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 Date : 2024/04/01 No:332 
 
 
 

Recent News

 
 
 
 
New Books
 
Period: 2024-4-1 ~ 2024-4-8
 
 
 
 
 
 

LSL Announcement

 
 
The library will be closed from April 4 to 5 for national holiday.
 
 
The library will be closed from April 4 to 5 for national holiday.

 
 
 
 
 
 
 

Training Courses

 
 
 
【Bioinformatics series】4:PRS(In Chinese)(Physical and Video Class)
 
2024-04-16(Tue)14:00~16:00
Mr.JIA-WEI CHEN(Institute of Statistical Science, Academia Sinica)
B1 Auditorium, Institute of Statistical Science
 
 
 
   
 
 
 

Lectures

 
 
 
 
4/2 IBC Seminar

 
Topic:Acrigen Biosciences: Building a High Precision Gene Editing Platform
Speaker:Dr. David Rabuka (Acrigen Biosciences Inc., USA
Date:2024-04-02 11:00 - 12:00
Place:IBC R209
 
 
 
 
 
 
 
4/2 IMB Seminar

 
Topic:Advancing long COVID research through mouse model development
Speaker:Dr. Si-Han Chen (Senior Scientist, Lead Discovery and Optimization Bristol Myers Squibb, USA)
Date:2024-04-02 11:00 - 12:00
Place:1F Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
4/8 ICOB Seminar

 
Topic:What is aging, and why do we die of it?
Speaker:Dr. Edward Giniger (Senior Investigator, Axon Guidance and Neural Connectivity Section, NINDS, NIH, US)
Date:2024-04-08 11:00 - 12:00
Place:1F, Auditorium, Institute of Cellular and Organismic Biology
 
 
 
 
 
 
 
4/8 IBMS Seminar

 
Topic:Unraveling a Mystery: How Do NK Cells Recognize Cancer Cells via NKp46 Receptor?
Speaker:Dr. Dian-Jang Lee (Takeda Oncology)
Date:2024-04-08 11:00 - 12:00
Place:B1C Lecture Room, IBMS
 
 
 
 
 
 
 
4/12 IBMS Seminar

 
Topic:AI-Enhanced Precision Medicine for Diabetic Kidney Disease
Speaker:Dr. Ting-Fen Tsai (National Yang Ming Chiao Tung Univ.)
Date:2024-04-12 11:00 - 12:00
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 

Important Research

 
 
 
 
Modeling alternative translation initiation sites in plants reveals evolutionarily conserved cis-regulatory codes in eukaryotes

 
mRNA translation relies on identifying translation initiation sites (TISs) in mRNAs. Alternative TISs are prevalent across plant transcriptomes, but the mechanisms for their recognition are unclear.
 
 
 
 
 
 
 
 
Expression of low-sulfated keratan sulfate in non-mucinous ovarian carcinoma

 
Keratan sulfate glycosaminoglycan is composed of repeating N-acetyllactosamine (LacNAc) disaccharide units consisting of galactose (Gal) and N-acetylglucosamine (GlcNAc), both often 6-O-sulfated.
 
 
 
 
 
 
 
 
Structural Insight into the ZFAND1-p97 Interaction Involved in Stress Granule Clearance

 
Arsenite-induced stress granule (SG) formation can be cleared by the ubiquitin-proteasome system aided by the ATP-dependent unfoldase p97.
 
 
 
 
 
 
 
 
Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human α-Galactosidase

 
The use of pharmacological chaperones (PCs) to stabilize specific enzymes and impart a therapeutic benefit is an emerging strategy in drug discovery. However, designing molecules that can bind optimally to their targets at physiological pH remains a major challenge.
 
 
 
 
 
 
 
 
DDX3 regulates cancer immune surveillance via 3

 
Programmed death-1 (PD-1)/PD ligand-1 (PD-L1)-mediated immune escape contributes to cancer development and has been targeted as an anti-cancer strategy.
 
 
 
 
 
 
 
 
Importin α2 participates in RNA interference against bamboo mosaic virus accumulation in Nicotiana benthamiana via NbAGO10a-mediated small RNA clearance

 
Importin α, a member of karyopherins, participate in multiple RNA silencing stages by transporting associated proteins into the nucleus. While plant RNA viruses typically replicate in the cytoplasm, the effects of importin α on plant RNA virus replication remains largely unknown.
 
 
 
 
 
 
 
 
The Next Chapter of Precision Chemical Modification: From Natural Product Inspirations to Efficient Drugs for Rare Disease

 
"Natural is Still the Best!" Scientists have isolated numerous small molecules with potential biological activity from natural sources. However, these molecules often require chemical modifications and structural refinements to unleash their full potential.
 
 
 
 
 
 
 
 
Sulfated Disaccharides Repair Toxic Protein Gain-of-Function, a New Approach to Treatment of Amyotrophic Lateral Sclerosis

 
ALS patients experience progressive muscle atrophy and paralysis due to the degeneration of motor neurons in the spinal cord, brainstem, or motor cortex.
 
 
 
 
 
 
 
 
Discovery: Severe Warming Found in 17 Mountain Regions Worldwide. Interdisciplinary Research from Academia Sinica Published in the Journal Nature

 
The lack of long-term meteorological observation stations in mountain regions worldwide has long made quantifying climate change in these areas a major challenge. Using a thermodynamic principle, the study maps the vertical migration of isotherms with unprecedented precision. The results are alarming: in seventeen mountain ranges around the world, from the arid areas of Alaska-Yukon to the highlands of northern Sumatra, isotherms are rising at rates exceeding 11.67 meters per year——a rate far exceeding previous estimates and posing a significant threat to the unique species of these high-altitude ecological regions.
 
 
 
 
 
 
 
 
Comparative analysis of Deinagkistrodon acutus venom from Taiwan and China utilizing chromatographic, electrophoretic, and bioinformatic approaches, along with ELISA employing a monospecific antivenom

 
Deinagkistrodon acutus is a medically important pitviper inhabiting mainly South China and Taiwan. The hemorrhagic effects of its envenoming are compatible to its venom, which is abundant in metalloproteases (svMPs) and C-type lectin-like proteins.
 
 
 
 
 
 
 
 
 
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