Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 陳儀莊 Chern, Yijuang

Journal 133

1.Siew JJ, Chen H-M, Chiu F-L, Lee C-W, Chang Y-M, Chen H-L, Nguyen TNA, Liao H-T, Liu M, Hagar H-T, Sun Y-C, Lai H-L, Kuo M-H, Blum D, Buee L, Jin L-W, Chen S-Y, Ko T-M, Huang J-r, Kuo H-C, Liu F-T, Chern Y*. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. JOURNAL OF CLINICAL INVESTIGATION. , 2023-11-21. [JCR]　[WOS]
Hsu Yi-Ting, Chang Ya-Gin, Liu Yu-Chao, Wang Kai-Yi, Chen Hui-Mei, Lee Ding-Jin, Yang Sung-Sen, Tsai Chon-Haw, Lien Cheng-Chang, Chern Yijuang. Enhanced Na+-K+-2Cl- cotransporter 1 underlies motor dysfunction in huntington's disease. Movement Disorders. 34(6),845-857, 2019-06. [JCR]　[WOS]
Ho S-Y, Chen I-C, Tsai C-W, Chang K-C, Lin C-J, Chern Y, Liou H-H*. Anticonvulsant effect of equilibrative nucleoside transporters 1 inhibitor in a mouse model of Dravet syndrome. HIPPOCAMPUS. 34(1), 7-13, 2023-11-06. [JCR]　[WOS]
Siew Jian Jing, Chern Yijuang, Khoo Kay-Hooi, Angata Takashi. Roles of Siglecs in neurodegenerative diseases. Molecular Aspects of Medicine. 90, 101141, 2023-04. [JCR]　[WOS]
Chen Ching-Ya, Chou Fang-Yi, Chang Ya-Gin, Ho Chin-Jui, Wu Kuo-Chen, Hsu Chia-Lin, Chern Yijuang, Lin Chun-Jung. Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease. Neurobiology of Disease. 177, 106004, 2023-02. [JCR]　[WOS]
Chen Kuan-Yu, Lu Chiao-Shin, Pang Cheng-Yoong, Ho Chin-Jui, Wu Kuo-Chen, Yang Hsiu-Wei, Lai Hsin-Lin, Chern Yijuang, Lin Chun-Jung. Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury. Molecular Neurobiology. 60(1), 369-381, 2023-01. [JCR]　[WOS]
Lee Yan Hua, Lee Yi‐Chung, Tsai Yu‐Shuen, Yang Ueng‐Cheng, Cheng Tzu‐Hao, Chern Yijuang, Soong Bing‐Wen. Reply to: “Low Frequency of p.S510G in PIAS1 Challenges Its Relevance for Modifying Repeat Expansion Disorders”. Movement Disorders. 37(10), 2169-2169, 2022-10-17. [JCR]　[WOS]
Yu-Ting Weng, Hui-Mei Chen, Ting Chien, Feng-Lan Chiu, Hung-Chih Kuo, (Yijuang Chern)*. TRAX Provides Neuroprotection for Huntington's Disease Via Modulating a Novel Subset of MicroRNAs. Movement Disorders. 37(10), 2008-2020, 2022-10-17. [JCR]　[WOS]
Wang Lee-Hsin, Lin Chien-Yu, Lin Yu-Mei, Buée Luc, Sergeant Nicolas, Blum David, Chern Yijuang, Wang Guey-Shin. Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration. The Journal of Neuroscience. 42(25), 5102-5114, 2022-05-23. [JCR]　[WOS]
Peyton L, Leon B, Essa H, Chern Y, Choi DS. N$^6$-Substituated Adenosine Analog J4 Attenuates Anxiety-like Behaviors in Mice. PSYCHOPHARMACOLOGY. 239, 887-895, 2022-01-31. [JCR]　[WOS]
Yan Hua Lee, BSc, Yu-Shuen Tsai, Che-Chang Chang, Chun-Chen Ho, Hsiu-Ming Shih, Hui-Mei Chen, Hsing-Lin Lai, Chia-Wei Lee, Yi-Chung Lee, Yi-Chu Liao, Ueng-Cheng Yang, Tzu-Hao Cheng, Yijuang Chern, and Bing-Wen Soong,. A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis. MOVEMENT DISORDERS. 10.1002/mds.28896, 1-12, 2021-12. [JCR]　[WOS]
Liu Yu-Ju, Kuo Hung-Chih, Chern Yijuang. A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS. Neurobiology of Disease. 160, 105531, 2021. [JCR]　[WOS]
Wu Kuo-Chen, Lee Chih-Yu, Chern Yijuang, Lin Chun-Jung. Amelioration of lipopolysaccharide-induced memory impairment in equilibrative nucleoside transporter-2 knockout mice is accompanied by the changes in glutamatergic pathways. Brain, Behavior, and Immunity. 96, 187-199, 2021. [JCR]　[WOS]
Yu-Ju Liu, Yijuang Chern. Contribution of energy dysfunction to impaired protein translation in neurodegenerative diseases. Frontiers in Cellular Neuroscience. 15, 668500, 2021. [JCR]　[WOS]
Chang Ching-Pang, Wu Kuo-Chen, Lin Chien-Yu, Chern Yijuang. Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases. Journal of Biomedical Science. 28(1), 70-94, 2021. [JCR]　[WOS]
Ching-Pang Chang; Ya-Gin Chang; Pei-Yun Chuang; Anh Thi Ngoc Nguyen; Kuo-Chen Wu; Fang-Yi Chou; Sin-Jhong Cheng; Hui-Mei Chen; Lee-Way Jin; Kevin Carvalho; Vincent Huin; Luc Buée; Yung-Feng Liao; Chun-Jung Lin; David Blum; Yijuang Chern. Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy. Acta Neuropathologica Communications. 9, 112-129, 2021. [JCR]　[WOS]
Jen Wei-Ping, Chen Hui-Mei, Lin Yow-Sien, Chern Yijuang, Lee Yi-Ching. Twist1 Plays an Anti-apoptotic Role in Mutant Huntingtin Expression Striatal Progenitor Cells. Molecular Neurobiology. 57(3),1688-1703, 2020-03. [JCR]　[WOS]
Wu Kuo-Chen, Lee Chih-Yu, Chou Fang-Yi, Chern Yijuang, Lin Chun-Jung. Deletion of equilibrative nucleoside transporter-2 protects against lipopolysaccharide-induced neuroinflammation and blood-brain barrier dysfunction in mice. Brain, Behavior, and Immunity. 84, 59-71, 2020. [JCR]　[WOS]
Carvalho Kevin, Faivre Emilie, Pietrowski Marie J, Marques Xavier, Gomez-Murcia Victoria, Deleau Aude, Huin Vincent, Hansen Jan N, Kozlov Stanislav, Danis Clément, Temido-Ferreira Mariana, Coelho Joana E, Mériaux Céline, Eddarkaoui Sabiha, Gras Stéphanie Le, Dumoulin Mélanie, Cellai Lucrezia, Landrieu Isabelle, Chern Yijuang, Hamdane Malika, Buée Luc, Boutillier Anne-Laurence, Levi Sabine, Halle Annett, Lopes Luisa V, Blum David, . Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor. Brain. 142(11) 3636-3654, 2019-11. [JCR]　[WOS]
Hong Sa-Ik, Peyton Lee, Chern Yijuang, Choi Doo-Sup. Novel Adenosine Analog, N6-(4-Hydroxybenzyl)-Adenosine, Dampens Alcohol Drinking and Seeking Behaviors. Journal of Pharmacology and Experimental Therapeutics. 371(2) 260-267, 2019-11. [JCR]　[WOS]
Lin Chien-Yu, Lai Hsing-Lin, Chen Hui-Mei, Siew Jian-Jing, Hsiao Cheng-Te, Chang Hua-Chien, Liao Kuo-Shiang, Tsai Shih-Chieh, Wu Chung-Yi, Kitajima Ken, Sato Chihiro, Khoo Kay-Hooi, Chern Yijuang. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors. Translational Psychiatry. 9(1), 2019-08. [JCR]　[WOS]
Chern Yijuang, Rei Nádia, Ribeiro Joaquim A., Sebastião Ana M. Adenosine and Its Receptors as Potential Drug Targets in Amyotrophic Lateral Sclerosis. Journal of Caffeine and Adenosine Research. 9(4), 157-166, 2019. [JCR]
Siew Jian Jing, Chen Hui-Mei, Chen Huan-Yuan, Chen Hung-Lin, Chen Chiung-Mei, Soong Bing-Wen, Wu Yih-Ru, Chang Ching-Pang, Chan Yi-Chen, Lin Chun-Hung, Liu Fu-Tong, Chern Yijuang. Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease. Nature Communications. 10(1), 2019. [JCR]　[WOS]
Chien T, Weng Y-T, Chang S-Y, Lai H-L, Chiu F-L, Kuo H-C, Chuang D-M and Chern Y. GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons. MOLECULAR PSYCHIATRY. 23(12), 2375-2390, 2018-12. [JCR]　[WOS]
Hsu Yi-Ting, Chang Ya-Gin, Chern Yijuang. Insights into GABA A ergic system alteration in Huntington's disease. Open Biology. 8(12) 180165, 2018-12. [JCR]　[WOS]
Faivre Emilie, Coelho Joana E., Zornbach Katja, Malik Enas, Baqi Younis, Schneider Marion, Cellai Lucrezia, Carvalho Kevin, Sebda Shéhérazade, Figeac Martin, Eddarkaoui Sabiha, Caillierez Raphaëlle, Chern Yijuang, Heneka Michael, Sergeant Nicolas, Müller Christa E., Halle Annett, Buée Luc, Lopes Luisa V., Blum David. Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease. Frontiers in Molecular Neuroscience. 11, 2018-07. [JCR]　[WOS]
Lee CC, Chang CP, Lin CJ, Lai HL, Kao YH, Cheng SJ, Chen HM, Liao YP, Faivre E, Buee L, Blum D, Fang JM, Chern Y. Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer\'s Disease. Molecular neurobiology. 55(12), 8936-8952, 2018-04. [JCR]　[WOS]
Lai CY, Liu YJ, Lai HL, Chen HM, Kuo HC, Liao YP, Chern Y. The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration. Frontiers in neuroscience. 20(12), 187, 2018-03. [JCR]　[WOS]
Chern Yijuang, Chien Ting, Fu Xiuping, Shah Aparna P., Abel Ted, Baraban Jay M. Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair. Neurobiology of Learning and Memory. 159, 46-51, 2018-03. [JCR]　[WOS]
Lin Meng-Syuan, Liao Po-Yu, Chen Hui-Mei, Chang Ching-Pang, Chen Shih-Kuo, Chern Yijuang. Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment. The Journal of Neuroscience. 39(8), 1505-1524, 2018. [JCR]　[WOS]
Jian Jing Siew, Yijuang Chern. Microglial Lectins in Health and Neurological Diseases. Frontiers in Molecular Neuroscience. 11, 158, 2018. [JCR]　[WOS]
Blum David, Chern Yijuang, Domenici Maria Rosaria, Buée Luc, Lin Chien-Yu, Rea William, Ferré Sergi, Popoli Patrizia. The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease. Journal of Caffeine and Adenosine Research. 8(2), 43-58, 2018. [JCR]
Hsiao C-T, Wang P-W, Chang H-C, Chen Y-Y, Wang S-H, Chern Y and Khoo K-H. Advancing a high throughput glycotope-centric glycomics workflow based on nanoLC-MS(2)-product dependent-MS(3) analysis of permethylated glycans. MOLECULAR & CELLULAR PROTEOMICS. 16(12), 2268-2280, 2017-10. [JCR]　[WOS]
Ferrante A, Pezzola A, Matteucci A, Di Biase A, Attorri L, Armida M, Martire A, Chern Y and Popoli P. The adenosine A2A receptor agonist T1-11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease. NEUROBIOLOGY OF DISEASE. 110, 1-11, 2017-10. [JCR]　[WOS]
Wu Y-S, Chen C-C, Chien C-L, Lai H-L, Jiang S-T, Chen Y-C, Lai L-P, Hsiao W-F, Chen W-P, Chern Y. The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway. JOURNAL OF BIOMEDICAL SCIENCE. 24(1), 68, 2017-09. [JCR]　[WOS]
Hsu Y-T, Chang Y-G, Chang C-P, Siew J-J, Chen H-M, Tsai C-H, Chern Y. Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease. MOVEMENT DISORDERS. 32(11), 1600-1609, 2017-08. [JCR]　[WOS]
Liu Y-J, Tsai P-Y, Chern Y*. Energy homeostasis and abnormal RNA metabolism in amyotrophic lateral sclerosis. FRONTIERS IN CELLULAR NEUROSCIENCE. 11, 126, 2017-05. [JCR]　[WOS]
Guitart X, Chern Y, Ferre S. Targeting the equilibrative nucleoside transporter ENT1 in Huntington disease. ONCOTARGET. 8(8), 12550-12551, 2017-02. [JCR]　[WOS]
Kao Y-H*, Lin M-S*, Chen C-M, Wu Y-R, Chen H-M, H-L Lai, Chern Yξ, and Lin C-J. Targeting ENT1 and adenosine tone for the treatment of Huntington’s disease. HUMAN MOLECULAR GENETICS. 26, 467, 2017-01. [JCR]　[WOS]
Guitart X, Bonaventura J, Rea W, Orru M, Cellai L, Dettori I, Pedata F, Brugarolas M, Cortes A, Casado V, Chang C-P, Narayanan M, Chern Y, and Ferre S. Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease. NEUROBIOLOGY OF DISEASE. 96, 47, 2016-10. [JCR]　[WOS]
Chang C-P, Lee C-T, Hou W-H, Lin M-S, Lai H-L, Chien C-L, Chang C, Cheng P-L, Lien CC, and Chern Y*. Type VI adenylyl cyclase regulates NR2B-mediated LTD via a cyclase-independent pathway. Scientific Reports. 6, 22529, 2016-03. [JCR]　[WOS]
Wang J-Y, Chen S-Y, Sun C-N, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 35(13), 1657-1670, 2016. [JCR]　[WOS]
Sun C-S, Lee C-C, Li Y-N, Yang S Y-C, Lin C-H, Chang Y-C, Liu P-F, He R-Y, Wang C-H, Chen W, Chern Y*, Huang J J-T. Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect. Scientific Reports. 5, 14992, 2015-10. [JCR]　[WOS]
Hsiao H-Y*, Chen Y-C*, Huang C-H*, Chen C-C, Hsu Y-H, Chen H-M, Chiu F-L, Kuo H-C, Chang C, Chern Y. Aberrant Astrocytes Impair Vascular Reactivity in Huntington’s Disease. Annals of Neurology. 78(2), 78-192, 2015-08. [JCR]　[WOS]
Chiu F-L, Lin J-T, Chuang C-Y, Chien T, Chen C-M, Chen K-H, Hsiao H-Y, Lin Y-S, Chern Y, Kuo HC. Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington’s disease iPSCs. . Human Molecular Genetics. 24(21), 6066-6079, 2015-07. [JCR]　[WOS]
Kao YH, Chern Y, Yang HT, Chen HM, Lin CJ. Regulation of P-glycoprotein expression in brain capillaries of Huntington’s disease transgenic mice and its impact on brain availability of antipsychotic agents risperidone and paliperidone. . Journal of Cerebral Blood Flow and Metabolism. 36, 1412, 2015-07. [JCR]　[WOS]
Shen W-C, Li H-Y, Gen G-C, Chern Y and Tu P-h*. Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism. Autophagy. 11(4), 685-700, 2015-04. [JCR]　[WOS]
Liu, K. Y. Shyu, Y. C. Barbaro, B. A. Lin, Y. T. Chern, Y. Thompson, L. M. James Shen, C. K. Marsh, J. L. Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease. Human molecular genetics. 24(6), 1602-1616, 2015-03. [JCR]　[WOS]
Cheng, H.M., Y. Chern, I.H. Chen, C.R. Liu, S.H. Li, S.J. Chun, F. Rigo, C.F. Bennett, N. Deng, Y. Feng, C.S. Lin, Y.T. Yan, S.N. Cohen, and T.H. Cheng. Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown. . PLoS Genetics. 11(3), e1005043, 2015-03. [JCR]　[WOS]
Liu, Y. J. Lee, L. M. Lai, H. L. Chern, Y. Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis. FEBS letters. 589, 432-439, 2015-02. [JCR]　[WOS]
Liu Y-J, Ju T-C, Chen H-M, Jang Y-s, Lee L-M, Lai H-L, Tai H-C, Fang J-M, Lin Y-L, Tu P-H*, Chern Y. Activation of AMP-activated protein kinase alpha1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. Human molecular genetics. 24, 787-801, 2015-02. [JCR]　[WOS]
Hsiao, H.Y., Y.C. Chen, C.H. Huang, C.C. Chen, Y.H. Hsu, H.M. Chen, F.L. Chiu, H.C. Kuo, C. Chang, and Y. Chern. . Aberrant astrocytes impair vascular reactivity in huntington's disease. Annals of neurology. Annals of neurology. 78(2), 178-192, 2015. [JCR]　[WOS]
Liu Y-J and Chern Y. AMPK-mediated regulation of neuronal metabolism and function in brain diseases. . Journal of Neurogenetics. 29(2-3), 50-58, 2015. [JCR]　[WOS]
Chen CM, Lin YS, Wu YR, Chen P, Tsai FJ, Yang CL, Tsao YT, Chang W, Hsieh IS, Chern Y, Soong BW. High Protein Diet and Huntington's Disease. PloS one. 10(5), e0127654, 2015. [JCR]　[WOS]
Ju T-C, Chen H-M, Chen Y-C, Chang C-P, Chang Ch, Chern Y*. AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington’s disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1842, 1668-1680, 2014-09. [JCR]　[WOS]
Hsiao Y-H, Chiu F-L, Chen C-M, Wu Y-R, Chen H-M, Chen Y-C Kuo H-C, Chern Y*. Inhibition of soluble tumor necrosis factor is therapeutic in Huntington’s disease. . Human molecular genetics. 23(16), 4328-4344, 2014-08. [JCR]　[WOS]
Sun C-S, Wang C Y-H, Chen B P-W, Wang C-H, Chen W, Chern Y, Huang J J-T*. The influence of pathological mutations and proline substitutions in TDP-43 C-terminal peptides on its amyloid properties and cellular toxicity. PLoS One.. 9(8), e103644, 2014-08. [JCR]　[WOS]
Huang P-C, Hsiao T-Y, Kao S-Y, Chen C-F, Chen Y-C, Chiang C-W, Lee C-f, Lu J-C, Chern Y, Wang C-T. Adenosine A2A receptor up-regulates retinal wave frequency via starbust amacrine cells in the developing rat retina. PLoS One. 9(4), e95090, 2014-04. [JCR]　[WOS]
Lee C-F, Lai H-L, Lee Y-C, Chien C-L, Chern Y*. The A2A adenosine receptor is a dual-coding gene: a novel mechanism of gene usage and signal transduction. JOURNAL OF BIOLOGICAL CHEMISTRY. 289(3), 1257-1270, 2014-01. [JCR]　[WOS]
Hsiao H-Y, Chen Y-C, Chen H-M, Tu P-H, Chern Y*. A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease. . HUMAN MOLECULAR GENETICS. 22(9), 1826-1842, 2013. [JCR]　[WOS]
Wu Y-C, Lai H-L, Chang W-C, Liu Y-J, Chern Y. A novel Gas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1833(12), 3145-3154, 2013. [JCR]　[WOS]
Lin Y, Cheng T-H, Chang C-P, Chen H-M, Chern Y*. Enhancement of brain-type creatine kinase activity ameliorates neuronal deficits in Huntington's disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1832(6), 742-753, 2013. [JCR]　[WOS]
Lin J-T, Chang W-C, Chen H-M, Lai H-L, Chen C-Y, and Chern Y*. Feedback regulation between protein kinase A and the proteasome system worsens Huntington’s disease. MOLECULAR AND CELLULAR BIOLOGY. 33(5), 1073-1084, 2013. [JCR]　[WOS]
Chien C-L, Lin M-S, Lai H-L, Wu Y-S, Chang C-P, Chen H-M, Chang, C, Su C-K, Chern Y*. Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice. EXPERIMENTAL NEUROLOGY. 248, 10-15, 2013. [JCR]　[WOS]
Chen C-C, Chen Y-C, Hsiao, H-Y, Chang Cx, Chern Y. Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging (MRI) studies. JOURNAL OF BIOMEDICAL SCIENCE. 20, 47, 2013. [JCR]　[WOS]
Lin C-Y, Hsu Y-H, Lin M-H, Yang T-H, Chen H-M, Chen Y-C, Hsiao H-Y, Chen C-C, Chern Y, Chang C. Neurovascular abnormalities in humans and mice with Huntington's disease. EXPERIMENTAL NEUROLOGY. 250, 20-30, 2013. [JCR]　[WOS]
Ju T-C, Lin-Y-S, Chern Yx. Energy Dysfunction in Huntington’s Disease: Insights from PGC-1α, AMPK, and CKB. CELLULAR AND MOLECULAR LIFE SCIENCES. 69(24), 4107-4120, 2012-05. [JCR]　[WOS]
Chiang M-Cx, Chern Y, Huang, R-N. PPARgamma rescue of the mitochondrial dysfunction in Huntington's Disease. . Neurobiology of Disease. 45, 322-328, 2012. [JCR]　[WOS]
Liu Chia-Rung; Chang Chuang-Rung; ChernYijuang; et al. Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats . CELL. 148(4), 690-701, 2012. [JCR]　[WOS]
Wu C-S , Lin J-T , -Chien C-L, Chang W-C, Lai H-L, Chang C-P, Chern Y. Type VI adenylyl cyclase (AC6) regulates neurite extension by binding to Snapin and Snap25. MOLECULAR AND CELLULAR BIOLOGY. 31(24), 4874-4886, 2011-12. [JCR]　[WOS]
Lin Yow-Sien; Wang Chih-Hung; Chern Yijuang. Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause? . Aging-US. 3(6), 657-662, 2011. [JCR]　[WOS]
Lin Yuan-Ta; Chern Yijuang; Shen Che-KunJames; et al. Human Mesenchymal Stem Cells Prolong Survival and Ameliorate Motor Deficit through Trophic Support in Huntington's Disease Mouse Models . PLOS ONE. 6(8), e22924, 2011. [JCR]　[WOS]
Huang N-K*, Lin J-H*, Lin J-T, Lin C-I, Liu E M, Lin C-J, Chen W-P, Shen Y-C, Chen H-M, Chen J-B, Lai H-L, Yang C-W, Chiang C-M, Wu Y-S, Chang C, Chen J-F, Fang J-Mx, Lin Y-Lx and Chern Y. A New Drug Design Targeting the Adenosinergic System for Huntington's Disease. PLoS ONE. 6, e20934, 2011. [JCR]　[WOS]
Wu Y, Williamson R, Li Z, Vicario A, Xu J, Kasai M, Chern Y, Tongiorgi E, Baraban J. Dendritic trafficking of BDNF mRNA: regulation by translin-dependent and -independent mechanisms. Journal of Neurochemistry. 116, 1112-1121, 2011. [JCR]　[WOS]
Chen J-B, Liu EM, Chern T-R, Yang C-W, Lin C-I, Huang N-K, LinY-L, Chern Y, Lin J-H, and Fang J-M. Design and Synthesis of Novel Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection. ChemMedChem. 6, 1390-1400, 2011. [JCR]　[WOS]
Lin Y-S, Chen C-M, Soong B-W, Wu Y-R, Chen H-M, Yeh W-Y, Wu D-R, Lin Y-J, Poon P-W, Cheng M-L, Wang C-H, and Chern Y*. Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease. Journal of Clinical Investigation. 121(4), 1519, 2011. [JCR]　[WOS]
Ju T-C, Chen H-M, Lin J-T, Chang C-P, Chang W-C, Kang J-J, Sun C-P, Tao M-H, Tu P-H, Chang C, Dickson DW, and Chern Y. Nuclear translocation of AMP-activated protein kinase a1 potentiates striatal neurodegeneration in Huntington’s disease. Journal of Cell Biology 194: 209 - 227. JOURNAL OF CELL BIOLOGY. 194, 209-227, 2011. [JCR]　[WOS]
Chiang M-Cx, Chern Y, Juo C-G. The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1812(9), 1111-1120, 2011. [JCR]　[WOS]
Chiang M-C, Chen C-M, Lee M-R, Chen H-W, Chen H-M, Wu Y-S, Hung C-H, Kang J-J, Chang C-P, Chang C, Wu Y-R, Tsai Y-S, Chern Y*. Modulation of energy deficiency in Huntington’s disease via activation of the peroxisome proliferator-activated receptor gamma. Human Molecular Genetics. 19, 4043, 2010-10. [JCR]　[WOS]
Su C-K*, Fan Y-P, Chen C-C, Chern Y. Supraspinal contribution to splanchnic sympathetic activity in neonatal mouse and rat brainstem-spinal cord in vitro . AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL. 156, 51-59, 2010-08. [JCR]　[WOS]
Chien C-L, Wu-Y-S, Lai H-L, Chen Y-H, Jiang S-T, Shih C-M, Lin S-S, Chang C, and Chern Y. Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6). FEBS LETTERS. 584, 2883-2890, 2010-07. [JCR]　[WOS]
Sun C-N, Chuang H-C, Wang J-Y, Chen S-Y, Cheng Y-Y, Chern Y. The A2A adenosine receptor rescues neuritogenesis impaired by p53 blockage via KIF2A, a kinesin family member. Developmental Neurobiology. 70, 604-621, 2010-07. [JCR]　[WOS]
Hsiao H-Y and Chern Y. Targeting glial cells to elucidate the pathogenesis of Huntington's disease. Molecular Neurobiology. 41, 248-255, 2010-06. [JCR]　[WOS]
Lee M-J, Chang C-P, Lee Y-H, Wu Y-C, Tseng H-W, Tung Y-Y, Wu M-T, Chen Y-H, Kuo L-T, Stephenson D, Hung S-I, Wu J-Y, Chang C, Chen Y-T, "Chern Y"*. Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus. PLoS One. 4(11), e7868., 2009-11. [JCR]　[WOS]
Wang S-C, Lin J-T, and "Chern Y"*. Novel regulation of adenylyl cyclases by direct protein-protein interactions: insights from Sanpin and Ric8a. NeuroSignals. 17(3), 169-180, 2009-08. [JCR]　[WOS]
Chiang M-C, Chen H-M, Lai H-L, Chen H-W, Chou, S-Y, Chen C-M, Tsai F-J, and (Chern Y)*. The A2A adenosine receptor rescues the urea cycle deficiency of Huntington’s disease by enhancing the activity of the ubiquitin-proteasome system. Human Molecular Genetics. 18(16), 2929-2942, 2009-05. [JCR]　[WOS]
P. Popoli, D. Blum, M. R. Domenici, S. Burnouf and Y. Chern. A critical evaluation of adenosine A2A receptors as potentially ""druggable"" targets in Huntington's disease. CURRENT PHARMACEUTICAL DESIGN. 14(15), 1500-1511, 2008. [JCR]　[WOS]
S. Y. Chou, J. Y. Weng, H. L. Lai, F. Liao, S. H. Sun, P. H. Tu, D. W. Dickson and Y. Chern. Expanded-polyglutamine Huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J Neurosci. 28(13), 3277-3290, 2008. [JCR]　[WOS]
B. B. Fredholm, Y. Chern, R. Franco, and M. Sitkovsky. Aspects of the general biology of adenosine A2A signaling. Prog Neurobiol. 83(5), 263-276, 2007. [JCR]　[WOS]
M. C. Chiang, H. M. Chen, Y. H. Lee, H. H. Chang, Y. C. Wu, B. W. Soong, C. M. Chen, Y. R. Wu, C. S. Liu, D. M. Niu, J. Y. Wu, Y. T. Chen and Y. Chern. Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Hum Mol Genet. 16(5), 483-498, 2007. [JCR]　[WOS]
N. K. Huang, Y. Chern, J. M. Fang, C. I. Lin, W. P. Chen and Y. L. Lin. Neuroprotective principles from Gastrodia elata. J Nat Prod. 70, 571-574, 2007. [JCR]　[WOS]
S. C. Wang, H. L. Lai, Y. T. Chiu, R. Ou, C. L. Huang and Y. Chern. Regulation of type V adenylyl cyclase by Ric8a, a guanine nucleotide exchange factor. Biochem J. 406(3), 383-388, 2007. [JCR]　[WOS]
M. C. Chiang, C. G. Juo, H. H. Chang, H. M. Chen, E. C. Yi and Y. Chern. Systematic uncovering of multiple pathways underlying the pathology of Huntington's disease by an acid-cleavable isotope-coded affinity tag approach. Mol Cell Proteomics. 6, 781-797, 2007. [JCR]　[WOS]
C. N. Sun, H. C. Cheng, J. L. Chou, S. Y. Lee, Y. W. Lin, H. L. Lai, H. M. Chen and Y. Chern. Rescue of p53 blockage by the A2A adenosine receptor via a novel interacting protein, Translin-associated protein X. Mol Pharmacol. 70(2), 454-466, 2006. [JCR]　[WOS]
S. Y. Chou, Y. C. Lee, H. M. Chen, M. C. Chiang, H. L. Lai, H. H. Chang, Y. C. Wu, C. N. Sun, C. L. Chien, Y. S. Lin, S. C. Wang, Y. Y. Tung, C. Chang and C. Chern. CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. J Neurochem. 93, 310-320, 2005. [JCR]　[WOS]
M. C. Chiang, Y. C. Lee, C. L. Huang and Y. Chern. CREB contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues. J Biol Chem. 280, 14331-14340, 2005. [JCR]　[WOS]
Y. Y. Kao, H. L. Lai, M. J. Hwang and Y. Chern. An Important functional role of the N terminus domain of type VI adenylyl cyclase (ACVI) in Gia-mediated inhibition. J Biol Chem. 279, 34440-34448, 2004. [JCR]　[WOS]
Chou J-l, Huang C-L, Lai H-L, Hong A. C., Chien C-L, Kao Y-Y and Chern Y. Regulation of type VI adenylyl cyclase by Snapin, a SNAP25 interacting protein. J. Biol. Chem.. 279, 46271-46279, 2004. [JCR]　[WOS]
Lee Y-C, Chien C-L, Sun C-N, MC Chiang, Huang C-L, Huang N-K, Lai H-L, Lin Y-S, Chiou S-Y, Liao W-L, Liu F-C, Wang L, Tai M-H, Lin T-N and Chern Y. Characterization of the rat A2A adenosine receptor gene: a 4.8-kb promoter-proximal DNA fragment confers selective expression in the central nervous system. Eur. J. Neurosci.. 18, 1786-1796, 2003. [JCR]　[WOS]
Huang C-L, Huang N-K, Shyue S-K and Chern Y. H2O2 induces loss of dopamine transporter activity: a calcium-dependent oxidative mechanism. J. Neurochem.. 86, 1247-1259, 2003. [JCR]　[WOS]
C. L. Huang, N. K. Huang, S. K. Shyue and Y. Chern. Hydrogen peroxide induces loss of dopamine transporter activity: a calcium-dependent oxidative mechanism. J Neurochem. 86, 1247-1259, 2003. [JCR]　[WOS]
Y. C. Lee, H. L. Lai, C. N. Sun, C. L. Chien and Y. Chern. Identification of nuclear factor 1 (NF1) as a transcriptional modulator of rat A(2A) adenosine receptor. Brain Res Mol Brain Res. 111, 61-73, 2003. [JCR]　[WOS]
H. C. Cheng, H. M. Shih and Y. Chern. Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade. J Biol Chem. 277, 33930-33942, 2002. [JCR]　[WOS]
T. H. Lin, H. L. Lai, Y. Y. Kao, C. N. Sun, M. J. Hwang and Y. Chern. Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains. J Biol Chem. 277, 15721-15728, 2002. [JCR]　[WOS]
N. K. Huang, Y. W. Lin, C. L. Huang, R. O. Messing and Y. Chern. Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells. J Biol Chem. 276, 13838-13846, 2001. [JCR]　[WOS]
G. C. Wu, H. L. Lai, Y. W. Lin, Y. T. Chu and Y. Chern. N-glycosylation and residues Asn805 and Asn890 are involved in the functional properties of type VI adenylyl cyclase. J Biol Chem. 276, 35450-35457, 2001. [JCR]　[WOS]
Y. Chern. Regulation of adenylyl cyclase in the central nervous system. Cell Signal. 12, 195-204, 2000. [JCR]　[WOS]
C. L. Huang, H. C. Chen, N. K. Huang, D. M. Yang, L. S. Kao, J. C. Chen, H. L. Lai and Y. Chern. Modulation of dopamine transporter activity by nicotinic acetylcholine receptors and membrane depolarization in rat pheochromocytoma PC12 cells. J Neurochem. 72, 2437-2444, 1999. [JCR]　[WOS]
Y. C. Lee, C. W. Chang, C. W. Su, T. N. Lin, S. H. Sun, H. L. Lai and Y. Chern. The 5' untranslated regions of the rat A2A adenosine receptor gene function as negative translational regulators. J Neurochem. 73, 1790-1798, 1999. [JCR]　[WOS]
H. L. Lai, T. H. Lin, Y. Y. Kao, W. J. Lin, M. J. Hwang and Y. Chern. The N terminus domain of type VI adenylyl cyclase mediates its inhibition by protein kinase C. Mol Pharmacol. 56, 644-650, 1999. [JCR]　[WOS]
F. C. Liu, G. C. Wu, S. T. Hsieh, H. L. Lai, H. F. Wang, T. W. Wang and Y. Chern. Expression of type VI adenylyl cyclase in the central nervous system: implication for a potential regulator of multiple signals in different neurotransmitter systems. FEBS Lett. 436, 92-98, 1998. [JCR]　[WOS]
Y. H. Chang, M. Conti, Y. C. Lee, H. L. Lai, Y. H. Ching and Y. Chern. Activation of phosphodiesterase IV during desensitization of the A2A adenosine receptor-mediated cyclic AMP response in rat pheochromocytoma (PC12) cells. J Neurochem. 69, 1300-1309, 1997. [JCR]　[WOS]
H. L. Lai, T. H. Yang, R. O. Messing, Y. H. Ching, S. C. Lin and Y. Chern. Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response. J Biol Chem. 272, 4970-4977, 1997. [JCR]　[WOS]
Y. Y. Chu, K. H. Tu, Y. C. Lee, Z. J. Kuo, H. L. Lai and Y. Chern. Characterization of the rat A2a adenosine receptor gene. DNA Cell Biol. 15, 329-337, 1996. [JCR]　[WOS]
Y. Chern, E. H. Lee, H. L. Lai, H. L. Wang, Y. C. Lee and Y. H. Ching. Circadian rhythm in the Ca(2+)-inhibitable adenylyl activity of the rat striatum. FEBS Lett. 385, 205-208, 1996. [JCR]　[WOS]
I. Uphues, Y. Chern and J. Eckel. Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats. FEBS Lett. 377, 109-112, 1995. [JCR]　[WOS]
Y. Chern, J. Y. Chiou, H. L. Lai and M. H. Tsai. Regulation of adenylyl cyclase type VI activity during desensitization of the A2a adenosine receptor-mediated cyclic AMP response: role for protein phosphatase 2A. Mol Pharmacol. 48, 1-8, 1995. [JCR]　[WOS]
Chen L -M, Liang Y, Tai J-H and Chern Y. Comparison of nitrocellulose and PVDF membranes in GTP-overlay assay and Western blot analysis. BIOTECHNIQUES. 16(4), 600-601, 1994. [JCR]　[WOS]
Y. C. Su, L. S. Kao, Y. Y. Chu, Y. Liang, M. H. Tsai and Y. Chern. Distribution and regulation of rab3C, a small molecular weight GTP-binding protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 200, 1257-1263, 1994. [JCR]　[WOS]
L. M. Chen, Y. Chern, S. J. Ong and J. H. Tai. Molecular cloning and characterization of a ras-related gene of ran/tc4/spi1 subfamily in Giardia lamblia. J Biol Chem. 269, 17297-17304, 1994. [JCR]　[WOS]
Y. Chern, H. L. Lai, J. C. Fong and Y. Liang. Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells. Mol Pharmacol. 44, 950-958, 1993. [JCR]　[WOS]
L. Feldman, R. Heinzerling, R.P. Hillam, Y. Chern, J.G. Frazier, K.L. Davis and A.J. Sytkowski. Four unique monoclonal antibodies to the putative receptor binding domain of erythropoietin inhibit the biological function of the hormone. Exp Hematol. 20, 64-68, 1992. [JCR]　[WOS]
Y. Chern, K. King, H. L. Lai and H. T. Lai. Molecular cloning of a novel adenosine receptor gene from rat brain. Biochemical and Biophysical Research Communications. 185, 304-309, 1992. [JCR]　[WOS]
Y. J. Chern, S. H. Chueh, Y. J. Lin, C. M. Ho and L. S. Kao. Presence of Na+/Ca2+ exchange activity and its role in regulation of intracellular calcium concentration in bovine adrenal chromaffin cells. Cell Calcium. 13, 99-106, 1992. [JCR]　[WOS]
Y. J. Chern, M. Bott, P. J. Chu, Y. J. Lin, L. S. Kao and E. W. Westhead. The adenosine analogue, N6-L-phenylisopropyladenosine inhibits catecholamine secretion from bovine adrenal medulla cells by inhibiting calcium influx. J Neurochem. 59, 1399-1404, 1992. [JCR]　[WOS]
Y.J. Chern, R. Spangler, H. S. Choi and A. J. Sytkowski. Erythropoietin activates the receptor in both Rauscher and Friend murine erythroleukemia cells. J Biol Chem. 266, 2009-2012, 1991. [JCR]　[WOS]
S. Yonekura, Y.J. Chern, K.A. Donahue, L. Feldman, G.J. Vanasse and A. J. Sytkowski. Erythropoietin receptor induced by dimethyl sulfoxide exhibit positive cooperativity associated with an amplified biologic response. Proceedings of the National Academy of Sciences of the United States of America. 88, 2535-2539, 1991. [JCR]　[WOS]
Y. J. Chern, C. J. O'hara and A. J. Sytkowski. Induction of hemoglobin synthesis by down-regulation of myb protein with an antisense oligodeoxynucleotide. Blood. 78, 991-996, 1991. [JCR]　[WOS]
Y. Chern, T. Chung and A. J. Sytkowski. Structural role of amino acids 99-110 recombinant human erythropoietin. Eur J Biochem. 202, 225-229, 1991. [JCR]　[WOS]
Y. J. Chern, S. Yonekura and A. J. Sytkowski. Dimethyl sulfoxide amplification of the erythropoietin response: clues to the signal transduction pathway. Progress in clinical and biological research. 352, 161-167, 1990. [JCR]
Y. J. Chern, S. Yonekura and A. J. Sytkowski. Potentiation of the erythropoietin response by dimethyl sulfoxide priming of erythroleukemia cells: evidence for interaction of two signaling pathways. Blood. 76, 2204-2209, 1990. [JCR]　[WOS]
Y. J. Chern, K. T. Kim, L. L. Slakey and E. W. Westhead. Adenosine receptors activate adenylate cyclase and enhance secretion from bovine adrenal chromaffin cells in the presence of forskolin. J Neurochem. 50, 1484-1493, 1988. [JCR]　[WOS]
Y. J. Chern, M. Herrera, L. S. Kao and E. W. Westhead. Inhibition of catecholamine secretion from bovine chromaffin cells by adenine nucleotides and adenosine. JOURNAL OF NEUROCHEMISTRY. 48, 1573-1576, 1987. [JCR]　[WOS]

Book 4

Chen J-F, Lee C-F, Chern Y Adenosine Receptors in Neurology and Psychiatry- Adenosine receptor neurobiology: overview. 119: 1-19, 2014-10.
Lee, C. F. Chern, Y. International review of neurobiology-Adenosine receptors and Huntington's disease. 119:195-232., 2014-10.
Chen J-Fx and Chern Y. Impacts of Methylxanthines and Adenosine Receptors on Neurodegeneration: Human and Experimental Studies. B. 200, 267-310, 2011.
Chern Y, Yonekura S and Sytkowski AJ Dimethyl sulfoxide amplification of the erythropoietin response: clues to the signal transduction pathway. in The Biology of Hematopoiesis. 352, 161-167, 1990.