Academia Sinica Life Science Library -- Research Findings

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Research Findings

Inst. of Biomedical Sciences - 譚婉玉 Tarn, Woan-Yuh

Journal 75

Chia-Lin Yu, Tzu-Wei Chuang, Sabrina Yeo Samuel, Yuan-Chao Lou, and Woan-Yuh Tarn*. Co-phase separation of Y14 and RNA in vitro and its implication for DNA repair. RNA. 29, 1-15, 2023-03. [JCR]　[WOS]
Ko, S.-H., Liau, Y.-J., Chi, Y.-H., Lai, M.-J., Chiang, Y.-P., Lu, C.-Y., Chang, L.-Y., Tarn, W.-Y.*, and Huang, L.-M.*. Interference of DNAJB6/MRJ isoform switch by morpholino inhibits replication of HIV-1 and RSV. MOLECULAR THERAPY-NUCLEIC ACIDS. 14, 251-261, 2019-03. [JCR]　[WOS]
Shen CL, Tsai YY, Chou SJ, Chang YM, (Tarn WY)*. RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation. Communications Biology. 7, 1712, 2024-12-30.
Chen HH, Hsin-I Yu HI, Chang J JS, Li CW, Yang MH, Hung MC, (Tarn WY)*. DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1. Cell Reports. 43, 113937, 2024-03-26. [JCR]　[WOS]
Tsai YY, Shen CL, D D, Tsai CY, Tarn WY. Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Communications biology. 6, 910, 2023-09. [JCR]　[WOS]
Tzu-Wei Chuang, Chun-Hao Su, Pei-Yu Wu, Yao-Ming Chang and Woan-Yuh Tarn*. LncRNA HOTAIRM1 functions in DNA double-strand break repair via its association with DNA repair and mRNA surveillance factors. NUCLEIC ACIDS RESEARCH. 51, 1-19, 2023-03. [JCR]　[WOS]
Lai MC*, Chen YP, Li DA, Yu JS, Hung HY, Tarn WY*. DDX3 interacts with USP9X and participates in deubiquitination of the anti-apoptotic protein MCL1. The FEBS journal. 289, 1043-1061, 2022-02. [JCR]　[WOS]
Tarn, W.-Y.*, Cheng, Y., Ko, S-H., and Huang, L.-M.*. Antisense oligonucleotide-based therapy of viral infections. Pharmaceutics. 13, 2015, 2021-11. [JCR]　[WOS]
Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY*. The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia. iScience. 24(11), 103368, 2021-10. [JCR]　[WOS]
Chen HH, Yu HI, Rudy R, Lim SL, Chen YF, Wu SH, Lin SC, Yang MH, Tarn WY*. DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience. 24(9), 103086, 2021-09. [JCR]　[WOS]
Tsai YY, Su CH, Tarn WY*. p53 Activation in Genetic Disorders: Different Routes to the Same Destination. International journal of molecular sciences. 22(17), 9307, 2021-08. [JCR]　[WOS]
Ko SH, Huang LM*, Tarn WY*. The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection. Frontiers in microbiology. 10, 2885, 2019-12. [JCR]　[WOS]
Chen HH, Tarn WY*. uORF-mediated translational control: recently elucidated mechanisms and implications in cancer. RNA biology. 16(10), 1327-1338, 2019-10. [JCR]　[WOS]
Chuang, T.-W., Lu, C.-C., Su, C.-H., Wu, P.-Y., Easwvaran S., Lee, C.-C., Kuo, H.-C., Hung, K.-Y., Lee, K.-M., Tsai, C.-Y., and Tarn, W.-Y.*. The RNA processing factor Y14 participates in DNA damage response and repair. iScience. 13, 402-415, 2019-03. [JCR]　[WOS]
Ku, Y.-C., Lai, M.-H., Lo, C.-C., Cheng, Y.-C., Qiu, J.-T., Tarn, W.-Y., Lai, M.-C. DDX3 participates in translational control of inflammation induced by infections and injuries. MOLECULAR AND CELLULAR BIOLOGY. 39, pii: e00285-18, 2018-12. [JCR]　[WOS]
Chen, H.-H., Yu, H.-I., Yang, M.-H., Tarn, W.-Y.*. DDX3 activates CBC-eIF3-mediated translation of uORF-containing oncogenic mRNAs to promote metastasis in HNSCC. CANCER RESEARCH. 78, 4512-4523, 2018-08. [JCR]　[WOS]
D, D., Hung, K.-Y., and Tarn, W.-Y.*. RBM4 modulates radial migration via alternative splicing of Dab1 during cortex development. MOLECULAR AND CELLULAR BIOLOGY. 38, e00007-18, 2018-05. [JCR]　[WOS]
Su, C.-H., Dhananjaya, D., and Tarn, W.-Y.*. Alternative splicing in neurogenesis and brain development. Frontiers in molecular biosciences. 5, 12, 2018-02. [JCR]　[WOS]
Lu Chia-Chen, Lee Chi-Chieh, Tseng Ching-Tzu, Tarn Woan-Yuh. Y14 governs p53 expression and modulates DNA damage sensitivity. Scientific Reports. 7, 45558, 2017-03. [JCR]　[WOS]
Su CH, Hung KY, Hung SC, and Tarn WY.*. RBM4 regulates neuronal differentiation of mesenchymal stem cells by modulating alternative splicing of pyruvate kinase M. . MOLECULAR AND CELLULAR BIOLOGY. 37(3), e00466-16, 2017-02. [JCR]　[WOS]
Chen HH, Yu HI, and Tarn WY.*. DDX3 modulates neurite development via translationally activating an RNA regulon involved in Rac1 activation. The Journal of Neuroscience. 36(38), 792-804, 2016-09. [JCR]　[WOS]
Chuang TW, Lee KM, Lou YC, Lu CC, and Tarn WY.*. A point mutation in Y14 disrupts its function in mRNA cap binding and translation enhancement. J. Biol. Chem.. 291(16), 565-574, 2016-04. [JCR]　[WOS]
Tarn WY,* Kuo HC, Yu HI, Liu SW, Tseng CT, Dhananjaya D, Hung KY, Tu CC, Chang SS, Huang GJ, and Chiu IM. RBM4 promotes neuronal differentiation and neurite outgrowth via modulating Numb isoform expression. . Mol. Biol. Cell.. 27(10), 1676-1683, 2016-03. [JCR]　[WOS]
Lai MC*, Sun HS, Wang SW, and Tarn WY.*. DDX3 functions in antiviral innate immunity through translational control of PACT. FEBS J.. 1843(4), 769-779, 2016-01. [JCR]　[WOS]
Chen HH, Yu HI, Cho WC, and Tarn WY.*. DDX3 modulates cell adhesion and motility, and cancer cell metastasis via the Rac1-mediated signaling pathway. Oncogene. 34, 2790-2800, 2015. [JCR]　[WOS]
Chuang TW, Lee KM, and Tarn WY.*. Function and pathological implications of exon junction complex factor Y14. Biomolecules. 5(2), 343-355, 2015. [JCR]　[WOS]
Tu CC, Zhong Y, Nguyen L, Tsai A, Sridevi P, Tarn WY, and Wang JY. The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage. Sci. Signal.. 8(383), 64, 2015. [JCR]　[WOS]
Chang SH, Chang WL, Lu CC, and Tarn WY.*. Alanine repeats influence protein localization in splicing speckles and paraspeckles. Nucleic Acids Res.. 42 (22), 13788-13798, 2014. [JCR]　[WOS]
Chen HH, and Tarn WY.*. DDX3-mediated translational activation drives β-catenin signaling and cancer cell motility. Cancer Cell and Microenvironment. 1(4), e392, 2014. [JCR]
Lin JC, Lin CY, Tarn WY, and Li FY. Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events. RNA. 20, 1621-1631, 2014. [JCR]　[WOS]
Lin JC, Tarn WY, and Hsieh WK. Emerging role for RNA binding motif protein 4 in the development of brown adipocytes. Biochimica et Biophysica Acta-Molecular Cell Research. 1843(4), 769-779, 2014. [JCR]　[WOS]
Lee KM, and Tarn WY.*. TRAP150 activates splicing in composite terminal exon. Nucleic Acids Res.. 42 (20), 12822-12832, 2014. [JCR]　[WOS]
Lai MC, Wang SW, Cheng L, Tarn WY, Tsai SJ, and Sun HS. Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. . PLoS One. 8(7), 0, 2013-07. [JCR]　[WOS]
Lee KM, and Tarn WY.*. Coupling pre-mRNA processing to transcription on the RNA factory assembly line. RNA Biol.. 10(3), 380-390, 2013-03. [JCR]　[WOS]
Lu CC, Chen TH, Wu JR, Chen HH, Yu HY, and Tarn WY.*. Phylogenetic and molecular characterization of the splicing factor RBM4. PLoS One. 8, 0, 2013-03. [JCR]　[WOS]
Chen PH, Lee CI, Weng YT, Tarn WY, Tsao YP, Kuo PC, Hsu PH, Huang CW, Huang CS, Wu JT, and Chen SL. BCAS2 is essential for Drosophila development and functions in pre-mRNA splicing. RNA. 19(2), 208-218, 2013-02. [JCR]　[WOS]
Lin JC, Yan YT, Hsieh WK, Peng PJ, Su CH, and Tarn WY.*. RBM4 promotes pancreas cell differentiation and insulin expression. Mol. Cell Biol.. 33(2), 319-327, 2013-01. [JCR]　[WOS]
Chuang TW, Chang WL, Lee KM, and Tarn WY.*. The RNA binding protein Y14 inhibits mRNA decapping and modulates processing body formation. . Mol. Biol. Cell.. 24(1), 1-13, 2013-01. [JCR]　[WOS]
Chen HH, Yu HY, Chiang WC, Lin YD, Shia BC, and Tarn WY.*. hnRNP Q regulates Cdc42-mediated neuronal morphogenesis. Mol. Cell. Biol.. 32(12), 2224-2238, 2012-06. [JCR]　[WOS]
Lin JC, and Tarn WY.*. Multiple roles of RBM4 in muscle cell differentiation. Front Biosci. (Schol Ed). 1(4), 181-189, 2012. [JCR]
Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chang YW, Chen JS, Yang PC, and Kuo ML. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. . J. Clin. Invest.. 121(9), 3442-3455, 2011-09. [JCR]　[WOS]
Sabbagha NGAA, Kao HJ, Yang CF, Huang CC, Lin WD, Tsai FJ, Chen TH, Tarn WY, Wu JY, and Chen YT. Alternative splicing in Acad8 resulting a mitochondrial defect, lower metabolic rate and progressive hepatic steatosis in mice. . Pediatric Research. 70, 31-36, 2011-08. [JCR]　[WOS]
Lin JC, and Tarn WY.*. RBM4 downregulates PTB and antagonizes its activity in muscle cell-specific alternative splicing. J. Cell Biol.. 193(3), 509-520, 2011. [JCR]　[WOS]
Lai MC, and Tarn WY.*. Translation control of cyclins. Cell Division. 6(5), 9, 2011. [JCR]　[WOS]
Chuang TW, Peng PJ, and Tarn WY.*. Y14 modulates the activity of the methylosome in biogenesis of spliceosomal snRNPs. J. Biol. Chem.. 286(11), 8722-8728, 2011. [JCR]　[WOS]
Lai MC, Chang WC, Shieh SY, and Tarn WY.*. DDX3 regulates cell growth through translational control of cyclin E1. Mol. Cell. Biol.. 30(22), 5444-5453, 2010. [JCR]　[WOS]
Maquat LE, Tarn WY, and Isken O. The pioneer round of translation: features and functions. Cell. 142(3), 368-374, 2010. [JCR]　[WOS]
Lee KM, Hsu IW, and Tarn WY.*. TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation. Nucleic Acids Res.. 38(10), 3340-3350, 2010. [JCR]　[WOS]
Lin JC, and Tarn WY.*. RBM4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation. J. Biol. Chem.. 284(50), 34658-346565, 2009-12. [JCR]　[WOS]
Chang WL, and Tarn WY.*. A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay. Nucleic Acids Res.. 37(19), 6600-6612, 2009-10. [JCR]　[WOS]
Lai MC, Peng TY, and Tarn WY.*. Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation. FEBS J. 276(6), 1517-1526, 2009. [JCR]　[WOS]
Tarn WY,* and Cheng TH.*. The current understanding of DDX3 homologs from yeast to human. RNA Biology. 6(1), 17-20, 2009. [JCR]　[WOS]
Chang WC, Chen HS, and Tarn WY.*. Alternative splicing of U12-type introns. Frontiers in Bioscience-Landmark. 13, 1681-1690, 2008. [JCR]　[WOS]
Peng TY, Lee KR, and Tarn WY.*. Phosphorylation of the arginine/serine dipeptide-rich motif of the SARS coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization. FEBS J. 275(16), 4152-63, 2008. [JCR]　[WOS]
Bose JK, Wang IF, Hung L, Tarn WY, and Shen CK. TDP-43 overexpression enhances exon-7 inclusion during SMN pre-mRNA splicing. J. Biol. Chem.. 283(43), 28852-28859, 2008. [JCR]　[WOS]
Lai MC, Lee YH, and Tarn WY.*. The DEAD-box RNA Helicase DDX3 Associates with Export mRNPs as well as TAP and Participates in Translational Control. Mol. Biol. Cell.. 19(9), 3847-3858, 2008. [JCR]　[WOS]
Chen HH, Leu RM, Peng TY, Chang JK, and Tarn WY.*. The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene. Mol. Cell. Biol.. 28(22), 6929-6938, 2008. [JCR]　[WOS]
Chang WC, Chen YC, Lee KM, and Tarn WY.*. Alternative splicing and bioinformatic analysis of human U12-type introns. Nucleic Acids Res.. 35(6), 1833-1841, 2007. [JCR]　[WOS]
Lin JC, Hsu M, and Tarn WY.*. Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. Proceedings of the National Academy of Sciences of the United States of America. 104(7), 2235-2240, 2007. [JCR]　[WOS]
Tarn WY.*. Cellular signals modulate alternative splicing. J. Biomed. Sci.. 14(4), 517-522, 2007. [JCR]　[WOS]
Tsai KW, Tarn WY*, and Lin WC. Wobble splicing reveals the role of the BPS-to-NAGNAG region in 3' tandem splice site selection. Mol. Cell. Biol.. 27(16), 5835-5848, 2007. [JCR]　[WOS]
Kar A, Havlioglu N, Tarn WY, and Wu JY. RBM4 interacts with an intronic element and stimulates Tau exon 10 inclusion. J. Biol. Chem.. 281(34), 24479-24488, 2006. [JCR]　[WOS]
Lin JC, and Tarn WY.*. Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. Mol. Cell. Biol.. 25(22), 10111-10121, 2005. [JCR]　[WOS]
Hsu IW, Hsu M, Li C, Chuang TW, Lin RI, and Tarn WY.*. Phosphorylation of Y14 modulates its interaction with proteins involved mRNA metabolism and influences its methylation. J. Biol. Chem.. 280(41), 34507-34512, 2005. [JCR]　[WOS]
Lai MC, and Tarn WY.*. Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins. J. Biol. Chem.. 279(30), 31745-31749, 2004. [JCR]　[WOS]
Lin KT, Leu RM, and Tarn WY.*. The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. Mol. Cell. Biol.. 24(20), 9176-9185, 2004. [JCR]　[WOS]
Lai MC, Kuo HW, Chang WC, and Tarn WY.*. A novel splicing regulator shares a nuclear import pathway with SR proteins. EMBO J.. 22(6), 1359-1369, 2003. [JCR]　[WOS]
Lai MC, Lin RI, and Tarn WY.*. Differential effects of hyperphosphorylation on splicing factor SRp55. Biochem. J.. 371(Pt 3), 937-945, 2003. [JCR]　[WOS]
Li C, Lin RI, Lai MC, Ouyang P, and Tarn WY.*. Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. Mol. Cell. Biol.. 23(20), 7363-7376, 2003. [JCR]　[WOS]
Lai MC, Lin RI, and Tarn WY.*. Transportin-SR2 mediates nuclear import of phosphorylated SR proteins. Proceedings of the National Academy of Sciences of the United States of America. 98(18), 10154-10159, 2001. [JCR]　[WOS]
Lai MC, Lin RI, Huang SY, Tsai CW, and Tarn WY.*. A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins. J. Biol. Chem.. 275(11), 7950-7957, 2000. [JCR]　[WOS]
Lai MC, The BH, and Tarn WY.*. A human papillomavirus E2 transcriptional activator. The interactions with cellular splicing factors and potential function in pre-mRNA processing. J. Biol. Chem.. 274(17), 11832-11841, 1999. [JCR]　[WOS]
Tarn WY, and Steitz JA. Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge. Trends Biochem. Sci.. 22(4), 132-137, 1997. [JCR]　[WOS]
Tarn WY. Site-specific substitution of inosine at the terminal positions of a pre-mRNA intron: implications for the configuration of the terminal base interaction. Biochimie.. 78(11-12), 1057-1065, 1996. [JCR]　[WOS]
Cheng S.-C., Tarn, W.-Y., Tsao, T. Y., and Abelson, J. PRP19: A novel spliceosomal component. MOLECULAR AND CELLULAR BIOLOGY. 13, 1876-1882, 1993. [JCR]　[WOS]

Book 5

Tu CC, and Tarn WY.* Splicing of pre-mRNA. 1, 2015.
Chen HH, Lin JC, and Tarn WY.* Recent advances in understanding of alternative splicing in neuronal pathogenesis. 207-228, 2011.
Lu YS, and Tarn WY.* Splicing of pre-mRNA. On-line, 2010-09.
Gopal G, and Tarn WY. RNA Binding Proteins in Development and Disease. 35-60, 2008.
Li C, and Tarn WY.* Splicing. 1788-1792, 2006.