Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Plant and Microbial Biology - 吳志航 Wu, Chih-Hang

Journal 30

Wang Hung-Yu, Yuen Enoch Lok Him, Lee Kim-Teng, Goh Foong-Jing, Bozkurt Tolga O., Wu Chih-Hang. A hydrophobic core in the coiled-coil domain is essential for NRC resistosome function. bioRxiv. NA, NA, 2025. [JCR]　[WOS]
Seager Benjamin A., Harant Adeline, Contreras Mauricio P., Hou Liang-Yu, Wu Chih-Hang, Kamoun Sophien, Madhuprakash Jogi. A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome. bioRxiv. NA, NA, 2025.
Ludke D, Sakai T, Kourelis J, Toghani A, Adachi H, Posbeyikian A, Frijters R, Pai H, Harant A, Lopez-Agudelo JC, Tang B, Ernst K, Ganal M, Verhage A, Wu CH, Kamoun S. A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes. The Plant Cell. 37(7), koaf145, 2025. [JCR]　[WOS]
Wu Y, Chang HY, Wu CH, Lai EM, Kuo CH. Comparative transcriptomics reveals context- and strain-specific regulatory programmes of Agrobacterium during plant colonization. Microbial genomics. 11(8), mgen.0.001485, 2025. [JCR]　[WOS]
Liu MS, Huang TK, Wang YC, Wang SC, Wu CH, Kuo CH, Lai EM. Floral stage optimization and immune evasion enhance Agrobacterium-mediated genome editing in Arabidopsis. The New phytologist. nph.70795, nph.70795, 2025. [JCR]　[WOS]
Lopez‐Agudelo Juan Carlos, Goh Foong‐Jing, Tchabashvili Sopio, Huang Yu‐Seng, Huang Ching‐Yi, Lee Kim‐Teng, Wang Yi‐Chieh, Wu Yu, Chang Hao‐Xun, Kuo Chih‐Horng, Lai Erh‐Min, Wu Chih‐Hang. Rhizobium rhizogenes A4-derived strains mediate hyper-efficient transient gene expression in Nicotiana benthamiana and other solanaceous plants. Plant Biotechnology Journal. pbi., 70083, 2025. [JCR]　[WOS]
Chen Yi-Feng, Lin Kuan-Yu, Huang Ching-Yi, Hou Liang-Yu, Yuen Enoch Lok Him, Sun Wei-Che, Chiang Bing-Jen, Chang Chin-Wen, Wang Hung-Yu, Bozkurt Tolga O., Wu Chih-Hang. Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death. bioRxiv. NA, NA, 2025.
Ludke D, Pai H, Toghani A, Harant A, Wu CH, Kamoun S. The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in Nicotiana benthamiana prf mutants. Plant physiology. 199(2), kiaf506, 2025. [JCR]　[WOS]
Hou Liang-Yu, Wu Chih-Hang, Lin Na-Sheng. Virus-induced upregulation of mitochondrial metabolism modulates cytosolic redox balance and defense responses. BMC Plant Biology. NA, NA, 2025.
Ibrahim Tarhan, Yuen Enoch Lok Him, Wang Hung-Yu, King Freddie J., Toghani AmirAli, Kourelis Jiorgos, Vuolo Cristina, Adamkova Vanda, Castel Baptiste, Jones Jonathan D. G., Wu Chih-Hang, Kamoun Sophien, Bozkurt Tolga O. A helper NLR targets organellar membranes to trigger immunity. bioRxiv. NA, NA, 2024.
Selvaraj M, Toghani A, Pai H, Sugihara Y, Kourelis J, Yuen ELH, Ibrahim T, Zhao H, Xie R, Maqbool A, De la Concepcion JC, Banfield MJ, Derevnina L, Petre B, Lawson DM, Bozkurt TO, Wu CH, Kamoun S, Contreras MP. Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome. PLOS BIOLOGY. 22(10), e3002868, 2024. [JCR]　[WOS]
Chen JY, Sang H, Chilvers MI, Wu CH, Chang HX. Characterization of soybean chitinase genes induced by rhizobacteria involved in the defense against Fusarium oxysporum. Frontiers in plant science. 15, 1341181, 2024. [JCR]　[WOS]
Chiang BJ, Lin KY, Chen YF, Huang CY, Goh FJ, Huang LT, Chen LH, Wu CH*. Development of a tightly regulated copper-inducible transient gene expression system in Nicotiana benthamiana incorporating a suicide exon and Cre recombinase. The New phytologist. 244(1), 318-331, 2024. [JCR]　[WOS]
Goh FJ, Huang CY, Derevnina L, Wu CH*. NRC Immune receptor networks show diversified hierarchical genetic architecture across plant lineages. The Plant Cell. 36(9), 3399-3418, 2024. [JCR]　[WOS]
Huang CY, Huang YS, Sugihara Y, Wang HY, Huang LT, Lopez-Agudelo JC, Chen YF, Lin KY, Chiang BJ, Toghani A, Kourelis J, Wang CH, Derevnina L, Wu CH*. Subfunctionalization of NRC3 altered the genetic structure of the Nicotiana NRC network. PLOS GENETICS. 20(9), e1011402, 2024. [JCR]　[WOS]
Sakai T, Contreras MP, Martinez-Anaya C, Ludke D, Kamoun S*, Wu CH*, Adachi H*. The NRC0 gene cluster of sensor and helper NLR immune receptors is functionally conserved across asterid plants. The Plant cell. 36(9), 3344-3361, 2024. [JCR]　[WOS]
Wu Chih-hang, Derevnina Lida. The battle within: How pathogen effectors suppress NLR-mediated immunity. Current Opinion in Plant Biology. 74, 102396, 2023-08. [JCR]　[WOS]
Sheikh Arsheed H., Zacharia Iosif, Pardal Alonso J., Dominguez-Ferreras Ana, Sueldo Daniela J., Kim Jung-Gun, Balmuth Alexi, Gutierrez Jose R., Conlan Brendon F., Ullah Najeeb, Nippe Olivia M., Girija Anil M., Wu Chih-Hang, Sessa Guido, Jones Alexandra M. E., Grant Murray R., Gifford Miriam L., Mudgett Mary Beth, Rathjen John P., Ntoukakis Vardis. Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition. Nature Communications. 14(1), 2568, 2023-05-04. [JCR]　[WOS]
Contreras Mauricio P., Pai Hsuan, Selvaraj Muniyandi, Toghani AmirAli, Lawson David M., Tumtas Yasin, Duggan Cian, Yuen Enoch Lok Him, Stevenson Clare E. M., Harant Adeline, Maqbool Abbas, Wu Chih-Hang, Bozkurt Tolga O., Kamoun Sophien, Derevnina Lida. Resurrection of plant disease resistance proteins via helper NLR bioengineering. Science Advances. 9(18), eadg3861, 2023-05-03. [JCR]　[WOS]
Oh Soohyun, Kim Sejun, Park Hyo‐Jeong, Kim Myung‐Shin, Seo Min‐Ki, (Wu Chih‐Hang), Lee Hyun‐Ah, Kim Hyun‐Soon, Kamoun Sophien, Choi Doil. Nucleotide‐binding leucine‐rich repeat network underlies nonhost resistance of pepper against the Irish potato famine pathogen Phytophthora infestans. Plant Biotechnology Journal. 21(7), 1361-1372, 2023-03-13. [JCR]　[WOS]
Adachi Hiroaki, Sakai Toshiyuki, Harant Adeline, Pai Hsuan, Honda Kodai, Toghani AmirAli, Claeys Jules, Duggan Cian, Bozkurt Tolga O., (Wu Chih-hang), Kamoun Sophien. An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana. PLOS Genetics. 19(1), e1010500, 2023-01-19. [JCR]　[WOS]
Ahn Hee‐Kyung, Lin Xiao, Olave‐Achury Andrea Carolina, Derevnina Lida, Contreras Mauricio P, Kourelis Jiorgos, (Wu Chih‐Hang), Kamoun Sophien, Jones Jonathan D G. Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1. The EMBO Journal. 2023, e111484, 2023-01-02. [JCR]　[WOS]
Kourelis Jiorgos, Contreras Mauricio P., Harant Adeline, Pai Hsuan, Lüdke Daniel, Adachi Hiroaki, Derevnina Lida, (Wu Chih-Hang), Kamoun Sophien. The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4. PLOS Genetics. 18(9), e1010414, 2022-9-22. [JCR]　[WOS]
Contreras Mauricio P, Pai Hsuan, Tumtas Yasin, Duggan Cian, Yuen Enoch Lok Him, Cruces Angel Vergara, Kourelis Jiorgos, Ahn Hee‐Kyung, Lee Kim‐Teng, (Wu Chih‐Hang), Bozkurt Tolga O, Derevnina Lida, Kamoun Sophien. Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens. The EMBO Journal. 2022, e111519, 2022-12-29. [JCR]　[WOS]
Zane Duxbury, Chih-hang Wu*, Pingtao Ding*. A comparative overview of the intracellular guardians of plants and animals: NLRs in innate immunity and beyond. Annual Review of Plant Biology. 72, 155-184, 2021. [JCR]　[WOS]
Kamil Witek, Xiao Lin, Hari S. Karki, Florian Jupe, Agnieszka I. Witek, Burkhard Steuernagel, Remco Stam, Cock van Oosterhout, Sebastian Fairhead, Robert Heal, Jonathan M. Cocker, Shivani Bhanvadia, William Barrett, Chih-Hang Wu, Hiroaki Adachi, Tianqiao Song, Sophien Kamoun, Vivianne G. A. A. Vleeshouwers, Laurence Tomlinson, Brande B. H. Wulff, Jonathan D. G. Jones*. A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector. NATURE PLANTS. 7, 198-208, 2021. [JCR]　[WOS]
Cian Duggan, Eleonora Moratto, Zachary Savage, Eranthika Hamilton, Hiroaki Adachi, Chih-Hang Wu, Alexandre Y. Leary, Yasin Tumtas, Stephen M. Rothery, Abbas Maqbool, Seda Nohut, Toby Ross Martin, Sophien Kamoun, Tolga Osman Bozkurt*. Dynamic accumulation of a helper NLR at the plant-pathogen interface underpins pathogen recognition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 118(34), e2104997118, 2021. [JCR]　[WOS]
Lida Derevnina, Mauricio P. Contreras, Hiroaki Adachi, Jessica Upson, Angel Vergara Cruces, Rongrong Xie, Jan Skłenar, Frank L. H. Menke,Sam T. Mugford, Dan MacLean, Wenbo Ma,Saskia A. Hogenhout, Aska Goverse, Abbas Maqbool, Chih-Hang Wu* ,Sophien Kamoun*. Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network. PLOS Biology. 19(8), e3001136, 2021. [JCR]　[WOS]
Wu Chih-Hang, Lee Shu-Chuan, Wang Chao-Wen. Viral protein targeting to the cortical endoplasmic reticulum is required for cell–cell spreading in plants. Journal of Cell Biology. 193(3) 521-535, 2011. [JCR]　[WOS]
Lee Shu-Chuan, Wu Chih-Hang, Wang Chao-Wen. Traffic of a Viral Movement Protein Complex to the Highly Curved Tubules of the Cortical Endoplasmic Reticulum. Traffic. 11(7) 912-930, 2010. [JCR]　[WOS]

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