Period: 2022-10-31 ~ 2022-11-07

Date: 10/31/2022-11/27/2022
Place: Life Science Library

Congratulations for Dr. Han-Chung Wu granted 2022 Future Tech Award!
Congratulations to Dr. Hsiao-Ching Lin for being awarded the 2022 Academia Sinica Early-Career Investigator Research Achievement Award.
Congratulations to Dr. Cheng-Hsun Ho Received the “2022 Professor CY Lin Memorial Award for Innovative Research Program”.

Period: 2022/10/31-2022/11/18.

HSTalks: The Biomedical & Life Sciences Collection New Releases for October.

Topic：BIOMIMESYS hydroscaffold, a ready-to-use organ-specific Extracellular Matrix for relevant phenotypic drug screening.
Speaker：Dr. Nathalie MAUBON (HCS Pharma)
Date：2022-11-01 14:00 ～ 15:00
Place：B1C Lecture Room, IBMS

Topic：Illuminating the Structural Basis for Drug Discovery: An Integrated View of Nucleases on Immune Regulation and DNA Repair
Speaker：Dr. Yu-Yuan Hsiao (National Yang Ming Chiao Tung University, Taiwan)
Date：2022-11-03 11:00 ～ 12:00
Place：IBC R209

Topic：Cardiac biological pacing to rescue failing heart.
Speaker：D. Hu, Yu-Feng (Nat'l Yang-Ming Univ.)
Date：2022-11-04 14:00 ～ 15:00
Place：B1C Auditorium, IBMS

Topic 1：Expansion Microscopy for Research in Plants: Challenges & Applications
Speaker：Dr. Ding-Hua Lee

Topic 2：Image processing, Expansion Microscopy and Meiosis
Speaker：Dr. Jeremy Catinot

Date：2022-11-04 10:30
Place：A134 & A133 (Synchronous Broadcasting)

Topic：Intracellular architecture by noncoding RNAs.
Speaker：Dr. Tetsuro HIROSE (Osaka Univ.)
Date：2022-11-07 11:00 ～ 12:00
Place：Webex Only

Topic：CryoEM Structures of Chaperonins and RNAs in Action
Speaker：Dr. Wah Chiu (Stanford University, USA)
Date：2022-11-08 11:00 ～ 12:00
Place：IBC R209

Topic：Exciting Carotenoids: From Biofortification to Striga Control
Speaker：Dr. Salim Al-Babili
Date：2022-11-09 10:00 ～ 11:00
Place：Auditorium A134 & A133 (Synchronous Broadcasting) Agricultural Technology Building, Academia Sinica

Topic：My service and research on biomolecular NMR and structural biology
Speaker：Dr. Wen-Jin Wu
Date：2022-11-10 11:00 ～ 12:00
Place： IBC R209

Topic：Thylakogenesis: maintenance of thylakoid membrane architecture and integrity in Arabidopsis
Speaker：Dr. Wataru Sakamoto
Date：2022-11-10 11:00 ～ 13:00
Place： Auditorium A134, Agricultural Technology Building & Webex

Topic：Mechanistic Insights and Genetic Control of Meiotic Recombination
Speaker：Dr. Chung-Ju Rachel Wang
Date：2022-11-11 11:00 ～ 12:00
Place：Auditorium A134 & A133 (Synchronous Broadcasting) Agricultural Technology Building, Academia Sinica

Topic：Ubiquitin-dependent control of development and disease
Speaker：Dr. Michael Rapé
Date：2022-11-14 11:00 ~ 12:00
Place：IMB B1 Auditorium

Every hospitable habitat is defined by its pH, a property that can undergo dramatic changes in space and time. Information on ambient pH is critical for virtually all organisms under virtually all circumstances, and not seldom the ability to sense the external hydrogen ion concentration becomes a decisive factor for survival. This holds true in particular for plants, which lack motility and are therefore dependent on rapid adaptive responses to changes in their environment......

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The research teams of Dr. Shih-Chieh Hung, China Medical University, and Dr. Han-Chung Wu, Academia Sinica, collaborated to discover new strategies of diagnosis and therapy for osteoarthritis. They successfully developed osteoarthritic collagen-binding peptides and a bifunctional peptide, which have good potential in regenerative medicines for early diagnosis, therapy, and regeneration for osteoarthritis. These peptides can also be used to facilitate regeneration of injured corneal epithelium and endothelium, potentially obviating the need for corneal transplantation......

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All living organisms on Earth, from bacteria to blue whales, must correctly process and remember critical environmental information to respond to changes in a manner conducive to survival and reproduction. For animals, which use the brain to store information, memory is taken for granted. Plant memory, however, easily goes unnoticed because people do not readily recognize its existence, perhaps due to the immobile lifestyle of plants. Recently, the scientific community has discovered that plants generally “remember” environmental adversity. Now work is underway to understand how plants can hold on to such “memory” without a brain. In particular, it is essential to know how plants maintain stress memory due to its possible effect on agricultural production in the face of climate change......

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A team led by Dr. Cheng-Hsun Ho at the Agricultural Biotechnology Research Center has developed for the first time, a genetically engineered fluorescence resonance energy transfer (FRET) nitrate biosensor that measures the levels of nitrate in individual plant cells in real time. The biosensor, named NitraMeter 3.0, quantitatively visualizes the nitrate distribution in Arabidopsis thaliana......

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A research team led by Dr. Che Ma and Dr. Wen-Hwa Lee in the Genomics Research Center reported they solved complex structure of IL-17RB with D9, and this structure provides important paratope information to guide the design of antibody humanization and affinity maturation of D9. Eventually, the affinity matured humanized antibody clone 1B12 was demonstrated significant inhibition of pancreatic tumorigenesis in an orthotopic mouse model. This research has been published in the journal "Cell Reports"......

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