Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 嚴仲陽 Yen, Jeffrey J.Y.

Journal 43

Chen LY, Lin KR, Chen YJ, Chiang YJ, Ho KC, Shen LF, Song IW, Liu KM, Yang-Yen HF, Chen YJ, Chen YT, Liu FT, (Yen JJY)*. Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 140(5),959-, 2020-05. [JCR]　[WOS]
Yun-Jung Chiang, Wei-Ting Liao, Kun-Chin Ho, Shih-Hao Wang, Yu-Guang Chen, Ching-Liang Ho, Shiu-Feng Huang, Lee-Yung Shih, Hsin-Fang Yang-Yen & Jeffrey Jong-Young Yen. CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia. ONCOGENE. 38(9), 1432-1447, 2019. [JCR]　[WOS]
Liu CS, Yang-Yen HF, Suen CS, Hwang MJ, Yen JJ. Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction. Scientific reports. 7(1), 4613, 2017. [JCR]　[WOS]
Yao L, Mustafa N, Tan EC, Poulsen A, Singh P, Duong-Thi MD, Lee JXT, Ramanujulu PM, Chng WJ, Yen JJY, Ohlson S, Dymock BW. Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat. Journal of medicinal chemistry. 60(20), 8336-8357, 2017. [JCR]　[WOS]
Chen LY, Yang-Yen HF, Tsai CC, Thio CL, Chuang HL, Yang LT, Shen LF, Song IW, Liu KM, Huang YT, Liu FT, Chang YJ, Chen YT, Yen JJY. Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis. The Journal of investigative dermatology. 137(4), 894-904, 2017. [JCR]　[WOS]
Shen LF, Chen YJ, Liu KM, Haddad ANS, Song IW, Roan HY, Chen LY, Yen JJY, Chen YJ, Wu JY, Chen YT. Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver. Scientific reports. 7(1), 2182, 2017. [JCR]　[WOS]
Wei Shu-Chen, Yang-Yen Hsin-Fang, Tsao Po-Nien, Weng Meng-Tzu, Tung Chien-Chih, Yu Linda C. H., Lai Liang-Chuan, Hsiao Jen-Hao, Chuang Eric Y., Shun Chia-Tung, Ni Yen-Hsuan, Xavier Ramnik J., Podolsky Daniel K., Yen Jeffery J. Y., Wong Jau-Min. SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway. Inflammatory Bowel Diseases. 23(10), 1730-1740, 2017. [JCR]　[WOS]
Yang EG, Mustafa N, Tan EC, Poulsen A, Ramanujulu PM, Chng WJ, Yen JJ, Dymock BW. Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines. Journal of medicinal chemistry. 59(18), 8233-62, 2016. [JCR]　[WOS]
Lu CH, Wu CJ, Chan CC, Nguyen DT, Lin KR, Lin SJ, Chen LC, Yen JJ, Kuo ML. DNA Methyltransferase Inhibitor Promotes Human CD4+CD25hFOXP3+ Regulatory T Lymphocyte Induction under Suboptimal TCR Stimulation. Frontiers in immunology. 7, 488, 2016. [JCR]　[WOS]
Lin KR, Yang-Yen HF, Lien HW, Liao WH, Huang CJ, Lin LI, Li CL, Yen JJ. Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice. Scientific reports. 6, 31444, 2016. [JCR]　[WOS]
Lee YL, Yen JJ, Hsu LC, Kuo NW, Su MW, Yang MF, Hsiao YP, Wang IJ, Liu FT. Association of STAT6 genetic variants with childhood atopic dermatitis in Taiwanese population. Journal of dermatological science. 79(3), 222-8, 2015. [JCR]　[WOS]
Liu KM, Chen YJ, Shen LF, Haddad AN, Song IW, Chen LY, Chen YJ, Wu JY, Yen JJ, Chen YT. Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. The Journal of investigative dermatology. 135(11), 2603-10, 2015. [JCR]　[WOS]
Ho KC, Chiang YJ, Lai AC, Liao NS, Chang YJ, Yang-Yen HF, Yen JJ. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell death & disease. 5, e1518, 2014. [JCR]　[WOS]
Song IW, Li WR, Chen LY, Shen LF, Liu KM, Yen JJ, Chen YJ, Chen YJ, Kraus VB, Wu JY, Lee MT, Chen YT. Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. PloS one. 9(3), e92194, 2014. [JCR]　[WOS]
Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF, Yen JJ. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PloS one. 8(4), e61761, 2013. [JCR]　[WOS]
Lin KR, Li CL, Yen JJ, Yang-Yen HF. Constitutive phosphorylation of GATA-1 at serine(2)(6) attenuates the colony-forming activity of erythrocyte-committed progenitors. PloS one. 8(5), e64269, 2013. [JCR]　[WOS]
Liang CC, You LR, Yen JJ, Liao NS, Yang-Yen HF, Chen CM. Thymic epithelial beta-catenin is required for adult thymic homeostasis and function. Immunology and cell biology. 91(8), 511-523, 2013. [JCR]　[WOS]
Chen PH, Chien FC, Lee SP, Chan WE, Lin IH, Liu CS, Lee FJ, Lai JS, Chen P, Yang-Yen HF, Yen JJ. Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2. Cell Cycle. 11(19), 3611-3626, 2012. [JCR]　[WOS]
Yang SH, Teng HW, Hong YC, Liu CY, Yu YB, Yang CF, Gau JP, Liu JH, Chang TJ, Yen JJ, Chen PM, Chiou TJ, Tzeng CH, Hsiao LT. International Staging System predicts prognosis of Chinese patients with multiple myeloma across different calendar periods with application of novel agents. Annals of hematology. 91(1), 93-102, 2012. [JCR]　[WOS]
4. Weng SY, Yang CY, Li CC, Sun TP, Tung SY, (Yen JJ), Tsai TF, Chen CM, Chen SH, Hsiao M, Huang PH, Yang-Yen HF*. . Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. JOURNAL OF HEPATOLOGY. 54, 685-694, 2011-04. [JCR]　[WOS]
Krebs P, Fan W, Chen YH, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EM, Boyer TG, Lo CW, Yen J, Evans RM, Beutler B. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proceedings of the National Academy of Sciences of the United States of America. 108(49), 19678-19682, 2011. [JCR]　[WOS]
Saleem AN, Chen YH, Baek HJ, Hsiao YW, Huang HW, Kao HJ, Liu KM, Shen LF, Song IW, Tu CP, Wu JY, Kikuchi T, Justice MJ, Yen JJ, Chen YT. Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. PLoS Genetics. 6(6), e1000985, 2010-06. [JCR]　[WOS]
Peih-Shan Wu, Chia-Yu Yang, "Jeffrey Jong-Young Yen", Chiang-Hung Chou, Sung Ho Chen, Chi-Kuang Leo Wang, Yein-Gei Lai, Nan-Shih Liao, and Hsin-fang Yang-Yen*. Critical Roles of Translationally Controlled Tumor Protein in the Homeostasis and TCR-Mediated Proliferation of Peripheral T Cells. JOURNAL OF IMMUNOLOGY. 183(4), 2373-2381, 2009-08. [JCR]　[WOS]
Chia-Yu Yang, Nai-Hui Lin, Jan-Mou Lee, Ching-Yu Huang, Hsiang-Ju Min, "Jeffrey Jong-Young Yen", Nan-Shih Liao, and Hsin-Fang Yang-Yen*. Promoter Knock-In Mutations Reveal a Role of Mcl-1 in Thymocyte-Positive Selection and Tissue or Cell Lineage-Specific Regulation of Mcl-1 Expression. JOURNAL OF IMMUNOLOGY. 182(5), 2959-2968, 2009-03. [JCR]　[WOS]
C. J. Kao, Y. J. Chiang, P. H. Chen, K. R. Lin, P. I. Hwang, H. F. Yang-Yen and J. J. Yen. CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. Oncogene. 27(10), 1397-1403, 2008. [JCR]　[WOS]
H. W. Huang, Y. J. Chiang, S. I. Hung, C. L. Li and J. J. Yen. An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis. J Biomed Sci. 14(2), 169-181, 2007. [JCR]　[WOS]
K. R. Lin, S. F. Lee, C. M. Hung, C. L. Li, H. F. Yang-Yen, and J. J. Y. Yen. Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1-axis-dependent pathway. J Biol Chem. 282(30), 21962-21972, 2007. [JCR]　[WOS]
S. H. Juan, J. J. Yen, H. M. Lee and H. M. Huang. IL-5 inhibits apoptosis by upregulation of c-myc expression in human hematopoietic cells. Annals of the New York Academy of Sciences. 1042, 481-487, 2005. [JCR]　[WOS]
Y. L. Yu, Y. J. Chiang, Y. C. Chen, M. Papetti, C. G. Juo, A. I. Skoultchi and J. J. Yen. MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. J Biol Chem. 280, 29533-29542, 2005. [JCR]　[WOS]
Hsieh, Y.C., Chang, M.S., Chen, J.Y., Yen, J.J.Y., Lu, I.C., Chou, C.M., and Huang, C.J.2003. Cloning of zebrafish BAD, a BH3-only proapototic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos. Biochemical and Biophysical Research Communications. 304, 667-675, 2003. [JCR]　[WOS]
Y. L. Yu, Y. J. Chiang and J. J. Yen. GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells. J Biol Chem. 277, 27144-27153, 2002. [JCR]　[WOS]
W. Chen, Y. L. Yu, S. F. Lee, Y. J. Chiang, J. R. Chao, J. H. Huang, J. H. Chiong, C. J. Huang, M. Z. Lai, H. F. Yang-Yen and J. J. Yen. CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal. Mol Cell Biol. 21, 4636-4646, 2001. [JCR]　[WOS]
Y. H. Lin, C. J. Huang, J. R. Chao, S. T. Chen, S. F. Lee, J. J. Yen and H. F. Yang-Yen. Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor. Mol Cell Biol. 20, 2734-2742, 2000. [JCR]　[WOS]
H. M. Huang, C. J. Huang and J. J. Yen. Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways. Blood. 96, 1764-1771, 2000. [JCR]　[WOS]
S. F. Lee, H. M. Huang, J. R. Chao, S. Lin, H. F. Yang-Yen and J. J. Yen. Cytokine receptor common beta chain as a potential activator of cytokine withdrawal-induced apoptosis. Mol Cell Biol. 19, 7399-7409, 1999. [JCR]　[WOS]
H. M. Huang, J. C. Li, Y. C. Hsieh, H. F. Yang-Yen and J. J. Yen. Optimal proliferation of a hematopoietic progenitor cell line requires either costimulation with stem cell factor or increase of receptor expression that can be replaced by overexpression of Bcl-2. Blood. 93, 2569-2577, 1999. [JCR]　[WOS]
J. M. Wang, J. R. Chao, W. Chen, M. L. Kuo, J. J. Yen and H. F. Yang-Yen. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol. 19, 6195-6206, 1999. [JCR]　[WOS]
J. R. Chao, J. M. Wang, S. F. Lee, H. W. Peng, Y. H. Lin, C. H. Chou, J. C. Li, H. M. Huang, C. K. Chou, M. L. Kuo, J. J. Yen and H. F. Yang-Yen. mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol Cell Biol. 18, 4883-4898, 1998. [JCR]　[WOS]
Chao, J.R., Chen, C.S. Wang, T.F., Tseng, L.H., Tsai, J.J., Kuo, M.L., Yen, J.J.Y. andYang-Yen, H.F. Characterization of factor-independent variants dervied from TF-1 hematopoietic progentor cells: the role of the Raf/MAP kinase pathway in the anti-apoptic effect of GM-CSF. Oncogene. 14, 721-728, 1997. [JCR]　[WOS]
K. Peck, S. L. Wung, G. S. Chang, J. J. Yen and Y. Z. Hsieh. Restriction mapping of genes by capillary electrophoresis with laser-induced fluorescence detection. Anal Chem. 69, 1380-1384, 1997. [JCR]　[WOS]
M. C. Jiang, H. F. Yang-Yen, J. K. Lin and J. J. Yen. Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells. Oncogene. 13, 609-616, 1996. [JCR]　[WOS]
Liu, J.J., J.R. Chao, M.C. Jiang, S.Y. Ng, J.J-Y.Yen, and H.F. Yang-Yen. Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol Cell Biol. 15, 3654-3663, 1995. [JCR]　[WOS]
J. J. Yen, Y. C. Hsieh, C. L. Yen, C. C. Chang, S. Lin and H. F. Yang-Yen. Restoring the apoptosis suppression response to IL-5 confers on erythroleukemic cells a phenotype of IL-5-dependent growth. J Immunol. 154, 2144-2152, 1995. [JCR]　[WOS]

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