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 Date : 2022/08/29 No:293 

Recent News

New Books
Period: 2022-08-29 ~ 2022-09-05
Significant Research Achievements of poster show Dr. Yoko Nozawa, Dr. Han-Chung Wu
Significant Research Achievements of poster show Dr. Yoko Nozawa, Dr. Han-Chung Wu

Date: 8/29/2022-09/25/2022
Place: Life Science Library

Training Courses

【Clinical Trial Lecture-Basic Course】Lesson 1-Basic concepts of clinical trials(In Chinese)(physical + online courses)
Dr.Mey Wang(Academia Sinica Data Science Statistical Cooperation Center)
B1 Auditorium, Institute of Statistical Science
How to improve research competitiveness -WOS(In Chinese)
MS.Nicole Ke (Consultant,Shou Ray Information Service Co. Ltd.)
Briefly introduction of data visualization (In Chinese)
Dr.Ya-Hsuan Chang(Institute of Statistical Science, Academia Sinica)
B1 Auditorium, Institute of Statistical Science

Database Introduction

Database Trial (Sinica Network Only)
BioCyc version 26.1 available
Version 26.1 is a minor release that includes updates to the BioCyc website and downloadable data files.

Version 26.1 of BioCyc contains 20,010 Pathway/Genome Databases. Approximately 2500 databases were rebuilt for this release, of which approximately 1100 were for HMP (Human Microbiome Project) organisms.


8/31 IBMS Seminar
Topic:Environment Matters: Mesothelium-Derived Factors Shape GATA6-Positive Large Cavity Macrophages.
Speaker:Dr. Chin-Wen Lai
Date:2022-08-31 11:00 ~ 12:00
Place:B1C lecture room, IBMS
9/1 IPMB Seminar
Topic:Roles of immunity to coordinate plant-microbiota homeostasis
Speaker:Dr. Ka-Wai Ma
Date:2022-09-01 10:00 ~ 11:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
9/5 IPMB Seminar
Topic:Recognition of microbes and regulation of plant immunity
Speaker:Dr. Chung-Ju Rachel Wang
Date:2022-09-05 10:00 ~ 11:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica
9/8 IMB Seminar
Topic:Aging-relevant human neurons to model neurodegeneration
Speaker:Dr. Chun-Li Zhang
Date:2022-09-08 11:00 ~ 12:00
Place:IMB B1 Auditorium
9/12 IPMB Seminar
Topic:Developmental patterning in emerging microbial paradigms
Speaker:Dr. Jian-geng Chiou
Date:2022-09-12 10:00 ~ 11:00
Place:Auditorium A134, Agricultural Technology Building, Academia Sinica

Important Research

Comparative analysis reveals distinctive genomic features of Taiwan hot-spring cyanobacterium Thermosynechococcus sp. TA-1
Thermosynechococcus is a genus of thermophilic unicellular cyanobacteria that dominates microbial mats in Asian non-acidic hot springs. These cyanobacteria are the major primary producers in their ecological niches and are promising sources of thermostable enzymes for biotechnology applications. A novel strain, Thermosynechococcus sp. TA-1, was collected from the Tai-An hot-spring in Miaoli and isolated by Dr. Jyh-Yih Leu at Fu-Jen Catholic University. Two research groups in IPMB, leading by Drs. Hsiu-An Chu and Chih-Horng Kuo, collaborated to complete the whole genome sequencing and comparative analysis across different species.......
Cultivar-specific markers, mutations, and chimerisim of Cavendish banana somaclonal variants resistant to Fusarium oxysporum f. sp. cubense tropical race 4
Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) is a destructive soil-borne fungus threatening global banana production. The effective control of Foc using fungicides is not available. The Taiwan Banana Research Institute developed disease-resistant somaclonal variants from Giant Cavendish bananas through tissue culture to control this disease. However, the mutations in these Foc TR4 resistant somaclonal variants have not yet been determined......
Evolution of mitochondrial RNA editing in extant gymnosperms
RNA editing, a post-transcriptional process, alters RNA molecules to carry genetic information differing from their genomic templates. Dr. Shu-Miaw Chaw of Biodiversity Research Center and her Project Manager Dr. Chung-Shien Wu conducted the first systematic and comprehensive investigation on mitochondrial RNA editing in living gymnosperms. They demonstrated regains of editing sites and elucidated the underlying editing mechanism. Their results not only unveil the evolution of RNA-editing sites across gymnosperms but also highlight RNA editing site prevalence being linked with PPR protein diversity......
Cryo-electron tomography reveals the structure and dynamics of an alphacoronavirus spike protein
Porcine epidemic diarrhea virus (PEDV) belongs to the alphacoronavirus family. PEDV is highly contagious and particularly lethal for infected piglets. Despite its apparent threat to the pork industry, Taiwan has no effective vaccination program. The research team led by Dr. Shang-Te Danny Hsu at the Institute of Biological Chemistry, Academia Sinica, in collaboration with Dr. Kay-Hooi Khoo at the same institute, and Prof. Hui-Wen Chang at the School of Veterinary, National Taiwan University, integrated cryo-electron tomography (cryo-ET), cryo-electron microscopy (cryo-EM), mass spectrometry (MS), and protein engineering to reveal the dynamic nature of the spike protein of a highly infectious strain of PEDV identified in Pingtung (PT52)......
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming
Acquired resistance to vemurafenib (PLX4032) is a thorny issue in BRAFV600E mutant melanoma therapy. Ferroptotic programmed cell death is a potential strategy for combating therapy-resistant cancers. This study uncovers the adaptation and abnormal upregulation of PUFAs and bioactive oxylipin metabolism in PLX4032 resistant melanoma cells......
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