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 Date : 2024/11/18 No:348 
 
 
 

Recent News

 
 
 
 
New Books
 
Period: 2024-11-18 ~ 2024-11-25
 
 
 
 
 
 
 
Henry Stewart Talks November recently added

 
 
 
 
 
 
 

Training Courses

 
 
 
【Clinical Trial Lecture-Basic Course】Lesson 5—Study design of Phase II clinical trialstrials(In Chinese)(Physical and Video Class)
 
2024-11-26(Tue)10:00~12:00
Dr.Mey Wang
Research Building of Environmental Changes, AS, 6005 Room
 
 
 
   
 
 
 

Lectures

 
 
 
 
11/19 IBC Seminar

 
Topic:Therapeutic Mechanisms of Microtubule Drugs
Speaker:Dr. Timothy Mitchison (Harvard Medical School, USA)
Date:2024-11-19 14:00 - 15:00
Place:IBC R209
 
 
 
 
 
 
 
11/20 IBMS Seminar

 
Topic:Decoding Our Computational Medicine Core
Speaker:Dr. Chang, Yao-Ming (Assistant Research Scientist)
Date:2024-11-20 10:30 - 11:30
Place:B1C Auditorium, IBMS
 
 
 
 
 
 
 
11/21 IBMS Seminar

 
Topic:Biomembrane-inspired Materials Innovation for Therapeutics Development
Speaker:Dr. Hu, Che-Ming (Jack) (Associate Research Fellow)
Date:2024-11-21 11:00 - 12:00
Place:B1C Auditorium, IBMS
 
 
 
 
 
 
 
11/21 BRCAS Seminar

 
Topic:Chorus of the Ocean: Exploring Marine Biodiversity and Ecosystem Dynamics through Underwater Soundscapes
Speaker:Dr. Tzu-Hao Lin (Biodiversity Research Center, Academia Sinica)
Date:2024-11-21 15:00 - 16:30
Place:Auditorium, 1st Floor, Interdisciplinary Research Building
 
 
 
 
 
 
 
11/21 IBMS Seminar

 
Topic:From Cold Sensor to Lipid Sentinel: The Unexpected Role of TRPM8 Against Hyperlipidemia and Atherosclerosis
Speaker:Prof. Tzong-Shyuan Lee (NTU)
Date:2024-11-21 16:00 - 17:00
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
11/25 IMB Seminar

 
Topic:The Atypical Cell Biology of Predatory Bacteria
Speaker:Dr. Géraldine Laloux (Associate Professor, Faculty of Pharmacy and Biomedical Science, UCLouvain, Belgium)
Date:2024-11-25 11:00 - 12:00
Place:1F Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
11/26 IBMS-NPAS Joint Seminar

 
Topic:Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation
Speaker:Dr. Kanghoon Jung (Allen Inst. for Neural Dynamics)
Date:2024-11-26 11:00 - 12:00
Place:B1B Lecture Room, IBMS
 
 
 
 
 
 
 
11/26 IPMB Seminar

 
Topic:The Extraordinary Algal Genomes: From Coral Symbionts to Toxic Bloomers
Speaker:Dr. Cheong Xin Chan (Associate Professor, Australian Centre for Ecogenomics, School of Chemistry & Molecular Biosciences, The University of Queensland)
Date:2024-11-26 11:00 - 13:00
Place:Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica
 
 
 
 
 
 
 
11/27 NPAS Seminar

 
Topic:Searching for “Magic Pills”: The Journey of RS-D7 in Addressing Unmet Needs in Schizophrenia, MSA, and Other Neuropsychiatric Disorders
Speaker:Speaker Name Prof. Wen-Sung Lai (Department of Psychology, NTU)
Date:2024-11-27 11:00 - 12:00
Place:1F Auditorium (B106), IST
 
 
 
 
 
 
 
11/27 IMB Seminar

 
Topic:Unraveling complex genetic interaction landscapes in streptococcus pneumoniae through High-throughput dual randomly barcoded Transposon Sequencing (Dual Tn-seq)
Speaker:Dr. Chris Lok To Sham (Assistant Professor, Dept. of Microbiology and Immunology, National University of Singapore)
Date:2024-11-27 11:00 - 12:00
Place:B1 Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 
 
11/29 IPMB Seminar

 
Topic:Population Genomics of Hot-Spring Cyanobacteria in Taiwan
Speaker:Dr. Chih-Horng Kuo (Research Fellow, Institute of Plant and Microbial Biology, Academia Sinica)
Date:2024-11-29 11:00 - 13:00
Place:Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica
 
 
 
 
 
 

Seminars

 
 
 
 
2025 IMB Symposium

 
Speaker:Drs. Liqun Luo, Claude Desplan, Ying-Hui Fu, Frank Bradke, Loren Frank, Hitoshi Okamoto 
Date:2024-11-20 10:00 - 17:35 
Place:1F Auditorium, Institute of Molecular Biology, Academia Sinica
 
 
 
 
 
 

Important Research

 
 
 
 
Non-ubiquitin binding functions for two major ubiquitin receptors RPN10 and RPN13 from Arabidopsis

 
Although it is well perceived that conserved ubiquitin receptors play a vital role in recognition and targeting ubiquitinated cellular regulators to proteasome for degradation, solid evidence to support the in vivo importance of ubiquitin-binding activities for these ubiquitin receptors in vivo is scarce. Dr. Hongyong Fu’s group reported previously the ubiquitin binding activities of the major ubiquitin receptor RPN10 is dispensable for in vivo functions observed with rpn10-2 null mutant.
 
 
 
 
 
 
 
 
Site-Specific Histidine Aza-Michael Addition in Proteins Enabled by a Ferritin-Based Metalloenzyme

 
Histidine modifications of proteins are broadly based on chemical methods triggering N-substitution reactions such as aza-Michael addition at histidine's moderately nucleophilic imidazole side chain.
 
 
 
 
 
 
 
 
Molecular mechanisms for DNA methylation defects induced by ICF syndrome-linked mutations in DNMT3B

 
DNA methyltransferase 3B (DNMT3B) plays a crucial role in DNA methylation during mammalian development. Mutations in DNMT3B are associated with human genetic diseases, particularly immunodeficiency, centromere instability, facial anomalies (ICF) syndrome.
 
 
 
 
 
 
 
 
The role of adiponectin-AMPK axis in TDP-43 mislocalization and disease severity in ALS

 
Hypermetabolism is a prominent characteristic of ALS patients. Aberrant activation of AMPK, an energy sensor regulated by adiponectin, is known to cause TDP-43 mislocalization, an early event in ALS pathogenesis.
 
 
 
 
 
 
 
 
Separate anterior paraventricular thalamus projections differentially regulate sensory and affective aspects of pain

 
The experience of pain is complex, involving both sensory and affective components, yet the underlying neural mechanisms remain elusive. Here, we show that formalin-induced pain behaviors coincide with increased responses in glutamatergic neurons within the anterior paraventricular nucleus of the thalamus (PVA).
 
 
 
 
 
 
 
 
 
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