Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 林榮信 Lin, Jung-Hsin

Journal 48

Dhananjay C. Joshi, Charlie Gosse, Shu-Yu Huang and (Jung-Hsin Lin*). A curvilinear-path umbrella sampling approach to characterizing the interactions between rapamycin and three FKBP12 variants. FRONTIERS IN MOLECULAR BIOSCIENCES. 9, 879000-879000, 2022-07-08. [JCR]
Wei Lim Chonga, Visit Vao-soongnern, Piyarat Nimmanpipug, Chatchai Tayapiwatana, (Jung-Hsin Lin,) Yi-Ling Lin, Hui Yee Cheeg, Sharifuddin Md Zain. Molecular dynamics simulations and Gaussian network model for designing antibody mimicking protein towards dengue envelope protein. JOURNAL OF MOLECULAR LIQUIDS. 346, 118086-118086, 2022-01-15. [JCR]
Antonio Mucherino, Douglas Gonçalves, Leo Liberti, (Jung-Hsin Lin*), Carlile Lavor, Nelson Maculan. MD-jeep: a New Release for Discretizable Distance Geometry Problems with Interval Data. Annals of Computer Science and Information Systems. 21, 289-294, 2020-10. [JCR]
Chen, CT, Liao, LZ, Lu, CH,Huang, YH, Lin, YK, (Lin, JH),Chow, LP. Quantitative phosphoproteomic analysis identifies the potential therapeutic target EphA2 for overcoming sorafenib resistance in hepatocellular carcinoma cells. EXPERIMENTAL AND MOLECULAR MEDICINE. 52(3), 497-513, 2020-03. [JCR]　[WOS]
Joshi Dhananjay C., (Lin Jung‐Hsin*). Delineating Protein–Protein Curvilinear Dissociation Pathways and Energetics with Naïve Multiple‐Walker Umbrella Sampling Simulations. Journal of Computational Chemistry. 40(17) 1652-1663, 2019-06. [JCR]　[WOS]
Hsien-Tsung Chiu, Li-Jiuan Shen, Yee-Chun Chen, (Jung-Hsin Lin), Chi-Chuan Wang. Effect of Statin Use on the Risk of Medically Attended Acute Respiratory Illness among Influenza Vaccinated Elderly. VACCINE. 36, 6133-6137, 2018-10. [JCR]　[WOS]
Shin-Fu Chen, Nan-Lan Huang, (Jung-Hsin Lin), Chyuan-Chuan Wu, Ying-Ren Wang, Yu-Jen Yu, Michael K. Gilson, and Nei-Li Chan. Structural insights into the gating of DNA passage by the topoisomerase II DNA gate. NATURE COMMUNICATIONS. 9, 3085, 2018-08. [JCR]　[WOS]
Yu-Hsuan Chen and (Jung-Hsin Lin*). Can ligands of different functional types induce distinct dynamics in G protein-coupled receptors? . CURRENT MEDICINAL CHEMISTRY. 17, 2370-2380, 2017-03. [JCR]　[WOS]
Ronald D Gorham, Vicente Nunez, (Jung-Hsin Lin), Suzan HM Rooijakkers, Valentine I. Vullev, and Dimitrios Morikis. Discovery of small molecules for fluorescent detection of complement activation product C3d. JOURNAL OF MEDICINAL CHEMISTRY. 58, 9535-9545, 2015-12. [JCR]　[WOS]
(Jung-Hsin Lin*). Structure- and dynamics-based computational design of anticancer drugs. BIOPOLYMERS. 105, 2-9, 2015-10. [JCR]　[WOS]
Pei-Lung Chen, Shyang-Rong Shih, Pei-Wen Wang, Ying-Chao Lin, Chen-Chung Chu, (Jung-Hsin Lin), Szu-Chi Chen, Ching-Chung Chang, Tien-Shang Huang, Keh Sung Tsai, Fen-Yu Tseng, Chih-Yuan Wang, Jin-Ying Lu, Wei-Yih Chiu, Chien-Ching Chang, Yu-Hsuan Chen, Yuan-Tsong Chen, Cathy Shen-Jang Fann, Wei-Shiung Yang and Tien-Chun Chang. Concurrent direct human leukocyte antigen (HLA) genotyping and genome-wide association study (GWAS) reveal major genetic determinants of anti-thyroid drug-induced agranulocytosis. Nature Communications. 6, 7633, 2015-07. [JCR]　[WOS]
Nanlan Huang and (Jung-Hsin Lin*). Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation. NUCLEIC ACIDS RESEARCH. 43, 6772-6786, 2015-07. [JCR]　[WOS]
Yu-Hsuan Chen, (Jung-Hsin Lin*). Prediction of functional types of ligands for G protein-coupled receptors with dynamically discriminable states embedded in low dimension. Lecture Notes in Computer Science. 9044, 627-634, 2015-04. [JCR]
Pei-Teh Chang, Rahul Subhash Talekar, Fan-Lu Kung, Ting-Rong Chern, Chen-Wei Huang, Qing-qing Ye, Min-Yan Yang, Chao-Wu Yu, Shin-Yu Lai, Ravindra Ramesh Deore, (Jung-Hsin Lin), Chien-Shu Chen, Grace Shiahuy Chen, Ji-Wang Chern. A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth. NEUROPHARMACOLOGY. 92, 146-157, 2015-01. [JCR]　[WOS]
Laurent Sabater, Pei-Ju Fang, Chi-Fon Chang, Aurore De Rache, Enora Prado, Jerôme Dejeu, Antonio Garofalo, (Jung-Hsin Lin), Jean-Louis Mergny, Eric Defrancq and Geneviève Pratviel. Cobalt(III)porphyrin to target G-quadruplex DNA. DALTON TRANSACTIONS. 44, 3701-3707, 2015-01. [JCR]　[WOS]
Yi-Shan Lin, (Jung-Hsin Lin), Chia-Chuan Chang, and Shoei-Sheng Lee. Tetrahydropyran and Tetrahydrofuran Containing Diarylheptanoids from Hedychium coronarium Rhizomes. JOURNAL OF NATURAL PRODUCTS. 78, 181-187, 2015-01. [JCR]　[WOS]
Nan-Lan Huang and (Jung-Hsin Lin*). Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes. MOLECULES. 15, 7415-7428, 2014-06. [JCR]
2.Chiou-Tsun Tsai, Pei-Ming Yang, Ting-Rong Chern, Shu-Hui Chuang, Jung-Hsin Lin, Lars Klemm, Markus Müschen and Ching-Chow Chen. AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine. Oncotarget. 5(1), 211-223, 2014-01. [JCR]
Jhih-Bin Chen , Ting-Rong Chern , Tzu-Tang Wei , Ching-Chow Chen , (Jung-Hsin Lin)*, and Jim-Min Fang*. Design and synthesis of dual-action inhibitors targeting histone deacetylases and HMG-CoA reductase for cancer treatment. JOURNAL OF MEDICINAL CHEMISTRY. 56(9),3645-3655, 2013-04. [JCR]
Jui-Chih Wang and (Jung-Hsin Lin*). Scoring functions for prediction of protein-ligand interactions . CURRENT PHARMACEUTICAL DESIGN. 19, 2174-2182, 2013-03. [JCR]
(Jung-Hsin Lin*). Target prediction of small molecules with information of key molecular interactions. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 12(17), 1903-1910, 2012-12. [JCR]
Darby Tien-Hao Chang, Chao-Hsuan Ke, (Jung-Hsin Lin), and Jung-Hsien Chiang . AutoBind: Automatic extraction of protein-ligand binding affinity data from biological literature . BIOINFORMATICS. 28, 2162-2168, 2012-08. [JCR]
Ravindra Ramesh Deore, Grace Shiahuy Chen, Pei-Teh Chang, Ting-Rong Chern, Shin-Yu Lai, Ming-Hsieh Chuang, Jung-Hsin Lin, Fan-Lu Kung, Chien-Shu Chen, Chun-Tang Chiou, Ji-Wang Chern. Discovery of N-Arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors . ChemMedChem. 7,850-860, 2012-03. [JCR]
Jui-Chih Wang,(Jung-Hsin Lin*),Chung-Ming Chen, Alex L. Perryman, Arthur J. Olson. Robust scoring functions for protein-ligand interactions with quantum chemical charge models. J. Chem. Inf. Model.. 51, 2528-2537, 2011-09. [JCR]　[WOS]
Nai-Kuei Huang,¥ Jung-Hsin Lin,¥ Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijung Chern . A new drug design targeting the adenosinergic system for Huntington's disease . PLoS ONE. 6,e20934, 2011-06. [JCR]　[WOS]
Jhih-Bin Chen, Eric Minwei Liu, Ting-Rong Chern, Chieh-Wen Yang, Chia-I Lin, Nai-Kuei Huang, Yun-Lian Lin, Yijuang Chern,Jung-Hsin Lin,* and Jim-Min Fang*. Design and synthesis of novel dual-action compounds targeting adenosine A2A receptor and adenosine transporter for neuroprotection . ChemMedChem. 6, 1390-1400, 2011-06. [JCR]　[WOS]
Jung-Hsin Lin*. Accommodating protein flexibility for structure-based drug design. Current Topics in Medicinal Chemistry. 11, 171-178, 2011-01. [JCR]　[WOS]
Wei-Jan Huang, Chih-Chiang Huang, Ling-Wei Hsin, Yeun-Min Tsai, Chin-Ting Lin, Jung-Hsin Lin, and Shoei-Sheng Lee . Improved enamine-type addition of dehydroaporphine using microwave irradiation. TETRAHEDRON LETTERS. 51, 3062-3064, 2010-04. [JCR]　[WOS]
Yang-Shan Lin, Jung-Hsin Lin*, and Chien-Cheng Chang . Molecular dynamics simulations of the rotary motor Fo under external electric fields across the membrane . Biophysical Journal. 98, 1009-1017, 2010-03. [JCR]　[WOS]
Pei-Ming Yang, Jung-Hsin Lin, Wen-Yu Huang, Yi-Chu Lin, Shu-Hao Yeh, and Ching-Chow Chen . Inhibition of histone deacetylase activity is a novel function of antifolate drug methotrexate . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 391, 1396-1399, 2010-02. [JCR]　[WOS]
Po-Hsien Lee, Kuei-Ling Kuo, Pei-Ying Chu, Eric M. Liu, and Jung-Hsin Lin*. SLITHER: a web server for generating contiguous conformations of substrate molecules entering into deep active sites of proteins or migrating through channels in membrane transporters . Nucleic Acids Research. 37, W559-W564, 2009-07. [JCR]　[WOS]
Y. C. Lin, J. H. Lin, C. W. Chou, Y. F. Chang, S. H. Yeh and C. C. Chen. Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2. Cancer Research. 68(7), 2375-2383, 2008. [JCR]　[WOS]
S. S. Lee, U. Venkatesham, C. P. Rao, S. H. Lam and J. H. Lin. Preparation of secolycorines against acetylcholinesterase. Bioorganic & Medicinal Chemistry. 15(2), 1034-1043, 2007. [JCR]
R. E. Amaro, D. D. L. Minh, L. S. Cheng, W. M. Jr. Lindstrom, A. J. Olson, J. H. Lin, W. W. Li and J. A McCammon. Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design. J Am Chem Soc. 129(25), 7764-7765, 2007. [JCR]
D. Vigil, J.-H. Lin, C. A. Sotriffer, J. K. Pennypacker, J. A. McCammon and S. S. Taylor. A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Science. 15, 113-121, 2006. [JCR]　[WOS]
J. R. Giorgione, J.-H. Lin, J. A. McCammon and A. C. Newton. Increased membrane affinity of the C1 domain of protein kinase Cdelta components for the lack of involvement of its C2 Domain in membrane recruitment. J. Biol. Chem. 281, 1660-1669, 2006. [JCR]　[WOS]
A. L. Perryman, J.-H. Lin and J.A. McCammon. Optimization and computational evaluation of a series of potential active site inhibitors of the V82F/I84V drug-resistant mutant of HIV-1 protease: an application of the relaxed complex method of structure-based drug design. Chemical Biology & Drug Design. 67(5), 336-345, 2006. [JCR]
D. T.-H. Chang, Y.-Z. Weng, J.-H. Lin, M.-J. Hwang and Y.-J. Oyang. Promtemot: prediction of protein binding sites with automatically extracted geometrical templates. Nucleic Acids Res. 34(Web Server issue), W303-309, 2006. [JCR]
A. L. Perryman, J.-H. Lin and J. A. McCammon. Restrained molecular dynamics of HIV-1 protease: Validating a new target for drug design. Biopolymers. 82, 272-284, 2006. [JCR]　[WOS]
D. T.-H. Chang, Y.-J. Oyang and J.-H. Lin*. MEDock: a web server for efficient prediction of ligand binding sites based on a novel optimization algorithm. Nucleic Acids Res. 33, W233-W238, 2005. [JCR]　[WOS]
A. L. Perryman, J.-H. Lin and J. A. McCammon. HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: Possible contributions to drug resistance and a potential new drug target site for drugs. Protein Science. 13, 1108-1123, 2004. [JCR]　[WOS]
Lin JH, Perryman AL, Schames JR, McCammon JA. The relaxed complex method: Accommodating receptor flexibility for drug design with an improved scoring scheme. Biopolymers. 68(1), 47-62, 2003. [JCR]　[WOS]
J.-H Lin*, N. A. Baker and J. A. McCammom. Bridging implicit and explicit solvent approaches for membrane electrostatics. Biophysical Journal. 83, 1374-1379, 2002-09. [JCR]　[WOS]
Lin JH, Perryman AL, Schames JR, McCammon JA. Computational drug design accommodating receptor flexibility: the relaxed complex scheme. Journal of the American Chemical Society. 124(20), 5632-3, 2002. [JCR]
J.-H Lin*, A. L. Perryman, J. R. Schames and J. A. McCammom. Computational drug design acommodating receptor flexibility: The relaxed complex scheme. J. Am. Chem. Soc. 124, 5632-5633, 2002. [JCR]　[WOS]
Lin JH, Baumgaertner A. Stability of a melittin pore in a lipid bilayer: a molecular dynamics study. Biophysical journal. 78, 1714-1724, 2000-04. [JCR]
J.-H. Lin, A. Baumgaertner. Adsorption of melittin to a lipid bilayer : a molecular dynamics study. Journal of Molecular Liquids. 84, 89-98, 2000. [JCR]　[WOS]
J.-H. Lin, A. Baumgaertner. Molecular dynamics simulations of hydrophobic and amphiphatic proteins interacting with a lipid bilayer membrane. Comput. Theor. Poly. Sci.. 10, 97-102, 2000. [JCR]　[WOS]

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