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 Date : 2022/10/31 No:297 

Recent News

New Books
Period: 2022-10-31 ~ 2022-11-07
Significant Research Achievements of poster show Dr. Cheng-Hsun Ho
Significant Research Achievements of poster show Dr. Cheng-Hsun Ho

Date: 10/31/2022-11/27/2022
Place: Life Science Library
Awards & Honors
Congratulations for Dr. Han-Chung Wu granted 2022 Future Tech Award!
Congratulations to Dr. Hsiao-Ching Lin for being awarded the 2022 Academia Sinica Early-Career Investigator Research Achievement Award.
Congratulations to Dr. Cheng-Hsun Ho Received the “2022 Professor CY Lin Memorial Award for Innovative Research Program”.
Magazine Giveaways
Magazine Giveaways

Period: 2022/10/31-2022/11/18.

Training Courses

【Clinical Trial Lecture-Basic Course】Lesson5-Study design in Phase I clinical trials
Dr.Mey Wang(Academia Sinica Data Science Statistical Cooperation Center)
B1 Auditorium, Institute of Statistical Science
Basic statistical analysis for genome‐wide association studies(In Chinese)
Dr. Chien-Hsiun Chen (Research Scientist, Institute of Biomedical Sciences, Academia Sinica
Analysis of Bulk and Single-Cell RNA Sequencing Data in R Language (In Chinese)
Dr. Chen-Hsin Yu (Assistant Research Specialist, Insittute of Molecular Biology, Academia Sinica)
209 Seminar Room, IBC

Database Introduction

HSTalks New Releases
HSTalks: The Biomedical & Life Sciences Collection New Releases for October.


11/1 IBMS Seminar
Topic:BIOMIMESYS hydroscaffold, a ready-to-use organ-specific Extracellular Matrix for relevant phenotypic drug screening.
Speaker:Dr. Nathalie MAUBON (HCS Pharma)
Date:2022-11-01 14:00 ~ 15:00
Place:B1C Lecture Room, IBMS
11/3 IBC Seminar
Topic:Illuminating the Structural Basis for Drug Discovery: An Integrated View of Nucleases on Immune Regulation and DNA Repair
Speaker:Dr. Yu-Yuan Hsiao (National Yang Ming Chiao Tung University, Taiwan)
Date:2022-11-03 11:00 ~ 12:00
Place:IBC R209
11/4 IBMS Seminar
Topic:Cardiac biological pacing to rescue failing heart.
Speaker:D. Hu, Yu-Feng (Nat'l Yang-Ming Univ.)
Date:2022-11-04 14:00 ~ 15:00
Place:B1C Auditorium, IBMS
11/4 IPMB Seminar
Topic 1:Expansion Microscopy for Research in Plants: Challenges & Applications
Speaker:Dr. Ding-Hua Lee

Topic 2:Image processing, Expansion Microscopy and Meiosis
Speaker:Dr. Jeremy Catinot

Date:2022-11-04 10:30
Place:A134 & A133 (Synchronous Broadcasting)
11/7 IBMS Seminar
Topic:Intracellular architecture by noncoding RNAs.
Speaker:Dr. Tetsuro HIROSE (Osaka Univ.)
Date:2022-11-07 11:00 ~ 12:00
Place:Webex Only
11/8 IBC Seminar
Topic:CryoEM Structures of Chaperonins and RNAs in Action
Speaker:Dr. Wah Chiu (Stanford University, USA)
Date:2022-11-08 11:00 ~ 12:00
Place:IBC R209
11/9 IPMB Seminar
Topic:Exciting Carotenoids: From Biofortification to Striga Control
Speaker:Dr. Salim Al-Babili
Date:2022-11-09 10:00 ~ 11:00
Place:Auditorium A134 & A133 (Synchronous Broadcasting) Agricultural Technology Building, Academia Sinica
11/10 IBC Seminar
Topic:My service and research on biomolecular NMR and structural biology
Speaker:Dr. Wen-Jin Wu
Date:2022-11-10 11:00 ~ 12:00
Place: IBC R209
11/10 ABRC Seminar
Topic:Thylakogenesis: maintenance of thylakoid membrane architecture and integrity in Arabidopsis
Speaker:Dr. Wataru Sakamoto
Date:2022-11-10 11:00 ~ 13:00
Place: Auditorium A134, Agricultural Technology Building & Webex
11/11 IPMB Seminar
Topic:Mechanistic Insights and Genetic Control of Meiotic Recombination
Speaker:Dr. Chung-Ju Rachel Wang
Date:2022-11-11 11:00 ~ 12:00
Place:Auditorium A134 & A133 (Synchronous Broadcasting) Agricultural Technology Building, Academia Sinica
11/14 IMB、IBC Joint Special Seminar
Topic:Ubiquitin-dependent control of development and disease
Speaker:Dr. Michael Rapé
Date:2022-11-14 11:00 ~ 12:00
Place:IMB B1 Auditorium

Important Research

pH-sensing: Why plants can’t have it all
Every hospitable habitat is defined by its pH, a property that can undergo dramatic changes in space and time. Information on ambient pH is critical for virtually all organisms under virtually all circumstances, and not seldom the ability to sense the external hydrogen ion concentration becomes a decisive factor for survival. This holds true in particular for plants, which lack motility and are therefore dependent on rapid adaptive responses to changes in their environment......
New Diagnostic and Therapeutic Strategy for Osteoarthritis: Using “Collagen-Binding Peptides” to Facilitate Imaging, Lubrication, and Regeneration of Articular Cartilage。
The research teams of Dr. Shih-Chieh Hung, China Medical University, and Dr. Han-Chung Wu, Academia Sinica, collaborated to discover new strategies of diagnosis and therapy for osteoarthritis. They successfully developed osteoarthritic collagen-binding peptides and a bifunctional peptide, which have good potential in regenerative medicines for early diagnosis, therapy, and regeneration for osteoarthritis. These peptides can also be used to facilitate regeneration of injured corneal epithelium and endothelium, potentially obviating the need for corneal transplantation......
How do plants remember their stresses?
All living organisms on Earth, from bacteria to blue whales, must correctly process and remember critical environmental information to respond to changes in a manner conducive to survival and reproduction. For animals, which use the brain to store information, memory is taken for granted. Plant memory, however, easily goes unnoticed because people do not readily recognize its existence, perhaps due to the immobile lifestyle of plants. Recently, the scientific community has discovered that plants generally “remember” environmental adversity. Now work is underway to understand how plants can hold on to such “memory” without a brain. In particular, it is essential to know how plants maintain stress memory due to its possible effect on agricultural production in the face of climate change......
Watching biochemistry live - Genetically encoded FRET sensor for nitrate dynamics in plants
A team led by Dr. Cheng-Hsun Ho at the Agricultural Biotechnology Research Center has developed for the first time, a genetically engineered fluorescence resonance energy transfer (FRET) nitrate biosensor that measures the levels of nitrate in individual plant cells in real time. The biosensor, named NitraMeter 3.0, quantitatively visualizes the nitrate distribution in Arabidopsis thaliana......
Crystal structure of 17B receptor complexed with antibody D9 provides solution for guiding antibody humanization and affinity maturation
A research team led by Dr. Che Ma and Dr. Wen-Hwa Lee in the Genomics Research Center reported they solved complex structure of IL-17RB with D9, and this structure provides important paratope information to guide the design of antibody humanization and affinity maturation of D9. Eventually, the affinity matured humanized antibody clone 1B12 was demonstrated significant inhibition of pancreatic tumorigenesis in an orthotopic mouse model. This research has been published in the journal "Cell Reports"......
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