展期 ： 2025-05-12~ 2025-05-19

第五屆臺灣研究世界大會
時間：2025年5月21日（星期三）至5月23日（星期五）
地點：中央研究院人文社會科學館（報到處位於三樓）
*為讓與會者能更深入理解，主題演講將提供同步口譯服務。

EndNote 2025 for Windows-相容 Windows 10/11

EndNote 2025 for MAC-相容 MacOS 15.x Sequoia /14.x Sonoma /13.x Ventura/12.x. Monterey /11.x BigSur / 10.15 Catalina/ 10.14 Mojave

4/29 MR(In Chinese)
5/02 Turnitin教師版教育訓練課程(In Chinese)
5/09 Ingenuity Pathway Analysis (IPA) 前沿應用工作坊：多組學數據整合與毒性機轉解析(In English)

北海岸擁有非常豐富的自然生態資源，再搭配鄰近的海岸林區以及北海岸本身坐落的地理位置特殊性，使得北海岸擁有相當豐富而多元的生物相。

國科會科展中心專訪本院生物化學研究所吳昆峯副研究員

講題：Understanding the Specialized Chemistry of the Ocean’s Living Wonders to Improve Human Health
主講者：Prof. Bradley Moore (美國UC San Diego and Scripps Institution of Oceanography)
時間：2025-05-13 10:30 - 12:00
地點：基因體研究中心一樓演講廳

講題：Molecular analysis of Type 9 protein secretion - how disulfide bonds link protein transport and motility in bacteria
主講者：Dr. Ben Berks (Professor of Biochemistry, Department of Biochemistry University of Oxford, UK)
時間：2025-05-13 11:00 - 12:00
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

講題：IPMB Seminar: When mRNA decay meets translation : Lessons from Arabidopsis and beyond
主講者：Dr. Rémy Merret (Team Leader, Institut de biologie moléculaire des plantes (IBMP), CNRS, Université de Strasbourg, France)
時間：2025-05-14 15:00 - 17:00
地點：中央研究院植物暨微生物學研究所農業科技大樓 A134演講廳

講題：Biological Phase Transitions: Where Chemistry and Physics Meet Biology
主講者：Samrat Mukhopadhyay 教授 (Indian Institute of Science Education and Research)
時間：2025-05-14 15:00 - 16:30
地點：基因體研究中心三樓會議室

講題：Molecular Control of Organ Regeneration: Insights from Echidnas, Anteater, Bats and Whales
主講者：Dr. Guo Huang (UCSF)
時間：2025-05-16 11:00 - 12:00
地點：生醫所地下室B1C演講廳

講題：與福壽螺和解：一個自然解方的在地實踐
主講者：林芳儀 博士 (默語生態農業有限公司執行長)
時間：2025-05-16 14:30 - 16:30
地點：跨領域科技研究大樓1樓演講廳

講題：Scientific Publishing at JEM: What, How and Why
主講者：Dr. Montserrat Cols (Senior Scientific Editor, Journal of Experimental Medicine, USA)
時間：2025-05-19 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：Reading the genomic regulatory code for development: new views from immune cell specification
主講者：Dr. Ellen Rothenberg (Lewis Professor, Division of Biology & Biological Engineering, California Institute of Technology, USA)
時間：2025-05-19 11:00 - 12:00
地點：細生所1樓演講廳

講題：Bioconjugation Approaches for Therapeutic Applications
主講者：David Rabuka博士 (美國Acrigen Biosciences Inc.)
時間：2025-05-19 14:00 - 15:00
地點：生化所209研討室

講題：Computationally designed proteins to understand the in cell biochemistry of cancer signaling molecules
主講者：Jason Zhang博士 ( 美國華盛頓大學)
時間：2025-05-20 11:00 - 12:00
地點：生化所209研討室

講題：Recording the Physiological History of Cells with Chemical Labeling
主講者：Kai Johnsson 教授 (德國Max Planck Institute for Medical Research)
時間：2025-05-20 10:00 - 12:00
地點：基因體研究中心一樓演講廳

講題：Axonal endoplasmic reticulum: an organelle continuous over metres, and its links to axon degeneration
主講者：Dr. Cahir O'Kane (Deputy Head of Department, and Director of Postgraduate Studies, Dept of Genetics, University of Cambridge, UK)
時間：2025-05-21 11:00 - 12:00
地點：中央研究院分子生物研究所一樓演講廳

講題：Targeted Tau Modification via Bifunctional PROTACs and PhosTACs
主講者：陳伯翰博士 (成功大學)
時間：2025-05-23 11:00 - 12:00
地點：跨領域大樓一樓演講廳

講題：SUMO binding and conjugation in cancer
主講者：2025-05-26 11:00 - 12:00
時間：施修明 博士 (中研院生醫所 研究員)
地點：生醫所地下室B1B演講廳

本院分子生物研究所陳俊安研究員團隊近日發現，過去被視為「無編碼功能」的長鏈非編碼RNA（lncRNA），實際上，可編碼出一段具有重要功能的微型胜肽—Sertm2。這項研究顛覆傳統對非編碼RNA的認知，揭示微型胜肽在脊髓運動神經元發育中的關鍵角色。

本院分子生物學研究所陳俊安研究員所領導的研究團隊，近日發表關於漸凍症（肌萎縮性脊髓側索硬化症，amyotrophic lateral sclerosis, ALS）的最新研究成果。研究團隊發現透過調控RNA上的化學標記─ m6A，能有效延緩運動神經細胞退化，不僅能改善漸凍症小鼠的運動能力，還延長了他們的壽命。此研究將可望為ALS的治療和早期診斷開闢新契機，未來若能研發安全有效的m6A調節藥物，將有機會為ALS患者帶來新的希望。

Recent studies have shown that acid-sensing ion channels (ASICs) represent a novel class of promising targets for developing effective therapies for anxiety.

Neuronal inhibition is largely mediated by type-A GABA receptors (GABAARs), a family of ligand-gated chloride-permeable channels, which can be sub-classified by their subunit composition. GABAARs are potential therapeutic targets for many disorders. Az-IGU may enable photopharmacological studies of α4/6β3δ GABAARs, providing new opportunities for biomedical and neurobiological applications.

To avoid off-target effects, targeted cancer therapy offers a feasible alternative to traditional cancer therapies such as chemotherapy and radiotherapy.

Single-particle analysis by Cryo-electron microscopy (CryoEM) provides direct access to the conformations of macromolecules. Traditional methods assume discrete conformations, while newer algorithms estimate conformational landscapes representing the different structural states a biomolecule explores.

Our findings provide new insights into the molecular mechanisms of glycosylation in tardigrades and its relevance to their extreme stress tolerance.

Tuberculosis (TB), a leading cause of death among infectious diseases globally, is caused by Mycobacterium tuberculosis (Mtb). Our integrated approach provides comprehensive insights into PimE function and informs potential strategies for anti-TB therapeutics.

The global challenge of tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is compounded by the emergence of drug-resistant strains. We delineate the molecular basis of AftB's reaction mechanism and propose a model for its catalytic function.

For the prokaryotic 6-4 photolyase of Caulobacter crescentus, we investigated structural changes associated with its different redox states by damage-free crystallography using X-ray free-electron lasers.

To study whether the upregulation of HtrA4 expression in extravillous trophoblasts and the downregulation of HtrA1 expression in defective deciduae underlined the mechanisms of placenta accreta spectrum (PAS) development.