Period: 2025-05-26~ 2025-06-02

Trial Period：Current until July 07

Trial Period：Current until June 30

The Life Sciences Library will be closed on May 30th for the Dragon Boat Festival and will reopen on June 2nd

5/13 Local alignments & BLAST online and offline (In English)

Topic：Alocasia and Colocasia in Asia and the Pacific: Cultivar Diversity, Domestication, and Wild Relatives
Speaker：Dr. Peter J. Matthews (National Museum of Ethnology, Japan)
Date：2025-05-27 10:00 - 11:30
Place：Auditorium, 1st Floor, Interdisciplinary Research Building

Topic：IPMB Seminar: Biogenesis and Control of a Pinpoint Bacterial Adhesive in Agrobacterium tumefaciens
Speaker：Dr. Clay Fuqua (Clyde Culbertson Professor of Biology, Indiana University, Bloomington, USA)
Date：2025-05-27 11:00 - 13:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：The Cross-talk between Sugar and Brassinosteroid Signaling in Plant Growth
Speaker：Dr. Zhenzhen Zhang (Associate Professor, Fujian Agriculture and Forestry University, China)
Date：2025-05-28 15:00 - 16:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：Regulation of translation dynamics in Arabidopsis under submergence
Speaker：Dr. Ming-Che Shih (ABRC)
Date：2025-05-29 11:00 - 12:00
Place：IBC R209

Topic：Multi-omics study reveals the significance of DNA damage repair pathways in exhausted T cells impacting on prognosis and immunotherapy
Speaker：Bugi Ratno Budiarto (TIGP-MM Student)
Date：2025-05-29 15:00 - 16:00
Place：B1B Lecture Room, IBMS

Topic：How Metabolic and Epigenetic Rewiring Shapes Tumor Development and Immune Escape
Speaker：Dr. Meng-Ju Wu (Univ. of Massachusetts Chan Medical School)
Date：2025-06-02 11:00 - 12:15
Place：B1B Lecture Room, IBMS

Topic：Role of ubiquitination in health and disease
Speaker：Dr. Sharad Kumar (University of South Australia, Australia)
Date：2025-06-02 11:00 - 12:00
Place：IBC R209

Topic：Building Next-Generation Gastric Cancer Models Using 3D Organoids to Decipher Cancer Biology and Therapeutic Response
Speaker：Yuan-Hung Lo, PhD, Assistant Professor, (Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Cente)
Date：10:00 am, June 3, 2025 (Tuesday) (Registration will start at 9:30)
Place：C212 Lecture Room, 2nd floor, Building C, National Biotechnology Research Park

Topic： Uncovering Hidden Microbial Conflicts Through the Lens of Genomics and Evolution
Speaker：Dr. Yu-Ying Phoebe Hsieh (Postdoctoral Fellow, Basic Science Division, Fred Hutchinson Cancer Center, USA )
Date：2025-06-04 15:00 - 17:00
Place：Auditorium A134, Agricultural Technology Building, Institute of Plant and Microbial Biology, Academia Sinica

Topic：Revealing structural dynamics of biomolecular complexes using electron imaging
Speaker：Dr. Po-Lin Chiu(Associate Professor, School of Molecular Sciences, Biodesign Center for Applied Structural Discovery, Arizona State University, USA)
Date：2025-06-05 11:00 - 12:00
Place：1F Auditorium, Institute of Molecular Biology, Academia Sinica

Topic：Advancing Biomedical Research with Organ-on-Chip Models
Speaker：Dr. Hsian-Jean Chin (Nat'l Center for Biomodels)
Date：2025-06-09 10:30 - 12:00
Place：B1B Lecture Room, IBMS

Autism spectrum disorders (ASD) are neurodevelopmental conditions influenced by genetic mutations, we investigate the sex-biased responses of mutant mice carrying an ASD-associated mutation in Cttnbp2 to dietary zinc supplementation using behavioral assays, proteomic and bioinformatic analyses, and puromycin pulse labeling to assess protein synthesis.

Asthma is a chronic inflammatory lung disease driven by a complex interplay between innate and adaptive immune components.We explore current therapies targeting these cells and their effector cytokines for asthma management.

We investigate a nanotherapeutic platform integrating immunostimulatory cytosine-phosphate-guanine oligodeoxynucleotides (CpG-ODNs, hereafter termed CpG) into mesoporous silica nanoparticles cloaked with OMVs (CpG@MSN-PEG/PEI@OMVs) for cancer immunotherapy.

Photolyases repair UV damage to DNA by using absorbed blue light.

Inhibition of PTGR2 is a new therapeutic approach to treat diabetes and obesity through increasing endogenous PPARγ ligands while avoiding side effects including increased adiposity, fluid retention, and osteoporosis.

To avoid off-target effects, targeted cancer therapy offers a feasible alternative to traditional cancer therapies such as chemotherapy and radiotherapy.

In this study, we demonstrate that analyzing as few as 27 skin cells within a single image of 0.01 mm2 is sufficient to predict the individual’s overall size, ranging from 0.9 to 3.1 mm2. Using a gradient-weighted class activation map (Grad-CAM), we further identified the cellular features influencing the model’s decisions.

A research team led by Drs. Hsiu-An Chu and Chih-Horng Kuo from the Institute of Plant and Microbial Biology, Academia Sinica, in collaboration with Dr. Ching-Nen Chen from the Department of Oceanography, National Sun Yat-sen University, has successfully decoded the complete genome sequence and conducted detailed study on a newly discovered unicellular cyanobacterial strain, Cyanobacterium sp. Dongsha4 (DS4).

This study reveals that RNA viruses can simultaneously exploit multiple organelles for replication, opening up a new dimension in the field of virology