輸。 |
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「天然ㄟ尚好！」科學家過去從天然物中分離出許多具有初步生物活性的小分子，然而這些分子往往需要透過化學改良和修飾（chemical modification）方能發揮其潛力。設計及合成出「更精準」、「更有效」的分子以提升藥效並減低副作用，是天然物藥物開發過程中最具挑戰性的課題。 |
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ALS病患因脊髓、腦幹或大腦運動皮質區運動神經元的退化，引起全身肌肉漸進性的萎縮與僵直，在台灣又稱作「漸凍人症」，知名的科學家史蒂芬‧霍金（Stephen William Hawking）與前美國棒球明星盧‧賈里格（Henry Louis Gehrig），皆是ALS的患者。 |
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探討了全球山區等溫線移動速度與生物反應之間的複雜關係。研究團隊運用熱力學第二定律，輔以衛星資料、生物資料進行驗證，開世界之先，研擬出計算山區氣候速度的方式，並發現全球各山區的海拔每上升1,000公尺，溫度遞減率為3℃到9℃不等，變異極大。 |
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Deinagkistrodon acutus is a medically important pitviper inhabiting mainly South China and Taiwan. The hemorrhagic effects of its envenoming are compatible to its venom, which is abundant in metalloproteases (svMPs) and C-type lectin-like proteins. |
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