Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 施修明 Shih, Hsiu-Ming

Journal 100

He Y. Pasupala, N, Zhi H, Dorjbal B, Hussain I, Shih HM, Bhattacharyya S, Biswas R, Semmes OJ, Waldmann TA, Snow AL, and Giam CZ. NF-κB-Induced R-loop Accumulation and DNA Damage Select for Nucleotide Excision Repair Deficiencies in Adult T-cell Leukemia. PNAS. 118(10), e2005568118, 2021-03-09. [JCR]　[WOS]
Huang YS, Lu KC, Chao HW, Chen A, Chao TK, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. J Cell Physiol. 236(3), 2023-2035, 2021-03. [JCR]　[WOS]
Hsieh YL, Su FY, Tsai LK, Huang CC, Ko YL, Su LW, Chen KY, Shih HM, Hu CM, Lee WH. NPGPx-mediated adaptation to oxidative stress protects motor neurons from degeneration in aging by directly modulating O-GlcNAcase. Cell Rep. 29(8), 2134-2143.e7, 2019-11. [JCR]　[WOS]
Ma HY, Lu CY, Tsao KC, Shih HM, Cheng AL, Huang LM, Chang LY. Association of EV71 3C polymorphisms with clinical severity. J Microbiol Immunol Infect.. 51(5), 608-613, 2018-10.　[WOS]
Chen SY, Ho CT, Liu WW, Lucanic M, Shih HM, Huang PH, Cheng HJ. Regulation of axon repulsion by MAX-1 sumoylation and AP-3. Proc Natl Acad Sci USA. 115(35), E8236-E8245, 2018-08.　[WOS]
Huang YS, Lu KC, Chao TK, Chen JS, Chen A, Guo CY, Hsieh HY, Shih HM, Sytwu HK and Wu CC. Role of melatonin receptor 1A and pituitary homeobox-1 coexpression in protecting tubular epithelial cells in membranous nephropathy. J Pineal Res. 65(1), e12482, 2018-08. [JCR]　[WOS]
Hu LY, Chang CC, Huang YS, Chou WC, Lin YM, Ho CC, Chen WT, Shih HM, Hsiung CN, Wu PE, and Shen CY. Sumoylation of XRCC1 activated by poly)ADP-ribosyl)ation regulates DNA repair. Hum Mol Genet.. 27(13), 2306-2317, 2018-07. [JCR]　[WOS]
Chang CC, Huang YS, Lin YM, Lin CJ, Jeng JC, Liu SM, Ho TL, Chang RT, Changou C, Ho CC, Shih HM*. The role of sentrin-specific protease 2 substrate recognition in TGF-b-induced tumorigenesis. Scientific Reports. 8(1), 9786, 2018-06. [JCR]　[WOS]
Lin CY, YangST, Shen SC, Hsieh YC, Hsu FT, Chen CY, Chiang YH, Chuang JY, Chen KY, Hsu TI, Leong WC, Su YK, Lo WL, Yeh YS, Patria YN, Shih HM, Chang CC and Chou SY. Serum amyloid A1 in combination with integrin V3 increases glioblastoma cells mobility and progression. Mol Oncol.. 12(5), 756-771, 2018-05. [JCR]　[WOS]
Cheng CW, Chang CC, Patria YN, Chang RT, Liu YR, Li FA, Shih HM, Lin CY. Sex hormone-binding globulin (SHBG) is a potential early diagnostic biomarker for gastric cancer. Cancer Medicine. 7(1), 64-74, 2018-01. [JCR]　[WOS]
Naik MT, Kang M, Ho CC, Hsieh YL, Nail NM, Wang SH, Chang I*, Shih HM*, and Huang TH*. Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction. Scientific Reports. 7(1), 17391, 2017-12. [JCR]　[WOS]
Ma HY, Lu CY, Tsao KC, Shih HM, Cheng AL, Huang LM, Chang LY. Association of EV71 3C polymorphisms with clinical severity. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION. 51(5), 608-613, 2017-06. [JCR]　[WOS]
Kuo CY, Li X, Stark JM, Shih HM, and Ann DK. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. CELL CYCLE. 15(6), 787-98, 2016-06. [JCR]　[WOS]
Lin GJ, Huang YS, Lin CK, Huang SH, Shih HM, Sytwu HK, Chen YW. Daxx and TCF4 interaction links to oral squamous cell carcinoma growth by promoting cell cycle progression via induction of cyclin D1 expression. Clinical oral investigations. 20(3), 533-540, 2016. [JCR]　[WOS]
Huang YS, Chang CC, Lee SS, Jou YS, Shih HM. Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget. 7(28), 43256-43266, 2016. [JCR]　[WOS]
Hunag SY, Chang CF, Fang PJ, Naik MT, Guntert P, Shih HM, Huang TH. The RING domain of human promyelocytic leukemia protein (PML). JOURNAL OF BIOMOLECULAR NMR. 61(2), 173-180, 2015-02. [JCR]　[WOS]
Qu D, Weygant N, May R, Chandrakesan P, Madhoun M, Ali N, Sureban SM, An G, Schlosser MJ, Houchen CW. Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PloS one. 10(8), e0134212, 2015. [JCR]　[WOS]
Ho YK, Zhi H, Bowlin T, Dorjbal B, Philip S, Zahoor MA, Shih HM, Semmes OJ, Schaefer B, Glover JN, Giam CZ. HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation. PLoS pathogens. 11(8), e1005102, 2015. [JCR]　[WOS]
Huang SY, Naik MT, Chang CF, Fang PJ, Wang YH, Shih HM, Huang TH. The B-box 1 dimer of human promyelocytic leukemia protein. JOURNAL OF BIOMOLECULAR NMR. 60(4), 275-281, 2014-12. [JCR]　[WOS]
Kuo HY, Huang YS, Tseng CH, Chen YC, Chang YW, Shih HM, Wu CW. PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2. CELL CYCLE. 13(19), 3132-3142, 2014-10. [JCR]　[WOS]
Huang YS, Hsieh HY, Shih HM, Sytwu HK, Wu CC. Urinary Xist is a potential biomarker for membranous nephropathy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 452(3), 415-421, 2014-09. [JCR]　[WOS]
Kung CC, Naik MT, Wang SH, Shih HM, Chang CC, Lin LY, Chen CL, Ma C, Chang CF, Huang TH. Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain. BIOCHEMICAL JOURNAL. 462(1), 53-65, 2014-08. [JCR]　[WOS]
Kuo CY, Li X, Kong XQ, Luo C, Chang CC, Chung Y, Shih HM, Li KK, Ann DK. An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Kruppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress. JOURNAL OF BIOLOGICAL CHEMISTRY. 289(30), 20757-20772, 2014-07. [JCR]　[WOS]
Chiang YP, Sheng WH, Shao PL, Chi YH, Chen YM, Huang SW, Shih HM, Chang LY, Lu CY, Chang SC, Hung CC, Huang LM. Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection. EBioMedicine. 1(2-3), 126-132, 2014. [JCR]
Kuo HY, Chen YC, Chang HY, Jeng JC, Lin EH, Pan CM, Chang YW, Wang ML, Chou YT, Shih H-M, and Wu CW*. The PML isoform IV is a negative regulator of nuclear EGFR’s transcriptional activity in lung cancer. CARCINOGENESIS. 34(8), 1708-1716, 2013-08. [JCR]　[WOS]
Lin YM, Wang CM, Jeng JC, Leprince D, and Shih H-M*. HIC1 interacts with and modulates the activity of STAT3. CELL CYCLE. 12(14), 2266-2276, 2013-07. [JCR]　[WOS]
Chen CH, Chang CC, Lee TH, Luo ML, Huang PY, Liao PH, Wei S, Chen RH, Zhou XZ, Shih H-M, and Lu KP*. SENP1 deSUMOylates and regulates Pin1 protein activity and cellular Function. CANCER RESEARCH. 73(13), 3951-3962, 2013-07. [JCR]　[WOS]
Lee YH, Kuo CY, Stark J, Shih H-M, and Ann DK*. HP1 Promotes Tumor Suppressor BRCA1 Functions During the DNA Damage response. NUCLEIC ACIDS RESEARCH. 41(11), 5784-5798, 2013-06. [JCR]　[WOS]
Lo YH, Huang YW, Wu YH, Tsai CS, Lin YC, Mo ST, Kuo WC, Chuang YT, Jiang ST, Shih H-M, and Lai MZ*. Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human. BLOOD. 121(16), 3185-3194, 2013-04. [JCR]　[WOS]
Hsieh YL, Kuo HY, Chang CC, Naik MT, Liao PH, Ho CC, Huang TC, Jeng JC, Hsu PH, Tsai MD, Huang TH and Shih, H.-M*. Ubc9 acetylation modulates distinct SUMO target modification and hypoxia respone. EMBO JOURNAL. 32(6), 791-804, 2013-03. [JCR]　[WOS]
Wu CC, Chen KY, Yo YW, Huang SW, Shih H.-M, Chiu WT, Chiang YH and Shiau CY. Different sham procedures for rats in traumatic brain injury experiments induce corresponding increases in levels of trauma markers. J Surg Res. 179(1), 138-144, 2013-01. [JCR]　[WOS]
Yang WC and Shih H-M*. Deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. ONCOGENE. 32(43), 5167-5175, 2012-12. [JCR]　[WOS]
Wu JC, Chen KY, Yu YW, Huang SW, Shih H-M, Chiu WT, Chiang YH, and Shiau CY. Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury. PLoS One. 7(6), e39226, 2012-06. [JCR]　[WOS]
Ying HY, Su ST, Hsu PH, Chang CC, Lin IY, Tseng YH, Tsai MD, Shih H-M and Lin KI*. PIAS1-mediated SUMOylation of Blimp-1 is critical for plasma cell differentiation. EMBO REPORTS. 13, 631-637, 2012-06. [JCR]　[WOS]
Lin HH, Li X, Chen JL, Sun X, Cooper FN, Chen YR, Zhang W, Chung Y, Li A, Cheng CT, Yang l, Deng X, Liu X, Yen Y, Johnson DL, Shih H-M, Yag, A, and Ann DK. Identification of an AAA-ATPase VPS4B-dependent pathway that modulates EGFR abundance and signaling during hypoxia. MOLECULAR AND CELLULAR BIOLOGY. 32, 1124-1138, 2012-03. [JCR]　[WOS]
Lan, HC, Wu, CF, Shih, H.-M, Chung, BC*. Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription. Journal of Biological Chemistry. 287, 5910-5916, 2012-02. [JCR]　[WOS]
Huang, YS, Chang, CC, Hsieh, YL, Huang, TC, and Shih, H.-M*. Daxx interacts with and modulates the activity of CREB. CELL CYCLE. 11, 99-108, 2012-01. [JCR]　[WOS]
Ho YK, Zhi H, DeBiaso D, Philip S, Shih H-M, and Giam CZ*. HTLV-1 Tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA. Journal of Virology. 86(17), 9474-9483, 2012. [JCR]　[WOS]
Chen, KY, Wu, CC, Chang, CF, Chen, YH, Chiu, WT, Lou, YH, Chen, YH, Shih, H.-M, and Chiang, YH*. Suppression of Etk/Bmx protects against ischemic brain injury. CELL TRANSPLANTATION. 21(1), 345-354, 2012. [JCR]　[WOS]
Chen, SC, Chang LY, Wang, YW, Chen, YC, Weng, KF, Shih, SR and Shih, H.-M.*. Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY. 286, 31373-31384, 2011-09. [JCR]　[WOS]
Yuan, WC, Lee, YR, Huang, SF, Lin, YM, Chen,TY, Chung, HC, Tsai, CH, Chen, HY, Chiang CT, Lai, CK, Lu, LT, Chen, CH, Gu, DL, Pu, YS, Jou, YS, Lu, KP, Hsiao, PW, Shih, H.-M, and Chen, RH. A cullin3-KLHL20 ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. CANCER CELL. 20(2), 214-228, 2011-08. [JCR]　[WOS]
Chang, CC, Naik, MT, Huang, YS, Jeng, JC, Liao, PH, Kuo, HY, Ho, CC, Hsieh, YL, Lin, CH, Huang, NJ, Naik, NM, Kung, CC-H, Lin, SY, Chen, RH, Chang, KS, Huang, TH *, and Shih, H.-M*. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralogue-selective binding and apoptosis modulation. MOLECULAR CELL. 42(1), 62-74, 2011-04. [JCR]　[WOS]
Zhi, H, Yang, L, Kuo, YL, Ho, YK, Shih, H.-M, and Giam, CZ. * . NF-kB hyper-activation by HTLV-1 Tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathogens. 7(4), e1002025, 2011. [JCR]　[WOS]
Lin CH, Hu CK, Shih HM. Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. Journal of Cell Biology. 189(7), 1097-105, 2010. [JCR]　[WOS]
Naik MT, Chang CC, Naik NM, Kung CC, Shih HM, Huang TH. NMR chemical shift assignments of a complex between SUMO-1 and SIM peptide derived from the C-terminus of Daxx. Biomolecular NMR assignments. 5(1), 75-77, 2010. [JCR]　[WOS]
Li X, Lin HH, Chen H, Xu X, Shih HM, Ann DK. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. Science signaling. 3(119), ra32, 2010. [JCR]　[WOS]
Lee YR, Yuan WC, Ho HC, Chen CH, Shih HM, Chen RH. The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. The EMBO journal. 29(10), 1748-61, 2010. [JCR]　[WOS]
Jeng, JC, Lin, YM, Lin, CH, and Shih, H.-M. Cdh1 controls the stability of TACC3. Cell Cycle. 8(21), 3529-36, 2009-11. [JCR]　[WOS]
Huang, YS and Shih, H.-M. Daxx positively modulates beta-catenin/TCF4-mediated transcriptional potential. Biochemical and Biophysical Research Communications. 386(4), 762-768, 2009-09. [JCR]　[WOS]
Wang, HC, Huang, YS, Ho, CC, Jeng, JC and Shih, H.-M. . SUMO modification modulates the activity of calpain-2. Biochemical and Biophysical Research Communications. 384(4), 444-449, 2009-07. [JCR]　[WOS]
Gao C, Ho CC, Reineke E, Lam M, Cheng X, Stanya KJ, Liu Y, Chakraborty S, Shih HM, Kao HY. Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation. Molecular and cellular biology. 28(18), 5658-67, 2008. [JCR]　[WOS]
Chang LY, Chang IS, Chen WJ, Huang YC, Chen GW, Shih SR, Juang JL, Shih HM, Hsiung CA, Lin TY, Huang LM. HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 122(6), 1271-1276, 2008. [JCR]　[WOS]
Y. H. Lo, C. C. Wu, H. M. Shih and M. Z. Lai. Selective activation of NFAT by promyelocytic leukemia protein. Oncogene. (in press), 2008. [JCR]　[WOS]
X. Cao, C. Clavijo, X. Li, H. H. Lin, Y. Chen, H. M. Shih and D. K. Ann. SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome. Mol Cancer Ther. 7(4), 923-934, 2008. [JCR]　[WOS]
H. M. Shih, C. C. Chang, H. Y. Kuo and D. Y. Lin. Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization. Biochemical Society Transactions. 35(Pt 6), 1397-1400, 2007. [JCR]　[WOS]
S. Hong, L. C. Wang, X. Gao, Y. L. Kuo, B. Liu, R. Merling, H. J. Kung, H. M. Shih and C. Z. Giam. Heptad repeats regulated protein phosphatase 2A recruitment to I-(kappa)B kinase (gamma)/NF-(kappa)B essential modulator and are targeted by human T-lymphotropic virus type 1 tax. J Biol Chem. 282(16), 12119-12126, 2007. [JCR]　[WOS]
X. Li, Y. K. Lee, J. C. Jeng, Y. Yen, D. C. Schultz, H. M. Shih and D. K. Ann. Role for KAP1 serine 824 phosphorylation and SUMOylation/deSUMOylation switch in regulating KAP1-mediated transcriptional repression. J Biol Chem. 282(50), 36177-36189, 2007. [JCR]　[WOS]
T. T. Chao, C. C. Chang and H. M. Shih. SUMO modification modulates the transrepression activity of PLZF. Biochemical and Biophysical Research Communications. 358(2), 475-482, 2007. [JCR]　[WOS]
M. W. Chiu, H. M. Shih, Y. H. Yang and Y. L. Yang. The type 2 dengue virus envelope protein interacts with small ubiquitin-like modifier-1 (SUMO-1) conjugating enzyme 9 (Ubc9). J Biomed Sci. 14(3), 429-444, 2007. [JCR]　[WOS]
L. Y. Li, M. Y. Liu, H. M. Shih, C. H. Tsai and J. Y. Chen. Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival. J Gen Virol. 87, 2869-2878, 2006. [JCR]　[WOS]
A. H. Ma, L. Xia, S. J. Desai, D. L. Boucher, Y. Guan, H. M. Shih, X. B. Shi, R. W. devere White, H. W. Chen, C. G. Tepper and H. J. Kung. Male Germ Cell-Associated Kinase, a Male-Specific Kinase Regulated by Androgen, Is a Coactivator of Androgen Receptor in Prostate Cancer Cells. Cancer Res. 66(17), 8439-8447, 2006. [JCR]　[WOS]
D. Y. Lin, Y. S. Huang, J. C. Jeng, H. Y. Kuo, C. C. Chang, T. T. Chao, C. C. Ho, Y. C. Chen, T. P. Lin, H. I. Fang, C. C. Hung, C. S. Suen, M. J. Hwang, K. S. Chang, G. G. Maul and H. M. Shih. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and respression of sumoylated transcription factors. Mol Cell. 24(3), 341-354, 2006. [JCR]　[WOS]
C. C. Chang, D. Y. Lin, H. I. Fang, R. H. Chen and H. M. Shih. Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4. J Biol Chem. 280, 10164-10173, 2005. [JCR]　[WOS]
E. van den Akker, S. Ano, H. M. Shih, L. C. Wang, M. Pironin, J. J. Palvimo, N. Kotaja, O. Kirsh, A. Dejean and J. Ghysdae. FLI-1 functionally interacts with PIASxa, a member of the PIAS E3 SUMO ligase family. J Biol Chem. 280, 38035-38046, 2005. [JCR]　[WOS]
V.S.R.K. Yedavalli, H. M. Shih, Y. P. Chiang, C. Y. Lu, L. Y. Chang, M. Y. Chen, C. Y. Chuang, A. I. Dayton, K. T. Jeang and L. M. Huang. Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1. J Virol. 79, 13735-13746, 2005. [JCR]　[WOS]
H. Y. Kuo, C. C. Chang, J. C Jeng, H. M. Hu, D. Y. Lin, G. G. Maul, R.P.S. Kwok and H. M. Shih. SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proceedings of the National Academy of Sciences of the United States of America. 102, 16973-16978, 2005. [JCR]　[WOS]
Z. Li, C. P. Day, J. Y. Yang, W. B. Tsai, G. Lozano, H. M. Shih and M. C. Hung. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Res. 64, 9080-9085, 2004. [JCR]　[WOS]
D. Y. Lin, H. I. Fang, A. H. Ma, Y. S. Huang, Y. S. Pu, G. Jenster, H. J. Kung and H. M. Shih. Negative modulation of androgen receptor transcriptional activity by Daxx. Mol Cell Biol. 24, 10529-10541, 2004. [JCR]　[WOS]
S. H. Yu, W. C. Chiang, H. M. Shih and K. J. Wu. Stimulation of c-Rel transcriptional activity by PKA catalytic subunit beta. J Mol Med. 82, 621-628, 2004. [JCR]　[WOS]
K. Y. Chen, L. M. Huang, H. J. Kung, D. K. Ann and H. M. Shih. The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells. Oncogene. 23, 1854-1862, 2004. [JCR]　[WOS]
C. Y. Wang, Y. J. Liang, Y. S. Lin, H. M. Shih, Y. S. Jou and W. C. Yu. YY1AP, a novel co-activator of YY1. J Biol Chem. 279, 17750-17755, 2004. [JCR]　[WOS]
C. C. Wu, S. C. Hsu, H. M. Shih and M. Z. Lai. Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells. Mol Cell Biol. 23, 6442-6454, 2003. [JCR]　[WOS]
D. Y. Lin, M. Z. Lai, D. K. Ann and H. M. Shih. Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential. J Biol Chem. 278, 15958-15965, 2003. [JCR]　[WOS]
C. Y. Huang, Y. M. Wu, C. Y. Hsu, W. S. Lee, M. D. Lai, T. J. Lu, C. L. Huang, T. H. Leu, H. M. Shih, H. I. Fang, D. R. Robinson, H. J. Kung and C. J. Yuan. Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. J Biol Chem. 277, 34367-34374, 2002. [JCR]　[WOS]
C. H. Chau, K. Y. Chen, H. T. Deng, K. J. Kim, K. Hosoya, T. Terasaki, H. M. Shih and D. K. Ann. Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation. Oncogene. 21, 8817-8829, 2002. [JCR]　[WOS]
H. C. Cheng, H. M. Shih and Y. Chern. Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade. J Biol Chem. 277, 33930-33942, 2002. [JCR]　[WOS]
D. Y. Lin, H. M. Shih. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. J Biol Chem. 277, 25446-25456, 2002. [JCR]　[WOS]
C. T. Yu, M. H. Feng, H. M. Shih and M. Z. Lai. Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection. Mol Cell Biol. 22, 4556-4566, 2002. [JCR]　[WOS]
J. L. Lin, H. C. Chen, H. I. Fang, D. Robinson, H. J. Kung and H. M. Shih. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene. 20, 6559-6569, 2001. [JCR]　[WOS]
L. M. Huang, M. F. Chao, M. Y. Chen, H. M. Shih, Y. P. Chiang, C. Y. Chuang and C. Y. Lee. Reciprocal regulatory interaction between human herpesvirus 8 and human immunodeficiency virus type 1. J Biol Chem. 276, 13427-13432, 2001. [JCR]　[WOS]
M. D. Zentner, H. H. Lin, H. T. Deng, K. J. Kim, H. M. Shih and D. K. Ann. Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells. J Biol Chem. 276, 29805-29814, 2001. [JCR]　[WOS]
L. Y. Li, H. M. Shih, M. Y. Liu and J. Y. Chen. The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr virus BHRF1, a homologue of Bcl-2, through direct interaction. J Biol Chem. 276, 27354-27362, 2001. [JCR]　[WOS]
Y. T. Tsai, Y. H. Su, S. S. Fang, T. N. Huang, Y. Qiu, Y. S. Jou, H. M. Shih, H. J. Kung and R. H. Chen. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol Cell Biol. 20, 2043-2054, 2000. [JCR]　[WOS]
C. T. Yu, H. M. Shih and M. Z. Lai. Multiple signals required for cyclic AMP-responsive element binding protein (CREB) binding protein interaction induced by CD3/CD28 costimulation. J Immunol. 166, 284-292, 2000. [JCR]　[WOS]
H. Y. Jui, R. J. Tseng, X. Wen, H. I. Fang, L. M. Huang, K. Y. Chen, H. J. Kung, D. K. Ann and H. M. Shih. Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases. J Biol Chem. 275, 41124-41132, 2000. [JCR]　[WOS]
A. J. DeMaggio, P. Goldman, H. M. Shih, R. H. Goodman and M. F. Hoekstra. The yeast split-hybrid system. Methods in Enzymology. 328, 128-137, 2000. [JCR]　[WOS]
R. H. Xu, R. J. Lechleider, H. M. Shih, C. F. Hao, D. Sredni, A. B. Roberts and H. Kung. Functional analysis of human Smad1: role of the amino-terminal domain. Biochem Biophys Res Commun. 258, 366-373, 1999. [JCR]　[WOS]
X. Wen, H. H. Lin, H. M. Shih, H. J. Kung and D. K. Ann. Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells. J Biol Chem. 274, 38204-38210, 1999. [JCR]　[WOS]
E. N. Kaytor, H. M. Shih and H. C. Towle. Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor. J Biol Chem. 272, 7525-7531, 1997. [JCR]　[WOS]
H. C. Towle, E. N. Kaytor and H. M. Shih. Regulation of the expression of lipogenic enzyme genes by carbohydrate. Annu Rev Nutr. 17, 405-433, 1997. [JCR]　[WOS]
H. M. Shih, P. S. Goldman, A. J. DeMaggio, S. M. Hollenberg, R. H. Goodman and M. F. Hoekstra. A positive genetic selection for disrupting protein-protein interactions: identification of CREB mutations that prevent association with the coactivator CBP. Proceedings of the National Academy of Sciences of the United States of America. 93, 13896-13901, 1996. [JCR]　[WOS]
R. P. Kwok, M. E. Laurance, J. R. Lundblad, P. S. Goldman, H. Shih, L. M. Connor, S. J. Marriott and R. H. Goodman. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature. 380, 642-646, 1996. [JCR]　[WOS]
H. C. Towle, E. N. Kaytor and H. M. Shih. Metabolic regulation of hepatic gene expression. Biochem Soc Trans. 24, 364-368, 1996. [JCR]　[WOS]
J. B. Kim, G. D. Spotts, Y. D. Halvorsen, H. M. Shih, T. Ellenberger, H. C. Towle and B. M. Spiegelman. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol. 15, 2582-2588, 1995. [JCR]　[WOS]
P. L. Bergad, H. M. Shih, H. C. Towle, S. J. Schwarzenberg and S. A. Berry. Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two gamma-activated sites. J Biol Chem. 270, 24903-24910, 1995. [JCR]　[WOS]
H. M. Shih, H. C. Towle. Matrigel treatment of primary hepatocytes following DNA transfection enhances responsiveness to extracellular stimuli. Biotechniques. 18, 813-816, 1995. [JCR]　[WOS]
H. M. Shih, Z. Liu and H. C. Towle. Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription. J Biol Chem. 270, 21991-21997, 1995. [JCR]　[WOS]
H. M. Shih, H. C. Towle. Definition of the carbohydrate response element of the rat S14 gene. Context of the CACGTG motif determines the specificity of carbohydrate regulation. J Biol Chem. 269, 9380-9387, 1994. [JCR]　[WOS]
H. M. Shih, H. C. Towle. Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes. J Biol Chem. 267, 13222-13228, 1992. [JCR]　[WOS]
C. L. Kao, C. N. Lee, W. L. Lee, M. T. Hsieh and H. M. Shih. Isolation and typing of herpes simplex virus from clinical specimens collected at National Taiwan University Hospital, 1981-1990. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 24, 255-263, 1991. [JCR]

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