Period:2025-05-12~ 2025-05-19

The 5th World Congress of Taiwan studies
Date: May 21 (Wednesday) through May 23 (Friday), 2025
Venue: Humanities and Social Sciences Building, Academia Sinica (Registration is on the 3rd floor)
(Simultaneous Chinese translation will be provided for both keynote speeches.)

4/29 MR(In Chinese)
5/02 Turnitin training course for instructor
5/09 Workshop on Advanced Applications of Ingenuity Pathway Analysis (IPA): Multi-omics Integration and Toxicity Mechanism Profiling(In English)

NSTC SPEC Interview with Associate Research Fellow Dr. Kuen-Phon Wu: Harnessing AI to Launch a New Era in Protein Research.

Topic：Understanding the Specialized Chemistry of the Ocean’s Living Wonders to Improve Human Health
Speaker：Prof. Bradley Moore (UC San Diego and Scripps Institution of Oceanography)
Date：2025-05-13 10:30 - 12:00
Place：

Topic：Molecular analysis of Type 9 protein secretion - how disulfide bonds link protein transport and motility in bacteria
Speaker：Dr. Ben Berks (Professor of Biochemistry, Department of Biochemistry University of Oxford, UK)
Date：2025-05-13 11:00 - 12:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：IPMB Seminar: When mRNA decay meets translation : Lessons from Arabidopsis and beyond
Speaker：Dr. Rémy Merret (Team Leader, Institut de biologie moléculaire des plantes (IBMP), CNRS, Université de Strasbourg, France)
Date：2025-05-14 15:00 - 17:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：Biological Phase Transitions: Where Chemistry and Physics Meet Biology
Speaker：Prof. Samrat Mukhopadhyay (Indian Institute of Science Education and Research, Indian)
Date：2025-05-14 15:00 - 16:30
Place：3F Meeting Room, Genomics Research Center

Topic：Molecular Control of Organ Regeneration: Insights from Echidnas, Anteater, Bats and Whales
Speaker：Dr. Guo Huang (UCSF)
Date：2025-05-16 11:00 - 12:00
Place：B1C Auditorium, IBMS

Topic：Scientific Publishing at JEM: What, How and Why
Speaker：Dr. Montserrat Cols (Senior Scientific Editor, Journal of Experimental Medicine, USA)
Date：2025-05-19 11:00 - 12:00
Place：1F Auditorium, Institute of Molecular Biology, Academia Sinica

Topic：Reading the genomic regulatory code for development: new views from immune cell specification
Speaker：Dr. Ellen Rothenberg (Lewis Professor, Division of Biology & Biological Engineering, California Institute of Technology, USA)
Date：2025-05-19 11:00 - 12:00
Place：1F, Auditorium, Institute of Cellular and Organismic Biology

Topic：Bioconjugation Approaches for Therapeutic Applications
Speaker：Dr. David Rabuka (Acrigen Biosciences Inc., USA)
Date：2025-05-19 14:00 - 15:00
Place：IBC R209

Topic：Computationally designed proteins to understand the in cell biochemistry of cancer signaling molecules
Speaker：Dr. Jason Zhang (University of Washington, USA)
Date：2025-05-20 11:00 - 12:00
Place：IBC R209

Topic：Recording the Physiological History of Cells with Chemical Labeling
Speaker：Prof. Kai Johnsson (Max Planck Institute for Medical Research, Germany)
Date：2025-05-20 10:00 - 12:00
Place：1F Auditorium, Genomics Research Center

Topic：Axonal endoplasmic reticulum: an organelle continuous over metres, and its links to axon degeneration
Speaker：Dr. Cahir O'Kane (Deputy Head of Department, and Director of Postgraduate Studies, Dept of Genetics, University of Cambridge, UK)
Date：2025-05-21 11:00 - 12:00
Place：1F Auditorium, Institute of Molecular Biology, Academia Sinica

Topic：Targeted Tau Modification via Bifunctional PROTACs and PhosTACs
Speaker：Dr. Po-Han Chen (Nat'l Cheng Kung Univ.)
Date：2025-05-23 11:00 - 12:00
Place：1F Auditorium (B106), IRBST

Topic：SUMO binding and conjugation in cancer
Speaker：2025-05-26 11:00 - 12:00
Date：Hsiu-Ming Shih, PhD(Research Fellow, Institute of Biomedical Sciences, Academia Sinica)
Place： B1B Lecture Room, IBMS

A study led by Dr. Jun-An Chen’s group at the Institute of Molecular Biology, Academia Sinica, has revealed a previously unrecognized micropeptide embedded within a misannotated long noncoding RNA (lncRNA). Motor neuron diversity in the spinal cord is crucial for coordinated movement, driven by a complex mix of internal programs and external cues. Dr. Jun-An Chen’s team, known for pioneering work on noncoding RNAs, has now uncovered a surprising discovery—a misannotated long noncoding RNA (lncRNA) that actually encodes a micropeptide named Sertm2.

The research team led by Dr. Jun-An Chen’s group at the Institute of Molecular Biology, Academia Sinica, has achieved a significant breakthrough in studying Amyotrophic Lateral Sclerosis (ALS) disease. This research, published in Nature Communications, provides a new direction for future ALS drug developm

Recent studies have shown that acid-sensing ion channels (ASICs) represent a novel class of promising targets for developing effective therapies for anxiety.

Neuronal inhibition is largely mediated by type-A GABA receptors (GABAARs), a family of ligand-gated chloride-permeable channels, which can be sub-classified by their subunit composition. GABAARs are potential therapeutic targets for many disorders. Az-IGU may enable photopharmacological studies of α4/6β3δ GABAARs, providing new opportunities for biomedical and neurobiological applications.

To avoid off-target effects, targeted cancer therapy offers a feasible alternative to traditional cancer therapies such as chemotherapy and radiotherapy.

Single-particle analysis by Cryo-electron microscopy (CryoEM) provides direct access to the conformations of macromolecules. Traditional methods assume discrete conformations, while newer algorithms estimate conformational landscapes representing the different structural states a biomolecule explores.

Our findings provide new insights into the molecular mechanisms of glycosylation in tardigrades and its relevance to their extreme stress tolerance.

Tuberculosis (TB), a leading cause of death among infectious diseases globally, is caused by Mycobacterium tuberculosis (Mtb). Our integrated approach provides comprehensive insights into PimE function and informs potential strategies for anti-TB therapeutics.

The global challenge of tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is compounded by the emergence of drug-resistant strains. We delineate the molecular basis of AftB's reaction mechanism and propose a model for its catalytic function.

For the prokaryotic 6-4 photolyase of Caulobacter crescentus, we investigated structural changes associated with its different redox states by damage-free crystallography using X-ray free-electron lasers.

To study whether the upregulation of HtrA4 expression in extravillous trophoblasts and the downregulation of HtrA1 expression in defective deciduae underlined the mechanisms of placenta accreta spectrum (PAS) development.