Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 林天南 Lin, Teng-Nan

Journal 78

Farooqui AA, Farooqui T, Sun GY, (Lin TN), Teh DBL, Ong WY*. COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines. 11(4), 1181-1189, 2023-04. [JCR]　[WOS]
Kao MH, Huang CY, Cheung WM, Yan YT, Chen JJ, Ho YS, Hsu CY, (Lin TN)*. Activating Transcription Factor 3 Diminishes Ischemic Cerebral Infarct and Behavioral Deficit by Downregulating Carboxyl-Terminal Modulator Protein. International journal of molecular sciences. 24(3), 2306-2306, 2023-02. [JCR]　[WOS]
Ong WY, Kao MH, Cheung WM, Leow DM, Cheah IK, (Lin TN)*. Protective Effect of Ergothioneine Against Stroke in Rodent Models. Neuromolecular medicine. Online first, 1-11, 2022-10. [JCR]　[WOS]
Ong WY, Herr DR, Sun GY, (Lin TN). Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans. Molecules (Basel, Switzerland). 27(11), 3607, 2022-06. [JCR]　[WOS]
Kao MH, Wu JS, Cheung WM, Chen JJ, Sun GY, Ong WY, Herr DR, (Lin TN*). Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF-kappaB-driven IL-1beta Transcription. Neuromolecular medicine. 23(1), 199-210, 2021-01. [JCR]　[WOS]
Chen HL, Lo CH, Huang CC, Lu MP, Hu PY, Chen CS, Chueh DY, Chen P, (Lin TN), Lo YH, Hsiao YP, Hsu DK, Liu FT. Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis. The Journal of clinical investigation. 131(1), 1-10, 2021-01. [JCR]　[WOS]
Wu KH, Lee WJ, Cheng TC, Chang HW, Chen LC, Chen CC, Lien HM*, (Lin TN)*, Ho YS*. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC complementary and alternative medicine. 19(1), 188, 2019-07. [JCR]　[WOS]
Kao MH, (Lin TN)*. Histone deacetylases in stroke. The Chinese journal of physiology. 62(3), 95-107, 2019-05-06. [JCR]　[WOS]
Wu JS, Kao MH, Tsai HD, Cheung WM, Chen JJ, Ong WY, Sun GY, (Lin TN*). Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPbeta-Driven PPAR-gamma Transcription. Molecular neurobiology. 55(7), 5425-5438, 2018. [JCR]　[WOS]
Ho CF, Bon CP, Ng YK, Herr DR, Wu JS, (Lin TN), Ong WY*. Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochemical research. 43(3), 540-555, 2018. [JCR]　[WOS]
Lee GA*, (Lin TN), Chen CY, Mau SY, Huang WZ, Kao YC, Ma RY, Liao NS*. Interleukin 15 blockade protects the brain from cerebral ischemia-reperfusion injury. Brain, behavior, and immunity. 73, 562-570, 2018.　[WOS]
Wu KH, Ho CT, Chen ZF, Chen LC, Whang-Peng J, (Lin TN)*, Ho YS*. The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter. Journal of food and drug analysis. 26(1), 221-231, 2018. [JCR]　[WOS]
Hou PS, Chuang CY, Yeh CH, Chiang W, Liu HJ, (Lin TN), Kuo HC*. Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors. Stem cell reports. 8(1), 54-68, 2017. [JCR]　[WOS]
Hung CC, Lin CH, Chang H, Wang CY, Lin SH, Hsu PC, Sun YY, (Lin TN), Shie FS, Kao LS, Chou CM, Lee YH*. Astrocytic GAP43 Induced by the TLR4/NF-kappaB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(6), 2027-43, 2016. [JCR]　[WOS]
Tan CS, Ho CF, Heng SS, Wu JS, Tan BK, Ng YK, Sun GY, (Lin TN)*, Ong WY*. Clinacanthus nutans Extracts Modulate Epigenetic Link to Cytosolic Phospholipase A2 Expression in SH-SY5Y Cells and Primary Cortical Neurons. Neuromolecular medicine. 18(3), 441-52, 2016. [JCR]　[WOS]
Tsai HD, Wu JS, Kao MH, Chen JJ, Sun GY, Ong WY*, (Lin TN)*. Clinacanthus nutans Protects Cortical Neurons Against Hypoxia-Induced Toxicity by Downregulating HDAC1/6. Neuromolecular medicine. 18(3), 274-82, 2016. [JCR]　[WOS]
Ong WY, Sun GY, Wood WG, Lin TN. Nutraceuticals in Neurodegeneration and Aging. Neuromolecular medicine. 18(3), 239-240, 2016. [JCR]　[WOS]
Wu JS, Tsai HD, Cheung WM, Hsu CY, (Lin TN)*. PPAR-gamma Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-kappaB-Driven p22phox Transcription. Molecular neurobiology. 53(6), 3626-3645, 2016. [JCR]　[WOS]
Huang CY, Chen JJ, Wu JS, Tsai HD, Lin H, Yan YT, Hsu CY, Ho YS, (Lin TN)*. Novel link of anti-apoptotic ATF3 with pro-apoptotic CTMP in the ischemic brain. Molecular neurobiology. 51(2), 543-57, 2015. [JCR]　[WOS]
Huang CH, Shih YY, Siow TY, Hsu YH, Chen CC, (Lin TN), Jaw FS, Chang C*. Temporal assessment of vascular reactivity and functionality using MRI during postischemic proangiogenenic vascular remodeling. Magnetic resonance imaging. 33(7), 903-10, 2015. [JCR]　[WOS]
Wu JS, Tsai HD, Huang CY, Chen JJ, (Lin TN)*. 15-Deoxy-12,14-PGJ 2, by activating peroxisome proliferator-activated receptor-gamma, suppresses p22phox transcription to protect brain endothelial cells against hypoxia-induced apoptosis. Molecular neurobiology. 50(1), 221-38, 2014. [JCR]　[WOS]
Chen HL, Liao F, (Lin TN), Liu FT*. Galectins and neuroinflammation. Advances in neurobiology. 9, 517-42, 2014. [JCR]
Li WW, Wei YH, Li H, Lai DM*, (Lin TN)*. Isolation and characterization of a novel strain of mesenchymal stem cells from mouse umbilical cord: potential application in cell-based therapy. PloS one. 8(8), e74478, 2013. [JCR]　[WOS]
Chen YC, Wu JS, Tsai HD, Huang CY, Chen JJ, Sun GY, (Lin TN)*. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and neurodegenerative disorders. Molecular neurobiology. 46(1), 114-24, 2012. [JCR]　[WOS]
Chen YC, Wu JS, Yang ST, Huang CY, Chang C, Sun GY, (Lin TN)*. Stroke, angiogenesis and phytochemicals. Frontiers in bioscience (Scholar edition). 4, 599-610, 2012. [JCR]
Fong WH, Tsai HD, Chen YC, Wu JS, (Lin TN)*. Anti-apoptotic actions of PPAR-gamma against ischemic stroke. Molecular neurobiology. 41(2-3), 180-6, 2010. [JCR]　[WOS]
Yang HC, Liang YJ, Wu YL, Chung CM, Chiang KM, Ho HY, Ting CT, Lin TH, Sheu SH, Tsai WC, Chen JH, Leu HB, Yin WH, Chiu TY, Chen CI, Fann CS, Wu JY, (Lin TN), Lin SJ, Chen YT, Chen JW, Pan WH*. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. PloS one. 4(5), e5459, 2009. [JCR]　[WOS]
Lin CY, Lin MH, Cheung WM, (Lin TN), Chen JH*, Chang C*. In vivo cerebromicrovasculatural visualization using 3D DeltaR2-based microscopy of magnetic resonance angiography (3DDeltaR2-mMRA). NeuroImage. 45(3), 824-31, 2009. [JCR]　[WOS]
Wu JS, Cheung WM, Tsai YS, Chen YT, Fong WH, Tsai HD, Chen YC, Liou JY, Shyue SK, Chen JJ, Chen YE, Maeda N, Wu KK*, (Lin TN)*. Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. Circulation. 119(8), 1124-34, 2009. [JCR]　[WOS]
Wu JS, (Lin TN)*, Wu KK*. Rosiglitazone and PPAR-gamma overexpression protect mitochondrial membrane potential and prevent apoptosis by upregulating anti-apoptotic Bcl-2 family proteins. Journal of cellular physiology. 220(1), 58-71, 2009. [JCR]　[WOS]
Lin CY, Chang C, Cheung WM, Lin MH, Chen JJ, Hsu CY, Chen JH*, (Lin TN)*. Dynamic changes in vascular permeability, cerebral blood volume, vascular density, and size after transient focal cerebral ischemia in rats: evaluation with contrast-enhanced magnetic resonance imaging. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 28(8), 1491-501, 2008. [JCR]　[WOS]
(Lin TN)*, Cheung WM, Wu JS, Chen JJ, Lin H, Chen JJ, Liou JY, Shyue SK, Wu KK*. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Arteriosclerosis, thrombosis, and vascular biology. 26(3), 481-7, 2006. [JCR]　[WOS]
Fang YC, Wu JS, Chen JJ, Cheung WM, Tseng PH, Tam KB, Shyue SK, Chen JJ, (Lin TN)*. Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 26(4), 491-501, 2006. [JCR]　[WOS]
Hu CJ, Chen SD, Yang DI, (Lin TN), Chen CM, Huang TH, Hsu CY*. Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivation in murine cerebral endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 26(12), 1519-26, 2006. [JCR]　[WOS]
Chang TC, Huang CJ, Tam K, Chen SF, Tan KT, Tsai MS, (Lin TN), Shyue SK*. Stabilization of hypoxia-inducible factor-1{alpha} by prostacyclin under prolonged hypoxia via reducing reactive oxygen species level in endothelial cells. The Journal of biological chemistry. 280(44), 36567-74, 2005. [JCR]　[WOS]
(Lin TN), Wang Q, Simonyi A, Chen JJ, Cheung WM, He YY, Xu J, Sun AY, Hsu CY, Sun GY*. Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain. Journal of neurochemistry. 90(3), 637-45, 2004. [JCR]　[WOS]
Lee YC, Chien CL, Sun CN, Huang CL, Huang NK, Chiang MC, Lai HL, Lin YS, Chou SY, Wang CK, Tai MH, Liao WL, (Lin TN), Liu FC, Chern Y*. Characterization of the rat A2A adenosine receptor gene: a 4.8-kb promoter-proximal DNA fragment confers selective expression in the central nervous system. The European journal of neuroscience. 18(7), 1786-96, 2003. [JCR]　[WOS]
(Lin TN), Kim GM, Chen JJ, Cheung WM, He YY, Hsu CY*. Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion. Stroke. 34(1), 177-86, 2003. [JCR]　[WOS]
Lin H, (Lin TN*), Cheung WM, Nian GM, Tseng PH, Chen SF, Chen JJ, Shyue SK, Liou JY, Wu CW, Wu KK*. Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Circulation. 105(16), 1962-9, 2002. [JCR]　[WOS]
(Lin TN), Sun SW, Cheung WM, Li F, Chang C*. Dynamic changes in cerebral blood flow and angiogenesis after transient focal cerebral ischemia in rats. Evaluation with serial magnetic resonance imaging. Stroke. 33(12), 2985-91, 2002. [JCR]　[WOS]
Yang JT, Chang CN, Lee TH, Hsu JC, (Lin TN), Hsu YH, Hsieh Wu J*. Effect of dexamethasone on the expression of brain-derived neurotrophic factor and neurotrophin-3 messenger ribonucleic acids after forebrain ischemia in the rat. Critical care medicine. 30(4), 913-8, 2002. [JCR]　[WOS]
Shih CL, Chi SI, Chiu TH, Sun GY, (Lin TN)*. Ethanol effects on nitric oxide production in cerebral pial cultures. Alcoholism, clinical and experimental research. 25(4), 612-8, 2001. [JCR]　[WOS]
Yang JT, Chang CN, Lee TH, (Lin TN), Hsu JC, Hsu YH, Wu JH*. Hyperbaric oxygen treatment decreases post-ischemic neurotrophin-3 mRNA down-regulation in the rat hippocampus. Neuroreport. 12(16), 3589-92, 2001. [JCR]　[WOS]
(Lin TN)*, Nian GM, Chen SF, Cheung WM, Chang C, Lin WC, Hsu CY. Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 21(6), 690-701, 2001. [JCR]　[WOS]
Hung AC, Huang HM, Tsay HJ, (Lin TN), Kuo JS, Sun SH*. ATP-stimulated c-fos and zif268 mRNA expression is inhibited by chemical hypoxia in a rat brain-derived type 2 astrocyte cell line, RBA-2. Journal of cellular biochemistry. 77(2), 323-32, 2000. [JCR]　[WOS]
Chi SI, Wang CK, Chen JJ, Chau LY, (Lin TN)*. Differential regulation of H- and L-ferritin messenger RNA subunits, ferritin protein and iron following focal cerebral ischemia-reperfusion. Neuroscience. 100(3), 475-84, 2000. [JCR]　[WOS]
Cheung WM, Chen SF, Nian GM, (Lin TN)*. Induction of angiogenesis related genes in the contralateral cortex with a rat three-vessel occlusion model. The Chinese journal of physiology. 43(3), 119-24, 2000. [JCR]　[WOS]
(Lin TN)*, Wang CK, Cheung WM, Hsu CY. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 20(2), 387-95, 2000. [JCR]　[WOS]
Cheung WM, Wang CK, Kuo JS, (Lin TN)*. Changes in the level of glial fibrillary acidic protein (GFAP) after mild and severe focal cerebral ischemia. The Chinese journal of physiology. 42(4), 227-35, 1999. [JCR]　[WOS]
Lee YC, Chang CW, Su CW, (Lin TN), Sun SH, Lai HL, Chern Y*. The 5\' untranslated regions of the rat A2A adenosine receptor gene function as negative translational regulators. Journal of neurochemistry. 73(5), 1790-8, 1999. [JCR]　[WOS]
Yang JT, Chang CN, Lee TH, Hsu JC, (Lin TN), Wu JH*. Dexamethasone inhibits ischemia-induced transient reduction of neurotrophin-3 mRNA in rat hippocampal neurons. Neuroreport. 9(15), 3477-80, 1998. [JCR]　[WOS]
(Lin TN)*, Wang PY, Chi SI, Kuo JS. Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFR alpha) expression following focal cerebral ischemia. Brain research. Molecular brain research. 55(1), 71-80, 1998. [JCR]　[WOS]
Hsu CY*, (Lin TN). Is transient acidosis detrimental to the nervous system?. Critical care medicine. 26(12), 1947-8, 1998. [JCR]　[WOS]
(Lin TN)*, Wong YP, Chen JJ, Cheng JT, Yu SF, Sun SH, Chi SI, Chai CY. Elevated basic fibroblast growth factor levels in stroke-prone spontaneously hypertensive rats. Neuroscience. 76(2), 557-70, 1997. [JCR]　[WOS]
(Lin TN)*, Te J, Lee M, Sun GY, Hsu CY. Induction of basic fibroblast growth factor (bFGF) expression following focal cerebral ischemia. Brain research. Molecular brain research. 49(1-2), 255-65, 1997. [JCR]　[WOS]
(Lin TN)*, Te J, Huang HC, Chi SI, Hsu CY. Prolongation and enhancement of postischemic c-fos expression after fasting. Stroke. 28(2), 412-8, 1997. [JCR]　[WOS]
(Lin TN)*, Chen JJ, Wang SJ, Cheng JT, Chi SI, Shyu AB, Sun GY, Hsu CY. Expression of NGFI-B mRNA in a rat focal cerebral ischemia-reperfusion model. Brain research. Molecular brain research. 43(1-2), 149-56, 1996. [JCR]　[WOS]
Sun GY*, Zhang JP, Lin TA, (Lin TN), He YY, Hsu CY. Inositol trisphosphate, polyphosphoinositide turnover, and high-energy metabolites in focal cerebral ischemia and reperfusion. Stroke. 26(10), 1893-900, 1995. [JCR]　[WOS]
(Lin TN), He YY, Wu G, Khan M, Hsu CY*. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke. 24(1), 117-21, 1993. [JCR]　[WOS]
Lin TA, Navidi M, James W, (Lin TN), Sun GY*. Effects of acute ethanol administration on polyphosphoinositide turnover and levels of inositol 1,4,5-trisphosphate in mouse cerebrum and cerebellum. Alcoholism, clinical and experimental research. 17(2), 401-5, 1993. [JCR]　[WOS]
Sun GY*, Lin TA, Wixom P, Zoeller RT, (Lin TN), He YY, Hsu CY. Effects of focal cerebral ischemia on expression and activity of inositol 1,4,5-trisphosphate 3-kinase in rat cortex. Annals of the New York Academy of Sciences. 679, 382-7, 1993. [JCR]　[WOS]
An G, (Lin TN), Liu JS, Xue JJ, He YY, Hsu CY*. Expression of c-fos and c-jun family genes after focal cerebral ischemia. Annals of neurology. 33(5), 457-64, 1993. [JCR]　[WOS]
Hsu CY*, An G, Liu JS, Xue JJ, He YY, (Lin TN). Expression of immediate early gene and growth factor mRNAs in a focal cerebral ischemia model in the rat. Stroke. 24(12 Suppl), I78-81, 1993. [JCR]　[WOS]
Stark WS*, (Lin TN), Brackhahn D, Christianson JS, Sun GY. Fatty acids in the lipids of Drosophila heads: effects of visual mutants, carotenoid deprivation and dietary fatty acids. Lipids. 28(4), 345-50, 1993. [JCR]　[WOS]
Stark WS*, (Lin TN), Brackhahn D, Christianson JS, Sun GY. Phospholipids in Drosophila heads: effects of visual mutants and phototransduction manipulations. Lipids. 28(1), 23-8, 1993. [JCR]　[WOS]
Lin TA, (Lin TN), He YY, Hsu CY, Sun GY*. Effects of focal cerebral ischemia on inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities in rat cortex. Biochemical and biophysical research communications. 184(2), 871-7, 1992. [JCR]　[WOS]
An G, (Lin TN), Liu JS, Hsu CY*. Induction of Krox-20 expression after focal cerebral ischemia. Biochemical and biophysical research communications. 188(3), 1104-10, 1992. [JCR]　[WOS]
Sun GY*, Navidi M, Yoa FG, (Lin TN), Orth OE, Stubbs EB Jr, MacQuarrie RA. Lithium effects on inositol phospholipids and inositol phosphates: evaluation of an in vivo model for assessing polyphosphoinositide turnover in brain. Journal of neurochemistry. 58(1), 290-7, 1992. [JCR]　[WOS]
(Lin TN), Liu TH, Xu J, Hsu CY, Sun GY*. Brain polyphosphoinositide metabolism during focal ischemia in rat cortex. Stroke. 22(4), 495-8, 1991. [JCR]　[WOS]
Sun GY*, Navidi M, Yoa FG, (Lin TN). Effects of acute and chronic ethanol administration on phosphoinositide metabolism in mouse brain. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. 1, 215-9, 1991. [JCR]　[WOS]
(Lin TN), Sun GY*, Premkumar N, MacQuarrie RA, Carter SR. Decapitation-induced changes in inositol phosphates in rat brain. Biochemical and biophysical research communications. 167(3), 1294-301, 1990. [JCR]　[WOS]
Sun GY*, Yoa FG, (Lin TN). Degradation of poly-phosphoinositides in brain subcellular membranes in response to decapitation insult. Neurochemistry international. 17(4), 529-35, 1990. [JCR]　[WOS]
Sun GY*, (Lin TN). Dynamic turnover of mouse brain phospholipids during normal aging and response to ischemia. Upsala journal of medical sciences. Supplement. 48, 209-23, 1990. [JCR]　[WOS]
Sun GY*, (Lin TN). Time course for labeling of brain membrane phosphoinositides and other phospholipids after intracerebral injection of [32P]-ATP. Evaluation by an improved HPTLC procedure. Life sciences. 44(10), 689-96, 1989. [JCR]　[WOS]
(Lin TN), MacQuarrie R, Sun GY*. Arachidonic acid uptake by phospholipids and triacylglycerols of rat brain subcellular membranes. Lipids. 23(10), 942-7, 1988. [JCR]　[WOS]
(Lin TN), Sun AY, Sun GY*. Effects of ethanol on arachidonic acid incorporation into lipids of a plasma membrane fraction isolated from brain cerebral cortex. Alcoholism, clinical and experimental research. 12(6), 795-800, 1988. [JCR]　[WOS]
Wei YH*, Lu CY, (Lin TN), Wei RD. Effect of ochratoxin A on rat liver mitochondrial respiration and oxidative phosphorylation. Toxicology. 36(2-3), 119-30, 1985. [JCR]　[WOS]
Wei YH*, (Lin TN), Hong CY, Chiang BN. Inhibition of the mitochondrial Mg2+-ATPase by propranolol. Biochemical pharmacology. 34(7), 911-7, 1985. [JCR]　[WOS]

Book 1

Ong WY, Sun GY, Wood WG, Lin TN (Guest editors) Special Issue: Nutraceuticals in neurodegeneration and Aging; NeuroMolecular Medicine 18(3) 2016; ISSN 1535-1084 (print). 257, 2016-09-01.