Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 陳燕輝 Chen, Yen-Hui

Journal 34

Mangala Gunatilake*, Qin Chuan, Yen-Hui Chen, . The Status and Emerging Developments in Laboratory Animal Science in Asia since 9th AFLAS Congress (2023) until 10th AFLAS Congress (2025). Animal Models and Experimental Medicine. 8(12), 2157-2175, 2025-12. [JCR]　[WOS]
Lin Ya-Hui, Wang Li-Wen, Chen Yen-Hui, Chan Yi-Chieh, Hu Shang-Hsiu, Wu Sheng-Yan, Chiang Chi-Shiun, Huang Guan-Jie, Yang Shang-Da, Chu Shi-Wei, Wang Kuo-Chuan, Lin Chin-Hsien, Huang Pei-Hsin, Cheng Hwai-Jong, Chen Bi-Chang, Chu Li-An. Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain. eLife. 13, 1-28, 2024. [JCR]　[WOS]
Sun Cheng-Pu, Chiu Chi-Wen, Wu Ping-Yi, Tsung Szu-I, Lee I-Jung, Hu Chih-Wei, Hsu Min-Feng, Kuo Tzu-Jiun, Lan Yu-Hua, Chen Li-Yao, Ng Hui-Yee, Chung Meng-Jhe, Liao Hsin-Ni, Tseng Sheng-Che, Lo Chia-Hui, Chen Yung-Jiun, Liao Chun-Che, Chang Chih-Shin, Liang Jian-Jong, Draczkowski Piotr, Puri Sarita, Chang Yuan-Chih, Huang Jing-Siou, Chen Cheng-Cheung, Kau Jyh-Hwa, Chen Yen-Hui, Liu Wen-Chun, Wu Han-Chung, Danny Hsu Shang-Te, Wang I-Hsuan, Tao Mi-Hua. Development of AAV-delivered broadly neutralizing anti-human ACE2 antibodies against SARS-CoV-2 variants. Molecular Therapy. 31(11), 3322-3336, 2023-11. [JCR]　[WOS]
Lee I-Jung, Lan Yu-Hua, Wu Ping-Yi, Wu Yan-Wei, Chen Yu-Hung, Tseng Sheng-Che, Kuo Tzu-Jiun, Sun Cheng-Pu, Jan Jia-Tsrong, Ma Hsiu-Hua, Liao Chun-Che, Liang Jian-Jong, Ko Hui-Ying, Chang Chih-Shin, Liu Wen-Chun, Ko Yi-An, Chen Yen-Hui, Sie Zong-Lin, Tsung Szu-I, Lin Yi-Ling, Wang I-Hsuan, Tao Mi-Hua. A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern. Emerging Microbes & Infections. 12(1), 1-14, 2022-12-24. [JCR]　[WOS]
Huang Han-Yi, Liao Hsin-Yu, Chen Xiaorui, Wang Szu-Wen, Cheng Cheng-Wei, Shahed-Al-Mahmud Md., Liu Yo-Min, Mohapatra Arpita, Chen Ting-Hua, Lo Jennifer M., Wu Yi-Min, Ma Hsiu-Hua, Chang Yi-Hsuan, Tsai Ho-Yang, Chou Yu-Chi, Hsueh Yi-Ping, Tsai Ching-Yen, Huang Pau-Yi, Chang Sui-Yuan, Chao Tai-Ling, Kao Han-Chieh, Tsai Ya-Min, Chen Yen-Hui, Wu Chung-Yi, Jan Jia-Tsrong, Cheng Ting-Jen Rachel, Lin Kuo-I, Ma Che, Wong Chi-Huey. Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models. Science Translational Medicine. 14(639), 1-13, 2022. [JCR]　[WOS]
Chiang Ming-Tsai, Chen I-Ming, Hsu Fu-Fei, Chen Yen-Hui, Tsai Min-Shao, Hsu Yaw-Wen, Leu Hsin-Bang, Huang Po-Hsun, Chen Jaw-Wen, Liu Fu-Tong, Chen Ying-Hwa, Chau Lee-Young. Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 41(1), 331-345, 2021-1. [JCR]　[WOS]
Lien Chia-En, Lin Yi-Jiun, Chen Charles, Lian Wei-Cheng, Kuo Tsun-Yung, Campbell John D., Traquina Paula, Lin Meei-Yun, Liu Luke Tzu-Chi, Chuang Ya-Shan, Ko Hui-Ying, Liao Chun-Che, Chen Yen-Hui, Jan Jia-Tsrong, Ma Hsiu-Hua, Sun Cheng-Pu, Lin Yin-Shiou, Wu Ping-Yi, Wang Yu-Chiuan, Tao Mi-Hua, Lin Yi-Ling. CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge. Scientific Reports. 11(1), 8761, 2021. [JCR]　[WOS]
Sun Cheng-Pu, Jan Jia-Tsrong, Wang I-Hsuan, Ma Hsiu-Hua, Ko Hui-Ying, Wu Ping-Yi, Kuo Tzu-Jiun, Liao Hsin-Ni, Lan Yu-Hua, Sie Zong-Lin, Chen Yen-Hui, Ko Yi-An, Liao Chun-Che, Chen Liang-Yu, Lee I-Jung, Tsung Szu-I, Lai Yun-Ju, Chiang Ming-Tsai, Liang Jian-Jong, Liu Wen-Chun, Wang Jing-Rong, Yuan Joyce Pei-Yi, Lin Yin-Shiou, Tsai Yi-Ching, Hsieh Shie-Liang, Li Chia-Wei, Wu Han-Chung, Ko Tai-Ming, Lin Yi-Ling, Tao Mi-Hua. Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19. PLOS Pathogens. 17(8), e1009758, 2021. [JCR]　[WOS]
Ke Hung‐Yen, Chin Li‐Han, Tsai Chien‐Sung, Lin Feng‐Zhi, Chen Yen‐Hui, Chang Yung‐Lung, Huang Shih‐Ming, Chen Yao‐Chang, Lin Chih‐Yuan. Cardiac calcium dysregulation in mice with chronic kidney disease. Journal of Cellular and Molecular Medicine. 24(6),3669-3677, 2020-02. [JCR]　[WOS]
Huang Shih-Ting, Wang Yi‑Ping, Chen Yen-Hui, Lin Chin-Tarng, Li Wen-Shan, Wu Han-Chung. Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol. International Journal of Oncology. 53(3), 1105-1117, 2018. [JCR]　[WOS]
Cheng Y-F, Chang Y-T, Chen W-H, Shih H-C, (Chen Y-H), Shyu B-C, Chen C-C. Cardioprotection induced in mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. Nature Communications. 8(1), 826, 2017. [JCR]　[WOS]
Liao W-C, Juo L-Y, Shih Y-L, (Chen Y-H), Yan Y-T. HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity. PLOS GENETICS. 13(8), e1006984, 2017. [JCR]　[WOS]
Hsu YJ, Hsu SC, Hsu CP, (Chen YH), Chang YL, Sadoshima J, Huang SM, Tsai CS, Lin CY. Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model. International journal of cardiology. 228, 543-552, 2017. [JCR]　[WOS]
Chin L-H, Hsu Y-J, Hsu S-C, (Chen Y-H), Chang Y-L, Huang S-M, Tsai C-S, Lin C-Y. The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease. Oncotarget. 8(69), 113303-113317, 2017. [JCR]　[WOS]
Sanjiv K, Chen CW, Kakadiya R, Tala S, Suman S, Wu MH, (Chen YH), Su TL, Lee TC. PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[alpha]indene Derivative in Lung Cancer Cells. Translational oncology. 7(2), 256-266.e5, 2014. [JCR]　[WOS]
Lin HH, (Chen YH), Chiang MT, Huang PL, Chau LY. Activator protein-2alpha mediates carbon monoxide-induced stromal cell-derived factor-1alpha expression and vascularization in ischemic heart. Arteriosclerosis Thrombosis and Vascular Biology. 33(4), 785-794, 2013. [JCR]　[WOS]
Chang YC, Yu YH, Shew JY, Lee WJ, Hwang JJ, (Chen YH), Chen YR, Wei PC, Chuang LM, Lee WH. Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human. EMBO molecular medicine. 5(8), 1165-1179, 2013. [JCR]　[WOS]
(Chen YH)*, Hsu YF, Wu HC. Using a combined procedure of rederivation to eliminate parasites, protozoa, Murine norovirus, Helicobacter spp., Pneumocystis spp. and several opportunistic bacteria from a running animal facility. Journal of the American Association for Laboratory Animal Science. 52(3), 402, 2013. [JCR]
Yeh SY, Pan HJ, Lin CC, Kao YH, (Chen YH), Lin CJ. Hyperglycemia induced down-regulation of renal P-glycoprotein expression. European journal of pharmacology. 690(1-3), 42-50, 2012. [JCR]　[WOS]
Tzeng BH, (Chen YH), Huang CH, Lin SS, Lee KR, Chen CC. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovascular research. 96(3), 533-542, 2012. [JCR]　[WOS]
Krebs P, Fan W, (Chen YH), Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EM, Boyer TG, Lo CW, Yen J, Evans RM, Beutler B. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proceedings of the National Academy of Sciences of the United States of America. 108(49), 19678-19682, 2011. [JCR]　[WOS]
Akgul B, Lin KW, Ou Yang HM, (Chen YH), Lu TH, Chen CH, Kikuchi T, Chen YT, Tu CP. Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. PloS one. 5(12), e15358, 2010. [JCR]　[WOS]
Chien CL, Wu YS, Lai HL, (Chen YH), Jiang ST, Shih CM, Lin SS, Chang C, Chern Y. Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6). FEBS letters. 584(13), 2883-2890, 2010. [JCR]　[WOS]
Saleem AN, (Chen YH), Baek HJ, Hsiao YW, Huang HW, Kao HJ, Liu KM, Shen LF, Song IW, Tu CP, Wu JY, Kikuchi T, Justice MJ, Yen JJ, Chen YT. Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. PLoS genetics. 6(6), e1000985, 2010. [JCR]　[WOS]
Lee MJ, Chang CP, Lee YH, Wu YC, Tseng HW, Tung YY, Wu MT, (Chen YH), Kuo LT, Stephenson D, Hung SI, Wu JY, Chang C, Chen YT, Chern Y. Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus. PloS one. 4(11), e7868, 2009. [JCR]　[WOS]
Cheng CH, Kikuchi T, (Chen YH), Sabbagha NG, Lee YC, Pan HJ, Chang C, Chen YT. Mutations in the SLC2A10 gene cause arterial abnormalities in mice. Cardiovascular research. 81(2), 381-388, 2009. [JCR]　[WOS]
Chiang CS, Huang CH, Chieng H, Chang YT, Chang D, Chen JJ, Chen YC, (Chen YH), Shin HS, Campbell KP, Chen CC. The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice. Circulation research. 104(4), 522-530, 2009. [JCR]　[WOS]
Lin HH, (Chen YH), Chang PF, Lee YT, Yet SF, Chau LY. Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1. Journal of molecular and cellular cardiology. 45(1), 44-55, 2008. [JCR]　[WOS]
Yang HY, Cheng CF, Djoko B, Lian WS, Tu CF, Tsai MT, (Chen YH), Chen CC, Cheng CJ, Yang RB. Transgenic overexpression of the secreted, extracellular EGF-CUB domain-containing protein SCUBE3 induces cardiac hypertrophy in mice. Cardiovascular research. 75(1), 139-147, 2007. [JCR]　[WOS]
Chen YH, Tsai HL, Chiang MT, Chau LY. Carbon monoxide-induced early thrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice. Journal of biomedical science. 13(5), 721-730, 2006. [JCR]　[WOS]
Kao HJ, Cheng CF, (Chen YH), Hung SI, Huang CC, Millington D, Kikuchi T, Wu JY, Chen YT. ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit. Human molecular genetics. 15(24), 3569-3577, 2006. [JCR]　[WOS]
(Chen YH), Stolla R. Using “Uterine Index” to diagnose embryonic death in mares. Journal of Equine Veterinary Science. 26(5), 219-224, 2006. [JCR]　[WOS]
Hu CM, (Chen YH), Chiang MT, Chau LY. Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo. Circulation. 110(3), 309-316, 2004. [JCR]　[WOS]
Stolla R, (Chen YH), Bollwein, H. Examination of embryonic death in mares using colour Doppler and B-mode sonography. PFERDEHEILKUNDE. 17(6), 543-547, 2001. [JCR]　[WOS]

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